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(+/-)-Narwedine | CAS:1668-86-6
(+/-)-Narwedine
  • Name:(+/-)-Narwedine
  • CAS:1668-86-6
  • Synonyms:(+/-)-3-Deoxy-3-oxogalanthamine; DL-Narwedine
  • Molecular Formula:C17H19NO3
  • Molecular Weight:285.34
  • EINESC:

Description

Properties

Density 1.28

Safety

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SDS

Source SDS/MSDS Samples
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Articles
Peer-Reviewed Papers
Comparative metabolomics analysis on invigorating blood circulation for herb pair Gui-Hong by ultra-high-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry and pattern recognition approach.Shujiao Li et al.Journal of pharmaceutical and biomedical analysis, 107, 456-463 (2015-02-11) A quantitative metabolomics peek into planarian regeneration.Nivedita Natarajan et al.The Analyst, 140(10), 3445-3464 (2015-03-31) Correlation of 3-mercaptopropionic acid induced seizures and changes in striatal neurotransmitters monitored by microdialysis.Eric W Crick et al.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 57, 25-33 (2014-01-28) Lysine and arginine biosyntheses mediated by a common carrier protein in Sulfolobus.Takuya Ouchi et al.Nature chemical biology, 9(4), 277-283 (2013-02-26) DHTKD1 mutations cause 2-aminoadipic and 2-oxoadipic aciduria.Katharina Danhauser et al.American journal of human genetics, 91(6), 1082-1087 (2012-11-13) [Pathophysiology of intraocular neovascularization].S Hori Nippon Ganka Gakkai zasshi, 94(12), 1103-1121 (1990-12-01) Variability of phenotype in two sisters with pyridoxine dependent epilepsy.Majid Alfadhel et al.The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 39(4), 516-519 (2012-06-26) Identification of the human mitochondrial oxodicarboxylate carrier. Bacterial expression, reconstitution, functional characterization, tissue distribution, and chromosomal location.G Fiermonte et al.The Journal of biological chemistry, 276(11), 8225-8230 (2000-11-18) A case of extreme prematurity and delayed diagnosis of pyridoxine-dependent epilepsy.Abdulaziz S Al-Saman et al.Neurosciences (Riyadh, Saudi Arabia), 17(4), 371-373 (2012-10-02) C. elegans metallothioneins: response to and defence against ROS toxicity.Sukaina Zeitoun-Ghandour et al.Molecular bioSystems, 7(8), 2397-2406 (2011-06-08) A new highly selective metabotropic excitatory amino acid agonist: 2-amino-4-(3-hydroxy-5-methylisoxazol-4-yl)butyric acid.H Bräuner-Osborne et al.Journal of medicinal chemistry, 39(16), 3188-3194 (1996-08-02) Engrafted human induced pluripotent stem cell-derived anterior specified neural progenitors protect the rat crushed optic nerveSatarian L, et al. Testing, 8(8), e71855-e71855 (2013) Tissue metabolite profiling identifies differentiating and prognostic biomarkers for prostate carcinoma.Klaus Jung et al.International journal of cancer, 133(12), 2914-2924 (2013-06-06) Amine metabolomics of hyperglycemic endothelial cells using capillary LC-MS with isobaric tagging.Wei Yuan et al.Journal of proteome research, 10(11), 5242-5250 (2011-10-04) Gas Chromatography-Quadrupole Time-of-Flight Mass Spectrometry-Based Determination of Isotopologue and Tandem Mass Isotopomer Fractions of Primary Metabolites for (13)C-Metabolic Flux Analysis.Teresa Mairinger et al.Analytical chemistry, 87(23), 11792-11802 (2015-10-30) [Regulatory mechanisms of novel lysine biosynthesis in thermophile].Makoto Nishiyama Seikagaku. The Journal of Japanese Biochemical Society, 84(4), 265-271 (2012-06-21) Functional coupling between neurons and glia.V Alvarez-Maubecin et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 20(11), 4091-4098 (2000-05-20) Lysine restricted diet for pyridoxine-dependent epilepsy: first evidence and future trials.Clara D M van Karnebeek et al.Molecular genetics and metabolism, 107(3), 335-344 (2012-10-02) Atherogenicity of amino acids in the lipid-laden macrophage model system in vitro and in atherosclerotic mice: a key role for triglyceride metabolism.Oren Rom et al.The Journal of nutritional biochemistry, 45, 24-38 (2017-04-22) Identification of N-acetyl-alpha-aminoadipic acid in the urine of a patient with alpha-aminoadipic and alpha-ketoadipic aciduria.T Takechi et al.Journal of inherited metabolic disease, 16(1), 119-126 (1993-01-01) Fluorescent HPLC for the detection of specific protein oxidation carbonyls - α-aminoadipic and γ-glutamic semialdehydes - in meat systems.Mariana Utrera et al.Meat science, 89(4), 500-506 (2011-06-07) Optimization and application of microwave-assisted acid hydrolysis for rapid quantification of protein oxidation markers using LC-MS.Somaieh Afiuni-Zadeh et al.Talanta, 85(4), 1835-1841 (2011-08-30) Dog rose (Rosa canina L.) as a functional ingredient in porcine frankfurters without added sodium ascorbate and sodium nitrite.Els Vossen et al.Meat science, 92(4), 451-457 (2012-06-16) Analysis of amino acid neurotransmitters from rat and mouse spinal cords by liquid chromatography with fluorescence detection.Nurullah Şanlı et al.Journal of pharmaceutical and biomedical analysis, 107, 217-222 (2015-01-18) Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression.Arun Sreekumar et al.Nature, 457(7231), 910-914 (2009-02-13) Reactive astrocytes contribute to increased epileptic susceptibility induced by subthreshold dose of pilocarpine.Wei Zhu et al.Epilepsy & behavior : E&B, 25(3), 426-430 (2012-11-06) Impact of gluconic fermentation of strawberry using acetic acid bacteria on amino acids and biogenic amines profile.J L Ordóñez et al.Food chemistry, 178, 221-228 (2015-02-24) Antidepressant-like effect of the mGluR5 antagonist MTEP in an astroglial degeneration model of depression.Helena Domin et al.Behavioural brain research, 273, 23-33 (2014-07-22) Role of Müller cells in cone mosaic rearrangement in a rat model of retinitis pigmentosa.Eun-Jin Lee et al.Glia, 59(7), 1107-1117 (2011-05-07) Profound neonatal hypoglycemia and lactic acidosis caused by pyridoxine-dependent epilepsy.Saadet Mercimek-Mahmutoglu et al.Pediatrics, 129(5), e1368-e1372 (2012-04-25) The fungal α-aminoadipate pathway for lysine biosynthesis requires two enzymes of the aconitase family for the isomerization of homocitrate to homoisocitrate.Felicitas Fazius et al.Molecular microbiology, 86(6), 1508-1530 (2012-10-31) Targeted analysis reveals alteration in pathway in 5p minus individuals.Danielle Zildeana Sousa Furtado et al.Biomedical chromatography : BMC, 34(1), e4673-e4673 (2019-08-07) Inhibition of reactive gliosis attenuates excitotoxicity-mediated death of retinal ganglion cells.Bhagyalaxmi S Ganesh et al.PloS one, 6(3), e18305-e18305 (2011-04-13) Oncosecretomics coupled to bioenergetics identifies α-amino adipic acid, isoleucine and GABA as potential biomarkers of cancer: Differential expression of c-Myc, Oct1 and KLF4 coordinates metabolic changes.Nadège Bellance et al.Biochimica et biophysica acta, 1817(11), 2060-2071 (2012-07-31) Gliotoxic effects of $\alpha$-aminoadipic acid on monolayer cultures of dissociated postnatal mouse cerebellumHuck S, et al. Neuroscience, 12(3), 783-791 (1984) Crosstalk between NFκB-dependent astrocytic CXCL1 and neuron CXCR2 plays a role in descending pain facilitation.Huadong Ni et al.Journal of neuroinflammation, 16(1), 1-1 (2019-01-05) Treatment with vigabatrin may mimic alpha-aminoadipic aciduria.C Vallat et al.Epilepsia, 37(8), 803-805 (1996-08-01) L-alpha-aminoadipic acid as a regulator of kynurenic acid production in the hippocampus: a microdialysis study in freely moving rats.H Q Wu et al.European journal of pharmacology, 281(1), 55-61 (1995-07-25) Aldehyde dehydrogenase 7A1 (ALDH7A1) attenuates reactive aldehyde and oxidative stress induced cytotoxicity.Chad Brocker et al.Chemico-biological interactions, 191(1-3), 269-277 (2011-02-23) Involvement of glial cells in the autoregulation of optic nerve head blood flow in rabbits.Maho Shibata et al.Investigative ophthalmology & visual science, 53(7), 3726-3732 (2012-05-17) Differential 12C-/13C-isotope dansylation labeling and fast liquid chromatography/mass spectrometry for absolute and relative quantification of the metabolome.Kevin Guo et al.Analytical chemistry, 81(10), 3919-3932 (2009-03-25) Dual-lifetime referencing (DLR): a powerful method for on-line measurement of internal pH in carrier-bound immobilized biocatalysts.Caterina Boniello et al.BMC biotechnology, 12, 11-11 (2012-03-30) Gliotoxin-induced swelling of astrocytes hinders diffusion in brain extracellular space via formation of dead-space microdomainsSherpa AD, et al. Glia, 62(7), 1053-1065 (2014) Structure-function investigation of 3-methylaspartate ammonia lyase reveals substrate molecular determinants for the deamination reaction.Veronica Saez-Jimenez et al.PloS one, 15(5), e0233467-e0233467 (2020-05-22) Free amino acids, biogenic amines, and ammonium profiling in tobacco from different geographical origins using microwave-assisted extraction followed by ultra high performance liquid chromatography.Kai Cai et al.Journal of separation science, 40(23), 4571-4582 (2017-11-14) Effects of irrigation over three years on the amino acid composition of Treixadura (Vitis vinifera L.) musts and wines, and on the aromatic composition and sensory profiles of its wines.Yolanda Bouzas-Cid et al.Food chemistry, 240, 707-716 (2017-09-28) Urinary AASA excretion is elevated in patients with molybdenum cofactor deficiency and isolated sulphite oxidase deficiency.Philippa B Mills et al.Journal of inherited metabolic disease, 35(6), 1031-1036 (2012-03-10) Pyridoxine-dependent epilepsy with elevated urinary α-amino adipic semialdehyde in molybdenum cofactor deficiency.Eduard Alexander Struys et al.Pediatrics, 130(6), e1716-e1719 (2012-11-14) Inhibition of the glutamate transporter and glial enzymes in rat striatum by the gliotoxin, alpha aminoadipate.G J McBean British journal of pharmacology, 113(2), 536-540 (1994-10-01) A QM/MM-based computational investigation on the catalytic mechanism of saccharopine reductase.Joel N Almasi et al.Molecules (Basel, Switzerland), 16(10), 8569-8589 (2011-10-14) 2-Aminoadipate-2-oxoglutarate aminotransferase isoenzymes in human liver: a plausible physiological role in lysine and tryptophan metabolism.E Okuno et al.Enzyme & protein, 47(3), 136-148 (1993-01-01) Aging, diabetes, and renal failure catalyze the oxidation of lysyl residues to 2-aminoadipic acid in human skin collagen: evidence for metal-catalyzed oxidation mediated by alpha-dicarbonyls.David R Sell et al.Annals of the New York Academy of Sciences, 1126, 205-209 (2008-05-02) The qualitative and quantitative crosslink chemistry of collagen matrices.G L Mechanic Advances in experimental medicine and biology, 86B, 699-708 (1977-01-01) Divergent Changes in Plasma AGEs and sRAGE Isoforms Following an Overnight Fast in T1DM.Edwin R Miranda et al.Nutrients, 11(2) (2019-02-20) The toxic effect of sodium glutamate and DL-$\alpha$-aminoadipic acid on rat retina: Changes in high affinity uptake of putative transmittersKarlsen RL, et al. Journal of Neurochemistry, 31(4), 1055-1061 (1978) Aging, diabetes, and renal failure catalyze the oxidation of lysyl residues to 2-aminoadipic acid in human skin collagen: evidence for metal-catalyzed oxidation mediated by alpha-dicarbonyls.David R Sell et al.Annals of the New York Academy of Sciences, 1126, 205-209 (2008-05-02) The toxic effect of sodium glutamate and DL-$\alpha$-aminoadipic acid on rat retina: Changes in high affinity uptake of putative transmittersKarlsen RL, et al. Journal of Neurochemistry, 31(4), 1055-1061 (1978) Untargeted metabolomics for plasma biomarker discovery for early chronic kidney disease diagnosis in pediatric patients using LC-QTOF-MS.S Benito et al.The Analyst, 143(18), 4448-4458 (2018-08-29) Amino acid metabolism in the Zucker diabetic fatty rat: effects of insulin resistance and of type 2 diabetes.Enoka P Wijekoon et al.Canadian journal of physiology and pharmacology, 82(7), 506-514 (2004-09-25) Reshaping the Cone-Mosaic in a Rat Model of Retinitis Pigmentosa: Modulatory Role of ZO-1 Expression in DL-Alpha-Aminoadipic Acid Reshaping.Wan-Qing Yu et al.PloS one, 11(3), e0151668-e0151668 (2016-03-16) Primate model of chronic retinal neovascularization and vascular leakage.Chintan Patel et al.Experimental eye research, 195, 108031-108031 (2020-04-11) Modeling of Photoreceptor Donor-Host Interaction Following Transplantation Reveals a Role for Crx, Müller Glia, and Rho/ROCK Signaling in Neurite Outgrowth.En L S Tsai et al.Stem cells (Dayton, Ohio), 37(4), 529-541 (2019-02-05) Characterization of L-alpha-aminoadipic acid transport in cultured rat astrocytes.M J Tsai et al.Brain research, 741(1-2), 166-173 (1996-11-25) 2-aminoadipic acid is a marker of protein carbonyl oxidation in the aging human skin: effects of diabetes, renal failure and sepsis.David R Sell et al.The Biochemical journal, 404(2), 269-277 (2007-02-23) Detection of autosomal dominant polycystic kidney disease by NMR spectroscopic fingerprinting of urine.Wolfram Gronwald et al.Kidney international, 79(11), 1244-1253 (2011-03-11) Gender-dependent and genotype-sensitive monoaminergic changes induced by polychlorinated biphenyl 153 in the rat brain.Kine S N Dervola et al.Neurotoxicology, 50, 38-45 (2015-07-29) Activated retinal glia mediated axon regeneration in experimental glaucoma.Barbara Lorber et al.Neurobiology of disease, 45(1), 243-252 (2011-08-27) Human antiquitin: structural and functional studies.Chi-Lung Chan et al.Chemico-biological interactions, 191(1-3), 165-170 (2010-12-28)
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