Density	1.436±0.06 g/cm3 (20 º

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Source	SDS/MSDS Samples
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Synthetic Route

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Peer-Reviewed Papers

Secretion of the methoxyindoles melatonin, 5-methoxytryptophol, 5-methoxyindoleacetic acid, and 5-methoxytryptamine from trout pineal organs in superfusion culture: effects of light intensity.J Yáñez et al.General and comparative endocrinology, 101(2), 165-172 (1996-02-01) Modulation of anticancer cytokines IL-2 and IL-12 by melatonin and the other pineal indoles 5-methoxytryptamine and 5-methoxytryptophol in the treatment of human neoplasms.P Lissoni Annals of the New York Academy of Sciences, 917, 560-567 (2001-03-28) 6-methoxytryptophol reduces lipopolysaccharide-induced lipid peroxidation in vitro more effectively than melatonin.Ewa Sewerynek et al.Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 62(6), 677-683 (2012-02-09) Possible involvement of neuropeptide Y in the seasonal control of hydroxyindole-O-methyltransferase activity in the pineal gland of the european hamster (Cricetus cricetus).C Ribelayga et al.Brain research, 801(1-2), 137-142 (1998-09-05) Daily variation in the concentration of melatonin and 5-methoxytryptophol in the goose pineal gland, retina, and plasma.Jolanta B Zawilska et al.General and comparative endocrinology, 134(3), 296-302 (2003-11-26) Total pineal endocrine substitution therapy (TPEST) as a new neuroendocrine palliative treatment of untreatable metastatic solid tumor patients: a phase II study.Paolo Lissoni et al.Neuro endocrinology letters, 24(3-4), 259-262 (2003-10-03) Pineal indoles stimulate the gene expression of immunomodulating cytokines.F Liu et al.Journal of neural transmission (Vienna, Austria : 1996), 108(4), 397-405 (2001-07-28) Effects of cycloheximide and aminophylline on 5-methoxytryptophol and melatonin contents in the chick pineal gland.J B Zawilska et al.General and comparative endocrinology, 120(2), 212-219 (2000-11-18) Endocrine effects of two pineal hormones other than melatonin in healthy volunteers: 5-methoxytryptophol and 5-methoxytryptamine.P Lissoni et al.Recenti progressi in medicina, 89(4), 183-185 (1998-06-05) Anticancer neuroimmunomodulation by pineal hormones other than melatonin: preliminary phase II study of the pineal indole 5-methoxytryptophol in association with low-dose IL-2 and melatonin.P Lissoni et al.Journal of biological regulators and homeostatic agents, 11(3), 119-122 (1997-07-01) Daily and light-at-night induced variations of circulating 5-methoxytryptophol (5-ML) in ewes with respectively high and low nocturnal melatonin secretion.B Vivien-Roels et al.Journal of pineal research, 27(4), 230-236 (1999-11-07) Effect of pineal indoles on activities of the antioxidant defense enzymes superoxide dismutase, catalase, and glutathione reductase, and levels of reduced and oxidized glutathione in rat tissues.F Liu et al.Biochemistry and cell biology = Biochimie et biologie cellulaire, 78(4), 447-453 (2000-09-30) 5-Methoxytryptophol rhythms in the chick pineal gland: effect of environmental lighting conditions.J B Zawilska et al.Neuroscience letters, 251(1), 33-36 (1998-08-26) Melatonin and 5-methoxytryptophol (5-ML) in nervous and/or neurosensory structures of a gastropod mollusc (Helix aspersa maxima): synthesis and diurnal rhythms.A Blanc et al.General and comparative endocrinology, 131(2), 168-175 (2003-04-08) Effect of 5-hydroxytryptamine and pineal metabolites on the secretion of neurohypophysial hormones.I Kostoglou-Athanassiou et al.Brain research bulletin, 46(5), 417-422 (1998-09-17) Daily variation in the concentration of 5-methoxytryptophol and melatonin in the duck pineal gland and plasma.Jolanta B Zawilska et al.Journal of pineal research, 32(4), 214-218 (2002-05-02) Melatonin and structurally-related compounds protect synaptosomal membranes from free radical damage.Sergio Millán-Plano et al.International journal of molecular sciences, 11(1), 312-328 (2010-02-18) Determination of tryptophan and metabolites in rat brain and pineal tissue by reversed-phase high-performance liquid chromatography with electrochemical detectionMefford.NI and Barchas.DJ Journal of Chromatography. B, Biomedical Applications, 181(2), 187-193 (1980) Effect of pineal indoles on the chick embryo.V E Ooi et al.General pharmacology, 32(2), 219-224 (1999-04-03) Photoperiod affects amplitude but not duration of in vitro melatonin production in the ruin lizard (Podarcis sicula).C Bertolucci et al.Journal of biological rhythms, 18(1), 63-70 (2003-02-06) Determination of 5-methoxyindoles in pineal gland and plasma samples by high-performance liquid chromatography with electrochemical detection Melatonin and the Mammalian Pineal Gland, 564(1), 103-113 (1994) Hypotensive activity of the pineal indoleamine hormones melatonin, 5-methoxytryptophol and 5-methoxytryptamine.H Wang et al.Pharmacology & toxicology, 86(3), 125-128 (2001-02-07) Indoleamines and 5-methoxyindoles in trout pineal organ in vivo: daily changes and influence of photoperiod.Rosa M Ceinos et al.General and comparative endocrinology, 144(1), 67-77 (2005-06-14) Anxiolytic-like actions of melatonin, 5-metoxytryptophol, 5-hydroxytryptophol and benzodiazepines on a conflict procedure.E B Naranjo-Rodriguez et al.Progress in neuro-psychopharmacology & biological psychiatry, 24(1), 117-129 (2000-02-05) 5-methoxytryptophol preserves hepatic microsomal membrane fluidity during oxidative stress.J J García et al.Journal of cellular biochemistry, 76(4), 651-657 (2000-02-02) Serine residues 110 and 114 are required for agonist binding but not antagonist binding to the melatonin MT(1) receptor.S Conway et al.Biochemical and biophysical research communications, 282(5), 1229-1236 (2001-04-17) 5-Methoxytryptophol and melatonin in children: differences due to age and sex.A Molina-Carballo et al.Journal of pineal research, 21(2), 73-79 (1996-09-01) Phase-shifting effects of light on the circadian rhythms of 5-methoxytryptophol and melatonin in the chick pineal gland.J B Zawilska et al.Journal of pineal research, 29(1), 1-7 (2000-08-19)

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