Melting point	100-102 ºC**
Density	1.44±0.1 g/cm3 (20 ºC

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Source	SDS/MSDS Samples
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Synthetic Route

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Articles

Peer-Reviewed Papers

Copper complexes of glycyl-histidyl-lysine and two of its synthetic analogues: chemical behaviour and biological activity.C Conato et al.Biochimica et biophysica acta, 1526(2), 199-210 (2001-04-28) Growth-modulating human plasma tripeptide: relationship between molecular structure and DNA synthesis in hepatoma cells.L Pickart et al.FEBS letters, 104(1), 119-122 (1979-08-01) Ternary Cu(II) Complex with GHK Peptide and Cis-Urocanic Acid as a Potential Physiologically Functional Copper Chelate.Karolina Bossak-Ahmad et al.International journal of molecular sciences, 21(17) (2020-09-02) Human skin retention and penetration of a copper tripeptide in vitro as function of skin layer towards anti-inflammatory therapy.Jurij J Hostynek et al.Inflammation research : official journal of the European Histamine Research Society ... [et al.], 59(11), 983-988 (2010-08-13) Apoptosis of NOD.H2 h4 thyrocytes by low concentrations of iodide is associated with impaired control of oxidative stress.Panayota Kolypetri et al.Thyroid : official journal of the American Thyroid Association, 24(7), 1170-1178 (2014-03-26) [Pharmacological correction of immuno-metabolic disorders with the peptide Gly-His-Lys in hepatic damage induced by tetrachloromethane].M Iu Smakhtin et al.Patologicheskaia fiziologiia i eksperimental'naia terapiia, (2)(2), 19-21 (2003-07-04) The human tripeptide GHK-Cu in prevention of oxidative stress and degenerative conditions of aging: implications for cognitive health.Loren Pickart et al.Oxidative medicine and cellular longevity, 2012, 324832-324832 (2012-06-06) Tripeptide-copper complex GHK-Cu (II) transiently improved healing outcome in a rat model of ACL reconstruction.Sai-Chuen Fu et al.Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 33(7), 1024-1033 (2015-03-04) Effects of copper tripeptide on the growth and expression of growth factors by normal and irradiated fibroblasts.Jeffrey D Pollard et al.Archives of facial plastic surgery, 7(1), 27-31 (2005-01-19) Effect of transition metals on recovery from plasma of the growth-modulating tripeptide glycylhistidyllysine.L Pickart et al.Journal of chromatography, 175(1), 65-73 (1979-07-11) Biological activities of selected peptides: skin penetration ability of copper complexes with peptides.Lena Mazurowska et al.Journal of cosmetic science, 59(1), 59-69 (2008-03-20) Glycyl-histidyl-lysine (GHK) is a quencher of alpha,beta-4-hydroxy-trans-2-nonenal: a comparison with carnosine. insights into the mechanism of reaction by electrospray ionization mass spectrometry, 1H NMR, and computational techniques.Giangiacomo Beretta et al.Chemical research in toxicology, 20(9), 1309-1314 (2007-08-04) Expression and activation of matrix metalloproteinases in wounds: modulation by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+.A Siméon et al.The Journal of investigative dermatology, 112(6), 957-964 (1999-06-26) The effect of topical tripeptide-copper complex on healing of ischemic open wounds.Sherman O Canapp et al.Veterinary surgery : VS, 32(6), 515-523 (2003-12-03) Evaluation of the effects of topical tripeptide-copper complex and zinc oxide on open-wound healing in rabbits.I Taci Cangul et al.Veterinary dermatology, 17(6), 417-423 (2006-11-07) Formation equilibria of nickel complexes with glycyl-histidyl-lysine and two synthetic analogues.Chiara Conato et al.Journal of inorganic biochemistry, 98(1), 153-160 (2003-12-09) Stem cell recovering effect of copper-free GHK in skin.Hye-Ryung Choi et al.Journal of peptide science : an official publication of the European Peptide Society, 18(11), 685-690 (2012-09-29) Effect of Gly-Gly-His, Gly-His-Lys and their copper complexes on TNF-alpha-dependent IL-6 secretion in normal human dermal fibroblasts.Arkadiusz Gruchlik et al.Acta poloniae pharmaceutica, 69(6), 1303-1306 (2013-01-05) Fibroblast-cytokine-extracellular matrix interactions in wound repair.A Siméon et al.Current topics in pathology. Ergebnisse der Pathologie, 93, 95-101 (1999-05-26) Expression of glycosaminoglycans and small proteoglycans in wounds: modulation by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu(2+).A Siméon et al.The Journal of investigative dermatology, 115(6), 962-968 (2000-12-20) X-ray and solution structures of Cu(II) GHK and Cu(II) DAHK complexes: influence on their redox properties.Christelle Hureau et al.Chemistry (Weinheim an der Bergstrasse, Germany), 17(36), 10151-10160 (2011-07-23) Copper.Lys-Gly-His-Lys mediated cleavage of tRNA(Phe): studies of reaction mechanism and cleavage specificity.Seth Bradford et al.Journal of inorganic biochemistry, 103(6), 871-875 (2009-04-24) A new fluorescent chemosensor for copper ions based on tripeptide glycyl-histidyl-lysine (GHK).Y Zheng et al.Organic letters, 3(21), 3277-3280 (2001-10-12) Effects of topical copper tripeptide complex on wound healing in an irradiated rat model.Noah P Parker et al.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 149(3), 384-389 (2013-06-08) In vitro evaluation of compression-coated glycyl-L-histidyl-L-lysine-Cu(II) (GHK-Cu2+)-loaded microparticles for colonic drug delivery.Timuçin Uğurlu et al.Drug development and industrial pharmacy, 37(11), 1282-1289 (2011-04-05) Thermodynamic study of Cu2+ binding to the DAHK and GHK peptides by isothermal titration calorimetry (ITC) with the weaker competitor glycine.Ana Trapaidze et al.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 17(1), 37-47 (2011-09-08) A synthetic tripeptide which increases survival of normal liver cells, and stimulates growth in hepatoma cells.L Pickart et al.Biochemical and biophysical research communications, 54(2), 562-566 (1973-09-18) Tripeptide Gly-His-Lys is a hepatotropic immunosuppressor.M Yu Smakhtin et al.Bulletin of experimental biology and medicine, 133(6), 586-587 (2002-11-26) Immobilization of tripeptide growth factor glycyl-L-histidyl-L-lysine on poly(vinylalcohol)-quarternized stilbazole (PVA-SbQ) and its use as a ligand for hepatocyte attachment.M Kawase et al.Biological & pharmaceutical bulletin, 22(9), 999-1001 (1999-10-08) Expression analysis of stemness genes in a rat thyroid cell line FRTL5.A Shimasue et al.Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 123(1), 48-54 (2014-10-15) Acrolein sequestering ability of the endogenous tripeptide glycyl-histidyl-lysine (GHK): characterization of conjugation products by ESI-MSn and theoretical calculations.Giangiacomo Beretta et al.Journal of pharmaceutical and biomedical analysis, 47(3), 596-602 (2008-04-02) A therapeutic approach for diabetic wound healing using biotinylated GHK incorporated collagen matrices.Vadivel Arul et al.Life sciences, 80(4), 275-284 (2006-10-20) The tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+ stimulates matrix metalloproteinase-2 expression by fibroblast cultures.A Siméon et al.Life sciences, 67(18), 2257-2265 (2000-10-25)

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