Boiling point	139-140 ºC (13 Torr)**
Flash point	101.5±22.9 ºC, 计算值*
Density	1.018±0.06 g/cm3 (20 º

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Source	SDS/MSDS Samples
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Peer-Reviewed Papers

Norcantharidin regulates ERα signaling and tamoxifen resistance via targeting miR-873/CDK3 in breast cancer cells.Xiumei Zhang et al.PloS one, 14(5), e0217181-e0217181 (2019-05-24) p38-NF-κB-promoted mitochondria-associated apoptosis and G2/M cell cycle arrest in norcantharidin-treated HeLa cells.Xiu Dong et al.Journal of Asian natural products research, 14(11), 1008-1019 (2013-01-04) Pharmacokinetics, tissue distribution, and metabolites of a polyvinylpyrrolidone-coated norcantharidin chitosan nanoparticle formulation in rats and mice, using LC-MS/MS.Xin-Yuan Ding et al.International journal of nanomedicine, 7, 1723-1735 (2012-05-24) Effect of norcantharidin on the human breast cancer Bcap-37 cells.Dongwu Liu et al.Connective tissue research, 53(6), 508-512 (2012-05-23) Cancer Cell enters reversible quiescence through Intracellular Acidification to resist Paclitaxel Cytotoxicity.Min Jia et al.International journal of medical sciences, 17(11), 1652-1664 (2020-07-17) In-vivo anti-tumor activity of a novel poloxamer-based thermosensitive in situ gel for sustained delivery of norcantharidin.Ming-Hua Xie et al.Pharmaceutical development and technology, 24(5), 623-629 (2018-11-21) Norcantharidin enhances TIMP‑2 anti‑vasculogenic mimicry activity for human gallbladder cancers through downregulating MMP‑2 and MT1‑MMP.Wei Zhu et al.International journal of oncology, 46(2), 627-640 (2014-11-19) Uptake and transport of a novel anticancer drug-delivery system: lactosyl-norcantharidin-associated N-trimethyl chitosan nanoparticles across intestinal Caco-2 cell monolayers.Min Guan et al.International journal of nanomedicine, 7, 1921-1930 (2012-05-19) Hepatocyte-targeted delivery using ph-sensitive liposomes loaded with lactosylnorcantharidin phospholipid complex: preparation, characterization, and therapeutic evaluation in vivo and in vitro.Z Qiao-ling et al.Current medicinal chemistry, 19(33), 5754-5763 (2012-09-12) Novel norcantharidin-loaded liver targeting chitosan nanoparticles to enhance intestinal absorption.Yong-yan Bei et al.International journal of nanomedicine, 7, 1819-1827 (2012-05-24) Cantharidin and norcantharidin inhibit the ability of MCF-7 cells to adhere to platelets via protein kinase C pathway-dependent downregulation of α2 integrin.Liu-Mei Shou et al.Oncology reports, 30(3), 1059-1066 (2013-07-10) A novel cantharidin analog N-benzylcantharidinamide reduces the expression of MMP-9 and invasive potentials of Hep3B via inhibiting cytosolic translocation of HuR.Ji-Yeon Lee et al.Biochemical and biophysical research communications, 447(2), 371-377 (2014-04-17) Repositioning of Hypoglycemic Drug Linagliptin for Cancer Treatment.Yong Li et al.Frontiers in pharmacology, 11, 187-187 (2020-03-21) Identification and biochemical characterization of protein phosphatase 5 from the cantharidin-producing blister beetle, Epicauta chinensis.Xi'en Chen et al.International journal of molecular sciences, 14(12), 24501-24513 (2013-12-20) Synthesis and anticancer activity of a series of norcantharidin analogues.Mark Tarleton et al.European journal of medicinal chemistry, 54, 573-581 (2012-07-17) Determination of norcantharidin in mouse tissues by liquid chromatography coupled to tandem mass spectrometry and its tissue distribution study.R Zhang et al.Arzneimittel-Forschung, 62(6), 290-294 (2012-04-05) Norcantharidin enhances bortezomib-antimyeloma activity in multiple myeloma cells in vitro and in nude mouse xenografts.Heng-Fei Du et al.Leukemia & lymphoma, 54(3), 607-618 (2012-08-15) Two triterpenoid glycosides from the roots of Camellia oleifera and their cytotoxic activity.Ping Yang et al.Journal of Asian natural products research, 17(8), 800-807 (2015-01-30) Effects of Cantharidin and Norcantharidin on Larval Feeding and Adult Oviposition Preferences of the Diamondback Moth (Lepidoptera: Plutellidae).Yi-Fan Li et al.Journal of economic entomology, 112(4), 1634-1637 (2019-03-30) Norcantharidin: a potential antiangiogenic agent for gallbladder cancers in vitro and in vivo.Jing-Tao Zhang et al.International journal of oncology, 40(5), 1501-1514 (2011-12-28) [Norcantharidin potentialize the chemosensitivity of adriamycin through the NF-κB/IκBα signaling pathway].Xiao-ning Song et al.Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi, 32(12), 809-813 (2012-02-22) Inhibition of protein phosphatase 5 suppresses non-small cell lung cancer through AMP-activated kinase activation.Feng-Shu Hsieh et al.Lung cancer (Amsterdam, Netherlands), 112, 81-89 (2017-12-02) Suppression of lymphangiogenesis in human lymphatic endothelial cells by simultaneously blocking VEGF-C and VEGF-D/VEGFR-3 with norcantharidin.Zhong-Yan Liu et al.International journal of oncology, 41(5), 1762-1772 (2012-08-28) Cantharidin represses invasion of pancreatic cancer cells through accelerated degradation of MMP2 mRNA.Meng Shen et al.Scientific reports, 5, 11836-11836 (2015-07-03) Aluminum exposure promotes the metastatic proclivity of human colorectal cancer cells through matrix metalloproteinases and the TGF-β/Smad signaling pathway.Chang Hee Jeong et al.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 141, 111402-111402 (2020-05-22) Preclinical evaluations of norcantharidin-loaded intravenous lipid microspheres with low toxicity.Xia Lin et al.Expert opinion on drug delivery, 9(12), 1449-1462 (2012-09-14) Norcantharidin induces melanoma cell apoptosis through activation of TR3 dependent pathway.Shujing Liu et al.Cancer biology & therapy, 12(11), 1005-1014 (2011-11-30) Norcantharidin facilitates LPS-mediated immune responses by up-regulation of AKT/NF-κB signaling in macrophages.Qufei Zhao et al.PloS one, 7(9), e44956-e44956 (2012-09-18) Norcantharidin inhibits tumor angiogenesis via blocking VEGFR2/MEK/ERK signaling pathways.Long Zhang et al.Cancer science, 104(5), 604-610 (2013-02-01) Antimetastatic effects of norcantharidin on hepatocellular carcinoma by transcriptional inhibition of MMP-9 through modulation of NF-kB activity.Chao-Bin Yeh et al.PloS one, 7(2), e31055-e31055 (2012-03-01) Norcantharidin-induced post-G(2)/M apoptosis is dependent on wild-type p53 gene.C Y Hong et al.Biochemical and biophysical research communications, 276(1), 278-285 (2000-09-28) CDC6 controls dynamics of the first embryonic M-phase entry and progression via CDK1 inhibition.Mohammed El Dika et al.Developmental biology, 396(1), 67-80 (2014-09-30) Norcantharidin modulates the miR-30a/Metadherin/AKT signaling axis to suppress proliferation and metastasis of stromal tumor cells in giant cell tumor of boneChen F, et al. Biomedicine and Pharmacotherapy, 103, 1092-1100 (2018) Synthesis of optically pure norcantharidin analogue NCA-01, a highly selective protein phosphatase 2B inhibitor, and its derivatives.Tadashi Shimizu et al.Chemistry, an Asian journal, 7(6), 1221-1230 (2012-04-11) Norcantharidin triggers cell death and DNA damage through S-phase arrest and ROS-modulated apoptotic pathways in TSGH 8301 human urinary bladder carcinoma cells.Chien-Chih Yu et al.International journal of oncology, 41(3), 1050-1060 (2012-06-12) Norcantharidin induces apoptosis in human prostate cancer cells through both intrinsic and extrinsic pathways.Pei-Yu Yang et al.Pharmacological reports : PR, 68(5), 874-880 (2016-06-29) Norcantharidin analogues: a patent review (2006 - 2010).Liping Deng et al.Expert opinion on therapeutic patents, 21(11), 1743-1753 (2011-10-25) Norcantharidin enhances antitumor immunity of GM-CSF prostate cancer cells vaccine by inducing apoptosis of regulatory T cells.Lijun Mo et al.Cancer science, 109(7), 2109-2118 (2018-05-18) Protein phosphatase 5 promotes hepatocarcinogenesis through interaction with AMP-activated protein kinase.Yao-Li Chen et al.Biochemical pharmacology, 138, 49-60 (2017-05-23) Involvement of bleomycin hydrolase and poly(ADP-ribose) polymerase-1 in Ubc9-mediated resistance to chemotherapy agents.Yang Chen et al.International journal of oncology, 50(1), 223-231 (2016-11-24) Norcantharidin inhibits SK-N-SH neuroblastoma cell growth by induction of autophagy and apoptosisHan Z, et al. Technology in Cancer Research & Treatment, 16(1), 33-44 (2017) Cell Division Cycle 6 Promotes Mitotic Slippage and Contributes to Drug Resistance in Paclitaxel-Treated Cancer Cells.Yue He et al.PloS one, 11(9), e0162633-e0162633 (2016-09-10) Norcantharidin, a protective therapeutic agent in renal tubulointerstitial fibrosis.Ying Li et al.Molecular and cellular biochemistry, 361(1-2), 79-83 (2011-10-01) Measurement of Microcystin and Nodularin Activity in Human Urine by Immunocapture-Protein Phosphatase 2A Assay.Rebekah E Wharton et al.Toxins, 11(12) (2019-12-19) Induction of apoptosis in human Hep3B hepatoma cells by norcantharidin through a p53 independent pathway via TRAIL/DR5 signal transduction.Chung-Hsin Yeh et al.Chinese journal of integrative medicine, 18(9), 676-682 (2012-09-01) Norcantharidin anti-angiogenesis activity possibly through an endothelial cell pathway in human colorectal cancer.Tao Yu et al.Asian Pacific journal of cancer prevention : APJCP, 13(2), 499-503 (2012-04-25) Preparation, characterization and anticancer activity of norcantharidin-loaded poly(ethylene glycol)-poly(caprolactone) amphiphilic block copolymer micelles.Shui-Fang Chen et al.Die Pharmazie, 67(9), 781-788 (2012-09-29) Small-molecule synthetic compound norcantharidin reverses multi-drug resistance by regulating Sonic hedgehog signaling in human breast cancer cells.Yu-Jen Chen et al.PloS one, 7(5), e37006-e37006 (2012-05-23) N-trimethyl chitosan nanoparticle-encapsulated lactosyl-norcantharidin for liver cancer therapy with high targeting efficacy.Min Guan et al.Nanomedicine : nanotechnology, biology, and medicine, 8(7), 1172-1181 (2012-02-11) Norcantharidin combined with EGFR-TKIs overcomes HGF-induced resistance to EGFR-TKIs in EGFR mutant lung cancer cells via inhibition of Met/PI3k/Akt pathway.Hongyan Wu et al.Cancer chemotherapy and pharmacology, 76(2), 307-315 (2015-06-13) A systems biology approach reveals the role of a novel methyltransferase in response to chemical stress and lipid homeostasis.Elena Lissina et al.PLoS genetics, 7(10), e1002332-e1002332 (2011-10-27) Development, optimization and in vitro evaluation of norcantharidin loadedself-nanoemulsifying drug delivery systems (NCTD-SNEDDS).Liya Zeng et al.Pharmaceutical development and technology, 22(3), 399-408 (2016-08-04) Mechanisms of inhibiting human leukemia cell lines by serum of rats treated with compound banmao capsule.Li Li et al.Oncology letters, 14(4), 4092-4098 (2017-10-11)

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