Melting point	153 ºC**
Density	1.177±0.06 g/cm3 (20 º

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Source	SDS/MSDS Samples
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Synthetic Route

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Peer-Reviewed Papers

MT1-MMP expression level status dictates the in vitro action of lupeol on inflammatory biomarkers MMP-9 and COX-2 in medulloblastoma cells.Borhane Annabi et al.Inflammopharmacology, 21(1), 91-99 (2012-06-19) Simultaneous HPTLC analysis of ursolic acid, betulinic acid, stigmasterol and lupeol for the identification of four medicinal plants commonly available in the Indian market as Shankhpushpi.Neeraj Kumar Sethiya et al.Journal of chromatographic science, 53(5), 816-823 (2014-09-14) alpha-Glucosidase inhibitory activity of triterpenoids from Cichorium intybus.Atta-ur-Rahman et al.Journal of natural products, 71(5), 910-913 (2008-03-18) Seco-terpenoids and other constituents from Elateriospermum tapos.Duangpen Pattamadilok et al.Journal of natural products, 71(2), 292-294 (2008-01-09) Synthesis of novel triterpenoid (lupeol) derivatives and their in vivo antihyperglycemic and antidyslipidemic activity.K Papi Reddy et al.Bioorganic & medicinal chemistry letters, 19(15), 4463-4466 (2009-06-12) Analysis of triterpenoids and phytosterols in vegetables by thin-layer chromatography coupled to tandem mass spectrometry.Katerina Naumoska et al.Journal of chromatography. A, 1381, 229-238 (2015-01-20) Lupeol inhibits LPS-induced neuroinflammation in cerebellar cultures and induces neuroprotection associated to the modulation of astrocyte response and expression of neurotrophic and inflammatory factors.Markley Silva Oliveira-Junior et al.International immunopharmacology, 70, 302-312 (2019-03-11) In vitro antituberculosis activities of the constituents isolated from Haloxylon salicornicum.Nazia Bibi et al.Bioorganic & medicinal chemistry letters, 20(14), 4173-4176 (2010-06-15) Scuteflorins A and B, dihydropyranocoumarins from Scutellaria lateriflora.Jing Li et al.Journal of natural products, 72(6), 983-987 (2009-06-27) Effect of Costus igneus stem extract on calcium oxalate urolithiasis in albino rats.K Manjula et al.Urological research, 40(5), 499-510 (2012-02-03) [Triterpene compounds from Cirsium setosum].Lingling Li et al.Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 37(7), 951-955 (2012-07-17) Negative regulation of signal transducer and activator of transcription-3 signalling cascade by lupeol inhibits growth and induces apoptosis in hepatocellular carcinoma cells.K S Siveen et al.British journal of cancer, 111(7), 1327-1337 (2014-08-08) Bioactive phenolic amides from Celtis africana.Areej Mohammad Al-Taweel et al.Molecules (Basel, Switzerland), 17(3), 2675-2682 (2012-03-07) Fruit characteristics and cuticle triterpenes as related to postharvest quality of highbush blueberries.Moggia C, et al. Sci. Hortic., 211, 449-457 (2016) Design of experiment approach for the process optimisation of microwave assisted extraction of lupeol from Ficus racemosa leaves using response surface methodology.Das AK, et al. Phytochemical Analysis, 24(3), 230-247 (2013) [Study on the chemical constituents of Chloranthus multistachys].Xia Liu et al.Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 35(8), 1254-1256 (2013-01-17) Simultaneous quantification of five marker compounds of Betula utilis stem bark using a validated high-performance thin-layer chromatography method.Imran Khan et al.Journal of separation science, 35(3), 392-399 (2012-01-04) Lupeol supplementation improves blood pressure and lipid metabolism parameters in stroke-prone spontaneously hypertensive rats.Ardiansyah et al.Bioscience, biotechnology, and biochemistry, 76(1), 183-185 (2012-01-11) Comparative binding mechanism of lupeol compounds with plasma proteins and its pharmacological importance.Monika Kallubai et al.Molecular bioSystems, 11(4), 1172-1183 (2015-02-25) Investigation of the interactions of lupane type pentacyclic triterpenes with outer leaflet membrane phospholipids--Langmuir monolayer and synchrotron X-ray scattering study.Marcin Broniatowski et al.Journal of colloid and interface science, 381(1), 116-124 (2012-06-12) Development and validation of High Performance Liquid Chromatographic Method for the Simultaneous Determination of ?-sitosterol and Lupeol in Veronica cinerea Linn.Shah, Willy, M. B. Kekare, and Vikas Vaidya. International Journal of Pharma and Bio Sciences, 1 (3), 1-5 (2010) A phytochemical investigation of Zanthoxylum setulosum.Tameka M Walker et al.Natural product communications, 6(12), 1807-1808 (2012-02-09) Long-chain alkanoic acid esters of lupeol from Dorstenia harmsiana Engl. (Moraceae).Herve Martial P Poumale et al.Natural product research, 26(8), 749-755 (2011-10-18) Grewialin and optivanin new constituents from the stem bark of Grewia optiva Drummond ex Burret (Tiliaceae).Ghias Uddin et al.Natural product research, 27(3), 215-220 (2012-03-16) Beneficial health effects of lupeol triterpene: a review of preclinical studies.Hifzur Rahman Siddique et al.Life sciences, 88(7-8), 285-293 (2010-12-02) Antiophidic activity of the extract of the Amazon plant Humirianthera ampla and constituents.Marcelo Abrahão Strauch et al.Journal of ethnopharmacology, 145(1), 50-58 (2012-11-06) Antiurolithic effect of lupeol and lupeol linoleate in experimental hyperoxaluria.Varatharajan Sudhahar et al.Journal of natural products, 71(9), 1509-1512 (2008-08-23) Mycobacterium tuberculosis and cholinesterase inhibitors from Voacanga globosa.Allan Patrick G Macabeo et al.European journal of medicinal chemistry, 46(7), 3118-3123 (2011-05-07) Pharmacological properties and related constituents of stem bark of Pterocarpus erinaceus Poir. (Fabaceae).Ouédraogo Noufou et al.Asian Pacific journal of tropical medicine, 5(1), 46-51 (2011-12-21) Pharmacological properties and related constituents of stem bark of Pterocarpus erinaceus Poir. (Fabaceae).Ouédraogo Noufou et al.Asian Pacific journal of tropical medicine, 5(1), 46-51 (2011-12-21) Antiurolithic effect of lupeol and lupeol linoleate in experimental hyperoxaluria.Varatharajan Sudhahar et al.Journal of natural products, 71(9), 1509-1512 (2008-08-23) Modulating effect of lupeol on the expression pattern of apoptotic markers in 7, 12-dimethylbenz(a)anthracene induced oral carcinogenesis.S Manoharan et al.Asian Pacific journal of cancer prevention : APJCP, 13(11), 5753-5757 (2013-01-16) The regulation of inflammatory cytokine secretion in macrophage cell line by the chemical constituents of Rhus sylvestris.Yan Ding et al.Bioorganic & medicinal chemistry letters, 19(13), 3607-3610 (2009-05-19) The triterpenes 3β-lup-20(29)-en-3-ol and 3β-lup-20(29)-en-3-yl acetate and the carbohydrate 1,2,3,4,5,6-hexa-O-acetyl-dulcitol as photosynthesis light reactions inhibitors.Djalma Menezes-de-Oliveira et al.Molecules (Basel, Switzerland), 16(12), 9939-9956 (2011-12-03) Changes in the triterpenoid content of cuticular waxes during fruit ripening of eight grape (Vitis vinifera) cultivars grown in the Upper Rhine Valley.Flora Pensec et al.Journal of agricultural and food chemistry, 62(32), 7998-8007 (2014-07-25) Lupeol long-chain fatty acid esters with antimalarial activity from Holarrhena floribunda.Jean Fotie et al.Journal of natural products, 69(1), 62-67 (2006-01-31) Antimalarials from nature.Kirandeep Kaur et al.Bioorganic & medicinal chemistry, 17(9), 3229-3256 (2009-03-21) Molecular characterization of the pentacyclic triterpenoid biosynthetic pathway in Catharanthus roseus.Lili Huang et al.Planta, 236(5), 1571-1581 (2012-07-28) Terpenoids from Daphne aurantiaca and their potential anti-inflammatory activity.Shuang Liang et al.Journal of natural products, 73(4), 532-535 (2010-03-03) Lupeol, a bioactive triterpene, prevents tumor formation during 7,12-dimethylbenz(a)anthracene induced oral carcinogenesis.D Palanimuthu et al.Pathology oncology research : POR, 18(4), 1029-1037 (2012-07-19) Three hydroxylated lupeol-based triterpenoid esters isolated from the Eastern Nigeria mistletoe parasitic on Kola acuminata.Edwin Ogechukwu Omeje et al.Natural product research, 26(19), 1775-1781 (2011-10-20) Effects of natural nuclear factor-kappa B inhibitors on anticancer drug efflux transporter human P-glycoprotein.Tomohiro Nabekura et al.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 70, 140-145 (2015-03-18) Choisyaternatine, a new alkaloid isolated from Choisya ternata.Ikarastika Rahayu Abdul Wahab et al.Planta medica, 78(14), 1597-1600 (2012-07-21) Lupeol prevents acetaminophen-induced in vivo hepatotoxicity by altering the Bax/Bcl-2 and oxidative stress-mediated mitochondrial signaling cascade.Archana Kumari et al.Life sciences, 90(15-16), 561-570 (2012-02-14) Lupeol inhibits proliferation and induces apoptosis of human pancreatic cancer PCNA-1 cells through AKT/ERK pathways.Yan Liu et al.Naunyn-Schmiedeberg's archives of pharmacology, 388(3), 295-304 (2014-11-25) Lupeol, a triterpenoid isolated from Calotropis gigantea latex ameliorates the primary and secondary complications of FCA induced adjuvant disease in experimental rats.Venkatesan Saratha et al.Inflammopharmacology, 20(1), 27-37 (2011-10-18) Antitrypanosomal activity of triterpenoids and sterols from the leaves of Strychnos spinosa and related compounds.Sara Hoet et al.Journal of natural products, 70(8), 1360-1363 (2007-07-20) Cultivar origin and admixture detection in Turkish olive oils by SNP-based CAPS assays.Ali Tevfik Uncu et al.Journal of agricultural and food chemistry, 63(8), 2284-2295 (2015-02-13) Lupeol against high-glucose-induced apoptosis via enhancing the anti-oxidative stress in rabbit nucleus pulposus cells.Ming-Bo Guo et al.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 27(10), 2609-2620 (2018-07-17) Lupane triterpenoids from Maytenus species.Marvin J Núñez et al.Journal of natural products, 68(7), 1018-1021 (2005-07-26) Lupeol, a novel anti-inflammatory and anti-cancer dietary triterpene.Mohammad Saleem Cancer letters, 285(2), 109-115 (2009-05-26) Synthesis, cytotoxicity, and haemolytic activity of chacotrioside lupane-type neosaponins and their germanicane-type rearrangement products.Charles Gauthier et al.Bioorganic & medicinal chemistry letters, 19(8), 2310-2314 (2009-03-17) Cytotoxicity and inhibition of DNA topoisomerase I of polyhydroxylated triterpenoids and triterpenoid glycosides.Ping Wang et al.Bioorganic & medicinal chemistry letters, 20(9), 2790-2796 (2010-04-08) Lupeol: connotations for chemoprevention.Pranav K Chaturvedi et al.Cancer letters, 263(1), 1-13 (2008-03-25) Structure Identification of Triterpene from the Mushroom Pleurotus eryngii with Inhibitory Effects Against Breast Cancer.Zhaohui Xue et al.Plant foods for human nutrition (Dordrecht, Netherlands), 70(3), 291-296 (2015-06-20) Lupeol protects against acetaminophen-induced oxidative stress and cell death in rat primary hepatocytes.Archana Kumari et al.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 50(5), 1781-1789 (2012-03-13) Evaluation of antidiabetic and antioxidant potential of lupeol in experimental hyperglycaemia.Rajnish Gupta et al.Natural product research, 26(12), 1125-1129 (2011-11-03) Hawthorn ethanolic extracts with triterpenoids and flavonoids exert hepatoprotective effects and suppress the hypercholesterolemia-induced oxidative stress in rats.Ali Rezaei-Golmisheh et al.Iranian journal of basic medical sciences, 18(7), 691-699 (2015-09-12) A new fatty aldol ester from the aerial part of Mimosa invisa (Mimosaceae).Frederic Nana et al.Natural product research, 26(19), 1831-1836 (2011-11-26) Ixorapeptide I and ixorapeptide II, bioactive peptides isolated from Ixora coccinea.Chia-Lin Lee et al.Bioorganic & medicinal chemistry letters, 20(24), 7354-7357 (2010-11-26) Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.Francisco J Prado-Prado et al.Bioorganic & medicinal chemistry, 18(6), 2225-2231 (2010-02-27) Involvement of monoaminergic systems in the antidepressant-like properties of Lafoensia pacari A. St. Hil.Pablinny M Galdino et al.Journal of ethnopharmacology, 170, 218-225 (2015-05-20)

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