Boiling point	99-100 ºC**
Density	1.551±0.06 g/cm3 (20 º
Refractive index	1.3247 (589.3 nm 25 ºC)**

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Source	SDS/MSDS Samples
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Synthetic Route

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Articles

Peer-Reviewed Papers

[Coma due to overdose of valnoctamide].A A Verheij Nederlands tijdschrift voor geneeskunde, 136(24), 1177-1177 (1992-06-13) Impairment of carbamazepine-10, 11-epoxide elimination by valnoctamide, a valpromide isomer, in healthy subjects.F Pisani et al.British journal of clinical pharmacology, 34(1), 85-87 (1992-07-01) Pharmacokinetic-pharmacodynamic relationships of (2S,3S)-valnoctamide and its stereoisomer (2R,3S)-valnoctamide in rodent models of epilepsy.Nina Isoherranen et al.Pharmaceutical research, 20(8), 1293-1301 (2003-09-02) Pharmacokinetics of a valpromide isomer, valnoctamide, in dogs.A Haj-Yehia et al.Journal of pharmaceutical sciences, 77(10), 831-834 (1988-10-01) Rapid gas chromatographic assay for monitoring valnoctamide in plasma.M Bialer et al.Journal of chromatography, 337(2), 408-411 (1985-02-08) Valnoctamide inhibits cytomegalovirus infection in developing brain and attenuates neurobehavioral dysfunctions and brain abnormalitiesOrnaghi S, et al. The Journal of Neuroscience, 37(29), 6877-6893 (2017) A comparative electrographic analysis of the effect of sec-butyl-propylacetamide on pharmacoresistant status epilepticus.W Pouliot et al.Neuroscience, 231, 145-156 (2012-11-20) [THE SPECTRUM OF ACTION OF VALNOCTAMIDE IN DAILY PSYCHIATRIC PRACTICE].P DAVIDOU Toulouse medical, 65, 1127-1158 (1964-11-01) Valnoctamide Inhibits Cytomegalovirus Infection in Developing Brain and Attenuates Neurobehavioral Dysfunctions and Brain Abnormalities.Sara Ornaghi et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 37(29), 6877-6893 (2017-06-21) Stereoselective pharmacokinetic analysis of valnoctamide in healthy subjects and in patients with epilepsy.S Barel et al.Clinical pharmacology and therapeutics, 61(4), 442-449 (1997-04-01) Amidic derivatives of valproic acid, valpromide and valnoctamide, inhibit HSV-1 infection in oligodendrocytes.B Praena et al.Antiviral research, 168, 91-99 (2019-05-28) Polycomb homologs are involved in teratogenicity of valproic acid in mice.Akinobu Okada et al.Birth defects research. Part A, Clinical and molecular teratology, 70(11), 870-879 (2004-11-04) Pharmacokinetics of a valpromide isomer, valnoctamide, in healthy subjects.M Bialer et al.European journal of clinical pharmacology, 38(3), 289-291 (1990-01-01) Valnoctamide, valpromide and valnoctic acid are much less teratogenic in mice than valproic acid.M Radatz et al.Epilepsy research, 30(1), 41-48 (1998-04-29) Structure activity relationship of human microsomal epoxide hydrolase inhibition by amide and acid analogues of valproic acid.O Spiegelstein et al.Pharmaceutical research, 17(2), 216-221 (2000-04-06) A new derivative of valproic acid amide possesses a broad-spectrum antiseizure profile and unique activity against status epilepticus and organophosphate neuronal damage.H Steve White et al.Epilepsia, 53(1), 134-146 (2011-12-14) In vivo study of the effect of valpromide and valnoctamide in the pilocarpine rat model of focal epilepsy.H Lindekens et al.Pharmaceutical research, 17(11), 1408-1413 (2001-02-24) Valnoctamide as a valproate substitute with low teratogenic potential in mania: a double-blind, controlled, add-on clinical trial.Y Bersudsky et al.Bipolar disorders, 12(4), 376-382 (2010-07-20) Amidic modification of valproic acid reduces skeletal teratogenicity in mice.Akinobu Okada et al.Birth defects research. Part B, Developmental and reproductive toxicology, 71(1), 47-53 (2004-03-03) Valnoctamide and sec-butyl-propylacetamide (SPD) for acute seizures and status epilepticusShekh A T, et al. Epilepsia, 54(29), 99-102 (2013) Carbamazepine-valnoctamide interaction in epileptic patients: in vitro/in vivo correlation.F Pisani et al.Epilepsia, 34(5), 954-959 (1993-09-01) [Coma due to an overdose of valnoctamide].C F Melissant et al.Nederlands tijdschrift voor geneeskunde, 136(16), 793-794 (1992-04-18) Mood stabilizers inhibit cytomegalovirus infection.Sara Ornaghi et al.Virology, 499, 121-135 (2016-09-23) Stereoselective pharmacokinetic analysis of valnoctamide, a CNS-active chiral amide analogue of valproic acid, in dogs, rats, and mice.O Spiegelstein et al.Therapeutic drug monitoring, 22(5), 574-581 (2000-10-18) Amidic derivatives of valproic acid as antiviral in HSV-1-infected oligodendrocytes.Praena B, et al. Antiviral Research, 54(29), 99-102 (2019) Disposition of valpromide, valproic acid, and valnoctamide in the brain, liver, plasma, and urine of rats.S Blotnik et al.Drug metabolism and disposition: the biological fate of chemicals, 24(5), 560-564 (1996-05-01) Mood stabilizers inhibit cytomegalovirus infectionOrnaghi S, et al. Virology, 499(29), 121-135 (2016) Pharmacokinetic considerations in the design of better and safer new antiepileptic drugs.M Bialer Journal of controlled release : official journal of the Controlled Release Society, 62(1-2), 187-192 (1999-10-16) [THE PLACE OF VALNOCTAMIDE IN CURRENT MEDICAL PRACTICE].J A COLSON Toulouse medical, 65, 969-992 (1964-10-01) Identifying Drugs that Bind Selectively to Intersubunit General Anesthetic Sites in the α1β3γ2 GABAAR Transmembrane Domain.Selwyn S Jayakar et al.Molecular pharmacology, 95(6), 615-628 (2019-04-07) Valnoctamide and sec-butyl-propylacetamide (SPD) for acute seizures and status epilepticus.Tawfeeq Shekh-Ahmad et al.Epilepsia, 54 Suppl 6, 99-102 (2013-09-06) Identification of early-responsive genes correlated to valproic acid-induced neural tube defects in mice.Akinobu Okada et al.Birth defects research. Part A, Clinical and molecular teratology, 73(4), 229-238 (2005-03-31)

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