Melting point	81-85 ºC
Boiling point	274-275 ºC

SDS/MSDS	S24/25

Source	SDS/MSDS Samples
Alfa-Aesar	View & Download
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TCI	View & Download

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Peer-Reviewed Papers

Anti-inflammatory effects of [6]-shogaol: potential roles of HDAC inhibition and HSP70 induction.Sehwan Shim et al.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 49(11), 2734-2740 (2011-08-26) Shogaols at proapoptotic concentrations induce G(2)/M arrest and aberrant mitotic cell death associated with tubulin aggregation.Fei-Fei Gan et al.Apoptosis : an international journal on programmed cell death, 16(8), 856-867 (2011-05-21) Metabolism of [6]-shogaol in mice and in cancer cells.Huadong Chen et al.Drug metabolism and disposition: the biological fate of chemicals, 40(4), 742-753 (2012-01-17) 6-Shogaol inhibits breast and colon cancer cell proliferation through activation of peroxisomal proliferator activated receptor γ (PPARγ).Boon Shing Tan et al.Cancer letters, 336(1), 127-139 (2013-04-25) [Effect of Zingiber offiicinale and Aconitum cainichaeli before and after compatibility on contents of four gingerols].Wenwen Peng et al.Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 37(14), 2076-2078 (2012-11-07) Pharmacological studies on ginger. IV. Effect of (6)-shogaol on the arachidonic cascadeMS, et al. Nihon Aruk?ru Yakubutsu Igakkai Zasshi = Japanese Journal of Alcohol Studies & Drug Dependence, 88, 263-269 (1986) Ginger suppresses phthalate ester-induced airway remodeling.Po-Lin Kuo et al.Journal of agricultural and food chemistry, 59(7), 3429-3438 (2011-03-05) Simultaneous determination of gingerols and shogaol using capillary liquid chromatography and its application in discrimination of three ginger varieties from Indonesia.Mohamad Rafi et al.Talanta, 103, 28-32 (2012-12-04) Pharmacokinetics of 6-gingerol, 8-gingerol, 10-gingerol, and 6-shogaol and conjugate metabolites in healthy human subjectsZick.MS, et al. Cancer Epidemiology, Biomarkers & Prevention, 17, 1930-1936 (2008) 6-Shogaol induces apoptosis in human hepatocellular carcinoma cells and exhibits anti-tumor activity in vivo through endoplasmic reticulum stress.Rong Hu et al.PloS one, 7(6), e39664-e39664 (2012-07-07) 6-Shogaol, a ginger product, modulates neuroinflammation: a new approach to neuroprotection.Sang Keun Ha et al.Neuropharmacology, 63(2), 211-223 (2012-04-03) 4-Shogaol, an active constituent of dietary ginger, inhibits metastasis of MDA-MB-231 human breast adenocarcinoma cells by decreasing the repression of NF-κB/Snail on RKIP.Ya-Ling Hsu et al.Journal of agricultural and food chemistry, 60(3), 852-861 (2012-01-10) Update on the chemopreventive effects of ginger and its phytochemicals.Manjeshwar Shrinath Baliga et al.Critical reviews in food science and nutrition, 51(6), 499-523 (2011-09-21) A novel shogaol analog suppresses cancer cell invasion and inflammation, and displays cytoprotective effects through modulation of NF-κB and Nrf2-Keap1 signaling pathways.Fei-Fei Gan et al.Toxicology and applied pharmacology, 272(3), 852-862 (2013-08-01) Molecular mechanism inhibiting human hepatocarcinoma cell invasion by 6-shogaol and 6-gingerol.Chia-Jui Weng et al.Molecular nutrition & food research, 56(8), 1304-1314 (2012-06-21) Cytotoxic, cytoprotective and antioxidant effects of isolated phenolic compounds from fresh ginger.Fang Peng et al.Fitoterapia, 83(3), 568-585 (2012-01-18) Identification of phase II metabolites of thiol-conjugated [6]-shogaol in mouse urine using high-performance liquid chromatography tandem mass spectrometry.Huadong Chen et al.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 907, 126-139 (2012-10-04) Antiinflammatory effects of ginger and some of its components in human bronchial epithelial (BEAS-2B) cells.Julia A Podlogar et al.Phytotherapy research : PTR, 26(3), 333-336 (2011-06-24) Zingiber officinale extract exhibits antidiabetic potential via modulating glucose uptake, protein glycation and inhibiting adipocyte differentiation: an in vitro study.M Priya Rani et al.Journal of the science of food and agriculture, 92(9), 1948-1955 (2012-01-21) Enhanced CD36 expression changes the role of Nrf2 activation from anti-atherogenic to pro-atherogenic in apoE-deficient mice.Hirotaka Sawada et al.Atherosclerosis, 225(1), 83-90 (2012-09-12) Effects of [6]-shogaol on cholinergic signaling in HT22 cells following neuronal damage induced by hydrogen peroxide.Sehwan Shim et al.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 50(5), 1454-1459 (2012-03-03) Effects of ginger constituents on the gastrointestinal tract: role of cholinergic M3 and serotonergic 5-HT3 and 5-HT4 receptors.Heinz H Pertz et al.Planta medica, 77(10), 973-978 (2011-02-10) In vitro antioxidant and anti-inflammatory activities of 1-dehydro-[6]-gingerdione, 6-shogaol, 6-dehydroshogaol and hexahydrocurcumin.Feng Li et al.Food chemistry, 135(2), 332-337 (2012-08-08) 6-shogaol-rich extract from ginger up-regulates the antioxidant defense systems in cells and mice.Min-Ji Bak et al.Molecules (Basel, Switzerland), 17(7), 8037-8055 (2012-07-06) Preparation of the monomers of gingerols and 6-shogaol by flash high speed counter-current chromatography.Qingliang Qiao et al.Journal of chromatography. A, 1218(36), 6187-6190 (2011-01-05) Protection by [6]-shogaol against lipopolysaccharide-induced toxicity in murine astrocytes is related to production of brain-derived neurotrophic factor.Sehwan Shim et al.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 50(3-4), 597-602 (2011-12-07) Examination of the pharmacokinetics of active ingredients of ginger in humans.Yanke Yu et al.The AAPS journal, 13(3), 417-426 (2011-06-04) 6-Shogaol reduced chronic inflammatory response in the knees of rats treated with complete Freund's adjuvantLevy SAA, et al. BioMed Central Pharmacology, 6, 12-12 (2006) Metabolites of ginger component [6]-shogaol remain bioactive in cancer cells and have low toxicity in normal cells: chemical synthesis and biological evaluation.Yingdong Zhu et al.PloS one, 8(1), e54677-e54677 (2013-02-06)

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