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Peer-Reviewed Papers

ATR enforces the topoisomerase II-dependent G2 checkpoint through inhibition of Plk1 kinase.Paula B Deming et al.The Journal of biological chemistry, 277(39), 36832-36838 (2002-07-31) Topoisomerase II poisoning by ICRF-193.K C Huang et al.The Journal of biological chemistry, 276(48), 44488-44494 (2001-09-29) The catalytic DNA topoisomerase II inhibitor dexrazoxane (ICRF-187) induces differentiation and apoptosis in human leukemia K562 cells.B B Hasinoff et al.Molecular pharmacology, 59(3), 453-461 (2001-02-17) Cellular DNA Topoisomerases Are Required for the Synthesis of Hepatitis B Virus Covalently Closed Circular DNA.Muhammad Sheraz et al.Journal of virology, 93(11) (2019-03-15) The catalytic DNA topoisomerase II inhibitor ICRF-193 and all-trans retinoic acid cooperatively induce granulocytic differentiation of acute promyelocytic leukemia cells: candidate drugs for chemo-differentiation therapy against acute promyelocytic leukemiaNiitsu, Experimental Hematology, 30(11), 1273-1282 (2002) Decreased thymosin beta4 in apoptosis induced by a variety of antitumor drugs.K Iguchi et al.Biochemical pharmacology, 57(10), 1105-1111 (2001-03-07) DNA topoisomerase II is dispensable for oocyte meiotic resumption but is essential for meiotic chromosome condensation and separation in miceLi X M, et al. Biology of Reproduction, 89(5), 1273-1282 (2013) Topoisomerase II Is Crucial for Fork Convergence during Vertebrate Replication Termination.Darren R Heintzman et al.Cell reports, 29(2), 422-436 (2019-10-10) DNA strand breaks induced by the anti-topoisomerase II bis-dioxopiperazine ICRF-193.N Hajji et al.Mutation research, 530(1-2), 35-46 (2003-10-18) ICRF-193, a catalytic inhibitor of DNA topoisomerase II, delays the cell cycle progression from metaphase, but not from anaphase to the G1 phase in mammalian cellsIwai M, et al. Febs Letters, 406(3), 267-270 (1997)

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