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Symbol(GHS)	Xn;N
Hazard Codes	R22;R43;R50/53
SDS/MSDS	S26;S29;S36/37;S46;S60;S61

Source	SDS/MSDS Samples
Sigma-Aldrich	View & Download
Accu-Standard	View & Download

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Articles

Peer-Reviewed Papers

ARID2 is a pomalidomide-dependent CRL4CRBN substrate in multiple myeloma cells.Junichi Yamamoto et al.Nature chemical biology, 16(11), 1208-1217 (2020-09-23) Targeted Degradation of SLC Transporters Reveals Amenability of Multi-Pass Transmembrane Proteins to Ligand-Induced Proteolysis.Ariel Bensimon et al.Cell chemical biology, 27(6), 728-739 (2020-05-11) Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome.Katherine A Donovan et al.eLife, 7 (2018-08-02) A novel effect of thalidomide and its analogs: suppression of cereblon ubiquitination enhances ubiquitin ligase function.Yaobin Liu et al.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(12), 4829-4839 (2015-08-02) Fetal haemoglobin induction in sickle cell disease.Alireza Paikari et al.British journal of haematology, 180(2), 189-200 (2017-11-17) A452, HDAC6-selective inhibitor synergistically enhances the anticancer activity of immunomodulatory drugs in IMiDs-resistant multiple myeloma.Go Woon Kim et al.Leukemia research, 95, 106398-106398 (2020-06-09) Targeting of BMI-1 with PTC-209 shows potent anti-myeloma activity and impairs the tumour microenvironment.Arnold Bolomsky et al.Journal of hematology & oncology, 9, 17-17 (2016-03-05) Decreased secretion of tumor necrosis factor-α attenuates macrophages-induced insulin resistance in skeletal muscle.Lixia Bu et al.Life sciences, 244, 117304-117304 (2020-01-19) Pomalidomide Alters Pancreatic Macrophage Populations to Generate an Immune-Responsive Environment at Precancerous and Cancerous Lesions.Ligia I Bastea et al.Cancer research, 79(7), 1535-1548 (2019-01-31) A validated UPLC-MS/MS assay using negative ionization mode for high-throughput determination of pomalidomide in rat plasma.Muzaffar Iqbal et al.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 983-984, 76-82 (2015-01-27) CK1α and IRF4 are essential and independent effectors of immunomodulatory drugs in primary effusion lymphoma.Ajinkya Patil et al.Blood, 132(6), 577-586 (2018-06-30) Cytokine correlation analysis based on drug perturbation.Fredrik K Wallner et al.Cytokine, 90, 73-79 (2016-11-07) Emma C Fink et al.Blood, 132(14), 1535-1544 (2018-08-02)Thalidomide and its derivatives, lenalidomide and pomalidomide, are clinically effective treatments for multiple myeloma and myelodysplastic syndrome with del(5q). These molecules lack activity in murine models, limiting investigation of their therapeutic activity or toxicity in vivo. Here, we report the... Pomalidomide: evaluation of cytochrome P450 and transporter-mediated drug-drug interaction potential in vitro and in healthy subjects.Claudia Kasserra et al.Journal of clinical pharmacology, 55(2), 168-178 (2014-08-28) Comprehensive characterization of the mutational landscape in multiple myeloma cell lines reveals potential drivers and pathways associated with tumor progression and drug resistance.Veronika Vikova et al.Theranostics, 9(2), 540-553 (2019-02-28) In vivo murine model of acquired resistance in myeloma reveals differential mechanisms for lenalidomide and pomalidomide in combination with dexamethasone.E M Ocio et al.Leukemia, 29(3), 705-714 (2014-08-12) Synergistic anti-myeloma activity of the proteasome inhibitor marizomib and the IMiD immunomodulatory drug pomalidomide.Deepika S Das et al.British journal of haematology, 171(5), 798-812 (2015-10-13) Chlorpyrifos and cypermethrin induce apoptosis in human neuroblastoma cell line SH-SY5Y.Grzegorz Raszewski et al.Basic & clinical pharmacology & toxicology, 116(2), 158-167 (2014-07-01) Thalidomide and Its Analogs Differentially Target Fibroblast Growth Factor Receptors: Thalidomide Suppresses FGFR Gene Expression while Pomalidomide Dampens FGFR2 Activity.Lakshmikirupa Sundaresan et al.Chemical research in toxicology, 32(4), 589-602 (2019-03-06) S-3-Amino-phthalimido-glutarimide inhibits angiogenesis and growth of B-cell neoplasias in mice.Suzanne Lentzsch et al.Cancer research, 62(8), 2300-2305 (2002-04-17) Mechanisms of Skin Toxicity Associated with Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators.Falgun Shah et al.Cell chemical biology, 24(7), 858-869 (2017-07-04) A genome-scale CRISPR-Cas9 screening in myeloma cells identifies regulators of immunomodulatory drug sensitivity.Jiye Liu et al.Leukemia, 33(1), 171-180 (2018-07-22) Role of IRF4 in resistance to immunomodulatory (IMid) compoundsElisabeth Bertrand et al.Oncotarget, 8(68), 112917-112927 (2018-01-20) Preclinical anti-myeloma activity of EDO-S101, a new bendamustine-derived molecule with added HDACi activity, through potent DNA damage induction and impairment of DNA repair.Ana-Alicia López-Iglesias et al.Journal of hematology & oncology, 10(1), 127-127 (2017-06-22) Blockade of deubiquitylating enzyme Rpn11 triggers apoptosis in multiple myeloma cells and overcomes bortezomib resistance.Y Song et al.Oncogene, 36(40), 5631-5638 (2017-06-06) Light-induced control of protein destruction by opto-PROTAC.Jing Liu et al.Science advances, 6(8), eaay5154-eaay5154 (2020-03-05) Development and Characterization of a Wee1 Kinase Degrader.Zhengnian Li et al.Cell chemical biology, 27(1), 57-65 (2019-11-19) Reimbursement of Orphan Drugs in Europe in Relation to the Type of Authorization by the European Medicines Agency and the Decision Making Based on Health Technology Assessment.Krzysztof Piotr Malinowski et al.Frontiers in pharmacology, 9, 1263-1263 (2018-11-30) MYC Controls the Epstein-Barr Virus Lytic Switch.Rui Guo et al.Molecular cell, 78(4), 653-669 (2020-04-22) Depletion of ID3 enhances mesenchymal stem cells therapy by targeting BMP4 in Sjögren's syndrome.Lei Hu et al.Cell death & disease, 11(3), 172-172 (2020-03-07) Microglia Dysfunction Caused by the Loss of Rhoa Disrupts Neuronal Physiology and Leads to Neurodegeneration.Renato Socodato et al.Cell reports, 31(12), 107796-107796 (2020-06-25) Thalidomide Inhibits Human iPSC Mesendoderm Differentiation by Modulating CRBN-dependent Degradation of SALL4.David G Belair et al.Scientific reports, 10(1), 2864-2864 (2020-02-20) Synergistic Antimyeloma Activity of Dendritic Cells and Pomalidomide in a Murine Myeloma Model.Manh-Cuong Vo et al.Frontiers in immunology, 9, 1798-1798 (2018-08-21) An IMiD-induced SALL4 degron system for selective degradation of target proteins.Satoshi Yamanaka et al.Communications biology, 3(1), 515-515 (2020-09-20) AirID, a novel proximity biotinylation enzyme, for analysis of protein-protein interactions.Kohki Kido et al.eLife, 9 (2020-05-12) CXCL12 and CXCR7 are relevant targets to reverse cell adhesion-mediated drug resistance in multiple myeloma.Johannes M Waldschmidt et al.British journal of haematology, 179(1), 36-49 (2017-07-04) Dynamic control of proinflammatory cytokines Il-1β and Tnf-α by macrophages in zebrafish spinal cord regeneration.Themistoklis M Tsarouchas et al.Nature communications, 9(1), 4670-4670 (2018-11-09) Myelosuppression, Bone Disease, and Acute Renal Failure: Evidence-Based Recommendations for Oncologic Emergencies.Kevin Brigle et al.Clinical journal of oncology nursing, 21(5 Suppl), 60-76 (2017-09-26) Immunomodulatory Drugs Alter the Metabolism and the Extracellular Release of Soluble Mediators by Normal Monocytes.Ida Marie Rundgren et al.Molecules (Basel, Switzerland), 25(2) (2020-01-23) Population pharmacokinetics of pomalidomide.Yan Li et al.Journal of clinical pharmacology, 55(5), 563-572 (2015-01-06) The kinesin spindle protein inhibitor filanesib enhances the activity of pomalidomide and dexamethasone in multiple myeloma.Susana Hernández-García et al.Haematologica, 102(12), 2113-2124 (2017-09-02) Unique anti-myeloma activity by thiazolidine-2,4-dione compounds with Pim inhibiting activity.Shiro Fujii et al.British journal of haematology, 180(2), 246-258 (2018-01-13) Soluble SLAMF7 promotes the growth of myeloma cells via homophilic interaction with surface SLAMF7.Jiro Kikuchi et al.Leukemia, 34(1), 180-195 (2019-07-31) HRI depletion cooperates with pharmacologic inducers to elevate fetal hemoglobin and reduce sickle cell formation.Scott A Peslak et al.Blood advances, 4(18), 4560-4572 (2020-09-22) MOR202, a novel anti-CD38 monoclonal antibody, in patients with relapsed or refractory multiple myeloma: a first-in-human, multicentre, phase 1-2a trial.Marc S Raab et al.The Lancet. Haematology, 7(5), e381-e394 (2020-03-15) Rational combination treatment with histone deacetylase inhibitors and immunomodulatory drugs in multiple myeloma.T Hideshima et al.Blood cancer journal, 5, e312-e312 (2015-05-16) Pomalidomide Ameliorates H₂O₂-Induced Oxidative Stress Injury and Cell Death in Rat Primary Cortical Neuronal Cultures by Inducing Anti-Oxidative and Anti-Apoptosis Effects.Yan-Rou Tsai et al.International journal of molecular sciences, 19(10) (2018-10-24) Inhibition of HIF1α-Dependent Upregulation of Phospho-l-Plastin Resensitizes Multiple Myeloma Cells to Frontline Therapy.Manon Bosseler et al.International journal of molecular sciences, 19(6) (2018-06-09) TNF Inhibitor Pomalidomide Sensitizes Glioblastoma Cells to EGFR Inhibition.Zhengxiang Luo et al.Annals of clinical and laboratory science, 50(4), 474-480 (2020-08-23) A novel agent SL-401 induces anti-myeloma activity by targeting plasmacytoid dendritic cells, osteoclastogenesis and cancer stem-like cells.A Ray et al.Leukemia, 31(12), 2652-2660 (2017-05-10) A novel 3D mesenchymal stem cell model of the multiple myeloma bone marrow niche: biologic and clinical applications.Jana Jakubikova et al.Oncotarget, 7(47), 77326-77341 (2016-10-21) Inhibition of Airway Contraction and Inflammation by Pomalidomide in a Male Wistar Rat Model of Ovalbumin-induced Asthma.Majid Ghaderi et al.Iranian journal of allergy, asthma, and immunology, 18(2), 209-217 (2019-05-09) Resistance to proteasome inhibitors and other targeted therapies in myeloma.Craig T Wallington-Beddoe et al.British journal of haematology, 182(1), 11-28 (2018-04-21) Immunomodulatory drugs improve the immune environment for dendritic cell-based immunotherapy in multiple myeloma patients after autologous stem cell transplantation.Brenda De Keersmaecker et al.Cancer immunology, immunotherapy : CII, 63(10), 1023-1036 (2014-06-21) C-X-C motif chemokine ligand 10 produced by mouse Sertoli cells in response to mumps virus infection induces male germ cell apoptosis.Qian Jiang et al.Cell death & disease, 8(10), e3146-e3146 (2017-10-27) A Drug Safety Rating System Based on Postmarketing Costs Associated with Adverse Events and Patient Outcomes.Keith B Hoffman et al.Journal of managed care & specialty pharmacy, 21(12), 1134-1143 (2015-12-19) Amiloride, An Old Diuretic Drug, Is a Potential Therapeutic Agent for Multiple Myeloma.Elizabeta A Rojas et al.Clinical cancer research : an official journal of the American Association for Cancer Research, 23(21), 6602-6615 (2017-08-10) The Novel Pan-PIM Kinase Inhibitor, PIM447, Displays Dual Antimyeloma and Bone-Protective Effects, and Potently Synergizes with Current Standards of Care.Teresa Paíno et al.Clinical cancer research : an official journal of the American Association for Cancer Research, 23(1), 225-238 (2016-07-22) Mumps virus infection disrupts blood-testis barrier through the induction of TNF-α in Sertoli cells.Han Wu et al.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(11), 12528-12540 (2019-08-28) RUNX proteins desensitize multiple myeloma to lenalidomide via protecting IKZFs from degradation.Nan Zhou et al.Leukemia, 33(8), 2006-2021 (2019-02-15) A Cereblon Modulator CC-885 Induces CRBN- and p97-Dependent PLK1 Degradation and Synergizes with Volasertib to Suppress Lung Cancer.Lifeng Li et al.Molecular therapy oncolytics, 18, 215-225 (2020-07-31) UNC0638 induces high levels of fetal hemoglobin expression in β-thalassemia/HbE erythroid progenitor cells.Tiwaporn Nualkaew et al.Annals of hematology, 99(9), 2027-2036 (2020-06-23)

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