Melting point	45-46 ºC
Density	1.281

Symbol(GHS)	N
Hazard Codes	R51/53
SDS/MSDS	S61

Source	SDS/MSDS Samples
Accu-Standard	View & Download

Synthetic Route

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Name	CAS

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Articles

Peer-Reviewed Papers

Oltipraz: a laboratory and clinical review.A B Benson Journal of cellular biochemistry. Supplement, 17F, 278-291 (1993-01-01) Hydrogen peroxide is a second messenger in phase 2 enzyme induction by cancer chemopreventive dithiolethiones.Ryan Holland et al.Chemical research in toxicology, 22(8), 1427-1434 (2009-09-30) Nuclear factor erythroid 2-related factor 2 is a positive regulator of human bile salt export pump expression.Jittima Weerachayaphorn et al.Hepatology (Baltimore, Md.), 50(5), 1588-1596 (2009-10-13) Catalase overexpression prevents nuclear factor erythroid 2-related factor 2 stimulation of renal angiotensinogen gene expression, hypertension, and kidney injury in diabetic mice.Shaaban Abdo et al.Diabetes, 63(10), 3483-3496 (2014-05-09) Oltipraz promotion of liver regeneration after partial hepatectomy: The role of PI3-kinase-dependent C/EBPbeta and cyclin E regulation.Il Je Cho et al.Archives of pharmacal research, 32(4), 625-635 (2009-05-02) Chemopreventive activity of oltipraz.M L Clapper Pharmacology & therapeutics, 78(1), 17-27 (1998-05-21) Parasitological and histo-pathological studies on schistosomiasis mansoni infected mice and treated with praziquatel and/or oltipraz.Gazaa H Morsy Journal of the Egyptian Society of Parasitology, 39(2), 687-701 (2009-10-03) Quantification of oltipraz using liquid chromatography-tandem mass spectrometry and its application to a pharmacokinetic study in rat plasma.Jong-Hwa Lee et al.Journal of pharmaceutical and biomedical analysis, 56(3), 623-626 (2011-07-16) Oltipraz chemoprevention trial in Qidong, Jiangsu Province, People's Republic of China.B C Zhang et al.Journal of cellular biochemistry. Supplement, 28-29, 166-173 (1997-01-01) Hypoxia-inducible factor-1α inhibition by a pyrrolopyrazine metabolite of oltipraz as a consequence of microRNAs 199a-5p and 20a induction.Seul Gi Kang et al.Carcinogenesis, 33(3), 661-669 (2012-01-10) Pharmacokinetic interaction between oltipraz and silymarin in rats.Min Kyung Kang et al.Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 12(1), 1-16 (2009-05-28) Therapeutic potential of dithiolethiones for hepatic diseases.Samuel Carroll Brooks et al.Pharmacology & therapeutics, 124(1), 31-43 (2009-07-01) Zinc oxide nanoparticles inhibit dimethylnitrosamine induced liver injury in rat.Varsha Rani et al.Chemico-biological interactions, 295, 84-92 (2017-10-13) Oltipraz upregulates the nuclear factor (erythroid-derived 2)-like 2 [corrected](NRF2) antioxidant system and prevents insulin resistance and obesity induced by a high-fat diet in C57BL/6J mice.Z Yu et al.Diabetologia, 54(4), 922-934 (2010-12-17) Nuclear factor erythroid 2-related factor 2 deletion impairs glucose tolerance and exacerbates hyperglycemia in type 1 diabetic mice.Lauren M Aleksunes et al.The Journal of pharmacology and experimental therapeutics, 333(1), 140-151 (2010-01-21) Cancer chemoprotection by oltipraz: experimental and clinical considerations.K J Helzlsouer et al.Preventive medicine, 22(5), 783-795 (1993-09-01) Antioxidant and mitochondrial protective effects of oxidized metabolites of oltipraz.Song Hwa Choi et al.Expert opinion on drug metabolism & toxicology, 6(2), 213-224 (2010-01-26) Oltipraz: clinical opportunities for cancer chemoprevention. p.T W Kensler et al.Journal of cellular biochemistry. Supplement, 22, 101-107 (1995-01-01) Oltipraz and dithiolethione congeners inhibit hypoxia-inducible factor-1alpha activity through p70 ribosomal S6 kinase-1 inhibition and H2O2-scavenging effect.Woo Hyung Lee et al.Molecular cancer therapeutics, 8(10), 2791-2802 (2009-10-01) Handling the limit of detection by extrapolation.Nicholas T Longford Statistics in medicine, 31(26), 3133-3146 (2012-04-26) This month in APR.Keon Wook Kang Archives of pharmacal research, 32(4), 463-464 (2009-05-02) Inhibition of colon carcinogenesis by post-initiation induction of NQO1 in Sprague-Dawley rats.Asher Begleiter et al.Oncology reports, 21(6), 1559-1565 (2009-05-09) A randomized phase IIb trial of anethole dithiolethione in smokers with bronchial dysplasiaLam S, et al. Journal of the National Cancer Institute, 94(13), 1001-1009 (2002) Role of adenosine monophosphate-activated protein kinase-p70 ribosomal S6 kinase-1 pathway in repression of liver X receptor-alpha-dependent lipogenic gene induction and hepatic steatosis by a novel class of dithiolethiones.Seong Hwan Hwahng et al.Hepatology (Baltimore, Md.), 49(6), 1913-1925 (2009-04-21) Development of cancer chemopreventive agents: oltipraz as a paradigm.T W Kensler et al.Chemical research in toxicology, 12(2), 113-126 (1999-02-23) Inactivation of protein tyrosine phosphatases by oltipraz and other cancer chemopreventive 1,2-dithiole-3-thiones.Sanjib Bhattacharyya et al.Bioorganic & medicinal chemistry, 18(16), 5945-5949 (2010-07-27) Nrf2 is essential for the chemopreventive efficacy of oltipraz against urinary bladder carcinogenesisIida K, et al. Cancer Research, 64(18), 6424-6431 (2004) Oltipraz therapy in patients with liver fibrosis or cirrhosis: a randomized, double-blind, placebo-controlled phase II trial.Sang Geon Kim et al.The Journal of pharmacy and pharmacology, 63(5), 627-635 (2011-04-16) Pharmacokinetics of oltipraz and its major metabolite (RM) in patients with liver fibrosis or cirrhosis: relationship with suppression of circulating TGF-beta1.S G Kim et al.Clinical pharmacology and therapeutics, 88(3), 360-368 (2010-07-29) Oxidized metabolites of oltipraz exert cytoprotective effects against arachidonic acid through AMP-activated protein kinase-dependent cellular antioxidant effect and mitochondrial protection.Young Nam Kwon et al.Drug metabolism and disposition: the biological fate of chemicals, 37(6), 1187-1197 (2009-03-21) Chemoprevention of cigarette smoke-induced alterations of MicroRNA expression in rat lungs.Alberto Izzotti et al.Cancer prevention research (Philadelphia, Pa.), 3(1), 62-72 (2010-01-07) Multi-layer polymeric implants for sustained release of chemopreventives.Farrukh Aqil et al.Cancer letters, 326(1), 33-40 (2012-07-24) Aryl hydrocarbon receptor and NF-E2-related factor 2 are key regulators of human MRP4 expression.Shuhua Xu et al.American journal of physiology. Gastrointestinal and liver physiology, 299(1), G126-G135 (2010-04-17) Decreased apoptosis during CAR-mediated hepatoprotection against lithocholic acid-induced liver injury in mice.Lisa D Beilke et al.Toxicology letters, 188(1), 38-44 (2009-05-13) Mechanisms of chemoprotection by oltipraz.T Kensler et al.Journal of cellular biochemistry. Supplement, 16I, 167-172 (1992-01-01) Involvement of pregnane X receptor in the regulation of CYP2B6 gene expression by oltipraz in human hepatocytes.Amélie Piton et al.Toxicology in vitro : an international journal published in association with BIBRA, 24(2), 452-459 (2009-10-17) Oltipraz, a novel inhibitor of human immunodeficiency virus type 1 (HIV-1) replication.H J Prochaska et al.Journal of cellular biochemistry. Supplement, 22, 117-125 (1995-01-01) The effects of oltipraz on tissue regeneration in the process of wound healing: a stereological studyNoorafshan A, et al. Bulletin of emergency and trauma, 2(4), 161-161 (2014) Effects of oltipraz and related chemoprevention compounds on gene expression in rat liver.L Anderson et al.Journal of cellular biochemistry. Supplement, 22, 108-116 (1995-01-01)

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