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Synthetic Route

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Articles

Peer-Reviewed Papers

Convenient synthesis of 2'-deoxy-2-fluoroadenosine from 2-fluoroadenine.Song Ye et al.Nucleosides, nucleotides & nucleic acids, 22(10), 1899-1905 (2003-11-12) Metabolism and metabolic actions of 6-methylpurine and 2-fluoroadenine in human cells.W B Parker et al.Biochemical pharmacology, 55(10), 1673-1681 (1998-06-20) Metabolic cooperation between mouse mammary tumor subpopulations in three-dimensional collagen gel cultures.B E Miller et al.Cancer research, 46(1), 89-93 (1986-01-01) Comparison of gene targeting efficiencies in two mosses suggests that it is a conserved feature of Bryophyte transformation.Bénédicte Trouiller et al.Biotechnology letters, 29(10), 1591-1598 (2007-06-15) Preclinical evaluation of a prostate-targeted gene-directed enzyme prodrug therapy delivered by ovine atadenovirus.X Y Wang et al.Gene therapy, 11(21), 1559-1567 (2004-09-03) Endothelin-1 promotes survival and chemoresistance in chronic lymphocytic leukemia B cells through ETA receptor.Rossana Maffei et al.PloS one, 9(6), e98818-e98818 (2014-06-06) Genetic and physiological characterization of Bacillus subtilis mutants resistant to purine analogs.H H Saxild et al.Journal of bacteriology, 169(7), 2977-2983 (1987-07-01) Structure of a mutant human purine nucleoside phosphorylase with the prodrug, 2-fluoro-2'-deoxyadenosine and the cytotoxic drug, 2-fluoroadenine.Sepideh Afshar et al.Protein science : a publication of the Protein Society, 18(5), 1107-1114 (2009-04-24) 2-fluoro-ATP: a toxic metabolite of 9-beta-D-arabinosyl-2-fluoroadenine.V I Avramis et al.Biochemical and biophysical research communications, 113(1), 35-43 (1983-05-31) Identification of a subversive substrate of Trichomonas vaginalis purine nucleoside phosphorylase and the crystal structure of the enzyme-substrate complex.Yang Zang et al.The Journal of biological chemistry, 280(23), 22318-22325 (2005-04-09) Preparation of a fludarabine intermediate via selective alkylation of 2-fluoroadenine.Brian E Schulmeier et al.Nucleosides, nucleotides & nucleic acids, 25(7), 735-745 (2006-08-11) Synthesis and biological activity of 2-fluoro adenine and 6-methyl purine nucleoside analogs as prodrugs for suicide gene therapy of cancer.A V Silamkoti et al.Nucleosides, nucleotides & nucleic acids, 24(5-7), 881-885 (2005-10-27) Enzymatic synthesis and 19F NMR studies of 2-fluoroadenine-substituted RNA.Lincoln G Scott et al.Journal of the American Chemical Society, 126(38), 11776-11777 (2004-09-24) Synthesis of carbocyclic and acyclic nucleosides possessing 2-fluoroadenine derivatives and their inhibitory activities against Plasmodium falciparum SAH hydrolase.Yukio Kitade et al.Nucleic acids research. Supplement (2001), (3)(3), 5-6 (2003-09-27) Gene therapy for prostate cancer delivered by ovine adenovirus and mediated by purine nucleoside phosphorylase and fludarabine in mouse models.D Voeks et al.Gene therapy, 9(12), 759-768 (2002-06-01) Reduced drug incorporation into DNA and antiapoptosis as the crucial mechanisms of resistance in a novel nelarabine-resistant cell line.Takahiro Yamauchi et al.BMC cancer, 14, 547-547 (2014-07-30) Phosphorolytic cleavage of 2-fluoroadenine from 9-beta-D-arabinofuranosyl-2-fluoroadenine by Escherichia coli. A pathway for 2-fluoro-ATP production.P Huang et al.Biochemical pharmacology, 36(18), 2945-2950 (1987-09-15)

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