Melting point	30-32 ºC
Water Solubility	0.15 g/L (20 º C)
Boiling point	268-270 ºC
Density	0.89

Symbol(GHS)	Xi
Hazard Codes	R36/38
SDS/MSDS	S26;S37/39

Source	SDS/MSDS Samples
Alfa-Aesar	View & Download
Sigma-Aldrich	View & Download
TCI	View & Download

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Articles

Peer-Reviewed Papers

Antitumor and antimetastatic activities of chloroquine diphosphate in a murine model of breast cancer.Pei-Du Jiang et al.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 64(9), 609-614 (2010-10-05) A super-ecliptic, pHluorin-mKate2, tandem fluorescent protein-tagged human LC3 for the monitoring of mammalian autophagy.Isei Tanida et al.PloS one, 9(10), e110600-e110600 (2014-10-24) In-vitro culture of Plasmodium falciparum: utility of modified (RPNI) medium for drug-sensitivity studies using SYBR Green I assay.Shubhra Singh et al.Experimental parasitology, 127(1), 318-321 (2010-08-24) Rapid spectrofluorimetric determination of chloroquine phosphate tabletsNelson O, et al. International Journal of Drug Development and Research, 2(2), 412-417 (2010) Ageing and reproduction: antioxidant supplementation alleviates telomere loss in wild birds.E P Badás et al.Journal of evolutionary biology, 28(4), 896-905 (2015-03-12) Scar sarcoidosis with a 50-year interval between an accident and onset of lesions.Hiram Larangeira de Almeida et al.Dermatology online journal, 14(11), 18-18 (2008-12-20) Variant Plasmodium ovale isolated from a patient infected in Ghana.David Tordrup et al.Malaria journal, 10, 15-15 (2011-01-25) An integrated biological approach to guide the development of metal-chelating inhibitors of influenza virus PA endonuclease.Annelies Stevaert et al.Molecular pharmacology, 87(2), 323-337 (2014-12-06) Aminoquinolines against coronavirus disease 2019 (COVID-19): chloroquine or hydroxychloroquineSahraei Z, et al. International Journal of Antimicrobial Agents, 105945(10.1016) (2020) [A case of imported vivax malaria in Tomsk].N P Chernyshova et al.Meditsinskaia parazitologiia i parazitarnye bolezni, (4)(4), 49-50 (2013-02-27) A combination therapy for KRAS-driven lung adenocarcinomas using lipophilic bisphosphonates and rapamycin.Yifeng Xia et al.Science translational medicine, 6(263), 263ra161-263ra161 (2014-11-21) Toxic epidermal necrolysis-like cutaneous lupus erythematosus: A series of three patients.Claudia G C Cisneros et al.Acta dermato-venereologica, 90(2), 175-178 (2010-02-20) Stereoisomer-specific anticancer activities of ginsenoside Rg3 and Rh2 in HepG2 cells: disparity in cytotoxicity and autophagy-inducing effects due to 20(S)-epimers.Jong Hye Cheong et al.Biological & pharmaceutical bulletin, 38(1), 102-108 (2015-03-07) Inhibition of influenza virus replication by targeting broad host cell pathways.Isabelle Marois et al.PloS one, 9(10), e110631-e110631 (2014-10-22) Role of curcumin on chloroquine phosphate-induced reproductive toxicity.Ketaki R Desai et al.Drug and chemical toxicology, 35(2), 184-191 (2011-07-22) SKP2 attenuates NF-κB signaling by mediating IKKβ degradation through autophagy.Kunpeng Liu et al.Journal of molecular cell biology, 10(3), 205-215 (2018-02-24) Amyloid-beta accumulation caused by chloroquine injections precedes ER stress and autophagosome formation in rat skeletal muscle.Koji Ikezoe et al.Acta neuropathologica, 117(5), 575-582 (2009-02-10) Effect of chloroquine phosphate treatment on serum MMP-9 and TIMP-1 levels in patients with systemic lupus erythematosus.A Lesiak et al.Lupus, 19(6), 683-688 (2010-01-13) Lupus erythematosus tumidus: response to antimalarial treatment in 36 patients with emphasis on smoking.Alexander Kreuter et al.Archives of dermatology, 145(3), 244-248 (2009-03-18) Determination of chloroquine and its decomposition products in various brands of different dosage forms by liquid chromatographyAbdelrahman AN, et al. Journal of Pharmaceutical and Biomedical Analysis, 12(2), 205-208 (1994) TRIM14 Promotes Noncanonical NF-κB Activation by Modulating p100/p52 Stability via Selective Autophagy.Meixin Chen et al.Advanced science (Weinheim, Baden-Wurttemberg, Germany), 7(1), 1901261-1901261 (2020-01-11) Inhibition of HDAC6 modifies tau inclusion body formation and impairs autophagic clearance.Janina Leyk et al.Journal of molecular neuroscience : MN, 55(4), 1031-1046 (2014-12-02) Resistance of colon cancer to 5-fluorouracil may be overcome by combination with chloroquine, an in vivo study.Kazuhito Sasaki et al.Anti-cancer drugs, 23(7), 675-682 (2012-05-09) Fever in a 20-year-old returned traveler.Stephen Y Liang et al.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 56(3), 423-423 (2013-01-10) Lysine acetylation in sexual stage malaria parasites is a target for antimalarial small molecules.Katharine Trenholme et al.Antimicrobial agents and chemotherapy, 58(7), 3666-3678 (2014-04-16) The cytoprotective role of gemcitabine-induced autophagy associated with apoptosis inhibition in triple-negative MDA-MB-231 breast cancer cells.Ming Chen et al.International journal of molecular medicine, 34(1), 276-282 (2014-05-09) Combination therapy with ropivacaine-loaded liposomes and nutrient deprivation for simultaneous cancer therapy and cancer pain relief.Jiqian Zhang et al.Theranostics, 10(11), 4885-4899 (2020-04-21) Monitoring of clinical efficacy and in vitro sensitivity of Plasmodium vivax to chloroquine in area along Thai Myanmar border during 2009-2010.Poonuch Muhamad et al.Malaria journal, 10, 44-44 (2011-02-18) [Monitoring delagil (chloroquine) efficacy against imported Plasmodium vivax strains].S A Rabinovich et al.Meditsinskaia parazitologiia i parazitarnye bolezni, (4)(4), 46-48 (2011-03-15) Seventy-five years of Resochin in the fight against malaria.Markus Jensen et al.Parasitology research, 105(3), 609-627 (2009-07-14) Doxorubicin and chloroquine coencapsulated liposomes: preparation and improved cytotoxicity on human breast cancer cells.Liyan Qiu et al.Journal of liposome research, 22(3), 245-253 (2012-05-23) Regulators of autophagosome formation in Drosophila muscles.Jonathan Zirin et al.PLoS genetics, 11(2), e1005006-e1005006 (2015-02-19) Design, synthesis and anti-itch activity evaluation of aromatic amino acid derivatives as gastrin-releasing peptide receptor antagonists.Ri-Sheng Yao et al.Medicinal chemistry (Shariqah (United Arab Emirates)), 8(5), 865-873 (2012-06-30) Retinal toxicity associated with hydroxychloroquine and chloroquine: risk factors, screening, and progression despite cessation of therapy.Michel Michaelides et al.Archives of ophthalmology (Chicago, Ill. : 1960), 129(1), 30-39 (2011-01-12) Chloroquine is a zinc ionophore.Jing Xue et al.PloS one, 9(10), e109180-e109180 (2014-10-02) Development of simplified HPLC methods for the detection of counterfeit antimalarials in resource-restraint environments.Ludwig Hoellein et al.Journal of pharmaceutical and biomedical analysis, 98, 434-445 (2014-07-13) In utero exposure to chloroquine alters sexual development in the male fetal rat.Rebecca A Clewell et al.Toxicology and applied pharmacology, 237(3), 366-374 (2009-04-28) Chloroquine -induced hair depigmentation.T B Di Giacomo et al.Lupus, 18(3), 264-266 (2009-02-14) Response characteristics of pruriceptive and nociceptive trigeminoparabrachial tract neurons in the rat.Nico A Jansen et al.Journal of neurophysiology, 113(1), 58-70 (2014-10-10) [Diagnostic methods for chloroquine diphosphate induced retinopathy in systemic lupus erythematosus].Luciana Duarte Rodrigues et al.Arquivos brasileiros de oftalmologia, 72(3), 313-320 (2009-08-12) Efficacy and pharmacokinetic evaluation of a novel anti-malarial compound (NP046) in a mouse model.Efrem T Abay et al.Malaria journal, 14, 8-8 (2015-01-08) Identification of Plasmodium relictum causing mortality in penguins (Spheniscus magellanicus) from São Paulo Zoo, Brazil.Marina Galvão Bueno et al.Veterinary parasitology, 173(1-2), 123-127 (2010-07-20) High absolute bioavailability of methylene blue given as an aqueous oral formulation.Ingeborg Walter-Sack et al.European journal of clinical pharmacology, 65(2), 179-189 (2008-09-24) Induction of autophagy contributes to crizotinib resistance in ALK-positive lung cancer.Cheng Ji et al.Cancer biology & therapy, 15(5), 570-577 (2014-02-22) Blood parasites mediate morph-specific maintenance costs in a colour polymorphic wild bird.P Karell et al.Journal of evolutionary biology, 24(8), 1783-1792 (2011-05-24) The NKG2D ligand ULBP2 is specifically regulated through an invariant chain-dependent endosomal pathway.Franziska Uhlenbrock et al.Journal of immunology (Baltimore, Md. : 1950), 193(4), 1654-1665 (2014-07-16) CREG1 ameliorates myocardial fibrosis associated with autophagy activation and Rab7 expression.Cheng-hui Yan et al.Biochimica et biophysica acta, 1852(2), 353-364 (2015-03-17) Cyanidin-3-O-glucoside improves non-alcoholic fatty liver disease by promoting PINK1-mediated mitophagy in mice.Xinwei Li et al.British journal of pharmacology, 177(15), 3591-3607 (2020-04-29) Systematic identification of CDC34 that functions to stabilize EGFR and promote lung carcinogenesis.Xin-Chun Zhao et al.EBioMedicine, 53, 102689-102689 (2020-03-03) [The specific features of imported Plasmodium vivax malaria, Chesson strain type].S A Rabinovich et al.Meditsinskaia parazitologiia i parazitarnye bolezni, (4)(4), 7-11 (2013-02-27)

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