Melting point	45.6 ºC**
Boiling point	281.5±15.0 ºC (760 Tor
Flash point	124.1±20.4 ºC, 计算值*
Density	1.403±0.06 g/cm3 (20 º

没有数据	没有数据

Source	SDS/MSDS Samples
没有数据	没有数据

Synthetic Route

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Name	CAS

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Articles

Peer-Reviewed Papers

Pharmacological Cognitive Enhancement in Healthy Individuals: A Compensation for Cognitive Deficits or a Question of Personality?Larissa J Maier et al.PloS one, 10(6), e0129805-e0129805 (2015-06-25) Enantioselective gas chromatographic assay with electron-capture detection for dl-ritalinic acid in plasma.N R Srinivas et al.Journal of chromatography, 530(2), 327-336 (1990-09-14) Dispensing errors: Ritalin v. ritodrine.P Hall CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 135(5), 432-432 (1986-09-01) Plasma and brain concentrations of oral therapeutic doses of methylphenidate and their impact on brain monoamine content in mice.Aygul Balcioglu et al.Neuropharmacology, 57(7-8), 687-693 (2009-07-28) Enantioselective analysis of ritalinic acids in biological samples by using a protein-based chiral stationary phase.Jianhua Zhang et al.Pharmaceutical research, 20(11), 1881-1884 (2003-12-10) Pharmacokinetics of methylphenidate in oral fluid and sweat of a pediatric subject.E Marchei et al.Forensic science international, 196(1-3), 59-63 (2010-01-26) Stereoselective urinary pharmacokinetics of dl-threo-methylphenidate and its major metabolite in humans.N R Srinivas et al.Journal of pharmaceutical sciences, 81(8), 747-749 (1992-08-01) HPLC determination of methylphenidate and its metabolite, ritalinic acid, by high-performance liquid chromatography with peroxyoxalate chemiluminescence detection.Mitsuhiro Wada et al.Analytical and bioanalytical chemistry, 400(2), 387-393 (2011-02-15) High-throughput selected reaction monitoring liquid chromatography-mass spectrometry determination of methylphenidate and its major metabolite, ritalinic acid, in rat plasma employing monolithic columns.Nicolas Barbarin et al.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 783(1), 73-83 (2002-11-27) Usefulness of sweat testing for the detection of methylphenidate after fast- and extended-release drug administration: a pilot study.Emilia Marchei et al.Therapeutic drug monitoring, 32(4), 508-511 (2010-06-11) Liquid chromatography-tandem mass spectrometry method for the simultaneous analysis of multiple hallucinogens, chlorpheniramine, ketamine, ritalinic acid, and metabolites, in urine.Maria del Mar Ramirez Fernandez et al.Journal of analytical toxicology, 31(8), 497-504 (2007-11-09) Correlation between methylphenidate and ritalinic acid concentrations in oral fluid and plasma.Emilia Marchei et al.Clinical chemistry, 56(4), 585-592 (2010-02-20) Potential trends in Attention Deficit Hyperactivity Disorder (ADHD) drug use on a college campus: wastewater analysis of amphetamine and ritalinic acid.Daniel A Burgard et al.The Science of the total environment, 450-451, 242-249 (2013-03-19) Pharmacokinetics, dose-range, and mutagenicity studies of methylphenidate hydrochloride in B6C3F1 mice.Mugimane G Manjanatha et al.Environmental and molecular mutagenesis, 49(8), 585-593 (2008-07-12) Occurrence and fate of the human pharmaceutical metabolite ritalinic acid in the aquatic system.Marion Letzel et al.Chemosphere, 81(11), 1416-1422 (2010-10-12) Determination of amphetamine and methylphenidate in exhaled breath of patients undergoing attention-deficit/hyperactivity disorder treatment.Olof Beck et al.Therapeutic drug monitoring, 36(4), 528-534 (2014-01-24) Influence of ethanol on the pharmacokinetics of methylphenidate's metabolites ritalinic acid and ethylphenidate.Michaela Koehm et al.Arzneimittel-Forschung, 60(5), 238-244 (2010-06-11) Analysis of methylphenidate and its metabolite ritalinic acid in monkey plasma by liquid chromatography/electrospray ionization mass spectrometry.D R Doerge et al.Rapid communications in mass spectrometry : RCM, 14(8), 619-623 (2000-04-29) A single-dose, two-way crossover, bioequivalence study of dexmethylphenidate HCl with and without food in healthy subjects.Steve K Teo et al.Journal of clinical pharmacology, 44(2), 173-178 (2004-01-30) A safer methylation procedure with boron trifluoride-methanol reagent for gas chromatographic analysis of ritalinic acid in urine.T Vu-Duc et al.Journal of pharmaceutical and biomedical analysis, 10(2-3), 187-191 (1992-02-01) Kinetic analysis of enantiomers of threo-methylphenidate and its metabolite in two healthy subjects after oral administration as determined by a gas chromatographic-mass spectrometric method.T Aoyama et al.Journal of pharmaceutical sciences, 79(6), 465-469 (1990-06-01) Detection of the novel metabolite ethylphenidate after methylphenidate overdose with alcohol coingestion.J S Markowitz et al.Journal of clinical psychopharmacology, 19(4), 362-366 (1999-08-10) Single-dose pharmacokinetics of methylphenidate in CYP2D6 extensive and poor metabolizers.C L DeVane et al.Journal of clinical psychopharmacology, 20(3), 347-349 (2000-06-01) Determination of methylphenidate and its metabolite ritalinic acid in urine by liquid chromatography/tandem mass spectrometry.Sharon M Paterson et al.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 881-882, 20-26 (2011-12-30) Enantioselective determination of methylphenidate and ritalinic acid in whole blood from forensic cases using automated solid-phase extraction and liquid chromatography-tandem mass spectrometry.Ragnar Thomsen et al.Journal of analytical toxicology, 36(8), 560-568 (2012-07-27) Simultaneous detection of methylphenidate and its main metabolite, ritalinic acid, in doping control.A Solans et al.Journal of chromatography. B, Biomedical applications, 658(2), 380-384 (1994-08-19) Determination of methylphenidate and ritalinic acid in blood, plasma and oral fluid from adolescents and adults using protein precipitation and liquid chromatography tandem mass spectrometry--a method applied on clinical and forensic investigations.Martin Josefsson et al.Journal of pharmaceutical and biomedical analysis, 55(5), 1050-1059 (2011-04-19)

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