Melting point	15.6 ºC
Boiling point	275 ºC
Flash point	146 ºC
Density	0.996
Refractive index	1.46-1.462

Symbol(GHS)	Xi
Hazard Codes	R36/37/38
SDS/MSDS	S26;S37/39

Source	SDS/MSDS Samples
Alfa-Aesar	View & Download
Sigma-Aldrich	View & Download
TCI	View & Download

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Articles

Peer-Reviewed Papers

Constrained phenylalanine analogues. Preferred conformation of the 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (Tic) residue.G Valle et al.International journal of peptide and protein research, 40(3-4), 222-232 (1992-09-01) A novel series of (S)-2,7-substituted-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids: peroxisome proliferator-activated receptor α/γ dual agonists with protein-tyrosine phosphatase 1B inhibitory activity.Kazuya Otake et al.Chemical & pharmaceutical bulletin, 59(10), 1233-1242 (2011-10-04) An exploration of the effects of L- and D-tetrahydroisoquinoline-3-carboxylic acid substitutions at positions 2, 3 and 7 in cyclic and linear antagonists of vasopressin and oxytocin and at position 3 in arginine vasopressin.M Manning et al.Journal of peptide science : an official publication of the European Peptide Society, 1(1), 66-79 (1995-01-01) 2-Substituted (S)-2-(3,3-dimethyl-1-oxo-10,10a-dihydroimidazo[1,5-b]isoquinolin-2(1H,3H,5H)-yl)acetic acids: Conformational prediction, synthesis, anti-thrombotic and vasodilative evaluation.Hong Wang et al.Bioorganic & medicinal chemistry, 19(2), 871-882 (2011-01-05) Synthesis of methylated phenylalanines via hydrogenolysis of corresponding 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids. Synthesis and biological activity of oxytocin analogs with methylated phenylalanines in position 2.P Majer et al.International journal of peptide and protein research, 43(1), 62-68 (1994-01-01) Theoretical conformational analysis of the opioid delta antagonist H-Tyr-Tic-Phe-OH and the mu agonist H-Tyr-D-Tic-Phe-NH2.B C Wilkes et al.Biopolymers, 34(9), 1213-1219 (1994-09-01) 1-Amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid as a Tic mimetic: application in the synthesis of potent human melanocortin-4 receptor selective agonists.Raman K Bakshi et al.Bioorganic & medicinal chemistry letters, 15(14), 3430-3433 (2005-06-14) Applications and modifications of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (Tic) in peptides and peptidomimetics design and discovery.Yingjie Zhang et al.Current protein & peptide science, 11(8), 752-758 (2011-01-18) Novel Dmt-Tic dipeptide analogues as selective delta-opioid receptor antagonists.D Pagé et al.Bioorganic & medicinal chemistry letters, 10(2), 167-170 (2000-02-15) Acid catalysis in the formation of dioxopiperazines from peptides containing tetrahydroisoquinoline-3-carboxylic acid at position 2.S Capasso et al.International journal of peptide and protein research, 45(6), 567-573 (1995-06-01) 2-Acyl-tetrahydroisoquinoline-3-carboxylic acids: lead compounds with triple actions, peroxisome proliferator-activated receptor α/γ agonist and protein-tyrosine phosphatase 1B inhibitory activities.Kazuya Otake et al.Chemical & pharmaceutical bulletin, 59(7), 876-879 (2011-07-02) Design, synthesis and biological evaluation of novel 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives as aminopeptidase N/CD13 inhibitors.Xiaopan Zhang et al.Bioorganic & medicinal chemistry, 19(20), 6015-6025 (2011-09-14) In position 7 L- and D-Tic-substituted oxytocin and deamino oxytocin: NMR study and conformational insights.Zinovia Spyranti et al.Amino acids, 39(2), 539-548 (2010-01-29) Discovery of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid diamides that increase CFTR mediated chloride transport.Bradford H Hirth et al.Bioorganic & medicinal chemistry letters, 15(8), 2087-2091 (2005-04-06) Selective opioid dipeptides.P A Temussi et al.Biochemical and biophysical research communications, 198(3), 933-939 (1994-02-15) [TIC4]endomorphins, analogues of endomorphins, have significantly enhanced vasorelaxant effects in rat aorta rings.Qian-Yu Zhao et al.Protein and peptide letters, 12(4), 323-326 (2005-05-24) Novel C-terminus modifications of the Dmt-Tic motif: a new class of dipeptide analogues showing altered pharmacological profiles toward the opioid receptors.D Pagé et al.Journal of medicinal chemistry, 44(15), 2387-2390 (2001-07-13) Deletion of Ac-NMePhe(1) from [NMePhe(1) ]arodyn under acidic conditions, part 1: effects of cleavage conditions and N-terminal functionality.Wei-Jie Fang et al.Biopolymers, 96(1), 97-102 (2010-06-19) pH-Dependent nanostructure based on isoquinoline-cyclodextrin conjugate for thrombosis therapy.Li Li et al.Nanomedicine : nanotechnology, biology, and medicine, 8(7), 1216-1222 (2012-01-18) Design, synthesis and preliminary activity assay of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives as novel Histone deacetylases (HDACs) inhibitors.Yingjie Zhang et al.Bioorganic & medicinal chemistry, 18(5), 1761-1772 (2010-02-23) Rational design of dynorphin A analogues with delta-receptor selectivity and antagonism for delta- and kappa-receptors.R Guerrini et al.Bioorganic & medicinal chemistry, 6(1), 57-62 (1998-03-21)

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