Melting point	113-116 ºC
Water Solubility	>=10 g/100 mL at 22 ºC
Density	1.50

Symbol(GHS)	Xn
Hazard Codes	R22

Source	SDS/MSDS Samples
Sigma-Aldrich	View & Download
Accu-Standard	View & Download

Synthetic Route

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Name	CAS

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Articles

Peer-Reviewed Papers

Antihyperglycemic effect of fraxetin on hepatic key enzymes of carbohydrate metabolism in streptozotocin-induced diabetic rats.Raju Murali et al.Biochimie, 95(10), 1848-1854 (2013-06-29) Bone morphogenetic protein-2 and -4 (BMP-2 and -4) mediates fraxetin-induced maturation and differentiation in human osteoblast-like cell lines.Po-Lin Kuo et al.Biological & pharmaceutical bulletin, 29(1), 119-124 (2006-01-06) Neuroprotective effect of fraxetin and myricetin against rotenone-induced apoptosis in neuroblastoma cells.María Francisca Molina-Jiménez et al.Brain research, 1009(1-2), 9-16 (2004-05-04) Natural coumarins as a novel class of neuroprotective agents.Francesco Epifano et al.Mini reviews in medicinal chemistry, 9(11), 1262-1271 (2009-11-26) Effect of fraxetin on antioxidant defense and stress proteins in human neuroblastoma cell model of rotenone neurotoxicity. Comparative study with myricetin and N-acetylcysteine.María Francisca Molina-Jiménez et al.Toxicology and applied pharmacology, 209(3), 214-225 (2005-05-21) Fraxetin prevents rotenone-induced apoptosis by induction of endogenous glutathione in human neuroblastoma cells.María Isabel Sánchez-Reus et al.Neuroscience research, 53(1), 48-56 (2005-07-06) Dual anti-oxidative effects of fraxetin isolated from Fraxinus rhinchophylla.Phuong Thien Thuong et al.Biological & pharmaceutical bulletin, 32(9), 1527-1532 (2009-09-02) Soil carbonate drives local adaptation in Arabidopsis thaliana.Joana Terés et al.Plant, cell & environment, 42(8), 2384-2398 (2019-04-25) [Studies on chemical constituents from stem barks of Fraxinus paxiana].Zhi-jing Ma et al.Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 33(16), 1990-1993 (2008-12-18) Effects of fraxetin on glutathione redox status.S Martín-Aragón et al.Zeitschrift fur Naturforschung. C, Journal of biosciences, 52(1-2), 55-59 (1997-01-01) HIV gp41 binding phenolic components from Fraxinus sieboldiana var. angustata.Hyoung Ja Kim et al.Planta medica, 68(11), 1034-1036 (2002-11-27) Effect of fraxetin and myricetin on rotenone-induced cytotoxicity in SH-SY5Y cells: comparison with N-acetylcysteine.M Francisca Molina-Jimenez et al.European journal of pharmacology, 472(1-2), 81-87 (2003-07-16) [Coumarins from branch of Fraxinus sieboldiana and their antioxidative activity].Sheng Lin et al.Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 33(14), 1708-1710 (2008-10-10) Fraxetin inhibits the induction of anti-Fas IgM, tumor necrosis factor-alpha and interleukin-1beta-mediated apoptosis by Fas pathway inhibition in human osteoblastic cell line MG-63.Po-Lin Kuo et al.International immunopharmacology, 6(7), 1167-1175 (2006-05-23) Antioxidant activity of Fraxetin: in vivo and ex vivo parameters in normal situation versus induced stress.B Fernandez-Puntero et al.Biological & pharmaceutical bulletin, 24(7), 777-784 (2001-07-18)

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