Melting point	163 ºC
Water Solubility	微溶.
Density	1.39

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Source	SDS/MSDS Samples
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Peer-Reviewed Papers

Molecular cloning and recombinant expression of cytochrome P450 CYP6B6 from Helicoverpa armigera in Escherichia coli.Xiaoning Liu et al.Molecular biology reports, 40(2), 1211-1217 (2012-10-26) Silkworm as a model animal to evaluate drug candidate toxicity and metabolism.Hiroshi Hamamoto et al.Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 149(3), 334-339 (2008-09-23) Acute toxicity and sublethal effects of fipronil on detoxification enzymes in juvenile zebrafish (Danio rerio).Haihua Wu et al.Pesticide biochemistry and physiology, 115, 9-14 (2014-10-14) Hydrogen peroxide-mediated dealkylation of 7-ethoxycoumarin by cytochrome P450 (CYP107AJ1) from Streptomyces peucetius ATCC27952.Narayan Prasad Niraula et al.Enzyme and microbial technology, 48(2), 181-186 (2011-11-25) Engineering bacterial cytochrome P450 (P450) BM3 into a prototype with human P450 enzyme activity using indigo formation.Sun-Ha Park et al.Drug metabolism and disposition: the biological fate of chemicals, 38(5), 732-739 (2010-01-27) Unravelling the molecular determinants of bee sensitivity to neonicotinoid insecticidesManjon C, et al. Current Biology, 28(7), 1137-1143 (2018) Engineering cytochrome P450 monooxygenase CYP 116B3 for high dealkylation activity.Luo Liu et al.Biotechnology letters, 32(6), 841-845 (2010-03-10) Designing a whole-cell biotransformation system in Escherichia coli using cytochrome P450 from Streptomyces peucetius.Pramod Shrestha et al.Biotechnology letters, 30(6), 1101-1106 (2008-02-09) Microfluidic biochip for the perifusion of precision-cut rat liver slices for metabolism and toxicology studies.Paul M van Midwoud et al.Biotechnology and bioengineering, 105(1), 184-194 (2009-09-01) Metabolism of 7-ethoxycoumarin, safrole, flavanone and hydroxyflavanone by cytochrome P450 2A6 variants.Tomohide Uno et al.Biopharmaceutics & drug disposition, 34(2), 87-97 (2012-11-01) In vitro evaluation of hepatic and extra-hepatic metabolism of coumarins using rat subcellular fractions: correlation of in vitro clearance with in vivo data.Dayanidhi Behera et al.Drug metabolism and drug interactions, 23(3-4), 329-350 (2008-01-01) Functional characterization of human CYP2C9 allelic variants in COS-7 cellsDu H, et al. Frontiers in Pharmacology, 7, 98-98 (2016) Analysis of hesperetin enantiomers in human urine after ingestion of blood orange juice by using nano-liquid chromatography.Kahina Si-Ahmed et al.Journal of pharmaceutical and biomedical analysis, 51(1), 225-229 (2009-09-11) Multiple UDP-glucuronosyltransferases in human liver microsomes glucuronidate both R- and S-7-hydroxywarfarin into two metabolites.C Preston Pugh et al.Archives of biochemistry and biophysics, 564, 244-253 (2014-12-03) Influence of dietary macronutrients on induction of hepatic drug metabolizing enzymes by Coleus forskohlii extract in mice.Kaori Yokotani et al.Journal of nutritional science and vitaminology, 59(1), 37-44 (2013-03-29) A comparison of in vitro ADME properties and pharmacokinetics of azithromycin and selected 15-membered ring macrolides in rodents.Astrid Milić et al.European journal of drug metabolism and pharmacokinetics, 39(4), 263-276 (2013-10-12) Design and synthesis of 2-heterocyclyl-3-arylthio-1H-indoles as potent tubulin polymerization and cell growth inhibitors with improved metabolic stability.Giuseppe La Regina et al.Journal of medicinal chemistry, 54(24), 8394-8406 (2011-11-03) Systematic screening of Escherichia coli single-gene knockout mutants for improving recombinant whole-cell biocatalysts.Ying Zhou et al.Applied microbiology and biotechnology, 87(2), 647-655 (2010-03-13) Variation in P450-mediated fenvalerate resistance levels is not correlated with CYP337B3 genotype in Chinese populations of Helicoverpa armigera.Yangchun Han et al.Pesticide biochemistry and physiology, 121, 129-135 (2015-06-06) In vivo indirect measurement of cytochrome P450-associated activities in freshwater gastropod molluscs.Beatrice Gagnaire et al.Environmental toxicology, 25(6), 545-553 (2009-06-16) Generation of human metabolites of 7-ethoxycoumarin by bacterial cytochrome P450 BM3.Dong-Hyun Kim et al.Drug metabolism and disposition: the biological fate of chemicals, 36(11), 2166-2170 (2008-08-02) Exploring the molecular basis of insecticide resistance in the dengue vector Aedes aegypti: a case study in Martinique Island (French West Indies).Sébastien Marcombe et al.BMC genomics, 10, 494-494 (2009-10-28) Antimalarial activity of novel pyrrolizidinyl derivatives of 4-aminoquinoline.Anna Sparatore et al.Bioorganic & medicinal chemistry letters, 18(13), 3737-3740 (2008-06-10) Optimization of an isolated perfused rainbow trout liver model: Clearance studies with 7-ethoxycoumarin.John W Nichols et al.Aquatic toxicology (Amsterdam, Netherlands), 95(3), 182-194 (2009-10-20) Cell isolation through whole-liver perfusion and preparation of hepatocytes for cytochrome p450 analysis.Sonya O Meheux Methods in molecular biology (Clifton, N.J.), 1001, 43-51 (2013-03-16) Antigenotoxic effect of Xanthohumol in rat liver slices.Janja Plazar et al.Toxicology in vitro : an international journal published in association with BIBRA, 22(2), 318-327 (2007-11-06) Precision-cut liver slices from rats of different ages: basal cytochrome P450-dependent monooxygenase activities and inducibility.Amelie Lupp et al.Analytical and bioanalytical chemistry, 392(6), 1173-1184 (2008-07-17) Drug metabolite heterogeneity in cultured single cells profiled by pico-trapping direct mass spectrometry.Yasufumi Fukano et al.Nanomedicine (London, England), 7(9), 1365-1374 (2012-05-16) Metabolism and absorption of auraptene (7-geranyloxylcoumarin) in male SD rats: comparison with 7-ethoxycoumarin.Wataru Kuki et al.Nutrition and cancer, 60(3), 368-372 (2008-04-30) Effect of Dimethyl Sulfoxide and Melatonin on the Isolation of Human Primary Hepatocytes.Estela Solanas et al.Cells, tissues, organs, 200(5), 316-325 (2015-09-19) Modeling K(m) values using electrotopological state: substrates for cytochrome P450 3A4-mediated metabolism.Yong-Hua Wang et al.Bioorganic & medicinal chemistry letters, 15(18), 4076-4084 (2005-07-02) Unusually broad substrate profile of self-sufficient cytochrome P450 monooxygenase CYP116B4 from Labrenzia aggregata.Yue-Cai Yin et al.Chembiochem : a European journal of chemical biology, 15(16), 2443-2449 (2014-09-23) Cryopreservation of primary porcine liver cells in an organotypical sandwich model in a clinically relevant flat membrane bioreactor.Shibashish Giri et al.Biotechnology letters, 32(6), 765-771 (2010-03-10) Evaluation of cytochrome P450 activity in field populations of Cydia pomonella (Lepidoptera: Tortricidae) resistant to azinphosmethyl, acetamiprid, and thiacloprid.L B Cichón et al.Journal of economic entomology, 106(2), 939-944 (2013-06-22) Effects of cucurbitacin e, a tetracyclic triterpene compound from Cucurbitaceae, on the pharmacokinetics and pharmacodynamics of warfarin in rats.Tonggui Ding et al.Basic & clinical pharmacology & toxicology, 116(5), 385-389 (2014-09-25) Substrate Selectivities and Catalytic Activities of Marmoset Liver Cytochrome P450 2A6 Differed from Those of Human P450 2A6.Shotaro Uehara et al.Drug metabolism and disposition: the biological fate of chemicals, 43(7), 969-976 (2015-04-11) Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.Alfonso Maresca et al.Journal of medicinal chemistry, 53(1), 335-344 (2009-11-17) Bioconversion by functional P450 1A9 and P450 1C1 of Anguilla japonica.Tomohide Uno et al.Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 147(3), 278-285 (2008-02-05) Percutaneous absorption and metabolism of [14C]-ethoxycoumarin in a pig ear skin model.Carine Jacques et al.Toxicology in vitro : an international journal published in association with BIBRA, 24(5), 1426-1434 (2010-04-27) Expression and characterization of dog cytochrome P450 2A13 and 2A25 in baculovirus-infected insect cells.Diansong Zhou et al.Drug metabolism and disposition: the biological fate of chemicals, 38(7), 1015-1018 (2010-04-13) Determination of CYP activity in precision-cut liver slices: whether to use intact slices or slice homogenate.R Glöckner et al.Analytical and bioanalytical chemistry, 392(6), 1167-1172 (2008-07-12)

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