Melting point	-55 ºC
Boiling point	101-102 ºC
Density	1.828
Refractive index	1.300

Symbol(GHS)	Xi
Hazard Codes	R36/37/38
SDS/MSDS	S26;S36

Source	SDS/MSDS Samples
Alfa-Aesar	View & Download
Sigma-Aldrich	View & Download
TCI	View & Download

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Articles

Peer-Reviewed Papers

Inhibitory effects of niclosamide on inflammation and migration of fibroblast-like synoviocytes from patients with rheumatoid arthritis.Liuqin Liang et al.Inflammation research : official journal of the European Histamine Research Society ... [et al.], 64(3-4), 225-233 (2015-02-25) Optimizing molluscicide treatment strategies in different control stages of schistosomiasis in the People's Republic of China.Guo-Jing Yang et al.Parasites & vectors, 5, 260-260 (2012-11-16) Niclosamide is a proton carrier and targets acidic endosomes with broad antiviral effects.Andreas Jurgeit et al.PLoS pathogens, 8(10), e1002976-e1002976 (2012-11-08) Niclosamide suppresses cell migration and invasion in enzalutamide resistant prostate cancer cells via Stat3-AR axis inhibition.Chengfei Liu et al.The Prostate, 75(13), 1341-1353 (2015-05-15) Phase I and phase II reductive metabolism simulation of nitro aromatic xenobiotics with electrochemistry coupled with high resolution mass spectrometry.Ugo Bussy et al.Analytical and bioanalytical chemistry, 406(28), 7253-7260 (2014-09-23) HSP90 inhibitor NVP-AUY922 enhances TRAIL-induced apoptosis by suppressing the JAK2-STAT3-Mcl-1 signal transduction pathway in colorectal cancer cells.Dae-Hee Lee et al.Cellular signalling, 27(2), 293-305 (2014-12-03) Taenia saginata a rare cause of acute cholangitis: a case report.O Uygur-Bayramiçli et al.Acta clinica Belgica, 67(6), 436-437 (2013-01-24) [Studies on standardization of methods for screening molluscicides in laboratory IV sensitivity of Oncomelania snails from different months to niclosamide].You-Zi Li et al.Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control, 24(1), 35-39 (2012-05-18) Antineoplastic mechanisms of niclosamide in acute myelogenous leukemia stem cells: inactivation of the NF-kappaB pathway and generation of reactive oxygen species.Yanli Jin et al.Cancer research, 70(6), 2516-2527 (2010-03-11) Growth inhibition of ovarian tumor-initiating cells by niclosamide.Yi-Te Yo et al.Molecular cancer therapeutics, 11(8), 1703-1712 (2012-05-12) Taenia solium: Development of an Experimental Model of Porcine Neurocysticercosis.Agnès Fleury et al.PLoS neglected tropical diseases, 9(8), e0003980-e0003980 (2015-08-08) [Acute toxicity of salicylanilides having anthelmintic activity].A V Buriakina et al.Meditsinskaia parazitologiia i parazitarnye bolezni, (2)(2), 53-54 (2012-07-11) [Molluscicidal effect of WPN and MNSC on Lymnaea].Shang-Wei Wang et al.Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control, 25(1), 61-63 (2013-05-22) Niclosamide, an old antihelminthic agent, demonstrates antitumor activity by blocking multiple signaling pathways of cancer stem cells.Jing-Xuan Pan et al.Chinese journal of cancer, 31(4), 178-184 (2012-01-13) LGR5 is associated with tumor aggressiveness in papillary thyroid cancer.Gregory Michelotti et al.Oncotarget, 6(33), 34549-34560 (2015-09-30) Altered Gene Expression in the Schistosome-Transmitting Snail Biomphalaria glabrata following Exposure to Niclosamide, the Active Ingredient in the Widely Used Molluscicide Bayluscide.Si-Ming Zhang et al.PLoS neglected tropical diseases, 9(10), e0004131-e0004131 (2015-10-10) Controlled delivery of bPEI-niclosamide complexes by PEO nanofibers and evaluation of its anti-neoplastic potentials.S Uday Kumar et al.Colloids and surfaces. B, Biointerfaces, 131, 170-181 (2015-05-20) Niclosamide, an anti-helminthic molecule, downregulates the retroviral oncoprotein Tax and pro-survival Bcl-2 proteins in HTLV-1-transformed T lymphocytes.Di Xiang et al.Biochemical and biophysical research communications, 464(1), 221-228 (2015-06-28) STAT3 modulation to enhance motor neuron differentiation in human neural stem cells.Rajalaxmi Natarajan et al.PloS one, 9(6), e100405-e100405 (2014-06-20) Human Dendritic Cell Subsets Undergo Distinct Metabolic Reprogramming for Immune Response.Farhan Basit et al.Frontiers in immunology, 9, 2489-2489 (2018-11-21) [Studies on spray of niclosamide ethanolamine salt. I. development and effect assessment of spray of niclosamide ethanolamine salt].Dai Jian-Rong et al.Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control, 23(5), 529-534 (2012-01-24) [Effect of niclosamide spreading oil on killing schistosome cercariae].Guo-Hua Peng et al.Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control, 24(3), 368-368 (2012-09-28) Structure-activity analysis of niclosamide reveals potential role for cytoplasmic pH in control of mammalian target of rapamycin complex 1 (mTORC1) signaling.Bruno D Fonseca et al.The Journal of biological chemistry, 287(21), 17530-17545 (2012-04-05) Addition of niclosamide to palladium(II) saccharinate complex of terpyridine results in enhanced cytotoxic activity inducing apoptosis on cancer stem cells of breast cancer.Didem Karakas et al.Bioorganic & medicinal chemistry, 23(17), 5580-5586 (2015-08-04) Suppression of lysosome function induces autophagy via a feedback down-regulation of MTOR complex 1 (MTORC1) activity.Min Li et al.The Journal of biological chemistry, 288(50), 35769-35780 (2013-11-01) Predominant Activation of JAK/STAT3 Pathway by Interleukin-6 Is Implicated in Hepatocarcinogenesis.In Hye Jung et al.Neoplasia (New York, N.Y.), 17(7), 586-597 (2015-08-25) New life for an old drug: the anthelmintic drug niclosamide inhibits Pseudomonas aeruginosa quorum sensing.Francesco Imperi et al.Antimicrobial agents and chemotherapy, 57(2), 996-1005 (2012-12-21) Niclosamide reverses adipocyte induced epithelial-mesenchymal transition in breast cancer cells via suppression of the interleukin-6/STAT3 signalling axis.Jones Gyamfi et al.Scientific reports, 9(1), 11336-11336 (2019-08-07) Inhibition of canonical WNT signaling attenuates human leiomyoma cell growth.Masanori Ono et al.Fertility and sterility, 101(5), 1441-1449 (2014-02-19) [Snail control effect of film covering method in fish ponds and ditches].Ke Zhang et al.Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control, 23(6), 695-696 (2012-03-03) Metabolic disease: Mitochondrial uncoupler reverses diabetes.Sarah Crunkhorn Nature reviews. Drug discovery, 13(12), 885-885 (2014-11-15) HTLV-1 Tax deregulates autophagy by recruiting autophagic molecules into lipid raft microdomains.T Ren et al.Oncogene, 34(3), 334-345 (2013-12-24) Niclosamide inhibits the cell proliferation and enhances the responsiveness of esophageal cancer cells to chemotherapeutic agents.Ming-Cheng Lee et al.Oncology reports, 43(2), 549-561 (2020-01-03) Validation of a streamlined multiclass, multiresidue method for determination of veterinary drug residues in bovine muscle by liquid chromatography-tandem mass spectrometry.Marilyn J Schneider et al.Analytical and bioanalytical chemistry, 407(15), 4423-4435 (2014-12-30) Education and Imaging. Gastrointestinal: An unexpected cause of refractory iron deficiency anemia; Taenia SPP. on capsule endoscopy.A Shorbagi et al.Journal of gastroenterology and hepatology, 27(4), 843-843 (2012-03-23) [Molluscicidal effect of LDS in mountainous areas of Yunnan Province].Bing-Gui Li et al.Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control, 23(4), 395-401 (2011-12-15) [Molluscicidal effect of buried niclosamide sustained-release method in plateau mountainous areas].Shang-Wei Wang et al.Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control, 25(2), 207-208 (2013-07-31) [Effect of snail control of niclosamide by soil mixing and spraying methods in high dam of terrace].Hui Yang et al.Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control, 24(2), 244-245 (2012-07-18) The salicylanilide derivatives inhibit signal transducer and activator of transcription 3 pathways in A549 lung cancer cells.Minhua Hu et al.Anti-cancer drugs, 27(1), 41-47 (2015-10-16) Inhibition of Wnt/β-catenin pathway by niclosamide: a therapeutic target for ovarian cancer.Rebecca C Arend et al.Gynecologic oncology, 134(1), 112-120 (2014-04-17) Multi-targeted therapy of cancer by niclosamide: A new application for an old drug.Yonghe Li et al.Cancer letters, 349(1), 8-14 (2014-04-16) Mechanism of action of reagents that uncouple oxidative phosphorylation.E C Weinbach et al.Nature, 221(5185), 1016-1018 (1969-03-15) Three-Dimensional Cell Culture-Based Screening Identifies the Anthelmintic Drug Nitazoxanide as a Candidate for Treatment of Colorectal Cancer.Wojciech Senkowski et al.Molecular cancer therapeutics, 14(6), 1504-1516 (2015-04-26) Th17 cell-derived IL-17A promoted tumor progression via STAT3/NF-κB/Notch1 signaling in non-small cell lung cancer.Ruirui Wang et al.Oncoimmunology, 7(11), e1461303-e1461303 (2018-11-01) Niclosamide suppresses cancer cell growth by inducing Wnt co-receptor LRP6 degradation and inhibiting the Wnt/β-catenin pathway.Wenyan Lu et al.PloS one, 6(12), e29290-e29290 (2011-12-24) Salinomycin inhibits prostate cancer growth and migration via induction of oxidative stress.K Ketola et al.British journal of cancer, 106(1), 99-106 (2012-01-05) [Determination of niclosamide ethanolamine residue in rice and paddy field by high performance liquid chromatography].Yihong Wu et al.Se pu = Chinese journal of chromatography, 29(11), 1098-1102 (2012-03-08) [Distribution of niclosamide spreading oil on water surface and its efficacy against cercariae of Schistosoma japonicum].Yun-Tian Xing et al.Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control, 24(4), 410-414 (2012-12-15) Antiprotozoal Activity Profiling of Approved Drugs: A Starting Point toward Drug Repositioning.Marcel Kaiser et al.PloS one, 10(8), e0135556-e0135556 (2015-08-14) [The preparation of antihymenolepidiasis activity of MCT-44].F S Mikhaĭlitsin et al.Meditsinskaia parazitologiia i parazitarnye bolezni, (4)(4), 38-39 (2012-02-09) [Molluscicidal effect of LDS in field in marshland areas].Jie Lu et al.Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control, 24(5), 613-614 (2013-02-05) Detection of Taenia solium taeniasis coproantigen is an early indicator of treatment failure for taeniasis.Javier A Bustos et al.Clinical and vaccine immunology : CVI, 19(4), 570-573 (2012-02-18) [Preparation of a prototype of the anthelmintic mitranox (MCT-31) and evaluation of its therapeutic efficacy in sheep moniesiosis and strongyloidiasis].F S Mikhaĭlitsyn et al.Meditsinskaia parazitologiia i parazitarnye bolezni, (2)(2), 51-52 (2012-07-11) Role of the IL-6-JAK1-STAT3-Oct-4 pathway in the conversion of non-stem cancer cells into cancer stem-like cells.Seog-Young Kim et al.Cellular signalling, 25(4), 961-969 (2013-01-22) Effective and new potent drug combination: Histone deacetylase and Wnt/β-catenin pathway inhibitors in lung carcinoma cells.Oguzhan Akgun et al.Journal of cellular biochemistry, 120(9), 15467-15482 (2019-05-01) [Molluscicidal effect of suspension concentrate of metaldehyde and niclosamide in fields of mountainous areas in Yunnan Province].Bing-Gui Li et al.Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control, 24(5), 564-566 (2013-02-05)

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