Melting point	246-248 ºC

Symbol(GHS)	Xi
Hazard Codes	R36/37/38
SDS/MSDS	S26;S37/39

Source	SDS/MSDS Samples
Sigma-Aldrich	View & Download
TCI	View & Download
Matrix	View & Download

Synthetic Route

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Name	CAS

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Articles

Peer-Reviewed Papers

NMDA receptor-mediated glutamate toxicity of cultured cerebellar, cortical and mesencephalic neurons: neuroprotective properties of amantadine and memantine.M Weller et al.Brain research, 613(1), 143-148 (1993-06-04) Patch clamp studies on the kinetics and selectivity of N-methyl-D-aspartate receptor antagonism by memantine (1-amino-3,5-dimethyladamantan).C G Parsons et al.Neuropharmacology, 32(12), 1337-1350 (1993-12-01) Chemical genetics reveals a complex functional ground state of neural stem cells.Phedias Diamandis et al.Nature chemical biology, 3(5), 268-273 (2007-04-10) PBT2 inhibits glutamate-induced excitotoxicity in neurons through metal-mediated preconditioning.Timothy Johanssen et al.Neurobiology of disease, 81, 176-185 (2015-02-24) Regulation of postsynaptic plasticity genes' expression and topography by sustained dopamine perturbation and modulation by acute memantine: relevance to schizophrenia.Felice Iasevoli et al.Progress in neuro-psychopharmacology & biological psychiatry, 54, 299-314 (2014-07-16) Memantine improves observational learning in day-old chicks.Teresa A Barber et al.Behavioural pharmacology, 26(4), 407-410 (2015-03-05) Anti-autophagic and anti-apoptotic effects of memantine in a SH-SY5Y cell model of Alzheimer's disease via mammalian target of rapamycin-dependent and -independent pathways.Guijun Song et al.Molecular medicine reports, 12(5), 7615-7622 (2015-10-16) Memantine, a Low-Affinity NMDA Receptor Antagonist, Protects against Methylmercury-Induced Cytotoxicity of Rat Primary Cultured Cortical Neurons, Involvement of CaWei Liu et al.Molecular neurobiology, 54(7), 5034-5050 (2016-08-20) The [18F]FDG μPET readout of a brain activation model to evaluate the metabotropic glutamate receptor 2 positive allosteric modulator JNJ-42153605.Tine Wyckhuys et al.The Journal of pharmacology and experimental therapeutics, 350(2), 375-386 (2014-06-06) No effect of riluzole and memantine on learning deficit following quinpirole sensitization - An animal model of obsessive-compulsive disorder.Martina Janikova et al.Physiology & behavior, 204, 241-247 (2019-03-04) In vitro model of the outer blood-retina barrierSteuer H, et al. Brain Res. Protoc., 13(1), 26-36 (2004) Neurophysiologic and antipsychotic profiles of TASP0433864, a novel positive allosteric modulator of metabotropic glutamate 2 receptor.Tetsuaki Hiyoshi et al.The Journal of pharmacology and experimental therapeutics, 351(3), 642-653 (2014-10-04) Erythropoietin protects adult retinal ganglion cells against NMDA-, trophic factor withdrawal-, and TNF-α-induced damage.Zhi-Yang Chang et al.PloS one, 8(1), e55291-e55291 (2013-02-06) N-methyl-D-aspartate receptor-mediated calcium influx connects amyloid-β oligomers to ectopic neuronal cell cycle reentry in Alzheimer's disease.Erin J Kodis et al.Alzheimer's & dementia : the journal of the Alzheimer's Association, 14(10), 1302-1312 (2018-10-09) Low doses of dextromethorphan have a beneficial effect in the treatment of neuropathic pain.Véronique Morel et al.Fundamental & clinical pharmacology, 28(6), 671-680 (2014-04-08) Extrasynaptic glutamate NMDA receptors: key players in striatal function.Marianela Garcia-Munoz et al.Neuropharmacology, 89, 54-63 (2014-09-23) Differential effects of NMDA receptor antagonists at lower and higher doses on basal gamma band oscillation power in rat cortical electroencephalograms.Tetsuaki Hiyoshi et al.Neuropharmacology, 85, 384-396 (2014-06-08) Acute and chronic effects of single dose memantine after controlled cortical impact injury in adult rats.Eric E Abrahamson et al.Restorative neurology and neuroscience, 37(3), 245-263 (2019-06-10) Targeting different pathophysiological events after traumatic brain injury in mice: Role of melatonin and memantineKelestemur T, et al. Neuroscience Letters, 612(1), 92-97 (2016) Dementia of Alzheimer?s disease and other neurodegenerative disorders-memantine, a new hopeSonkusare SK, et al. Pharmacological Research, 51(1), 1-17 (2005) Electrical high frequency stimulation modulates GABAergic activity in the nucleus accumbens of freely moving rats.Ramya Varatharajan et al.Neurochemistry international, 90, 255-260 (2015-10-10) Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.Jing Yuan et al.Nature chemical biology, 5(10), 765-771 (2009-09-08)

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