Melting point	231-236 ºC
Water Solubility	Insoluble

Symbol(GHS)	Xi
Hazard Codes	R36/37/38
SDS/MSDS	S26;S36

Source	SDS/MSDS Samples
Alfa-Aesar	View & Download
Sigma-Aldrich	View & Download
TCI	View & Download

Synthetic Route

More

Name	CAS

More

Articles

Peer-Reviewed Papers

Pharmacokinetic study of methotrexate, folinic acid and their serum metabolites in children treated with high-dose methotrexate and leucovorin rescue.C Wolfrom et al.European journal of clinical pharmacology, 39(4), 377-383 (1990-01-01) High-performance liquid chromatography of methotrexate analogs containing terminal lysine or ornithine and their dansyl derivatives.A A Kumar et al.Analytical biochemistry, 128(1), 191-195 (1983-01-01) Wild-type and drug-resistant Leishmania major hydrolyze methotrexate to N-10-methyl-4-deoxy-4-aminopteroate without accumulation of methotrexate polyglutamates.T E Ellenberger et al.The Journal of biological chemistry, 264(27), 15960-15966 (1989-09-25) Determination of methotrexate and its metabolites 7-hydroxymethotrexate and 2,4-diamino-N10-methylpteroic acid in biological fluids by liquid chromatography with fluorimetric detection.J Salamoun et al.Journal of chromatography, 378(1), 173-181 (1986-05-28) Interference of 4-amino-4-deoxy-N10-methylpteroic acid with the radioimmunoassay of methotrexate.J W Paxton Clinical chemistry, 25(3), 491-492 (1979-03-01) Rapid high-pressure liquid chromatographic determination of methotrexate and its metabolites 7-hydroxymethotrexate and 2,4-diamino-N(10)-methylpteroic acid in biological fluids.H Breithaupt et al.Analytical biochemistry, 121(1), 103-113 (1982-03-15) Rapid quantitation of methotrexate and its metabolites in human serum, urine and bile, using solid-phase extraction and high-performance liquid chromatography.B Nuernberg et al.Journal of chromatography, 487(2), 476-482 (1989-02-24) A simple preparation of the methotrexate metabolites 7-hydroxymethotrexate and 4-deoxy-4-amino-N10-methylpteroic acid.D A Cairnes et al.Therapeutic drug monitoring, 5(3), 363-366 (1983-01-01) Simple and sensitive HPLC method for the fluorometric determination of methotrexate and its major metabolites in human plasma by post-column photochemical reaction.Masanobu Uchiyama et al.Biomedical chromatography : BMC, 26(1), 76-80 (2011-03-26) High-performance liquid chromatographic determination of methotrexate in plasma.H N Alkaysi et al.Therapeutic drug monitoring, 12(2), 191-194 (1990-03-01) Mass spectrometry of permethylated folic acid analogs.R G Smith et al.Biomedical mass spectrometry, 8(4), 144-148 (1981-04-01) Pharmacokinetics and metabolism of the methotrexate metabolite 2, 4-diamino-N(10)-methylpteroic acid.B C Widemann et al.The Journal of pharmacology and experimental therapeutics, 294(3), 894-901 (2000-08-17) Chemically induced dimerization of dihydrofolate reductase by a homobifunctional dimer of methotrexate.S J Kopytek et al.Chemistry & biology, 7(5), 313-321 (2000-05-10) High-performance liquid chromatographic assay of methotrexate, 7-hydroxymethortrexate, 4-deoxy-4-amino-N10-methylpteroic acid and sulfamethoxazole in serum, urine and cerebrospinal fluid.D A Cairnes et al.Journal of chromatography, 231(1), 103-110 (1982-08-13) An investigation into the source of the deglutamated metabolites of methotrexate in patients treated with high dose infusions.M J Stewart et al.Annals of clinical biochemistry, 23 ( Pt 2), 210-215 (1986-03-01) The influence of 7-OH methotrexate metabolite on clinical relevance of methotrexate determination.Eva Klapkova et al.Clinical laboratory, 57(7-8), 599-606 (2011-09-06) Carboxypeptidase G2 rescue after high-dose methotrexate.L M DeAngelis et al.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 14(7), 2145-2149 (1996-07-01) Hepatic methotrexate content and progression of hepatic fibrosis: preliminary findings.M J Ahern et al.Annals of the rheumatic diseases, 50(7), 477-480 (1991-07-01) Commentary.Michael C Milone Clinical chemistry, 56(12), 1795-1796 (2010-12-02)

Remarks