Melting point	236-236.5 ºC**
Boiling point	257.3±35.0 ºC (760 Tor
Flash point	105.3±17.2 ºC, 计算值*
Density	1.109±0.06 g/cm3 (20 º

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Source	SDS/MSDS Samples
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Synthetic Route

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Peer-Reviewed Papers

[Aphthae or painful ulcers induced by nicorandil].S Boulinguez et al.Presse medicale (Paris, France : 1983), 29(33), 1828-1832 (2000-12-08) Protective mechanism of nicorandil on rat myocardial ischemia-reperfusion.Ailing Wang et al.Journal of cardiovascular medicine (Hagerstown, Md.), 13(8), 511-515 (2012-05-23) Leg ulcers associated with nicorandil are possibly underdiagnosed.K Shams et al.Clinical and experimental dermatology, 38(2), 193-194 (2012-10-23) Nicorandil ameliorates mitochondrial dysfunction in doxorubicin-induced heart failure in rats: possible mechanism of cardioprotection.Lamiaa A Ahmed et al.Biochemical pharmacology, 86(9), 1301-1310 (2013-07-23) The role of nicorandil in the treatment of myocardial ischaemia.B Falase et al.Expert opinion on pharmacotherapy, 2(5), 845-856 (2001-05-05) Nicorandil: do the dermatological and gastrointestinal risks outweigh the benefits?V M Smith et al.The British journal of dermatology, 167(5), 1048-1052 (2012-10-09) ATP-sensitive potassium (K(ATP)) channel openers diazoxide and nicorandil lower intraocular pressure in vivo.Uttio Roy Chowdhury et al.Investigative ophthalmology & visual science, 54(7), 4892-4899 (2013-06-20) Clinical trials update: The Heart Protection Study, IONA, CARISA, ENRICHD, ACUTE, ALIVE, MADIT II and REMATCH. Impact Of Nicorandil on Angina. Combination Assessment of Ranolazine In Stable Angina. ENhancing Recovery In Coronary Heart Disease patients. Assessment of Cardioversion Using Transoesophageal Echocardiography. AzimiLide post-Infarct surVival Evaluation. Randomised Evaluation of Mechanical Assistance for Treatment of Chronic Heart failure.Amala A Louis et al.European journal of heart failure, 4(1), 111-116 (2002-01-29) Nicorandil-induced oral ulceration: report of 3 cases and review of the Japanese literature.Kazuhiko Yamamoto et al.Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 112(6), 754-759 (2011-08-30) The relaxant action of nicorandil in bovine tracheal smooth muscle.Motonari Yunoki et al.Pharmacology, 89(5-6), 327-332 (2012-05-23) Cardioprotective effects of sarcolemmal and mitochondrial K-ATP channel openers in an experimental model of autoimmune myocarditis. Role of the reduction in calcium overload during acute heart failure.Shinichi Niwano et al.International heart journal, 53(2), 139-145 (2012-06-13) Nicorandil in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention: a systematic review and meta-analysis.Muli Wu et al.PloS one, 8(10), e78231-e78231 (2013-10-30) Nicorandil: a drug for many purposes: too good to be true?Eeckhout E European Heart Journal (2003) Pharmacologic prophylactic treatment for perioperative protection of skeletal muscle from ischemia-reperfusion injury in reconstructive surgery.Neil J Cahoon et al.Plastic and reconstructive surgery, 131(3), 473-485 (2013-03-01) Nicorandil: a drug for many purposes: too good to be true?Eric Eeckhout European heart journal, 24(14), 1282-1284 (2003-07-23) Nicorandil associated anal ulcers: an estimate of incidence.H S Colvin et al.Annals of the Royal College of Surgeons of England, 94(3), 170-172 (2012-04-18) Novel drugs for treating angina.Daniel A Jones et al.BMJ (Clinical research ed.), 347, f4726-f4726 (2013-09-11) Persistent nicorandil induced oral ulceration.C M Healy et al.Heart (British Cardiac Society), 90(7), e38-e38 (2004-06-18) [Nicorandil in the treatment of patients with ischemic heart disease].L O Minushkina et al.Kardiologiia, 53(5), 69-73 (2013-08-21) Nicorandil-associated perianal ulceration with prominent elastophagocytosis and flexural ulceration.T Wong et al.The British journal of dermatology, 152(6), 1360-1361 (2005-06-14) Combination of ACE inhibitor with nicorandil provides further protection in chronic kidney disease.Takeshi Shiraishi et al.American journal of physiology. Renal physiology, 307(12), F1313-F1322 (2014-10-17) Treating stable angina - is there a NICE way towards an international consensus?H Purcell et al.International journal of clinical practice, 66(7), 614-618 (2012-06-16) The involvement of potassium channels in the peripheral antiedematogenic effect of intrathecally injected morphine in rats.Vanessa R S Foletto et al.Anesthesia and analgesia, 116(1), 232-238 (2012-12-12) Anal ulceration associated with Nicorandil: case series and review of the literature.L Toquero et al.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland, 8(8), 717-720 (2006-09-15) Systemic ulcerative lesions in a patient with ischemic heart disease.Mitsuhiro Nikaido et al.Gastroenterology, 147(6), e7-e8 (2014-12-03) Use of nicorandil in cardiovascular disease and its optimization.Shigeo Horinaka Drugs, 71(9), 1105-1119 (2011-06-30) Drug-Mediated Shortening of Action Potentials in LQTS2 Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.Gary Duncan et al.Stem cells and development, 26(23), 1695-1705 (2017-10-11) Nicorandil: mucocutaneous ulceration (continued). Prescrire international, 21(131), 240-240 (2012-11-30) Nicorandil: a drug for many purposes: too good to be true?Eeckhout E European heart journal (2003) Nicorandil ameliorated hypertensive renal injury without lowering blood pressure in spontaneously hypertensive rats.Kenichi Serizawa et al.Pharmacology, 91(1-2), 92-103 (2013-01-12) Nicorandil, a K(atp) channel opener, alleviates chronic renal injury by targeting podocytes and macrophages.Yoshifuru Tamura et al.American journal of physiology. Renal physiology, 303(3), F339-F349 (2012-05-25) Cerebral protective effect of nicorandil premedication on patients undergoing liver transplantation.Yun-Fei Xia et al.Hepatobiliary & pancreatic diseases international : HBPD INT, 11(2), 132-136 (2012-04-10) Nicorandil prevents right ventricular remodeling by inhibiting apoptosis and lowering pressure overload in rats with pulmonary arterial hypertension.Xiang-Rong Zuo et al.PloS one, 7(9), e44485-e44485 (2012-09-13) Paclitaxel-induced endothelial dysfunction in living rats is prevented by nicorandil via reduction of oxidative stress.Ken-Ichi Serizawa et al.Journal of pharmacological sciences, 119(4), 349-358 (2012-08-02) Nicorandil-associated perianal ulceration: a case series of 10 patients.N S Cooke et al.The British journal of dermatology, 154(1), 199-200 (2006-01-13) Potassium channel openers prevent palmitate-induced insulin resistance in C2C12 myotubes.Dorota Dymkowska et al.Archives of biochemistry and biophysics, 541, 47-52 (2013-11-23) Drug-mediated shortening of action potentials in LQTS2 human induced pluripotent stem cell-derived cardiomyocytesDuncan G, et al. Stem Cells and Development, 26(23), 1695-1705 (2017) Nicorandil-associated ulcerations.Mohaned Egred European journal of gastroenterology & hepatology, 19(5), 395-398 (2007-04-07) Nicorandil: a review of its use in the management of stable angina pectoris, including high-risk patients.Dene Simpson et al.Drugs, 64(17), 1941-1955 (2004-08-27) [Cardioprotective characteristics of the drug nicorandil in patients with coronary heart disease].A M Malysheva et al.Terapevticheskii arkhiv, 83(9), 14-19 (2011-12-08) Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity.Ping Liang et al.Circulation, 127(16), 1677-1691 (2013-03-23) Potassium channel openers in myocardial ischaemia: therapeutic potential of nicorandil.A H Gomma et al.Drugs, 61(12), 1705-1710 (2001-11-06) Should nicorandil infusion be adapted in dialysis-dependent patients undergoing continuous renal replacement therapy after cardiac surgery?Norihisa Yasuda et al.Artificial organs, 37(3), 319-322 (2012-11-14) Non-healing anal ulcers associated with nicorandil.J Biggins et al.Journal of wound care, 15(5), 197-198 (2006-05-23) Nicorandil for angina--an update. Drug and therapeutics bulletin, 41(11), 86-88 (2003-12-09) Nicorandil: more cases of mucocutaneous ulceration. Prescrire international, 21(132), 267-267 (2012-12-06) Peristomal ulceration caused by nicorandil.A-M Skellett et al.Clinical and experimental dermatology, 34(1), 87-88 (2008-12-17) Nicorandil ameliorates hypertension-related bladder dysfunction in the rat.Motoaki Saito et al.Neurourology and urodynamics, 31(5), 695-701 (2012-04-05) Nicorandil induced perianal ulceration.J P Tiernan et al.JNMA; journal of the Nepal Medical Association, 48(175), 239-241 (2010-08-28) Preparative isolation and high-resolution mass identification of 10 stressed study degradants of nicorandil tablets.Lakkireddy Prakash et al.Journal of chromatographic science, 53(1), 122-126 (2014-05-20) Nicorandil prevents Gαq-induced progressive heart failure and ventricular arrhythmias in transgenic mice.Masamichi Hirose et al.PloS one, 7(12), e52667-e52667 (2013-01-04) Nicorandil. An updated review of its use in ischaemic heart disease with emphasis on its cardioprotective effects.A Markham et al.Drugs, 60(4), 955-974 (2000-11-21) Cardioprotective effects of nicorandil, a mitochondrial potassium channel opener against doxorubicin-induced cardiotoxicity in rats.Ihab T Abdel-Raheem et al.Basic & clinical pharmacology & toxicology, 113(3), 158-166 (2013-04-30) Gingival pain: an unusual side effect of ziprasidone.Ashwati Raghunath BMJ case reports, 2013, doi:10-doi:10 (2013-01-04) Blunted proarrhythmic effect of nicorandil in a Langendorff-perfused phase-2 myocardial infarction rabbit model.Hui-Ling Lee et al.Pacing and clinical electrophysiology : PACE, 36(2), 142-151 (2012-11-06) Nicorandil attenuates monocrotaline-induced vascular endothelial damage and pulmonary arterial hypertension.Makoto Sahara et al.PloS one, 7(3), e33367-e33367 (2012-04-06)

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