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Peer-Reviewed Papers

A UHPLC-UV Method Development and Validation for Determining Kavalactones and Flavokavains in Piper methysticum (Kava).Yijin Tang et al.Molecules (Basel, Switzerland), 24(7) (2019-04-03) Extracts and kavalactones of Piper methysticum G. Forst (kava-kava) inhibit P-glycoprotein in vitro.Johanna Weiss et al.Drug metabolism and disposition: the biological fate of chemicals, 33(11), 1580-1583 (2005-07-30) GABA-modulating phytomedicines for anxiety: A systematic review of preclinical and clinical evidence.Karen Savage et al.Phytotherapy research : PTR, 32(1), 3-18 (2017-11-24) Interaction of various Piper methysticum cultivars with CNS receptors in vitro.L D Dinh et al.Planta medica, 67(4), 306-311 (2001-07-19) Identification and characterization of kava-derived compounds mediating TNF-alpha suppression.Michael P Pollastri et al.Chemical biology & drug design, 74(2), 121-128 (2009-06-23) Inhibition of cytochrome P450 3A4 by extracts and kavalactones of Piper methysticum (Kava-Kava).Matthias Unger et al.Planta medica, 68(12), 1055-1058 (2002-12-21) Determination of six kavalactones in dietary supplements and selected functional foods containing Piper methysticum by isocratic liquid chromatography with internal standard.Lihong Hu et al.Journal of AOAC International, 88(1), 16-25 (2005-03-12) Anxiolytic effects of kava extract and kavalactones in the chick social separation-stress paradigm.K K Smith et al.Psychopharmacology, 155(1), 86-90 (2001-05-26) Kavain, dihydrokavain, and dihydromethysticin non-competitively inhibit the specific binding of [3H]-batrachotoxinin-A 20-alpha-benzoate to receptor site 2 of voltage-gated Na+ channels.J Friese et al.Planta medica, 64(5), 458-459 (1998-08-05) Cyclodextrins as carriers for kavalactones in aqueous media: spectroscopic characterization of (S)-7,8-dihydrokavain and beta-cyclodextrin inclusion complex.G Pescitelli et al.Journal of pharmaceutical and biomedical analysis, 52(4), 479-483 (2010-02-27) Chemical and in vitro toxicity analysis of a supercritical fluid extract of Kava kava (Piper methysticum).Greg E Petersen et al.Journal of ethnopharmacology, 235, 301-308 (2019-02-03) Kavalactones and dihydrokavain modulate GABAergic activity in a rat gastric-brainstem preparation.Chun-Su Yuan et al.Planta medica, 68(12), 1092-1096 (2002-12-21) Glial dysfunction in the mouse habenula causes depressive-like behaviors and sleep disturbance.Wanpeng Cui et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(49), 16273-16285 (2014-12-05) Efficient enantioselective hetero-Diels-Alder reaction of Brassard's diene with aliphatic aldehydes: a one-step synthesis of (R)-(+)-kavain and (S)-(+)-dihydrokavain.Lili Lin et al.Organic letters, 10(6), 1311-1314 (2008-02-29)

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