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Peer-Reviewed Papers

Severe methylenetetrahydrofolate reductase deficiency: clinical clues to a potentially treatable cause of adult-onset hereditary spastic paraplegia.Alexander Lossos et al.JAMA neurology, 71(7), 901-904 (2014-05-07) Exposure to the proton scavenger glycine under alkaline conditions induces Escherichia coli viability loss.Donna Vanhauteghem et al.PloS one, 8(3), e60328-e60328 (2013-04-02) Efficacy of osmoprotectants on prevention and treatment of murine dry eye.Wei Chen et al.Investigative ophthalmology & visual science, 54(9), 6287-6297 (2013-08-24) Choline catabolism to glycine betaine contributes to Pseudomonas aeruginosa survival during murine lung infection.Matthew J Wargo PloS one, 8(2), e56850-e56850 (2013-03-05) The effect of a continuous supply of betaine on the degradation of betaine in the rumen of dairy cows.Tomokazu Nakai et al.Bioscience, biotechnology, and biochemistry, 77(3), 666-669 (2013-03-09) Characterization of the GbdR regulon in Pseudomonas aeruginosa.Ken J Hampel et al.Journal of bacteriology, 196(1), 7-15 (2013-10-08) Betaine 0.77-perhydrate 0.23-hydrate and common structural motifs in crystals of amino acid perhydrates.Vasily S Minkov et al.Acta crystallographica. Section C, Crystal structure communications, 69(Pt 4), 416-420 (2013-04-13) Quantifying the temperature dependence of glycine-betaine RNA duplex destabilization.Jeffrey J Schwinefus et al.Biochemistry, 52(51), 9339-9346 (2013-11-14) Monepantel irreversibly binds to and opens Haemonchus contortus MPTL-1 and Caenorhabditis elegans ACR-20 receptors.Roland Baur et al.Molecular pharmacology, 87(1), 96-102 (2014-10-30) Choline concentrations are lower in postnatal plasma of preterm infants than in cord plasma.Wolfgang Bernhard et al.European journal of nutrition, 54(5), 733-741 (2014-08-26) Use of statistical modeling to predict the effect of formulation composition on conditioning shampoo performance.Carole Lepilleur et al.Journal of cosmetic science, 64(6), 411-427 (2014-01-09) Duplicated CCAAT/enhancer-binding protein β (C/EBPβ) gene: transcription and methylation changes in response to dietary betaine in Landes goose liver.S L Yu et al.Poultry science, 92(7), 1878-1887 (2013-06-19) Mutation of a single threonine in the cytoplasmic NH2 terminus disrupts trafficking of renal betaine-GABA transporter 1 during hypertonic stress.Eva S Schweikhard et al.American journal of physiology. Renal physiology, 307(1), F107-F115 (2014-05-16) Plasma choline metabolites and colorectal cancer risk in the Women's Health Initiative Observational Study.Sajin Bae et al.Cancer research, 74(24), 7442-7452 (2014-10-23) Low folate status enhances pregnancy changes in plasma betaine and dimethylglycine concentrations and the association between betaine and homocysteine.Sílvia Fernàndez-Roig et al.The American journal of clinical nutrition, 97(6), 1252-1259 (2013-04-19) Mallory-Denk Body (MDB) formation modulates Ufmylation expression epigenetically in alcoholic hepatitis (AH) and non-alcoholic steatohepatitis (NASH).Hui Liu et al.Experimental and molecular pathology, 97(3), 477-483 (2014-10-08) Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.W H Wilson Tang et al.The New England journal of medicine, 368(17), 1575-1584 (2013-04-26) Nicotinamide supplementation induces detrimental metabolic and epigenetic changes in developing rats.Da Li et al.The British journal of nutrition, 110(12), 2156-2164 (2013-06-19) Regioselectivity of the oxidative C-S bond formation in ergothioneine and ovothiol biosyntheses.Heng Song et al.Organic letters, 15(18), 4854-4857 (2013-09-11) The impact of structure on elasticity, switchability, stability and functionality of an all-in-one carboxybetaine elastomer.Bin Cao et al.Biomaterials, 34(31), 7592-7600 (2013-07-23) Effect of TMAO and betaine on the energy landscape of photosystem I.Jana B Nieder et al.Biochimica et biophysica acta, 1837(6), 849-856 (2014-01-21) Maternal choline concentrations during pregnancy and choline-related genetic variants as risk factors for neural tube defects.James L Mills et al.The American journal of clinical nutrition, 100(4), 1069-1074 (2014-09-23) Dynamics of serum metabolites in patients with chronic hepatitis C receiving pegylated interferon plus ribavirin: a metabolomics analysis.Takafumi Saito et al.Metabolism: clinical and experimental, 62(11), 1577-1586 (2013-08-21) Choline intake during pregnancy and child cognition at age 7 years.Caroline E Boeke et al.American journal of epidemiology, 177(12), 1338-1347 (2013-02-22) Cutaneous delayed-type hypersensitivity in patients with atopic dermatitis: reactivity to surfactants.Cristin N Shaughnessy et al.Journal of the American Academy of Dermatology, 70(4), 704-708 (2014-02-11) Deep eutectic solvent as a green solvent for enhanced extraction of narirutin, naringin, hesperidin and neohesperidin from Aurantii Fructus.Yongjing Liu et al.Phytochemical analysis : PCA, 30(2), 156-163 (2018-11-15) Betaine is a positive regulator of mitochondrial respiration.Icksoo Lee Biochemical and biophysical research communications, 456(2), 621-625 (2014-12-17) Stroke in a young man.Deepa Narayanan et al.BMJ (Clinical research ed.), 347, f4484-f4484 (2013-07-17) Zephgrabetaine: a new betaine-type amaryllidaceae alkaloid from Zephyranthes grandiflora.Deepali Katoch et al.Natural product communications, 8(2), 161-164 (2013-03-22) Can Phytochemicals be Effective in Preventing Ethanol-Induced Hepatotoxicity in the Geriatric Population? An Evidence-Based Revisit Foods and Dietary Supplements in the Prevention and Treatment of Disease in Older Adults, 163- 170 (2015) Effect of drying medium on the viability of driedSelmer OE, et al. Immobilized Cells: Basics and Applications, 11, 229-229 (1996) [Cryoprotection of compatible-solutes for Methanolobus psychrophilus R15].Yue Wu et al.Wei sheng wu xue bao = Acta microbiologica Sinica, 53(10), 1050-1055 (2014-01-15) Sarcosine and other metabolites along the choline oxidation pathway in relation to prostate cancer--a large nested case-control study within the JANUS cohort in Norway.Stefan de Vogel et al.International journal of cancer, 134(1), 197-206 (2013-06-26) Betaine supplement alleviates hepatic triglyceride accumulation of apolipoprotein E deficient mice via reducing methylation of peroxisomal proliferator-activated receptor alpha promoter.Lijun Wang et al.Lipids in health and disease, 12, 34-34 (2013-03-19) Folate and B12 in prostate cancer.Simon M Collin Advances in clinical chemistry, 60, 1-63 (2013-06-04) Diet influences expression of autoimmune-associated genes and disease severity by epigenetic mechanisms in a transgenic mouse model of lupus.Faith M Strickland et al.Arthritis and rheumatism, 65(7), 1872-1881 (2013-04-12) Estimation of usual intake and food sources of choline and betaine in New Zealand reproductive age women.Vanessa L Mygind et al.Asia Pacific journal of clinical nutrition, 22(2), 319-324 (2013-05-03) Improved preservation of ultrastructural morphology in human spermatozoa using betaine in the primary fixativeSwan MA International Journal of Andrology, 20(1), 45- 54 (1997) Metabolic profiling of plasma from sows before parturition and during lactation using a liquid chromatography-mass spectrometry-based approach.M S Hedemann et al.Journal of animal science, 90 Suppl 4, 200-202 (2013-02-13) Application of MS Transport Assays to the Four Human γ-Aminobutyric Acid Transporters.Sebastian Schmitt et al.ChemMedChem, 10(9), 1498-1510 (2015-07-30) Osmolyte effects on the self-association of concanavalin A: testing theoretical models.Thomas R Silvers et al.Biochemistry, 52(51), 9367-9374 (2013-11-13) Novel ternary vanadium-betaine-peroxido species suppresses H-ras and matrix metalloproteinase-2 expression by increasing reactive oxygen species-mediated apoptosis in cancer cells.Savvas Petanidis et al.Cancer letters, 335(2), 387-396 (2013-03-12) Strategies to improve medication reconciliation.Oscar M P Jolobe The American journal of medicine, 126(12), e49-e49 (2013-11-23) Dietary choline and betaine intakes vary in an adult multiethnic population.Kim M Yonemori et al.The Journal of nutrition, 143(6), 894-899 (2013-04-26) Transgenic Arabidopsis expressing osmolyte glycine betaine synthesizing enzymes from halophilic methanogen promote tolerance to drought and salt stress.Shu-Jung Lai et al.Plant molecular biology, 85(4-5), 429-441 (2014-05-08) Glycine betaine catabolism contributes to Pseudomonas syringae tolerance to hyperosmotic stress by relieving betaine-mediated suppression of compatible solute synthesis.Shanshan Li et al.Journal of bacteriology, 195(10), 2415-2423 (2013-03-26) Structural insights into the histidine trimethylation activity of EgtD from Mycobacterium smegmatis.Jae-Hee Jeong et al.Biochemical and biophysical research communications, 452(4), 1098-1103 (2014-09-25) Osmotic regulation of hepatic betaine metabolism.Lars Hoffmann et al.American journal of physiology. Gastrointestinal and liver physiology, 304(9), G835-G846 (2013-03-02) Silver-zwitterion organic-inorganic nanocomposite with antimicrobial and antiadhesive capabilities.Rong Hu et al.Langmuir : the ACS journal of surfaces and colloids, 29(11), 3773-3779 (2013-02-22) Structural evidence for functional lipid interactions in the betaine transporter BetP.Caroline Koshy et al.The EMBO journal, 32(23), 3096-3105 (2013-10-22) Membrane protein stability depends on the concentration of compatible solutes--a single molecule force spectroscopic study.Arpita Roychoudhury et al.Biological chemistry, 394(11), 1465-1474 (2013-09-12) Developing structure-activity relationships for the prediction of hepatotoxicity.Nigel Greene et al.Chemical research in toxicology, 23(7), 1215-1222 (2010-06-18) Sulfur amino acid metabolism in Zucker diabetic fatty rats.Hui Chan Kwak et al.Biochemical pharmacology, 96(3), 256-266 (2015-06-07) Quantifying additive interactions of the osmolyte proline with individual functional groups of proteins: comparisons with urea and glycine betaine, interpretation of m-values.Roger C Diehl et al.Biochemistry, 52(35), 5997-6010 (2013-08-06) A mysterious case of dysphagia demystified by medication reconciliation.Karthik Ragunathan et al.The American journal of medicine, 126(6), e1-e1 (2013-05-21) Trehalose/2-sulfotrehalose biosynthesis and glycine-betaine uptake are widely spread mechanisms for osmoadaptation in the Halobacteriales.Noha H Youssef et al.The ISME journal, 8(3), 636-649 (2013-09-21) Co-administration of methyl donors along with guanidinoacetic acid reduces the incidence of hyperhomocysteinaemia compared with guanidinoacetic acid administration alone.Sergej M Ostojic et al.The British journal of nutrition, 110(5), 865-870 (2013-01-29) System A amino acid transporter SNAT2 shows subtype-specific affinity for betaine and hyperosmotic inducibility in placental trophoblasts.Tomohiro Nishimura et al.Biochimica et biophysica acta, 1838(5), 1306-1312 (2014-01-18) Cobalamin C defect presenting with isolated pulmonary hypertension.Francesca G Iodice et al.Pediatrics, 132(1), e248-e251 (2013-06-12) Betaine protects against high-fat-diet-induced liver injury by inhibition of high-mobility group box 1 and Toll-like receptor 4 expression in rats.Wei Zhang et al.Digestive diseases and sciences, 58(11), 3198-3206 (2013-07-19) Betaine acts on a ligand-gated ion channel in the nervous system of the nematode C. elegans.Aude S Peden et al.Nature neuroscience, 16(12), 1794-1801 (2013-11-12) Mouse model for deficiency of methionine synthase reductase exhibits short-term memory impairment and disturbances in brain choline metabolism.Jadavji NM, Bahous RH, Deng L, et al. The Biochemical Journal, 461(2), 205-212 (2014) Low plasma vitamin B-12 is associated with a lower pregnancy-associated rise in plasma free choline in Canadian pregnant women and lower postnatal growth rates in their male infants.Brian Tf Wu et al.The American journal of clinical nutrition, 98(5), 1209-1217 (2013-09-06) DNA methylation potential: dietary intake and blood concentrations of one-carbon metabolites and cofactors in rural African women.Paula Dominguez-Salas et al.The American journal of clinical nutrition, 97(6), 1217-1227 (2013-04-12) Investigating multiple candidate genes and nutrients in the folate metabolism pathway to detect genetic and nutritional risk factors for lung cancer.Michael D Swartz et al.PloS one, 8(1), e53475-e53475 (2013-02-02) Maternal nicotinamide supplementation causes global DNA hypomethylation, uracil hypo-incorporation and gene expression changes in fetal rats.Yan-Jie Tian et al.The British journal of nutrition, 111(9), 1594-1601 (2014-02-11) Salinity impacts photosynthetic pigmentation and cellular morphology changes by distinct mechanisms in Fremyella diplosiphon.Shailendra P Singh et al.Biochemical and biophysical research communications, 433(1), 84-89 (2013-03-05) [Investigation of optimum concentrations of betaine for improving the resolution of sequencing G-C rich DNA with trinucleotide repeats].Dan Wang et al.Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics, 31(2), 163-169 (2014-04-09) Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes.Weijia Xie et al.Diabetes, 62(6), 2141-2150 (2013-02-05) Associations between dietary intake of choline and betaine and lung cancer risk.Jun Ying et al.PloS one, 8(2), e54561-e54561 (2013-02-06) A predictive ligand-based Bayesian model for human drug-induced liver injury.Sean Ekins et al.Drug metabolism and disposition: the biological fate of chemicals, 38(12), 2302-2308 (2010-09-17) Fenofibrate causes elevation of betaine excretion but not excretion of other osmolytes by healthy adults.Michael Lever et al.Journal of clinical lipidology, 8(4), 433-440 (2014-08-12) Chemical genetics reveals a complex functional ground state of neural stem cells.Phedias Diamandis et al.Nature chemical biology, 3(5), 268-273 (2007-04-10) Novel pH-sensitive micelles generated by star-shape copolymers containing zwitterionic sulfobetaine for efficient cellular internalization.Jun Cao et al.Journal of biomedical nanotechnology, 9(11), 1847-1861 (2013-09-26)

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