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3,5-Dimethylisoxasole-4-carboxylic acid | CAS:2510-36-3
3,5-Dimethylisoxasole-4-carboxylic acid
  • Name:3,5-Dimethylisoxasole-4-carboxylic acid
  • CAS:2510-36-3
  • Synonyms:
  • Molecular Formula:C6H7NO3
  • Molecular Weight:141.12
  • EINESC:219-724-5

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Properties

Melting point 141-142 ºC

Safety

SDS/MSDS S22;S24/25

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Peer-Reviewed Papers
Multifaceted innate immune responses engaged by astrocytes, microglia and resident dendritic cells against Chikungunya neuroinfection.Trina Das et al.The Journal of general virology, 96(Pt 2), 294-310 (2014-10-30) Cutting edge: CD69 interference with sphingosine-1-phosphate receptor function regulates peripheral T cell retention.Laura K Mackay et al.Journal of immunology (Baltimore, Md. : 1950), 194(5), 2059-2063 (2015-01-28) Increased risk for development of coronary artery calcification in subjects with non-alcoholic fatty liver disease and systemic inflammation.Jihyun Kim et al.PloS one, 12(7), e0180118-e0180118 (2017-07-08) Chemical, Biochemical and Medical Aspects, 792-792 null Investigation of a substrate-specifying residue within Papaver somniferum and Catharanthus roseus aromatic amino acid decarboxylases.Michael P Torrens-Spence et al.Phytochemistry, 106, 37-43 (2014-08-12) Correlation between ABO Blood Group, and Conventional Hematological and Metabolic Parameters in Blood Donors.Massimo Franchini et al.Seminars in thrombosis and hemostasis, 42(1), 75-86 (2015-11-26) Plasma choline metabolites and colorectal cancer risk in the Women's Health Initiative Observational Study.Sajin Bae et al.Cancer research, 74(24), 7442-7452 (2014-10-23) Nutritionally Variant Streptococci Interfere with Streptococcus mutans Adhesion Properties and Biofilm Formation.Fabrizio Angius et al.The new microbiologica, 38(2), 259-266 (2015-05-06) Nutritional Deficiencies and Syndromes Associated with Alcoholism Textbook of Clinical Neurology, 897-917 (2007) The gut microbiota regulates autism-like behavior by mediating vitamin B6 homeostasis in EphB6-deficient mice.Ying Li et al.Microbiome, 8(1), 120-120 (2020-08-21) Effects of forage family on apparent ruminal synthesis of B vitamins in lactating dairy cows.D S Castagnino et al.Journal of dairy science, 99(3), 1884-1894 (2016-01-18) Arg-265: a critical residue of L.donovani cytosolic SHMT in maintaining the binding of THF and catalysis.Shashi Gandhi et al.Experimental parasitology, 149, 16-23 (2014-12-17) Coimmobilization of l-methioninase and glutamate dehydrogenase: Novel approach for L-homoalanine synthesis.Ashraf S A El-Sayed et al.Biotechnology and applied biochemistry, 62(4), 514-522 (2014-10-03) N-Acetylaspartate Synthase Deficiency Corrects the Myelin Phenotype in a Canavan Disease Mouse Model But Does Not Affect Survival Time.Helena Maier et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(43), 14501-14516 (2015-10-30) Determination of key enzymes for threonine synthesis through in vitro metabolic pathway analysis.Yanfei Zhang et al.Microbial cell factories, 14, 86-86 (2015-06-14) Hydrogen sulfide accelerates the recovery of kidney tubules after renal ischemia/reperfusion injury.Sang Jun Han et al.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 30(9), 1497-1506 (2015-07-05) Diagnostic utility of aquaporin-4 in the analysis of active demyelinating lesions.Bogdan F G Popescu et al.Neurology, 84(2), 148-158 (2014-12-17) Remyelination After Cuprizone-Induced Demyelination Is Accelerated in Juvenile Mice.Sabine Pfeifenbring et al.Journal of neuropathology and experimental neurology, 74(8), 756-766 (2015-06-27) Apcdd1 stimulates oligodendrocyte differentiation after white matter injury.Hyun Kyoung Lee et al.Glia, 63(10), 1840-1849 (2015-05-07) Normothermic preservation of the rat hind limb with artificial oxygen-carrying hemoglobin vesicles.Jun Araki et al.Transplantation, 99(4), 687-692 (2015-01-22) Neurofascin 140 is an embryonic neuronal neurofascin isoform that promotes the assembly of the node of Ranvier.Ao Zhang et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(5), 2246-2254 (2015-02-06) Rapid method using two microbial enzymes for detection of L-abrine in food as a marker for the toxic protein abrin.Anthony G Dodge et al.Applied and environmental microbiology, 81(5), 1610-1615 (2014-12-21) N(6)-(3-methoxyl-4-hydroxybenzyl) adenine riboside induces sedative and hypnotic effects via GAD enzyme activation in mice.Y Shi et al.Pharmacology, biochemistry, and behavior, 126, 146-151 (2014-09-17) Assay of Ornithine Decarboxylase and Spermidine/Spermine N1-acetyltransferase ActivitiesHyvonen MT, et al. Bio-protocol (2014) Hydrogen sulfide production from subgingival plaque samples.A Basic et al.Anaerobe, 35(Pt A), 21-27 (2014-10-05) Regulation and function of pyridoxal phosphate in CNSMetzler DE Neurochemistry International, 3(3-4), 207-209 (1981) Role of ERK1/2 MAPK signaling in the maintenance of myelin and axonal integrity in the adult CNS.Akihiro Ishii et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(48), 16031-16045 (2014-11-28) Effect of postnatal progesterone therapy following preterm birth on neurosteroid concentrations and cerebellar myelination in guinea pigs.H K Palliser et al.Journal of developmental origins of health and disease, 6(4), 350-361 (2015-04-25) In situ allicin generation using targeted alliinase delivery for inhibition of MIA PaCa-2 cells via epigenetic changes, oxidative stress and cyclin-dependent kinase inhibitor (CDKI) expression.Sagar V Chhabria et al.Apoptosis : an international journal on programmed cell death, 20(10), 1388-1409 (2015-08-20) Oligodendrocyte precursor cell-intrinsic effect of Rheb1 controls differentiation and mediates mTORC1-dependent myelination in brain.Yi Zou et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(47), 15764-15778 (2014-11-21) Oligodendrocyte precursor cells synthesize neuromodulatory factors.Dominik Sakry et al.PloS one, 10(5), e0127222-e0127222 (2015-05-13) The EIIIA domain from astrocyte-derived fibronectin mediates proliferation of oligodendrocyte progenitor cells following CNS demyelination.Josephine M J Stoffels et al.Glia, 63(2), 242-256 (2014-08-27) Single active-site mutants are sufficient to enhance serine:pyruvate α-transaminase activity in an ω-transaminase.Dawid Deszcz et al.The FEBS journal, 282(13), 2512-2526 (2015-04-08) PLP-dependent enzymes as entry and exit gates of sphingolipid metabolism.Florence Bourquin et al.Protein science : a publication of the Protein Society, 20(9), 1492-1508 (2011-06-29) Pyridoxal-5′-phosphate-dependent enzymes involved in biotin biosynthesis: Structure, reaction mechanism and inhibition.Mann S, Ploux O. Biochemical and Biophysical Research Communications, 1814(11), 1459-1466 (2010) A high performance liquid chromatography fluorescence method for the analysis of both pyridoxal-5-phosphate and thiamine pyrophosphate in whole blood.Van Long Nguyen et al.Clinica chimica acta; international journal of clinical chemistry, 506, 129-134 (2020-03-22) Routes of administration and dose optimization of soluble antigen arrays in mice with experimental autoimmune encephalomyelitis.Sharadvi Thati et al.Journal of pharmaceutical sciences, 104(2), 714-721 (2014-12-03) Cuprizone Intoxication Induces Cell Intrinsic Alterations in Oligodendrocyte Metabolism Independent of Copper Chelation.Alexandra Taraboletti et al.Biochemistry, 56(10), 1518-1528 (2017-02-12) pH-responsive, lysine-based hydrogels for the oral delivery of a wide size range of molecules.Kira A Watkins et al.International journal of pharmaceutics, 478(2), 496-503 (2014-12-10) Protective Effect of a cAMP Analogue on Behavioral Deficits and Neuropathological Changes in Cuprizone Model of Demyelination.Gelareh Vakilzadeh et al.Molecular neurobiology, 52(1), 130-141 (2014-08-17) Measurement of pyridoxal 5′-phosphate, pyridoxal, and 4-pyridoxic acid in the cerebrospinal fluid of children.Akiyama T, et al. Clinica Chimica Acta; International Journal of Clinical Chemistry, 466, 1-5 (2017) Can Antibodies Against Glial Derived Antigens be Early Biomarkers of Hippocampal Demyelination and Memory Loss in Alzheimer's Disease?Ewa Papuć et al.Journal of Alzheimer's disease : JAD, 48(1), 115-121 (2015-09-25) An optimized coupled assay for quantifying diaminopimelate decarboxylase activity.Martin G Peverelli et al.Biochimie, 115, 78-85 (2015-05-20) Simultaneous Determination of Underivatized Vitamin B1 and B6 in Whole Blood by Reversed Phase Ultra High Performance Liquid Chromatography Tandem Mass Spectrometry.Johan Puts et al.PloS one, 10(7), e0132018-e0132018 (2015-07-03) Coimmobilization of l-methioninase and glutamate dehydrogenase: Novel approach for L-homoalanine synthesis.Ashraf S A El-Sayed et al.Biotechnology and applied biochemistry, 62(4), 514-522 (2014-10-03) Increased risk for development of coronary artery calcification in subjects with non-alcoholic fatty liver disease and systemic inflammation.Jihyun Kim et al.PloS one, 12(7), e0180118-e0180118 (2017-07-08) Chemical, Biochemical and Medical Aspects, 792-792 null Investigation of a substrate-specifying residue within Papaver somniferum and Catharanthus roseus aromatic amino acid decarboxylases.Michael P Torrens-Spence et al.Phytochemistry, 106, 37-43 (2014-08-12) Correlation between ABO Blood Group, and Conventional Hematological and Metabolic Parameters in Blood Donors.Massimo Franchini et al.Seminars in thrombosis and hemostasis, 42(1), 75-86 (2015-11-26) Plasma choline metabolites and colorectal cancer risk in the Women's Health Initiative Observational Study.Sajin Bae et al.Cancer research, 74(24), 7442-7452 (2014-10-23) Nutritionally Variant Streptococci Interfere with Streptococcus mutans Adhesion Properties and Biofilm Formation.Fabrizio Angius et al.The new microbiologica, 38(2), 259-266 (2015-05-06) Nutritional Deficiencies and Syndromes Associated with Alcoholism Textbook of Clinical Neurology, 897-917 (2007) The gut microbiota regulates autism-like behavior by mediating vitamin B6 homeostasis in EphB6-deficient mice.Ying Li et al.Microbiome, 8(1), 120-120 (2020-08-21) Effects of forage family on apparent ruminal synthesis of B vitamins in lactating dairy cows.D S Castagnino et al.Journal of dairy science, 99(3), 1884-1894 (2016-01-18) Multifaceted innate immune responses engaged by astrocytes, microglia and resident dendritic cells against Chikungunya neuroinfection.Trina Das et al.The Journal of general virology, 96(Pt 2), 294-310 (2014-10-30) Cutting edge: CD69 interference with sphingosine-1-phosphate receptor function regulates peripheral T cell retention.Laura K Mackay et al.Journal of immunology (Baltimore, Md. : 1950), 194(5), 2059-2063 (2015-01-28) N-Acetylaspartate Synthase Deficiency Corrects the Myelin Phenotype in a Canavan Disease Mouse Model But Does Not Affect Survival Time.Helena Maier et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(43), 14501-14516 (2015-10-30) Determination of key enzymes for threonine synthesis through in vitro metabolic pathway analysis.Yanfei Zhang et al.Microbial cell factories, 14, 86-86 (2015-06-14) Hydrogen sulfide accelerates the recovery of kidney tubules after renal ischemia/reperfusion injury.Sang Jun Han et al.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 30(9), 1497-1506 (2015-07-05) Diagnostic utility of aquaporin-4 in the analysis of active demyelinating lesions.Bogdan F G Popescu et al.Neurology, 84(2), 148-158 (2014-12-17) Remyelination After Cuprizone-Induced Demyelination Is Accelerated in Juvenile Mice.Sabine Pfeifenbring et al.Journal of neuropathology and experimental neurology, 74(8), 756-766 (2015-06-27) Apcdd1 stimulates oligodendrocyte differentiation after white matter injury.Hyun Kyoung Lee et al.Glia, 63(10), 1840-1849 (2015-05-07) Normothermic preservation of the rat hind limb with artificial oxygen-carrying hemoglobin vesicles.Jun Araki et al.Transplantation, 99(4), 687-692 (2015-01-22) Neurofascin 140 is an embryonic neuronal neurofascin isoform that promotes the assembly of the node of Ranvier.Ao Zhang et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(5), 2246-2254 (2015-02-06) Rapid method using two microbial enzymes for detection of L-abrine in food as a marker for the toxic protein abrin.Anthony G Dodge et al.Applied and environmental microbiology, 81(5), 1610-1615 (2014-12-21) PLP-dependent enzymes as entry and exit gates of sphingolipid metabolism.Florence Bourquin et al.Protein science : a publication of the Protein Society, 20(9), 1492-1508 (2011-06-29) Vitamin D rescues dysfunction of fetal endothelial colony forming cells from individuals with gestational diabetes.J Gui et al.Placenta, 36(4), 410-418 (2015-02-17) Vitamin B6 biosynthesis: charting the mechanistic landscape.Teresa B Fitzpatrick et al.Chembiochem : a European journal of chemical biology, 11(9), 1185-1193 (2010-04-17) Fluorescent probes for tracking the transfer of iron-sulfur cluster and other metal cofactors in biosynthetic reaction pathways.James N Vranish et al.Journal of the American Chemical Society, 137(1), 390-398 (2014-12-06) Simultaneous quantification of 21 water soluble vitamin circulating forms in human plasma by liquid chromatography-mass spectrometry.Karine Meisser Redeuil et al.Journal of chromatography. A, 1422, 89-98 (2015-11-03) Vitamin B6 and risk of colorectal cancer: a meta-analysis of prospective studies.Larsson SC, Orsini N, Wolk A. Journal of the American Medical Association, 303, 1077-1083 (2010) A new target region for changing the substrate specificity of amine transaminases.Li-Jun Guan et al.Scientific reports, 5, 10753-10753 (2015-06-02) Methyltetrahydrofolate vs Folic Acid Supplementation in Idiopathic Recurrent Miscarriage with Respect to Methylenetetrahydrofolate Reductase C677T and A1298C Polymorphisms: A Randomized Controlled Trial.Azita Hekmatdoost et al.PloS one, 10(12), e0143569-e0143569 (2015-12-03) Cysteine Metabolism and Oxidative Processes in the Rat Liver and Kidney after Acute and Repeated Cocaine Treatment.Danuta Kowalczyk-Pachel et al.PloS one, 11(1), e0147238-e0147238 (2016-01-26) Extensive acute axonal damage in pediatric multiple sclerosis lesions.Sabine Pfeifenbring et al.Annals of neurology, 77(4), 655-667 (2015-01-23) Liver X receptors alpha and beta promote myelination and remyelination in the cerebellum.Delphine Meffre et al.Proceedings of the National Academy of Sciences of the United States of America, 112(24), 7587-7592 (2015-05-30) Co-ultramicronized Palmitoylethanolamide/Luteolin Promotes the Maturation of Oligodendrocyte Precursor Cells.Massimo Barbierato et al.Scientific reports, 5, 16676-16676 (2015-11-19) Vitamin B6 biosynthesis: charting the mechanistic landscape.Teresa B Fitzpatrick et al.Chembiochem : a European journal of chemical biology, 11(9), 1185-1193 (2010-04-17) Hypothyroxinemia induced by maternal mild iodine deficiency impairs hippocampal myelinated growth in lactational rats.Wei Wei et al.Environmental toxicology, 30(11), 1264-1274 (2014-04-23) The Drosophila Pericentrin-like-protein (PLP) cooperates with Cnn to maintain the integrity of the outer PCM.Jennifer H Richens et al.Biology open, 4(8), 1052-1061 (2015-07-15) Altered Oligodendrocyte Maturation and Myelin Maintenance: The Role of Antiretrovirals in HIV-Associated Neurocognitive Disorders.Brigid K Jensen et al.Journal of neuropathology and experimental neurology, 74(11), 1093-1118 (2015-10-16) pH-responsive, lysine-based hydrogels for the oral delivery of a wide size range of molecules.Kira A Watkins et al.International journal of pharmaceutics, 478(2), 496-503 (2014-12-10) Protective Effect of a cAMP Analogue on Behavioral Deficits and Neuropathological Changes in Cuprizone Model of Demyelination.Gelareh Vakilzadeh et al.Molecular neurobiology, 52(1), 130-141 (2014-08-17) Measurement of pyridoxal 5′-phosphate, pyridoxal, and 4-pyridoxic acid in the cerebrospinal fluid of children.Akiyama T, et al. Clinica Chimica Acta; International Journal of Clinical Chemistry, 466, 1-5 (2017) Can Antibodies Against Glial Derived Antigens be Early Biomarkers of Hippocampal Demyelination and Memory Loss in Alzheimer's Disease?Ewa Papuć et al.Journal of Alzheimer's disease : JAD, 48(1), 115-121 (2015-09-25) An optimized coupled assay for quantifying diaminopimelate decarboxylase activity.Martin G Peverelli et al.Biochimie, 115, 78-85 (2015-05-20) Simultaneous Determination of Underivatized Vitamin B1 and B6 in Whole Blood by Reversed Phase Ultra High Performance Liquid Chromatography Tandem Mass Spectrometry.Johan Puts et al.PloS one, 10(7), e0132018-e0132018 (2015-07-03) Arg-265: a critical residue of L.donovani cytosolic SHMT in maintaining the binding of THF and catalysis.Shashi Gandhi et al.Experimental parasitology, 149, 16-23 (2014-12-17)
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