Water Solubility	20 g/L (20 ºC)

Symbol(GHS)	Xi
Hazard Codes	R36/37/38
SDS/MSDS	S26;S37/39

Source	SDS/MSDS Samples
TCI	View & Download
Carl-Roth	View & Download
LOBA	View & Download

Synthetic Route

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Name	CAS

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Articles

Peer-Reviewed Papers

Activation of ERK signalling by Src family kinases (SFKs) in DRG neurons contributes to hydrogen peroxide (HAjeet Kumar Singh et al.Free radical research, 51(9-10), 838-850 (2017-09-22) Properties of Xenopus Kv1.10 channels expressed in HEK293 cells.Mark Fry et al.Journal of neurobiology, 60(2), 227-235 (2004-07-22) Structural and functional alterations of spinal cord axons in adult Long Evans Shaker (LES) dysmyelinated rats.Eftekhar Eftekharpour et al.Experimental neurology, 193(2), 334-349 (2005-05-05) Potential roles of the aminopyrimidine ring in thiamin catalyzed reactions.F Jordan et al.Annals of the New York Academy of Sciences, 378, 14-31 (1982-01-01) Casein kinase II regulates N-methyl-D-aspartate receptor activity in spinal cords and pain hypersensitivity induced by nerve injury.Shao-Rui Chen et al.The Journal of pharmacology and experimental therapeutics, 350(2), 301-312 (2014-06-06) Formation of 4-aminopyrimidines via the trimerization of nitriles using focused microwave heating.Ian R Baxendale et al.Journal of combinatorial chemistry, 7(3), 483-489 (2005-05-10) Pharmacology of a slowly inactivating outward current in hippocampal CA3 pyramidal neurons.Riccardo Bianchi et al.Journal of neurophysiology, 96(3), 1116-1123 (2006-06-09) Does stacking restrain the photodynamics of individual nucleobases?Dana Nachtigallová et al.Journal of the American Chemical Society, 132(24), 8261-8263 (2010-06-02) Serotonergic regulation of excitability of principal cells of the dorsal cochlear nucleus.Zheng-Quan Tang et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(11), 4540-4551 (2015-03-20) Sixty years of thiamin diphosphate biochemistry.A Schellenberger Biochimica et biophysica acta, 1385(2), 177-186 (1998-07-10) Discovery of piperidinyl aminopyrimidine derivatives as IKK-2 inhibitors.Sora Kim et al.Bioorganic & medicinal chemistry letters, 21(10), 3002-3006 (2011-04-15) Tyrosine Phosphorylation Regulates Plasma Membrane Expression and Stability of the Human Bile Acid Transporter ASBT (SLC10A2).Paresh P Chothe et al.Molecular pharmaceutics, 16(8), 3569-3576 (2019-06-14) Two structurally distinct inhibitors of glycogen synthase kinase 3 induced centromere positive micronuclei in human lymphoblastoid TK6 cells.Masayuki Mishima et al.Mutation research, 643(1-2), 29-35 (2008-07-05) Amino-imino tautomerization reaction of the 4-aminopyrimidine/acetic acid system.Teruyoshi Kitamura et al.Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 69(2), 350-360 (2007-06-05) Pre-synaptic nicotinic and D receptors functionally interact on dopaminergic nerve endings of rat and mouse nucleus accumbens.Massimo Grilli et al.Journal of neurochemistry, 108(6), 1507-1514 (2009-01-27) Theoretical studies on the electronic and energetic properties of the aminopyrimidine part of thiamin diphosphate.R Friedemann et al.Biochimica et biophysica acta, 1385(2), 245-250 (1998-07-10) Characterization of a transient outward K+ current with inward rectification in canine ventricular myocytes.G R Li et al.The American journal of physiology, 274(3 Pt 1), C577-C585 (1998-04-08) Fully automated synthesis module for preparation of S-(2-[(18)F]fluoroethyl)-L-methionine by direct nucleophilic exchange on a quaternary 4-aminopyridinium resin.Ganghua Tang et al.Nuclear medicine and biology, 30(5), 509-512 (2003-07-02) Consequences of one-electron oxidation and one-electron reduction for 4-aminopyrimidine--DFT studies.Ewa D Raczyńska et al.Journal of molecular modeling, 18(8), 3523-3533 (2012-02-14) Hyperglycaemic impairment of PAR2-mediated vasodilation: Prevention by inhibition of aortic endothelial sodium-glucose-co-Transporter-2 and minimizing oxidative stress.Mahmoud El-Daly et al.Vascular pharmacology, 109, 56-71 (2018-06-17) Sodium currents in mesencephalic trigeminal neurons from Nav1.6 null mice.Akifumi Enomoto et al.Journal of neurophysiology, 98(2), 710-719 (2007-05-25) Bifunctionality of the thiamin diphosphate cofactor: assignment of tautomeric/ionization states of the 4'-aminopyrimidine ring when various intermediates occupy the active sites during the catalysis of yeast pyruvate decarboxylase.Anand Balakrishnan et al.Journal of the American Chemical Society, 134(8), 3873-3885 (2012-02-04) Changes in intracellular K+ and Na+ ion concentrations during cell growth and differentiation.K Takagi et al.Cell structure and function, 11(3), 235-243 (1986-09-01) Excitotoxic inactivation of constitutive oxidative stress detoxification pathway in neurons can be rescued by PKD1.Julia Pose-Utrilla et al.Nature communications, 8(1), 2275-2275 (2017-12-24) Simple pyrimidines. Part III. The methylation and structure of the aminopyrimidines.Brown DJ, et al. Journal of the Chemical Society, 4035-4040 (1955) 4-Aminopyrimidines as novel HIV-1 inhibitors.Venkat R Gadhachanda et al.Bioorganic & medicinal chemistry letters, 17(1), 260-265 (2006-10-13) Long-lasting anticonvulsant effect of focal cooling on experimental neocortical seizures.Xiao-Feng Yang et al.Epilepsia, 44(12), 1500-1505 (2003-11-26) Somatostatin release, electrical activity, membrane currents and exocytosis in human pancreatic delta cells.M Braun et al.Diabetologia, 52(8), 1566-1578 (2009-05-15) Prefrontal somatostatin interneurons encode fear memory.Kirstie A Cummings et al.Nature neuroscience, 23(1), 61-74 (2019-12-18) Investigation of the effects of the novel anticonvulsant compound carisbamate (RWJ-333369) on rat piriform cortical neurones in vitro.B J Whalley et al.British journal of pharmacology, 156(6), 994-1008 (2009-02-20) Induction of thermal and mechanical hypersensitivity by parathyroid hormone-related peptide through upregulation of TRPV1 function and trafficking.Aaron D Mickle et al.Pain, 156(9), 1620-1636 (2015-05-15) Exploration of piperidine-4-yl-aminopyrimidines as HIV-1 reverse transcriptase inhibitors. N-Phenyl derivatives with broad potency against resistant mutant viruses.Guozhi Tang et al.Bioorganic & medicinal chemistry letters, 20(20), 6020-6023 (2010-09-11)

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