Density	1.02±0.1 g/cm3 (20 ºC

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Source	SDS/MSDS Samples
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Peer-Reviewed Papers

Docosahexaenoic acid sensitizes colon cancer cells to sulindac sulfide-induced apoptosis.Soo-Jeong Lim et al.Oncology reports, 27(6), 2023-2030 (2012-03-08) First and second generation γ-secretase modulators (GSMs) modulate amyloid-β (Aβ) peptide production through different mechanisms.Tomas Borgegard et al.The Journal of biological chemistry, 287(15), 11810-11819 (2012-02-16) Sulindac sulfide induces autophagic death in gastric epithelial cells via survivin down-regulation: a mechanism of NSAIDs-induced gastric injury.Shiun-Kwei Chiou et al.Biochemical pharmacology, 81(11), 1317-1323 (2011-04-05) Docosahexaenoic acid sensitizes colon cancer cells to sulindac sulfide-induced apoptosis.Soo-Jeong Lim et al.Oncology reports, 27(6), 2023-2030 (2012-03-08) First and second generation γ-secretase modulators (GSMs) modulate amyloid-β (Aβ) peptide production through different mechanisms.Tomas Borgegard et al.The Journal of biological chemistry, 287(15), 11810-11819 (2012-02-16) Sulindac sulfide induces autophagic death in gastric epithelial cells via survivin down-regulation: a mechanism of NSAIDs-induced gastric injury.Shiun-Kwei Chiou et al.Biochemical pharmacology, 81(11), 1317-1323 (2011-04-05) Synergistic inhibition of Aβ production by combinations of γ-secretase modulators.Alan S Robertson et al.European journal of pharmacology, 812, 104-112 (2017-07-12) Sulindac metabolites decrease cerebrovascular malformations in CCM3-knockout mice.Luca Bravi et al.Proceedings of the National Academy of Sciences of the United States of America, 112(27), 8421-8426 (2015-06-26) Second generation γ-secretase modulators exhibit different modulation of Notch β and Aβ production.Johanna Wanngren et al.The Journal of biological chemistry, 287(39), 32640-32650 (2012-08-02) Sulindac derivatives inhibit growth and induce apoptosis in human prostate cancer cell lines.J T Lim et al.Biochemical pharmacology, 58(7), 1097-1107 (1999-09-14) Potential for drug interactions mediated by polymorphic flavin-containing monooxygenase 3 in human livers.Makiko Shimizu et al.Drug metabolism and pharmacokinetics, 30(1), 70-74 (2015-03-12) Sulindac sulfide inhibits Ras signaling.C Herrmann et al.Oncogene, 17(14), 1769-1776 (1998-10-20) Drug oxygenation activities mediated by liver microsomal flavin-containing monooxygenases 1 and 3 in humans, monkeys, rats, and minipigs.Miho Yamazaki et al.Biochemical pharmacology, 90(2), 159-165 (2014-05-14) Drug oxygenation activities mediated by liver microsomal flavin-containing monooxygenases 1 and 3 in humans, monkeys, rats, and minipigs.Miho Yamazaki et al.Biochemical pharmacology, 90(2), 159-165 (2014-05-14) FOXO3 is inhibited by oncogenic PI3K/Akt signaling but can be reactivated by the NSAID sulindac sulfide.Carl Weidinger et al.The Journal of clinical endocrinology and metabolism, 96(9), E1361-E1371 (2011-07-15) The molecular basis for inhibition of sulindac and its metabolites towards human aldose reductase.Xuehua Zheng et al.FEBS letters, 586(1), 55-59 (2011-12-14) WNT Signaling in Cardiac and Vascular Disease.Sébastien Foulquier et al.Pharmacological reviews, 70(1), 68-141 (2017-12-17) Capping of aβ42 oligomers by small molecule inhibitors.Ziao Fu et al.Biochemistry, 53(50), 7893-7903 (2014-11-26) Role of nonsteroidal anti-inflammatory drug-activated gene-1 in docetaxel-induced cell death of human colorectal cancer cells with different p53 status.Il-Yeob Kim et al.Archives of pharmacal research, 34(2), 323-330 (2011-03-08) Neuritogenic Activity of Tetradecyl 2,3-Dihydroxybenzoate Is Mediated through the Insulin-Like Growth Factor 1 Receptor/Phosphatidylinositol 3 Kinase/Mitogen-Activated Protein Kinase Signaling Pathway.Ruiqi Tang et al.Molecular pharmacology, 88(2), 326-334 (2015-05-28) Optimisation and validation of a fast HPLC method for the quantification of sulindac and its related impurities.Fabrice Krier et al.Journal of pharmaceutical and biomedical analysis, 54(4), 694-700 (2010-12-07) Malva sylvestris extract alleviates the astrogliosis and inflammatory stress in LPS-induced depression mice.Ye Wu et al.Journal of neuroimmunology, 336, 577029-577029 (2019-09-06) Combinatorial effect of non-steroidal anti-inflammatory drugs and NF-κB inhibitors in ovarian cancer therapy.Luiz F Zerbini et al.PloS one, 6(9), e24285-e24285 (2011-09-21) Par-4, a proapoptotic gene, is regulated by NSAIDs in human colon carcinoma cells.Z Zhang et al.Gastroenterology, 118(6), 1012-1017 (2000-06-02) Sulindac sulfide reverses aberrant self-renewal of progenitor cells induced by the AML-associated fusion proteins PML/RARα and PLZF/RARα.Gunnar Steinert et al.PloS one, 6(7), e22540-e22540 (2011-08-04) CTF1-51, a truncated carboxyl-terminal fragment of amyloid precursor protein, suppresses the effects of Aβ42-lowering γ-secretase modulators.Haruhiko Watahiki et al.Neuroscience letters, 526(2), 96-99 (2012-09-04) Nonsteroidal anti-inflammatory drug sulindac sulfide suppresses structural protein Nesprin-2 expression in colorectal cancer cells.Jason L Liggett et al.Biochimica et biophysica acta, 1840(1), 322-331 (2013-10-02) Entrapment of human flavin-containing monooxygenase 3 in the presence of gold nanoparticles: TEM, FTIR and electrocatalysis.Silvia Castrignanò et al.Biochimica et biophysica acta, 1820(12), 2072-2078 (2012-10-06) Sulindac sulfide--induced stimulation of eryptosis.Mohanad Zbidah et al.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 30(4), 1072-1082 (2012-12-04) Charge Exchange Reaction in Dopant-Assisted Atmospheric Pressure Chemical Ionization and Atmospheric Pressure Photoionization.Anu Vaikkinen et al.Journal of the American Society for Mass Spectrometry, 27(8), 1291-1300 (2016-04-30) RAC1 GTP-ase signals Wnt-beta-catenin pathway mediated integrin-directed metastasis-associated tumor cell phenotypes in triple negative breast cancers.Pradip De et al.Oncotarget, 8(2), 3072-3103 (2016-12-03) Inhibition of PDE5 by sulindac sulfide selectively induces apoptosis and attenuates oncogenic Wnt/β-catenin-mediated transcription in human breast tumor cells.Heather N Tinsley et al.Cancer prevention research (Philadelphia, Pa.), 4(8), 1275-1284 (2011-04-21) Sulindac sulfide, but not sulindac sulfone, inhibits colorectal cancer growth.C S Williams et al.Neoplasia (New York, N.Y.), 1(2), 170-176 (2000-08-10) Colon tumor cell growth-inhibitory activity of sulindac sulfide and other nonsteroidal anti-inflammatory drugs is associated with phosphodiesterase 5 inhibition.Heather N Tinsley et al.Cancer prevention research (Philadelphia, Pa.), 3(10), 1303-1313 (2010-09-30) The non-steroidal anti-inflammatory drugs Sulindac sulfide and Diclofenac induce apoptosis and differentiation in human acute myeloid leukemia cells through an AP-1 dependent pathway.Raminder Singh et al.Apoptosis : an international journal on programmed cell death, 16(9), 889-901 (2011-07-09) Substrate sequence influences γ-secretase modulator activity, role of the transmembrane domain of the amyloid precursor protein.Sarah A Sagi et al.The Journal of biological chemistry, 286(46), 39794-39803 (2011-08-27) Anti-Aβ drug screening platform using human iPS cell-derived neurons for the treatment of Alzheimer's disease.Naoki Yahata et al.PloS one, 6(9), e25788-e25788 (2011-10-11) Suppressor Mutations for Presenilin 1 Familial Alzheimer Disease Mutants Modulate γ-Secretase Activities.Eugene Futai et al.The Journal of biological chemistry, 291(1), 435-446 (2015-11-13) Identification of the Effects of Aspirin and Sulindac Sulfide on the Inhibition of HMGA2-Mediated Oncogenic Capacities in Colorectal Cancer.Titus Ime Ekanem et al.Molecules (Basel, Switzerland), 25(17) (2020-08-28) Antiangiogenic effect of sulindac sulfide could be secondary to induction of apoptosis and cell cycle arrest.S Flis et al.Anticancer research, 26(4B), 3033-3041 (2006-08-05) DNA methylation-mediated silencing of nonsteroidal anti-inflammatory drug-activated gene (NAG-1/GDF15) in glioma cell lines.Mitsutoshi Kadowaki et al.International journal of cancer, 130(2), 267-277 (2011-03-26) Sulindac sulfone inhibits K-ras-dependent cyclooxygenase-2 expression in human colon cancer cells.M T Taylor et al.Cancer research, 60(23), 6607-6610 (2000-12-16) [Antitumor effects of sulindac in ovarian cell cultures].Anna Jakubowska-Mućka et al.Ginekologia polska, 82(3), 195-199 (2011-07-09) In vitro drug metabolism by C-terminally truncated human flavin-containing monooxygenase 3.Gianluca Catucci et al.Biochemical pharmacology, 83(4), 551-558 (2011-12-20) Cyclooxygenase-1-selective inhibitors based on the (E)-2'-des-methyl-sulindac sulfide scaffold.Andy J Liedtke et al.Journal of medicinal chemistry, 55(5), 2287-2300 (2012-01-24) Anti-tumor activity of non-steroidal anti-inflammatory drugs: cyclooxygenase-independent targets.Jason L Liggett et al.Cancer letters, 346(2), 217-224 (2014-02-04) Myeloid zinc finger 1 mediates sulindac sulfide-induced upregulation of death receptor 5 of human colon cancer cells.Mano Horinaka et al.Scientific reports, 4, 6000-6000 (2014-08-12) Bidirectional reporter assay using HAL promoter and TOPFLASH improves specificity in high-throughput screening of Wnt inhibitors.Kiyoshi Yamaguchi et al.Biotechnology and bioengineering, 114(12), 2868-2882 (2017-07-30) Assessment of the involvement of oxidative stress and Mitogen-Activated Protein Kinase signaling pathways in the cytotoxic effects of arsenic trioxide and its combination with sulindac or its metabolites: sulindac sulfide and sulindac sulfone on human leukemic cell lines.M Stępnik et al.Medical oncology (Northwood, London, England), 29(2), 1161-1172 (2011-04-28) Sulindac and its metabolites: sulindac sulfide and sulindac sulfone enhance cytotoxic effects of arsenic trioxide on leukemic cell lines.Maciej Stępnik et al.Toxicology in vitro : an international journal published in association with BIBRA, 25(5), 1075-1084 (2011-04-26) Effect of sulindac sulfide on metallohydrolases in the human colon cancer cell line HT-29.Hector Guillen-Ahlers et al.PloS one, 6(10), e25725-e25725 (2011-10-13) ECRG2, a novel transcriptional target of p53, modulates cancer cell sensitivity to DNA damage.Harsh Patel et al.Cell death & disease, 11(7), 543-543 (2020-07-19)

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