Melting point	100-103 ºC
Density	1.218

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The effect of a methyl or 2-fluoroethyl substituent at the N-3 position of thymidine, 3'-fluoro-3'-deoxythymidine and 1-beta-D-arabinosylthymine on their antiviral and cytostatic activity in cell culture.Jan Balzarini et al.Antiviral chemistry & chemotherapy, 17(1), 17-23 (2006-03-18) Trastuzumab emtansine (T-DM1) renders HER2+ breast cancer highly susceptible to CTLA-4/PD-1 blockade.Philipp Müller et al.Science translational medicine, 7(315), 315ra188-315ra188 (2015-11-27) Synergistic therapeutic effect in gastric cancer cells produced by oncolytic adenovirus encoding Drosophila melanogaster deoxyribonucleoside kinase.Zhi Zhu et al.Cancer biology & therapy, 11(10), 874-882 (2011-03-09) Comparative pathology of HPCD pigs infected with wild-type and ara-T-resistant strains of Aujeszky's disease virus.M Narita et al.Journal of comparative pathology, 102(1), 63-69 (1990-01-01) Correlation between Chiral Modifier Adsorption and Enantioselectivity in Hydrogenation Catalysis.Yufei Ni et al.Angewandte Chemie (International ed. in English), 56(27), 7963-7966 (2017-05-16) Efficacies of antiherpesvirus nucleosides against two strains of herpes simplex virus type 1 in Vero and human embryo lung fibroblast cells.T Suzutani et al.Antimicrobial agents and chemotherapy, 32(7), 1046-1052 (1988-07-01) PGD2 deficiency exacerbates food antigen-induced mast cell hyperplasia.Tatsuro Nakamura et al.Nature communications, 6, 7514-7514 (2015-07-15) A new reverse transcription-polymerase chain reaction method for accurate quantification.Yih-Horng Shiao BMC biotechnology, 3, 22-22 (2003-12-11) Knockdown of brain-derived neurotrophic factor in specific brain sites precipitates behaviors associated with depression and reduces neurogenesis.D Taliaz et al.Molecular psychiatry, 15(1), 80-92 (2009-07-22) Evolutionary consequences of altered atmospheric oxygen in Drosophila melanogaster.Marc Charette et al.PloS one, 6(10), e26876-e26876 (2011-11-03) Variability of iodine concentrations in the human placenta.Kristof Y Neven et al.Scientific reports, 10(1), 161-161 (2020-01-15) ARD1/NAA10 acetylation in prostate cancer.Katherine J Kuhns et al.Experimental & molecular medicine, 50(7), 89-89 (2018-07-29) Cranberry intervention in patients with prostate cancer prior to radical prostatectomy. Clinical, pathological and laboratory findings.Vladimir Student et al.Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia, 160(4), 559-565 (2016-11-12) Zn3N2 nanowires: growth, properties and oxidation.Matthew Zervos et al.Nanoscale research letters, 8(1), 221-221 (2013-05-15) Differential gene expression patterns in developing sexually dimorphic rat brain regions exposed to antiandrogenic, estrogenic, or complex endocrine disruptor mixtures: glutamatergic synapses as target.Walter Lichtensteiger et al.Endocrinology, 156(4), 1477-1493 (2015-01-22) Characterization of an aphidicolin-resistant mutant of herpes simplex virus type 2 which induces an altered viral DNA polymerase.Y Nishiyama et al.Virology, 135(1), 87-96 (1984-05-01) Small espin: a third actin-bundling protein and potential forked protein ortholog in brush border microvilli.J R Bartles et al.The Journal of cell biology, 143(1), 107-119 (1998-10-08) Tracking transplanted bone marrow stem cells and their effects in the rat MCAO stroke model.Gregory V Goldmacher et al.PloS one, 8(3), e60049-e60049 (2013-04-05) Bromovinyl-deoxyuridine: A selective substrate for mitochondrial thymidine kinase in cell extracts.Elisa Franzolin et al.Biochemical and biophysical research communications, 344(1), 30-36 (2006-04-25) Enhanced cytotoxicity of antiviral drugs mediated by adenovirus directed transfer of the herpes simplex virus thymidine kinase gene in rat glioma cells.D S Shewach et al.Cancer gene therapy, 1(2), 107-112 (1994-06-01) Synthesis and incorporation of an alpha-hexofuranosyl thymidine into oligodeoxynucleotides via its two exocyclic OH-groups.Vyacheslav V Filichev et al.Bioorganic & medicinal chemistry letters, 14(3), 581-584 (2004-01-27) Sensing with superconducting point contacts.Argo Nurbawono et al.Sensors (Basel, Switzerland), 12(5), 6049-6074 (2012-07-11) Improved Visualization and Specific Binding for Metabotropic Glutamate Receptor Subtype 1 (mGluR1) Using [11C]ITMM with Ultra-High Specific Activity in Small-Animal PET.Tomoteru Yamasaki et al.PloS one, 10(6), e0130006-e0130006 (2015-06-16) A new acycloguanosine-specific supermutant of herpes simplex virus type 1 thymidine kinase suitable for PET imaging and suicide gene therapy for potential use in patients treated with pyrimidine-based cytotoxic drugs.Yury Likar et al.Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 49(5), 713-720 (2008-04-17) Clinical isolate of herpes simplex virus type 2 that induces a thymidine kinase with altered substrate specificity.M N Ellis et al.Antimicrobial agents and chemotherapy, 31(7), 1117-1125 (1987-07-01) Sensitivity of urethral flow-evoked voiding reflexes decline with age in the rat: insights into age-related underactive bladder.Arezoo Geramipour et al.American journal of physiology. Renal physiology, 318(6), F1430-F1440 (2020-05-05) Methyl oleate deoxygenation for production of diesel fuel aliphatic hydrocarbons over Pd/SBA-15 catalysts.Siew-Pei Lee et al.Chemistry Central journal, 7(1), 149-149 (2013-09-10) Retroviral transduction of cancer cell lines with the gene encoding Drosophila melanogaster multisubstrate deoxyribonucleoside kinase.X Zheng et al.The Journal of biological chemistry, 275(50), 39125-39129 (2000-09-20) Effects of rat anti-VEGF antibody in a rat model of corneal graft rejection by topical and subconjunctival routes.Nicolas Rocher et al.Molecular vision, 17, 104-112 (2011-01-20) A CD3-specific antibody reduces cytokine production and alters phosphoprotein profiles in intestinal tissues from patients with inflammatory bowel disease.Anna Vossenkämper et al.Gastroenterology, 147(1), 172-183 (2014-04-08) Incorporation of DPP6a and DPP6K variants in ternary Kv4 channel complex reconstitutes properties of A-type K current in rat cerebellar granule cells.Henry H Jerng et al.PloS one, 7(6), e38205-e38205 (2012-06-08) Propiolic Acid in Solid Nitrogen: NIR- and UV-Induced cis → trans Isomerization and Matrix-Site-Dependent trans → cis Tunneling.Susy Lopes et al.The journal of physical chemistry. A, 123(8), 1581-1593 (2019-01-31) Mechanical wounding induces a nitrosative stress by down-regulation of GSNO reductase and an increase in S-nitrosothiols in sunflower (Helianthus annuus) seedlings.Mounira Chaki et al.Journal of experimental botany, 62(6), 1803-1813 (2010-12-22) Insight into dynamic and steady-state active sites for nitrogen activation to ammonia by cobalt-based catalyst.Xiuyun Wang et al.Nature communications, 11(1), 653-653 (2020-02-02) Regenerable, innovative porous silicon-based polymer-derived ceramics for removal of methylene blue and rhodamine B from textile and environmental waters.Maria Concetta Bruzzoniti et al.Environmental science and pollution research international, 25(11), 10619-10629 (2018-02-01) Asymmetric Evolutionary Games.Alex McAvoy et al.PLoS computational biology, 11(8), e1004349-e1004349 (2015-08-27) Regulation of presynaptic anchoring of the scaffold protein Bassoon by phosphorylation-dependent interaction with 14-3-3 adaptor proteins.Markus S Schröder et al.PloS one, 8(3), e58814-e58814 (2013-03-22) Adipose-derived mesenchymal stem cells embedded in platelet-rich fibrin scaffolds promote angiogenesis, preserve heart function, and reduce left ventricular remodeling in rat acute myocardial infarction.Yung-Lung Chen et al.American journal of translational research, 7(5), 781-803 (2015-07-16) Cytostatic and antiherpesvirus type 1 and 2 activities of 1-beta-D-arabinofuranosylthymine (ara T) prodrugs.L B Allen et al.Chemotherapy, 33(4), 272-277 (1987-01-01) Immunosuppression strategies in elderly renal transplant recipients.Brian Camilleri et al.Transplantation reviews (Orlando, Fla.), 34(2), 100529-100529 (2020-01-18) DNA vaccines encoding DEC205-targeted antigens: immunity or tolerance?Thomas Niezold et al.Immunology, 145(4), 519-533 (2015-03-31) Wnt1 inhibits hydrogen peroxide-induced apoptosis in mouse cardiac stem cells.Jingjin Liu et al.PloS one, 8(3), e58883-e58883 (2013-03-28) Suppression of infectious virus spread to the liver by foscarnet following lethal infection of acyclovir-resistant herpes simplex virus type 2 in mice.Y Y Li et al.Antiviral research, 27(1-2), 111-121 (1995-05-01) Nucleoside analog cytotoxicity and bystander cell killing of cancer cells expressing Drosophila melanogaster deoxyribonucleoside kinase in the nucleus or cytosol.X Zheng et al.Biochemical and biophysical research communications, 289(1), 229-233 (2001-11-16) Preparation of NiMn2O4/C necklace-like microspheres as oxidase mimetic for colorimetric determination of ascorbic acid.Yu Ding et al.Talanta, 219, 121299-121299 (2020-09-06) Tracking cellular stress with labeled FMAU reflects changes in mitochondrial TK2.Tehrani OS, Douglas KA, et al. European Journal of Nuclear Medicine, 35, 1480-1488 (2008) Mesenchymal stem cells improve motor functions and decrease neurodegeneration in ataxic mice.Jonathan Jones et al.Molecular therapy : the journal of the American Society of Gene Therapy, 23(1), 130-138 (2014-07-30) Selective assays for thymidine kinase 1 and 2 and deoxycytidine kinase and their activities in extracts from human cells and tissues.E S Arnér et al.Biochemical and biophysical research communications, 188(2), 712-718 (1992-10-30) Resident alveolar macrophages are susceptible to and permissive of Coxiella burnetii infection.Matthew Calverley et al.PloS one, 7(12), e51941-e51941 (2013-01-04) Transcriptional activation is not responsible for increased levels of autonomously expressed simian virus 40 T-antigen in herpes simplex virus-infected cells.E D Blair et al.Virus genes, 2(3), 253-267 (1989-05-01) Arabinose furanosyl thymidine: uptake, phosphorylation and incorporation into DNA of mammalian cells.N Dahmen et al.In vivo (Athens, Greece), 4(1), 25-32 (1990-01-01) Synthesis and properties of alpha- and beta-oligodeoxynucleotides containing alpha- and beta-1-(2-O-methyl-D-arabino-furanosyl)thymine.C H Gotfredsen et al.Bioorganic & medicinal chemistry, 4(8), 1217-1225 (1996-08-01) Acute cytotoxicity of arabinofuranosyl nucleoside analogs is not dependent on mitochondrial DNA.Sophie Curbo et al.Experimental cell research, 315(15), 2539-2543 (2009-06-02) Curcumin attenuates radiation-induced inflammation and fibrosis in rat lungs.Yu Ji Cho et al.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, 17(4), 267-274 (2013-08-16) Ab initio vibrational calculations on ara-T molecule: application to analysis of IR and Raman spectra.B Hernández et al.Biopolymers, 62(4), 193-207 (2001-06-08) Substrate specificity of feline and canine herpesvirus thymidine kinase.N Solaroli et al.Antiviral research, 79(2), 128-132 (2008-05-06) iTRAQ-Based Quantitative Proteomic Analysis of Tear Fluid in a Rat Penetrating Keratoplasty Model With Acute Corneal Allograft Rejection.Feifei Huang et al.Investigative ophthalmology & visual science, 56(6), 4117-4124 (2015-06-27) Image guided drug release from pH-sensitive Ion channel-functionalized stealth liposomes into an in vivo glioblastoma model.Jesus Pacheco-Torres et al.Nanomedicine : nanotechnology, biology, and medicine, 11(6), 1345-1354 (2015-04-19) Lipid-mediated protein delivery of suicide nucleoside kinases.Xinyu Zheng et al.Cancer research, 63(20), 6909-6913 (2003-10-30) The new insight into the structure-activity relation of Pd/CeO2-ZrO2-Nd2O3 catalysts by Raman, in situ DRIFTS and XRD Rietveld analysis.X Yang et al.Physical chemistry chemical physics : PCCP, 18(4), 3103-3111 (2016-01-08) The nitridation of ZnO nanowires.Matthew Zervos et al.Nanoscale research letters, 7, 175-175 (2012-03-09) Cloning and characterization of the rat homologues of the Inhibitor of Apoptosis protein 1, 2, and 3 genes.Martin Holcik et al.BMC genomics, 3, 5-5 (2002-02-28) Channel catfish herpesvirus (CCV) encodes a functional thymidine kinase gene: elucidation of a point mutation that confers resistance to Ara-T.L A Hanson et al.Virology, 202(2), 659-664 (1994-08-01) 2'-O-Acyl/alkyl-substituted arabinosyl nucleosides as inhibitors of human mitochondrial thymidine kinase.J Balzarinia et al.Biochemical pharmacology, 61(6), 727-732 (2001-03-27) Halothane potentiates the alcohol-adduct induced TNF-alpha release in heart endothelial cells.Geoffrey M Thiele et al.BMC anesthesiology, 5(1), 3-3 (2005-04-14) Superior cytotoxicity with ganciclovir compared with acyclovir and 1-beta-D-arabinofuranosylthymine in herpes simplex virus-thymidine kinase-expressing cells: a novel paradigm for cell killing.L Z Rubsam et al.Cancer research, 58(17), 3873-3882 (1998-09-10) Impact of an Energy Drink on the Structure of Stomach and Pancreas of Albino Rat: Can Omega-3 Provide a Protection?Nasra Ayuob et al.PloS one, 11(2), e0149191-e0149191 (2016-02-20) In vitro sensitivity of macropodid herpesvirus 2 to selected anti-herpetic compounds.G Smith Journal of wildlife diseases, 32(1), 117-120 (1996-01-01) Radiolabeled nucleoside analogues for PET imaging of HSV1-tk gene expression.Mian M Alauddin et al.Current topics in medicinal chemistry, 10(16), 1617-1632 (2010-06-30) Preparation and hybridization properties of oligonucleotides containing 1-alpha-D-arabinofuranosylthymine.A D Adams et al.Nucleic acids research, 19(13), 3647-3651 (1991-07-21) Altered deoxyribonucleotide pools in T-lymphoblastoid cells expressing the multisubstrate nucleoside kinase of Drosophila melanogaster.Ada Bertoli et al.The FEBS journal, 272(15), 3918-3928 (2005-07-28) N1-substituted thymine derivatives as mitochondrial thymidine kinase (TK-2) inhibitors.Ana-Isabel Hernandez et al.Journal of medicinal chemistry, 49(26), 7766-7773 (2006-12-22) Synthesis and pKTamás Németh et al.Chirality, 29(9), 522-535 (2017-06-27) Probiotic fermented milk consumption modulates the allergic process induced by ovoalbumin in mice.Eva M M Velez et al.The British journal of nutrition, 114(4), 566-576 (2015-07-17) Differential spatial expression and subcellular localization of CtBP family members in rodent brain.Diana Hübler et al.PloS one, 7(6), e39710-e39710 (2012-06-30)

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