Boiling point	74 ºC (0.9 Torr)**
Flash point	83.5±18.0 ºC, 计算值*
Density	1.443±0.06 g/cm3 (20 º

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Source	SDS/MSDS Samples
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Synthetic Route

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Articles

Peer-Reviewed Papers

Survival and death strategies in glioma cells: autophagy, senescence and apoptosis triggered by a single type of temozolomide-induced DNA damage.Anna V Knizhnik et al.PloS one, 8(1), e55665-e55665 (2013-02-06) Activation of AMP-activated protein kinase by temozolomide contributes to apoptosis in glioblastoma cells via p53 activation and mTORC1 inhibition.Wen-bin Zhang et al.The Journal of biological chemistry, 285(52), 40461-40471 (2010-10-01) Simultaneous quantification of methylated purines in DNA by isotope dilution LC-MS/MS coupled with automated solid-phase extraction.Chiung-Wen Hu et al.Analytical and bioanalytical chemistry, 402(3), 1199-1208 (2011-11-19) Alkylation of transfer RNA by N-methyl-N-nitrosourea and N-ethyl-N-nitrosourea.A E Pegg Chemico-biological interactions, 6(6), 393-406 (1973-06-01) Exploring the roles of nucleobase desolvation and shape complementarity during the misreplication of O(6)-methylguanine.Delia Chavarria et al.Journal of molecular biology, 412(3), 325-339 (2011-08-09) Lesion-specific DNA-binding and repair activities of human O⁶-alkylguanine DNA alkyltransferase.Manana Melikishvili et al.Nucleic acids research, 40(18), 9060-9072 (2012-07-20) Chronic nicotine consumption does not influence 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis.Sharon E Murphy et al.Cancer prevention research (Philadelphia, Pa.), 4(11), 1752-1760 (2011-10-27) Atl1 regulates choice between global genome and transcription-coupled repair of O(6)-alkylguanines.Vitaly F Latypov et al.Molecular cell, 47(1), 50-60 (2012-06-05) [Induction of repair enzyme O6-methylguanine-DNA methyltransferase gene expression under the influence of cytokine EMAP II in human cells in vitro].V V Lylo et al.TSitologiia i genetika, 45(6), 53-60 (2012-02-15) Stabilization of MAPO1 by specific binding with folliculin and AMP-activated protein kinase in O⁶-methylguanine-induced apoptosis.Shiori Sano et al.Biochemical and biophysical research communications, 430(2), 810-815 (2012-12-04) Temozolomide: mechanisms of action, repair and resistance.Jihong Zhang et al.Current molecular pharmacology, 5(1), 102-114 (2011-11-30) Undetectable role of oxidative DNA damage in cell cycle, cytotoxic and clastogenic effects of Cr(VI) in human lung cells with restored ascorbate levels.Mindy Reynolds et al.Mutagenesis, 27(4), 437-443 (2012-01-14) Role of alkyltransferase-like (ATL) protein in repair of methylated DNA lesions in Thermus thermophilus.Takefumi Onodera et al.Mutagenesis, 26(2), 303-308 (2010-11-10) Malignant progression in O6-methylguanine-DNA methyltransferase-deficient esophageal cancer cells is associated with Ezrin protein.Yaoyao Su et al.DNA and cell biology, 31(5), 856-866 (2011-12-27) Mutagenicity associated with O6-methylguanine-DNA damage and mechanism of nucleotide flipping by AGT during repair.N R Jena et al.Physical biology, 8(4), 046007-046007 (2011-06-15) Inhibition of 1, 2-dimethylhydrazine-induced mucin-depleted foci and O⁶-methylguanine DNA adducts in the rat colorectum by boiled garlic powder.Takeshi Chihara et al.Asian Pacific journal of cancer prevention : APJCP, 11(5), 1301-1304 (2011-01-05) Repair and removal of azoxymethane-induced O6-methylguanine in rat colon by O6-methylguanine DNA methyltransferase and apoptosis.Laura S Nyskohus et al.Mutation research, 758(1-2), 80-86 (2013-10-22) Adaptive ligand binding by the purine riboswitch in the recognition of guanine and adenine analogs.Sunny D Gilbert et al.Structure (London, England : 1993), 17(6), 857-868 (2009-06-16) An approach based on ultra-high pressure liquid chromatography-tandem mass spectrometry to quantify O6-methyl and O6-carboxymethylguanine DNA adducts in intestinal cell lines.J Vanden Bussche et al.Journal of chromatography. A, 1257, 25-33 (2012-08-28) The identification of a novel gene, MAPO2, that is involved in the induction of apoptosis triggered by O⁶-methylguanine.Ryosuke Fujikane et al.PloS one, 7(9), e44817-e44817 (2012-10-03) Development and validation of a new, sensitive immunochemical assay for O⁶-methylguanine in DNA and its application in a population study.Panagiotis Georgiadis et al.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 20(1), 82-90 (2010-11-18) DNA damage-induced cell death: from specific DNA lesions to the DNA damage response and apoptosis.Wynand P Roos et al.Cancer letters, 332(2), 237-248 (2012-01-21) O6-Methylguanine DNA lesions induce an intra-S-phase arrest from which cells exit into apoptosis governed by early and late multi-pathway signaling network activation.Ericka M Noonan et al.Integrative biology : quantitative biosciences from nano to macro, 4(10), 1237-1255 (2012-08-16) Pol kappa partially rescues MMR-dependent cytotoxicity of O6-methylguanine.Eliana Lupari et al.DNA repair, 11(6), 579-586 (2012-04-11) Gene markers in brain tumors: what the epileptologist should know.Quinn Ostrom et al.Epilepsia, 54 Suppl 9, 25-29 (2013-12-18) Nijmegen breakage syndrome protein (NBN) causes resistance to methylating anticancer drugs such as temozolomide.Marcus Eich et al.Molecular pharmacology, 78(5), 943-951 (2010-08-24) O6-methylguanine induces altered proteins at the level of transcription in human cells.John A Burns et al.Nucleic acids research, 38(22), 8178-8187 (2010-08-13) Activity of irinotecan and temozolomide in the presence of O6-methylguanine-DNA methyltransferase inhibition in neuroblastoma pre-clinical models.W Cai et al.British journal of cancer, 103(9), 1369-1379 (2010-10-07) Structural basis for proficient incorporation of dTTP opposite O6-methylguanine by human DNA polymerase iota.Matthew G Pence et al.The Journal of biological chemistry, 285(52), 40666-40672 (2010-10-22)

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