Melting point	272 ºC
Specific optical rotation	-27.5 º (c=5, H2O 24 º
Water Solubility	soluble

Symbol(GHS)	Xi
Hazard Codes	R36/37/38
SDS/MSDS	S24/25

Source	SDS/MSDS Samples
Alfa-Aesar	View & Download
Sigma-Aldrich	View & Download
TCI	View & Download

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Articles

Peer-Reviewed Papers

Spermidine-mediated poly(lactic-Jing Tang et al.International journal of nanomedicine, 12, 6687-6704 (2017-09-22) EGFR-targeted immunoliposomes as a selective delivery system of simvastatin, with potential use in treatment of triple-negative breast cancers.Lucyna Matusewicz et al.International journal of pharmaceutics, 569, 118605-118605 (2019-08-11) Spray dried hyaluronic acid microparticles for adhesion controlled aggregation and potential stimulation of stem cells.Fabio S Palumbo et al.International journal of pharmaceutics, 519(1-2), 332-342 (2017-01-26) Methyl 4-mercaptobutyrimidate as a cleavable cross-linking reagent and its application to the Escherichia coli 30S ribosome.R R Traut et al.Biochemistry, 12(17), 3266-3273 (1973-08-14) Formulation development and in vitro evaluation of transferrin-conjugated liposomes as a carrier of ganciclovir targeting the retina.Rathapon Asasutjarit et al.International journal of pharmaceutics, 577, 119084-119084 (2020-01-29) Nasal delivery of donepezil HCl-loaded hydrogels for the treatment of Alzheimer's disease.Sitah Al Harthi et al.Scientific reports, 9(1), 9563-9563 (2019-07-04) Targeting Glioblastoma Cells Expressing CD44 with Liposomes Encapsulating Doxorubicin and Displaying Chlorotoxin-IgG Fc Fusion Protein.Hafizah Mahmud et al.International journal of molecular sciences, 19(3) (2018-03-03) Tuned Density of Anti-Tissue Factor Antibody Fragment onto siRNA-Loaded Polyion Complex Micelles for Optimizing Targetability into Pancreatic Cancer Cells.Hyun Su Min et al.Biomacromolecules, 19(6), 2320-2329 (2018-05-17) Phospholipase-Cγ1 Signaling Protein Down-Regulation by Oligoclonal-VHHs based Immuno-Liposome: A Potent Metastasis Deterrent in HER2 Positive Breast Cancer Cells.Ommolbanin Asadpour et al.Cell journal, 22(1), 30-39 (2019-10-14) Clickable decellularized extracellular matrix as a new tool for building hybrid-hydrogels to model chronic fibrotic diseases in vitro.Cassandra L Petrou et al.Journal of materials chemistry. B, 8(31), 6814-6826 (2020-04-29) A Polymeric Nanogel-Based Treatment Regimen for Enhanced Efficacy and Sequential Administration of Synergistic Drug Combination in Pancreatic Cancer.Kruti S Soni et al.The Journal of pharmacology and experimental therapeutics, 370(3), 894-901 (2019-01-27) Bioinspired Drug Delivery Carrier for Enhanced Tumor-Targeting in Melanoma Mice Model.Xu Wang et al.Journal of biomedical nanotechnology, 15(7), 1482-1491 (2019-06-15) Hyperbaric oxygen-generating hydrogels.Sujin Park et al.Biomaterials, 182, 234-244 (2018-08-25) Targeted co-delivery of polypyrrole and rapamycin by trastuzumab-conjugated liposomes for combined chemo-photothermal therapy.Hanh Thuy Nguyen et al.International journal of pharmaceutics, 527(1-2), 61-71 (2017-05-22) Defined pH-sensitive nanogels as gene delivery platform for siRNA mediated in vitro gene silencing.Mathias Dimde et al.Biomaterials science, 5(11), 2328-2336 (2017-10-17) Functionalization of phosphocalcic bioceramics for bone repair applications.Chantal Damia et al.Materials science & engineering. C, Materials for biological applications, 95, 343-354 (2018-12-24) Modification of nitric oxide donors onto a monoclonal antibody boosts accumulation in solid tumors.Takuma Yoshikawa et al.International journal of pharmaceutics, 583, 119352-119352 (2020-04-24) Effect of high intensity focused ultrasound (HIFU) in conjunction with a nanomedicines-microbubble complex for enhanced drug delivery.Hyounkoo Han et al.Journal of controlled release : official journal of the Controlled Release Society, 266, 75-86 (2017-09-21) Liposomes Loaded with the Proteasome Inhibitor Z-Leucinyl-Leucinyl-Norleucinal are Effective in Inducing Apoptosis in Colorectal Cancer Cell Lines.Katia Cortese et al.Membranes, 10(5) (2020-05-08) Use of maleimide-thiol coupling chemistry for efficient syntheses of oligonucleotide-enzyme conjugate hybridization probes.S S Ghosh et al.Bioconjugate chemistry, 1(1), 71-76 (1990-01-01) Liposome-polyethylenimine complexes (DPPC-PEI lipopolyplexes) for therapeutic siRNA delivery in vivo.Alexander Ewe et al.Nanomedicine : nanotechnology, biology, and medicine, 13(1), 209-218 (2016-08-25) Gelatin-siloxane nanoparticles to deliver nitric oxide for vascular cell regulation: synthesis, cytocompatibility, and cellular responses.Qin-Yuan Zhang et al.Journal of biomedical materials research. Part A, 103(3), 929-938 (2014-05-24) Protein structural changes in keratin fibers induced by chemical modification using 2-iminothiolane hydrochloride: a Raman spectroscopic investigation.Akio Kuzuhara Biopolymers, 79(4), 173-184 (2005-09-08) Topical drug delivery to retinal pigment epithelium with microfluidizer produced small liposomes.T Lajunen et al.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 62, 23-32 (2014-05-09) l-Histidine Crystals as Efficient Vehicles to Deliver Hydrophobic Molecules.Raheleh Ravanfar et al.ACS applied materials & interfaces, 11(42), 39376-39384 (2019-10-04) Enhanced doxorubicin delivery to hepatocellular carcinoma cells via CD147 antibody-conjugated immunoliposomes.Jian Wang et al.Nanomedicine : nanotechnology, biology, and medicine, 14(6), 1949-1961 (2017-10-19) Octreotide-conjugated PAMAM for targeted delivery to somatostatin receptors over-expressed tumor cells.Jianqing Peng et al.Journal of drug targeting, 22(5), 428-438 (2014-01-21) Formation of N-substituted 2-iminothiolanes when amino groups in proteins and peptides are modified by 2-iminothiolane.R Singh et al.Analytical biochemistry, 236(1), 114-125 (1996-04-05) Multifunctional micelles for cancer cell targeting, distribution imaging, and anticancer drug delivery.Huang CK, et al. Advances in Functional Materials, 17(14), 2291-2297 (2007) Decreased nonspecific adhesivity, receptor-targeted therapeutic nanoparticles for primary and metastatic breast cancer.Jimena G Dancy et al.Science advances, 6(3), eaax3931-eaax3931 (2020-01-31) In situ fabrication of cleavable peptide arrays on polydimethylsiloxane and applications for kinase activity assays.Huang-Han Chen et al.Analytica chimica acta, 865, 53-59 (2015-03-04) Intranasal Delivery of Targeted Nanoparticles Loaded With miR-132 to Brain for the Treatment of Neurodegenerative Diseases.Yu Su et al.Frontiers in pharmacology, 11, 1165-1165 (2020-08-28) Enhanced pulmonary systemic delivery of protein drugs via zwitterionic polymer conjugation.Caroline Tsao et al.Journal of controlled release : official journal of the Controlled Release Society, 322, 170-176 (2020-03-23) Step-by-step build-up of covalent poly(ethylene oxide) nanogel films.S Zahouani et al.Nanoscale, 9(46), 18379-18391 (2017-11-18) Simplified method for conjugating macrocyclic bifunctional chelating agents to antibodies via 2-iminothiolane.M J McCall et al.Bioconjugate chemistry, 1(3), 222-226 (1990-05-01) Composite liposome-PEI/nucleic acid lipopolyplexes for safe and efficient gene delivery and gene knockdown.Shashank Reddy Pinnapireddy et al.Colloids and surfaces. B, Biointerfaces, 158, 93-101 (2017-07-07) Complexation of novel thiomers and insulin to protect against in vitro enzymatic degradation - towards oral insulin delivery.C O Ibie et al.Drug development and industrial pharmacy, 45(1), 67-75 (2018-09-27) Decreased non-specific adhesivity, receptor targeted (DART) nanoparticles exhibit improved dispersion, cellular uptake, and tumor retention in invasive gliomas.Aniket S Wadajkar et al.Journal of controlled release : official journal of the Controlled Release Society, 267, 144-153 (2017-09-10) Development and evaluation of a CEACAM6-targeting theranostic nanomedicine for photoacoustic-based diagnosis and chemotherapy of metastatic cancer.Hohyeon Lee et al.Theranostics, 8(15), 4247-4261 (2018-08-22) Transferrin Modified Dioscin Loaded PEGylated Liposomes: Characterization and In Vitro Antitumor Effect.Yuanyuan Wang et al.Journal of nanoscience and nanotechnology, 20(3), 1321-1331 (2019-09-08) Overcoming anticancer resistance by photodynamic therapy-related efflux pump deactivation and ultrasound-mediated improved drug delivery efficiency.Doyeon Kim et al.Nano convergence, 7(1), 30-30 (2020-09-09) S-nitrosothiol-terminated poly(vinyl alcohol): Nitric oxide release and skin blood flow response.Leonardo P Giglio et al.Nitric oxide : biology and chemistry, 98, 41-49 (2020-03-10) Transferrin gated mesoporous silica nanoparticles for redox-responsive and targeted drug delivery.Xiaolu Chen et al.Colloids and surfaces. B, Biointerfaces, 152, 77-84 (2017-01-15) The effect of multistage nanovector targeting of VEGFR2 positive tumor endothelia on cell adhesion and local payload accumulation.Jonathan O Martinez et al.Biomaterials, 35(37), 9824-9832 (2014-09-02) Ultrasmall AGuIX theranostic nanoparticles for vascular-targeted interstitial photodynamic therapy of glioblastoma.Eloïse Thomas et al.International journal of nanomedicine, 12, 7075-7088 (2017-10-14) Biofunctional Nanofibrous Substrate for Local TNF-Capturing as a Strategy to Control Inflammation in Arthritic Joints.Elisa Bacelo et al.Nanomaterials (Basel, Switzerland), 9(4) (2019-04-11) Preparation of bioconjugates of CdTe nanocrystals for cancer marker detection.Hu F, et al. Nanotechnology, 17(12), 2972-2972 (2006)

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