Boiling point	98 ºC (50 mmHg)
Flash point	65 ºC
Density	0.89
Refractive index	1.4445-1.4465

Symbol(GHS)	Xn
Hazard Codes	R22;R36/37/38
SDS/MSDS	S26;S37/39

Source	SDS/MSDS Samples
TCI	View & Download
Georganics	View & Download

Synthetic Route

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Name	CAS

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Articles

Peer-Reviewed Papers

Synthetic chalcones, flavanones, and flavones as antitumoral agents: biological evaluation and structure-activity relationships.Mauricio Cabrera et al.Bioorganic & medicinal chemistry, 15(10), 3356-3367 (2007-03-27) Wattenberg L.W., et al. Cancer Letters, 15, 165-165 (1994) A review of anti-infective and anti-inflammatory chalcones.Zdzisława Nowakowska European journal of medicinal chemistry, 42(2), 125-137 (2006-11-23) Combretastatin-like chalcones as inhibitors of microtubule polymerization. Part 1: synthesis and biological evaluation of antivascular activity.Sylvie Ducki et al.Bioorganic & medicinal chemistry, 17(22), 7698-7710 (2009-10-20) Synthesis of new 2-(5-substituted-3-phenyl-2-pyrazolinyl)-1,3-thiazolino[5,4-b]quinoxaline derivatives and evaluation of their antiamoebic activity.Asha Budakoti et al.European journal of medicinal chemistry, 44(3), 1317-1325 (2008-04-02) Ferrocenyl chalcones versus organic chalcones: a comparative study of their nematocidal activity.Saeed Attar et al.Bioorganic & medicinal chemistry, 19(6), 2055-2073 (2011-02-26) Insect Antifeedant Potential of Xanthohumol, Isoxanthohumol, and Their Derivatives.Monika Stompor et al.Journal of agricultural and food chemistry, 63(30), 6749-6756 (2015-07-16) Antimycobacterial and anti-inflammatory activities of substituted chalcones focusing on an anti-tuberculosis dual treatment approach.Thatiana Lopes Biá Ventura et al.Molecules (Basel, Switzerland), 20(5), 8072-8093 (2015-05-08) Massive screening yields novel and selective Trypanosoma cruzi triosephosphate isomerase dimer-interface-irreversible inhibitors with anti-trypanosomal activity.Guzmán Alvarez et al.European journal of medicinal chemistry, 45(12), 5767-5772 (2010-10-05) Examination of growth inhibitory properties of synthetic chalcones for which antibacterial activity was predicted.Daniela Batovska et al.European journal of medicinal chemistry, 44(5), 2211-2218 (2008-07-01) Fluorinated 2'-hydroxychalcones as garcinol analogs with enhanced antioxidant and anticancer activities.Subhash Padhye et al.Bioorganic & medicinal chemistry letters, 20(19), 5818-5821 (2010-08-24) Chalcone-based inhibitors against hypoxia-inducible factor 1--structure activity relationship studies.Balasubramanian Srinivasan et al.Bioorganic & medicinal chemistry letters, 21(1), 555-557 (2010-11-30) Generation of ligand-based pharmacophore model and virtual screening for identification of novel tubulin inhibitors with potent anticancer activity.Yi-Kun Chiang et al.Journal of medicinal chemistry, 52(14), 4221-4233 (2009-06-11) Study on the substituents' effects of a series of synthetic chalcones against the yeast Candida albicans.D Batovska et al.European journal of medicinal chemistry, 42(1), 87-92 (2006-09-30) Trans-chalcone: a novel small molecule inhibitor of mammalian alpha-amylase.Mahmoud Najafian et al.Molecular biology reports, 38(3), 1617-1620 (2010-09-22) A chemical screening approach reveals that indole fluorescence is quenched by pre-fibrillar but not fibrillar amyloid-beta.Ashley A Reinke et al.Bioorganic & medicinal chemistry letters, 19(17), 4952-4957 (2009-07-31) Novel chalcone derivatives as potent Nrf2 activators in mice and human lung epithelial cells.Vineet Kumar et al.Journal of medicinal chemistry, 54(12), 4147-4159 (2011-05-05) Synthesis, antimycobacterial activity evaluation, and QSAR studies of chalcone derivatives.P M Sivakumar et al.Bioorganic & medicinal chemistry letters, 17(6), 1695-1700 (2007-02-06) Trans-chalcone and quercetin down-regulate fatty acid synthase gene expression and reduce ergosterol content in the human pathogenic dermatophyte Trichophyton rubrum.Tamires Aparecida Bitencourt et al.BMC complementary and alternative medicine, 13, 229-229 (2013-09-21) Antifungal activity of chalcones: a mechanistic study using various yeast strains.K L Lahtchev et al.European journal of medicinal chemistry, 43(10), 2220-2228 (2008-02-19) Structure-activity relationship studies of chalcone leading to 3-hydroxy-4,3',4',5'-tetramethoxychalcone and its analogues as potent nuclear factor kappaB inhibitors and their anticancer activities.Balasubramanian Srinivasan et al.Journal of medicinal chemistry, 52(22), 7228-7235 (2009-11-04) Asymmetric induction with β-cyclodextrin: cis-trans photoisomerization of diphenyl-cyclopropane and its derivatives.Koodanjeri S, et al. Proceedings of the Indian Academy of Sciences - Section A, 68(5), 453-463 (2002) Plasma membrane depolarization precedes photosynthesis damage and long-term leaf bleaching in (E)-chalcone-treated Arabidopsis shoots.C Díaz-Tielas et al.Journal of plant physiology, 218, 56-65 (2017-08-05) Chalcones: a valid scaffold for monoamine oxidases inhibitors.Franco Chimenti et al.Journal of medicinal chemistry, 52(9), 2818-2824 (2009-04-22) Synthesis of a series of novel dihydroartemisinin derivatives containing a substituted chalcone with greater cytotoxic effects in leukemia cells.Xuelin Yang et al.Bioorganic & medicinal chemistry letters, 19(15), 4385-4388 (2009-06-09) Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals.Markus A Lill et al.Journal of medicinal chemistry, 48(18), 5666-5674 (2005-09-02) Sulfonate chalcone as new class voltage-dependent K+ channel blocker.Oleg V Yarishkin et al.Bioorganic & medicinal chemistry letters, 18(1), 137-140 (2007-11-23) The natural compound trans-chalcone induces programmed cell death in Arabidopsis thaliana roots.Carla Díaz-Tielas et al.Plant, cell & environment, 35(8), 1500-1517 (2012-03-21) 2-Substituted 4-, 5-, and 6-[(1E)-3-oxo-3-phenylprop-1-en-1-yl]pyridazin-3(2H)-ones and 2-substituted 4,5-bis[(1E)-3-oxo-3-phenylprop-1-en-1-yl]pyridazin-3(2H)-ones as potent platelet aggregation inhibitors: design, synthesis, and SAR studies.Caroline Meyers et al.Bioorganic & medicinal chemistry letters, 18(2), 793-797 (2007-12-07) Surface intermediate species of the 4-isobutylacetophenone adsorption-reaction over fosfotungstic Wells-Dawson heteropoly acid.Matkovic SR, et al. Latin American Applied Research, 39(2), 173-178 (2009)

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