Melting point	175 ºC (dec.)

Symbol(GHS)	Xi
Hazard Codes	R36/37/38
SDS/MSDS	S26;S36

Source	SDS/MSDS Samples
Sigma-Aldrich	View & Download
TCI	View & Download
Apollo	View & Download

Synthetic Route

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Name	CAS

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Articles

Peer-Reviewed Papers

The mechanism of 1,2,3,4-tetrahydroisoquinolines neuroprotection: the importance of free radicals scavenging properties and inhibition of glutamate-induced excitotoxicity.Lucyna Antkiewicz-Michaluk et al.Journal of neurochemistry, 97(3), 846-856 (2006-03-07) Different action on dopamine catabolic pathways of two endogenous 1,2,3,4-tetrahydroisoquinolines with similar antidopaminergic properties.L Antkiewicz-Michaluk et al.Journal of neurochemistry, 78(1), 100-108 (2001-07-04) 1-methyl-1,2,3,4-tetrahydroisoquinoline protects against rotenone-induced mortality and biochemical changes in rat brain.Lucyna Antkiewicz-Michaluk et al.European journal of pharmacology, 466(3), 263-269 (2003-04-16) 1-Methyl-1,2,3,4-tetrahydroisoquinoline enhances the anticonvulsant action of carbamazepine and valproate in the mouse maximal electroshock seizure model.Jarogniew J Luszczki et al.Neuropharmacology, 50(2), 133-142 (2005-09-13) Evaluation of neurotoxicity of TIQ and MPTP and of parkinsonism-preventing effect of 1-MeTIQ by in vivo measurement of pre-synaptic dopamine transporters and post-synaptic dopamine D(2) receptors in the mouse striatum.K Ishiwata et al.Journal of neurochemistry, 79(4), 868-876 (2001-11-28) A synthesis of heteroaromatic analogues of 1-methyl-1,2,3,4-tetrahydroisoquinoline using the Pummerer-type cyclization reaction: observation of tandem cyclization reaction.Yoshie Horiguchi et al.Chemical & pharmaceutical bulletin, 52(2), 214-220 (2004-02-06) Protective effect of 1-methyl-1,2,3,4-tetrahydroisoquinoline against dopaminergic neurodegeneration in the extrapyramidal structures produced by intracerebral injection of rotenone.Lucyna Antkiewicz-Michaluk et al.The international journal of neuropsychopharmacology, 7(2), 155-163 (2004-01-27) The effect of an endogenous compound 1-methyl-1,2,3,4,-tetrahydroisoquinoline on morphine-induced analgesia, dependence and neurochemical changes in dopamine metabolism in rat brain structures.A Wasik et al.Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 58(2), 235-252 (2007-07-12) Directed evolution of an amine oxidase for the preparative deracemisation of cyclic secondary amines.Reuben Carr et al.Chembiochem : a European journal of chemical biology, 6(4), 637-639 (2005-02-19) 1-Methyl-1,2,3,4-tetrahydroisoquinoline antagonizes a rise in brain dopamine metabolism, glutamate release in frontal cortex and locomotor hyperactivity produced by MK-801 but not the disruptions of prepulse inhibition, and impairment of working memory in rat.Małgorzata Pietraszek et al.Neurotoxicity research, 16(4), 390-407 (2009-08-04) Comparative behavioral and neurochemical studies of R- and S-1-methyl-1,2,3,4-tetrahydroisoquinoline stereoisomers in the rat.Agnieszka Wąsik et al.Pharmacological reports : PR, 64(4), 857-869 (2012-10-23) 1-Methyl-1,2,3,4-tetrahydroisoquinoline and established uncompetitive NMDA receptor antagonists induce tolerance to excitotoxicity.Magdalena Kuszczyk et al.Pharmacological reports : PR, 62(6), 1041-1050 (2011-01-29) Interactions of 1-methyl-1,2,3,4-tetrahydroisoquinoline with lamotrigine, oxcarbazepine, pregabalin, and topiramate in the mouse maximal electroshock-induced seizure model: a type I isobolographic analysis.Jarogniew J Luszczki et al.Epilepsy research, 89(2-3), 207-219 (2010-02-02) Stereoselective effect of (R)- and (S)-1-methyl-1,2,3,4-tetrahydroisoquinolines on a mouse model of Parkinson's disease.K Abe et al.Brain research bulletin, 56(1), 55-60 (2001-10-18) Neuroprotective effect of 1-methyl-1,2,3,4-tetrahydroisoquinoline on cultured rat mesencephalic neurons in the presence or absence of various neurotoxins.Yaichiro Kotake et al.Brain research, 1033(2), 143-150 (2005-02-08) Decrease of 1-methyl-1,2,3,4-tetrahydroisoquinoline synthesizing enzyme activity in the brain areas of aged rat.Elhadi Absi et al.Brain research, 955(1-2), 161-163 (2002-11-07) Determination method of 1-methyl-1,2,3, 4-tetrahydroisoquinoline, an endogenous parkinsonism-preventing substance, by radioimmunoassay.Katsuhiro Okuda et al.Life sciences, 70(24), 2871-2883 (2002-09-25) The interaction of tetrahydroisoquinoline derivatives with antinociceptive action of morphine and oxotremorine in mice.J Vetulani et al.Journal of neural transmission (Vienna, Austria : 1996), 110(11), 1205-1213 (2003-11-25) Important role of 3-methoxytyramine in the inhibition of cocaine sensitization by 1-methyl-1,2,3,4-tetrahydroisoquinoline: an in vivo microdialysis study.Agnieszka Wąsik et al.Pharmacological reports : PR, 62(6), 983-997 (2011-01-29) Effects of 1-methyl-1,2,3,4-tetrahydroisoquinoline on the behavioral effects of cocaine in rats.M Filip et al.Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 58(4), 625-639 (2008-01-16) An endogenous neuroprotectant substance, 1-methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ), prevents the behavioral and neurochemical effects of cocaine reinstatement in drug-dependent rats.L Antkiewicz-Michaluk et al.Journal of neural transmission (Vienna, Austria : 1996), 114(3), 307-317 (2006-08-10) Isobolographic analysis of interactions between 1-methyl-1,2,3,4-tetrahydroisoquinoline and four conventional antiepileptic drugs in the mouse maximal electroshock-induced seizure model.Jarogniew J Luszczki et al.European journal of pharmacology, 602(2-3), 298-305 (2008-12-10)

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