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7-Chloro-3H-1,2,3-triazolo[4,5-d]pyrimidin-5-amine | CAS:88780-84-1
7-Chloro-3H-1,2,3-triazolo[4,5-d]pyrimidin-5-amine
  • Name:7-Chloro-3H-1,2,3-triazolo[4,5-d]pyrimidin-5-amine
  • CAS:88780-84-1
  • Synonyms:5-Amino-7-chloro-v-triazolo[4,5-d]pyrimidine
  • Molecular Formula:C4H3ClN6
  • Molecular Weight:170.56
  • EINESC:

Description

Properties

Boiling point 261.1±50.0 ºC (760 Tor
Flash point 111.7±30.1 ºC, 计算值*
Density 2.45±0.1 g/cm3 (20 ºC

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Articles
Peer-Reviewed Papers
Pro-inflammatory phenotype of COPD fibroblasts not compatible with repair in COPD lung.Zhang J., et al. Journal of Cellular and Molecular Medicine (2011) Phytoestrogen, tanshinone IIA diminishes collagen deposition and stimulates new elastogenesis in cultures of human cardiac fibroblasts.Shuai Mao et al.Experimental cell research, 323(1), 189-197 (2014-02-15) Enhanced caspase activity contributes to aortic wall remodeling and early aneurysm development in a murine model of Marfan syndrome.Fabian C Emrich et al.Arteriosclerosis, thrombosis, and vascular biology, 35(1), 146-154 (2014-11-02) Elastin staining patterns in primary cicatricial alopecia.Maxwell A Fung et al.Journal of the American Academy of Dermatology, 69(5), 776-782 (2013-09-17) Elastin sequences trigger transient proinflammatory responses by human dermal fibroblasts.Jessica F Almine et al.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 27(9), 3455-3465 (2013-05-15) Gender differences in biomechanical properties, thrombus age, mass fraction and clinical factors of abdominal aortic aneurysms.J Tong et al.European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 45(4), 364-372 (2013-02-12) Elastin-based molecular MRI of liver fibrosis.Josef Ehling et al.Hepatology (Baltimore, Md.), 58(4), 1517-1518 (2013-02-21) Elastin calcification and its prevention with aluminum chloride pretreatment.N Vyavahare et al.The American journal of pathology, 155(3), 973-982 (1999-09-17) [Investigation of fluorescent components of drug "heparin" and its complexing with phenylalanine, tyrosine and tryptophan].S S Astakhov et al.Bioorganicheskaia khimiia, 39(1), 55-60 (2013-07-13) In compressed lung tissue microscopic sections of adenocarcinoma in situ may mimic papillary adenocarcinoma.Erik Thunnissen et al.Archives of pathology & laboratory medicine, 137(12), 1792-1797 (2013-11-29) In compressed lung tissue microscopic sections of adenocarcinoma in situ may mimic papillary adenocarcinoma.Erik Thunnissen et al.Archives of pathology & laboratory medicine, 137(12), 1792-1797 (2013-11-29) Regeneration of human dermis by a multi-headed peptide.Joan Attia-Vigneau et al.The Journal of investigative dermatology, 134(1), 58-67 (2013-07-03) Two sides of MGP null arterial disease: chondrogenic lesions dependent on transglutaminase 2 and elastin fragmentation associated with induction of adipsin.Kelly E Beazley et al.The Journal of biological chemistry, 288(43), 31400-31408 (2013-09-17) Acellular vascular grafts generated from collagen and elastin analogs.Vivek A Kumar et al.Acta biomaterialia, 9(9), 8067-8074 (2013-06-08) Ectopic calcification in β-thalassemia patients is associated with increased oxidative stress and lower MGP carboxylation.Federica Boraldi et al.Biochimica et biophysica acta, 1832(12), 2077-2084 (2013-08-01) Increased aortic stiffness and attenuated lysyl oxidase activity in obesity.Ju-Yi Chen et al.Arteriosclerosis, thrombosis, and vascular biology, 33(4), 839-846 (2013-02-16) Assessing the functional mechanical properties of bioengineered organs with emphasis on the lung.Béla Suki Journal of cellular physiology, 229(9), 1134-1140 (2014-03-08) Elastin fibers display a versatile microfibril network in articular cartilage depending on the mechanical microenvironments.Bo He et al.Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 31(9), 1345-1353 (2013-05-08) Architecture of the subendothelial elastic fibers of small blood vessels and variations in vascular type and size.Akira Shinaoka et al.Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada, 19(2), 406-414 (2013-03-05) A novel approach to reconstruct a large full thickness abdominal wall defect: successful treatment with MatriDerm® and Split.E Tong et al.Journal of wound care, 23(7), 355-357 (2014-07-22) In vitro cross-linking of elastin peptides and molecular characterization of the resultant biomaterials.Andrea Heinz et al.Biochimica et biophysica acta, 1830(4), 2994-3004 (2013-02-05) Chronic intrauterine pulmonary hypertension increases main pulmonary artery stiffness and adventitial remodeling in fetal sheep.R Blair Dodson et al.American journal of physiology. Lung cellular and molecular physiology, 307(11), L822-L828 (2014-10-19) A new method to estimate abundances of multiple components using multi-spectral fluorescence lifetime imaging microscopy.O Gutierrez-Navarro et al.Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 2012, 1081-1084 (2013-02-01) Hydroxyapatite and calcified elastin induce osteoblast-like differentiation in rat aortic smooth muscle cells.Yang Lei et al.Experimental cell research, 323(1), 198-208 (2014-01-23) Overhauser-enhanced MRI of elastase activity from in vitro human neutrophil degranulation.Elodie Parzy et al.PloS one, 8(2), e57946-e57946 (2013-03-08) Smooth muscle cells from abdominal aortic aneurysms are unique and can independently and synergistically degrade insoluble elastin.Nathan Airhart et al.Journal of vascular surgery, 60(4), 1033-1041 (2013-10-02) Elastin binding protein and FKBP65 modulate in vitro self-assembly of human tropoelastin.Ming Miao et al.Biochemistry, 52(44), 7731-7741 (2013-10-11) Conditional overexpression of receptors for advanced glycation end-products in the adult murine lung causes airspace enlargement and induces inflammation.Megan P Stogsdill et al.American journal of respiratory cell and molecular biology, 49(1), 128-134 (2013-03-26) Glucose suppresses biological ferroelectricity in aortic elastin.Yuanming Liu et al.Physical review letters, 110(16), 168101-168101 (2013-05-18) Changes in elastin, elastin binding protein and versican in alveoli in chronic obstructive pulmonary disease.Mervyn J Merrilees et al.Respiratory research, 9, 41-41 (2008-05-20) A comparative study of matrix remodeling in chronic models for COPD; mechanistic insights into the role of TNF-α.Irene M J Eurlings et al.American journal of physiology. Lung cellular and molecular physiology, 307(7), L557-L565 (2014-08-12) Potassium channel openers increase aortic elastic fiber formation and reverse the genetically determined elastin deficit in the BN rat.Séverin Slove et al.Hypertension (Dallas, Tex. : 1979), 62(4), 794-801 (2013-08-07) Effect of elastin digestion on the quasi-static tensile response of medial collateral ligament.Heath B Henninger et al.Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 31(8), 1226-1233 (2013-04-05) Lysyl oxidases play a causal role in vascular remodeling in clinical and experimental pulmonary arterial hypertension.Alexander H Nave et al.Arteriosclerosis, thrombosis, and vascular biology, 34(7), 1446-1458 (2014-05-17) Vascular remodeling and plaque vulnerability in a rabbit model of atherosclerosis: comparison of delayed-enhancement MR imaging with an elastin-specific contrast agent and unenhanced black-blood MR imaging.Alkystis Phinikaridou et al.Radiology, 271(2), 390-399 (2014-01-31) Peritoneal elastic lamina invasion: limitations in its use as a prognostic marker in stage II colorectal cancer.Andrea Grin et al.Human pathology, 44(12), 2696-2705 (2013-10-01) Regulation of wound healing by granulocyte-macrophage colony-stimulating factor after vocal fold injury.Jae-Yol Lim et al.PloS one, 8(1), e54256-e54256 (2013-02-02) Twenty patients including 7 probands with autosomal dominant cutis laxa confirm clinical and molecular homogeneity.Smail Hadj-Rabia et al.Orphanet journal of rare diseases, 8, 36-36 (2013-02-28) Valve disease in chronic venous disorders: a quantitative ultrastructural analysis by transmission electron microscopy and stereology.Wolfgang G Mouton et al.Swiss medical weekly, 143, w13755-w13755 (2013-02-28) [Investigation of fluorescent components of drug "heparin" and its complexing with phenylalanine, tyrosine and tryptophan].S S Astakhov et al.Bioorganicheskaia khimiia, 39(1), 55-60 (2013-07-13) The effect of polymer degradation time on functional outcomes of temporary elastic patch support in ischemic cardiomyopathy.Ryotaro Hashizume et al.Biomaterials, 34(30), 7353-7363 (2013-07-06) Function of latent TGFβ binding protein 4 and fibulin 5 in elastogenesis and lung development.Branka Dabovic et al.Journal of cellular physiology, 230(1), 226-236 (2014-06-26) Protocol for the preparation of stimuli-responsive gold nanoparticles capped with elastin-based pentapeptides.Vincent Lemieux et al.Methods in molecular biology (Clifton, N.J.), 991, 353-362 (2013-04-03) Elastin-derived peptides are new regulators of insulin resistance development in mice.Sébastien Blaise et al.Diabetes, 62(11), 3807-3816 (2013-08-08) Ferroelectric switching of elastin.Yuanming Liu et al.Proceedings of the National Academy of Sciences of the United States of America, 111(27), E2780-E2786 (2014-06-25) Perspectives on stem cell-based elastic matrix regenerative therapies for abdominal aortic aneurysms.Chris A Bashur et al.Stem cells translational medicine, 2(6), 401-408 (2013-05-17) [The role of electrothermoadhesion in creation of artificial vocal cord, and the voice quality improvement following chordectomy for laryngeal cancer].R A Abyzov et al.Klinichna khirurhiia, (2)(2), 77-77 (2013-05-28) Interaction between leukocyte elastase and elastin: quantitative and catalytic analyses.H M Morrison et al.Biochimica et biophysica acta, 1430(2), 179-190 (1999-03-20) Mineralocorticoid receptor agonists induce mouse aortic aneurysm formation and rupture in the presence of high salt.Shu Liu et al.Arteriosclerosis, thrombosis, and vascular biology, 33(7), 1568-1579 (2013-05-11) The receptor for advanced glycation end-products supports lung tissue biomechanics.Samiya Al-Robaiy et al.American journal of physiology. Lung cellular and molecular physiology, 305(7), L491-L500 (2013-09-03) Skin extracellular matrix stimulation following injection of a hyaluronic acid-based dermal filler in a rat model.Sumit Paliwal et al.Plastic and reconstructive surgery, 134(6), 1224-1233 (2014-11-22) Augmented vascular smooth muscle cell stiffness and adhesion when hypertension is superimposed on aging.Nancy L Sehgel et al.Hypertension (Dallas, Tex. : 1979), 65(2), 370-377 (2014-12-03) Tissue engineered skin substitutes created by laser-assisted bioprinting form skin-like structures in the dorsal skin fold chamber in mice.Stefanie Michael et al.PloS one, 8(3), e57741-e57741 (2013-03-08) Elastogenesis at the onset of human cardiac valve development.Miriam Votteler et al.Development (Cambridge, England), 140(11), 2345-2353 (2013-05-03) The role of neprilysin in regulating the hair cycle.Naoko Morisaki et al.PloS one, 8(2), e55947-e55947 (2013-02-19) Development of abdominal aortic aneurysm is decreased in mice with plasma phospholipid transfer protein deficiency.Valérie Deckert et al.The American journal of pathology, 183(3), 975-986 (2013-07-09) Dynamics of uncrystallized water and protein in hydrated elastin studied by thermal and dielectric techniques.A Panagopoulou et al.Biochimica et biophysica acta, 1834(6), 977-988 (2013-03-27) Spectrum of elastin sequence variants and cardiovascular phenotypes in 49 patients with Williams-Beuren syndrome.Maria Delio et al.American journal of medical genetics. Part A, 161A(3), 527-533 (2013-02-13) Inhibition of elastin peptide-mediated angiogenic signaling mechanism(s) in choroidal endothelial cells by the α6(IV)NC1 collagen fragment.Venugopal Gunda et al.Investigative ophthalmology & visual science, 54(13), 7828-7835 (2013-11-07) Complete horizontal skin cell resurfacing and delayed vertical cell infiltration into porcine reconstructive tissue matrix compared to bovine collagen matrix and human dermis.Ursula Mirastschijski et al.Plastic and reconstructive surgery, 132(4), 861-869 (2013-10-01) Opposing changes in thoracic and abdominal aortic biomechanical properties in rodent models of vascular calcification and hypertension.Omar Z Ameer et al.American journal of physiology. Heart and circulatory physiology, 307(2), H143-H151 (2014-05-20) Enhancing cellular uptake of GFP via unfolded supercharged protein tags.Diego Pesce et al.Biomaterials, 34(17), 4360-4367 (2013-03-13) The potential of recombinant human elastin-like polypeptides for drug delivery.Gianni Ciofani et al.Expert opinion on drug delivery, 11(10), 1507-1512 (2014-06-10) Batch production of a silk-elastin-like protein in E. coli BL21(DE3): key parameters for optimisation.Tony Collins et al.Microbial cell factories, 12, 21-21 (2013-03-01) Non-linear optical microscopy sheds light on cardiovascular disease.Valentina Caorsi et al.PloS one, 8(2), e56136-e56136 (2013-02-15) Prophylactic effects of elastin peptide derived from the bulbus arteriosus of fish on vascular dysfunction in spontaneously hypertensive rats.Kumiko Takemori et al.Life sciences, 120, 48-53 (2014-12-03) The impact of atherosclerosis and vascular collagen on energy-based vessel sealing.Kimberly Martin et al.The Journal of surgical research, 185(2), 485-492 (2013-07-23) Elastin and collagen fibre microstructure of the human aorta in ageing and disease: a review.Alkiviadis Tsamis et al.Journal of the Royal Society, Interface, 10(83), 20121004-20121004 (2013-03-29) Decellularization of human and porcine lung tissues for pulmonary tissue engineering.John D O'Neill et al.The Annals of thoracic surgery, 96(3), 1046-1055 (2013-07-23) Photoresponsive retinal-modified silk-elastin copolymer.Zhongyuan Sun et al.Journal of the American Chemical Society, 135(9), 3675-3679 (2013-02-07) Reply to Elastin-based molecular MRI of liver fibrosis.Antonella Pellicoro et al.Hepatology (Baltimore, Md.), 58(4), 1518-1519 (2013-02-21) Three-in-one chromatography-free purification, tag removal, and site-specific modification of recombinant fusion proteins using sortase A and elastin-like polypeptides.Joseph J Bellucci et al.Angewandte Chemie (International ed. in English), 52(13), 3703-3708 (2013-02-21) Elastin degradation by cathepsin V requires two exosites.Xin Du et al.The Journal of biological chemistry, 288(48), 34871-34881 (2013-10-15) Smooth muscle cell deletion of low-density lipoprotein receptor-related protein 1 augments angiotensin II-induced superior mesenteric arterial and ascending aortic aneurysms.Frank M Davis et al.Arteriosclerosis, thrombosis, and vascular biology, 35(1), 155-162 (2014-11-15) [Purification and physicochemical properties of Bacillus thuringiensis IMB B-7324 peptidase with elastolytic and fibrinolytic activity].O V Matseliukh et al.Ukrains'kyi biokhimichnyi zhurnal (1999 ), 84(6), 25-36 (2013-02-08) A genetically engineered thermally responsive sustained release curcumin depot to treat neuroinflammation.S Michael Sinclair et al.Journal of controlled release : official journal of the Controlled Release Society, 171(1), 38-47 (2013-07-09) Sources of structural autofluorescence in the human trabecular meshwork.Alex S Huang et al.Investigative ophthalmology & visual science, 54(7), 4813-4820 (2013-06-08) Emodin-mediated cross-linking enhancement for extracellular matrix homeostasis.Lihua Jian et al.Biochemical and biophysical research communications, 446(4), 1022-1028 (2014-04-01) Identification and characterisation of regional variations in the material properties of ureter according to microstructure.Dimitrios P Sokolis Computer methods in biomechanics and biomedical engineering, 17(15), 1653-1670 (2013-02-27) Effect of collagen and elastin content on the burst pressure of human blood vessel seals formed with a bipolar tissue sealing system.Cassandra A Latimer et al.The Journal of surgical research, 186(1), 73-80 (2013-09-17)
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