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The microsomal metabolism and site of covalent binding to protein of 3'-hydroxyacetanilide, a nonhepatotoxic positional isomer of acetaminophen.A J Streeter et al.Drug metabolism and disposition: the biological fate of chemicals, 12(5), 565-576 (1984-09-01) Comparison of covalent binding of acetaminophen and the regioisomer 3'-hydroxyacetanilide to mouse liver protein.A M Matthews et al.Toxicology letters, 90(1), 77-82 (1997-01-15) Hepatic protein arylation, glutathione depletion, and metabolite profiles of acetaminophen and a non-hepatotoxic regioisomer, 3'-hydroxyacetanilide, in the mouse.M S Rashed et al.Drug metabolism and disposition: the biological fate of chemicals, 18(5), 765-770 (1990-09-01) Effect of sulfotransferase inhibitors on the 2-acetylaminofluorene-mediated lowering of rat liver N-hydroxy-2-acetylaminofluorene sulfotransferase activity.D P Ringer et al.Biochemical pharmacology, 34(18), 3380-3383 (1985-09-15) The metabolism of 2- and 3-hydroxyacetanilide. Determination of metabolic products by liquid chromatography/electrochemistry.M Hamilton et al.Drug metabolism and disposition: the biological fate of chemicals, 14(1), 5-12 (1986-01-01) Oral exposure to drugs with immune-adjuvant potential induces hypersensitivity responses to the reporter antigen TNP-OVA.Lydia M Kwast et al.Toxicological sciences : an official journal of the Society of Toxicology, 121(2), 312-319 (2011-03-16) The metabolic basis for inhibitory effects in chemical carcinogenesis by arylamines.P H Grantham National Cancer Institute monograph, (58)(58), 79-84 (1981-12-01) Functional characterization of 20 allelic variants of CYP1A2.Miyabi Ito et al.Drug metabolism and pharmacokinetics, 30(3), 247-252 (2015-05-30) Use of a systems model of drug-induced liver injury (DILIsym(®)) to elucidate the mechanistic differences between acetaminophen and its less-toxic isomer, AMAP, in mice.Brett A Howell et al.Toxicology letters, 226(2), 163-172 (2014-02-25) Hydrolysis of oleylanilide in the rat.V J Cunningham et al.Archives of toxicology, 54(2), 157-162 (1983-10-01) Developing structure-activity relationships for the prediction of hepatotoxicity.Nigel Greene et al.Chemical research in toxicology, 23(7), 1215-1222 (2010-06-18) Ocular disposition of acetaminophen and its metabolites following intravenous administration in rabbits.L Romanelli et al.Journal of ocular pharmacology, 7(4), 339-350 (1991-01-01) A predictive ligand-based Bayesian model for human drug-induced liver injury.Sean Ekins et al.Drug metabolism and disposition: the biological fate of chemicals, 38(12), 2302-2308 (2010-09-17) Investigations of the N-hydroxylation of 3'-hydroxyacetanilide, a non-hepatotoxic positional isomer of acetaminophen.M S Rashed et al.Drug metabolism and disposition: the biological fate of chemicals, 17(4), 355-359 (1989-07-01) Acetaminophen-induced oxidation of protein thiols. Contribution of impaired thiol-metabolizing enzymes and the breakdown of adenine nucleotides.M A Tirmenstein et al.The Journal of biological chemistry, 265(6), 3059-3065 (1990-02-25) Metabolic alterations resulting from the inhibition of mitochondrial respiration by acetaminophen in vivo.R L Esterline et al.Biochemical pharmacology, 38(14), 2390-2392 (1989-07-15) Cellular apoptosis and cytotoxicity of phenolic compounds: a quantitative structure-activity relationship study.Cynthia D Selassie et al.Journal of medicinal chemistry, 48(23), 7234-7242 (2005-11-11) Comparative cytotoxic effects of acetaminophen (N-acetyl-p-aminophenol), a non-hepatotoxic regioisomer acetyl-m-aminophenol and their postulated reactive hydroquinone and quinone metabolites in monolayer cultures of mouse hepatocytes.J A Holme et al.Biochemical pharmacology, 42(5), 1137-1142 (1991-08-08) Acetaminophen and protein thiol modification.S D Nelson et al.Advances in experimental medicine and biology, 283, 579-588 (1991-01-01) Subcellular binding and effects on calcium homeostasis produced by acetaminophen and a nonhepatotoxic regioisomer, 3'-hydroxyacetanilide, in mouse liver.M A Tirmenstein et al.The Journal of biological chemistry, 264(17), 9814-9819 (1989-06-15) Identification of hepatic protein targets of the reactive metabolites of the non-hepatotoxic regioisomer of acetaminophen, 3'-hydroxyacetanilide, in the mouse in vivo using two-dimensional gel electrophoresis and mass spectrometry.Y Qiu et al.Advances in experimental medicine and biology, 500, 663-673 (2002-01-05) Immunochemical comparison of 3'-hydroxyacetanilide and acetaminophen binding in mouse liver.W F Salminen et al.Drug metabolism and disposition: the biological fate of chemicals, 26(3), 267-271 (1998-04-04) Acetaminophen induces apoptosis of C6 glioma cells by activating the c-Jun NH(2)-terminal protein kinase-related cell death pathway.M A Bae et al.Molecular pharmacology, 60(4), 847-856 (2001-09-20) Favipiravir inhibits acetaminophen sulfate formation but minimally affects systemic pharmacokinetics of acetaminophen.Yanli Zhao et al.British journal of clinical pharmacology, 80(5), 1076-1085 (2015-03-27) 2-Acetamido-p-benzoquinone: a reactive arylating metabolite of 3'-hydroxyacetanilide.A J Streeter et al.Biochemical pharmacology, 34(16), 2871-2876 (1985-08-15) Differential gene expression analysis of a known hepatotoxin, N-acetyl-p-amino-phenol (APAP) as compared to its non-toxic analog, N-acetyl-m-amino-phenol (AMAP) in mouse liver.Priyanka Priyadarsiny et al.The Journal of toxicological sciences, 33(2), 163-173 (2008-06-12) Glutathione depletion in human erythrocytes as an indicator for microsomal activation of cyclophosphamide and 3-hydroxyacetanilide.N G Palmen et al.Toxicology, 84(1-3), 157-170 (1993-11-12) A comparative study of mouse liver proteins arylated by reactive metabolites of acetaminophen and its nonhepatotoxic regioisomer, 3'-hydroxyacetanilide.T G Myers et al.Chemical research in toxicology, 8(3), 403-413 (1995-04-01) Cell culture model for acetaminophen-induced hepatocyte death in vivo.Robert H Pierce et al.Biochemical pharmacology, 64(3), 413-424 (2002-07-31) Characterization of glutathione conjugates of reactive metabolites of 3'-hydroxyacetanilide, a nonhepatotoxic positional isomer of acetaminophen.M S Rashed et al.Chemical research in toxicology, 2(1), 41-45 (1989-01-01)

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