Melting point	152-153 ºC**
Density	1.28±0.1 g/cm3 (20 ºC

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Source	SDS/MSDS Samples
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Synthetic Route

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Articles

Peer-Reviewed Papers

Phytochemical analysis, molecular docking and antiamnesic effects of methanolic extract of Silybum marianum (L.) Gaertn seeds in scopolamine induced memory impairment in mice.Nazir N, et al. Journal of Ethnopharmacology, 210(7), 198-208 (2018) Milk thistle in liver diseases: past, present, future.Ludovico Abenavoli et al.Phytotherapy research : PTR, 24(10), 1423-1432 (2010-06-22) Silymarin extraction from milk thistle using hot water.Lijun Duan et al.Applied biochemistry and biotechnology, 113-116, 559-568 (2004-04-01) Head-to-head comparison of ultra-high-performance liquid chromatography with diode array detection versus quantitative nuclear magnetic resonance for the quantitative analysis of the Silymarin complex in Silybum marianum fruit extracts.Cheilari A, et al. Journal of Agricultural and Food Chemistry, 64(7), 1618-1626 (2016) Separation and characterization of silybin, isosilybin, silydianin and silychristin in milk thistle extract by liquid chromatography-electrospray tandem mass spectrometry.James I Lee et al.Journal of chromatography. A, 1116(1-2), 57-68 (2006-04-25) A silychristin isomer and variation of flavonolignan levels in milk thistle (Silybum marianum) fruits.Wendy A Smith et al.Planta medica, 71(9), 877-880 (2005-10-06) Stimulatory effects of silibinin and silicristin from the milk thistle Silybum marianum on kidney cells.J Sonnenbichler et al.The Journal of pharmacology and experimental therapeutics, 290(3), 1375-1383 (1999-08-24) Identifying the differential effects of silymarin constituents on cell growth and cell cycle regulatory molecules in human prostate cancer cells.Gagan Deep et al.International journal of cancer, 123(1), 41-50 (2008-04-26) Pharmacokinetics of pure silybin diastereoisomers and identification of their metabolites in rat plasma.Marhol P, et al. Journal of functional foods, 14, 570-580 (2015) Optimization and single-laboratory validation of a method for the determination of flavonolignans in milk thistle seeds by high-performance liquid chromatography with ultraviolet detection.Mudge E, et al. Analytical and Bioanalytical Chemistry, 407(25), 7657-7666 (2015) Synchronized and sustained release of multiple components in silymarin from erodible glyceryl monostearate matrix system.Cheng Lu et al.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 66(2), 210-219 (2007-01-02) Extraction of nutraceuticals from milk thistle: I. Hot water extraction.Jose F Barreto et al.Applied biochemistry and biotechnology, 105 -108, 881-889 (2003-05-02) Analysis and comparison of active constituents in commercial standardized silymarin extracts by liquid chromatography-electrospray ionization mass spectrometry.James I Lee et al.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 845(1), 95-103 (2006-09-01) Influence of exogenous salicylic acid on flavonolignans and lipoxygenase activity in the hairy root cultures of Silybum marianum.Masumeh Khalili et al.Cell biology international, 33(9), 988-994 (2009-06-16) [Bioavailability of silymarin, I: Volumes of distribution of silybin, silydianin, and silychristin from in-vitro data (author's transl)].H P Koch et al.Archiv der Pharmazie, 314(6), 515-517 (1981-06-01) Inhibition of the superoxide anion release and hydrogen peroxide formation in PMNLs by flavonolignans.Z Varga et al.Phytotherapy research : PTR, 15(7), 608-612 (2001-12-18) A new approach to the rapid separation of isomeric compounds in a Silybum marianum extract using UHPLC core-shell column with F5 stationary phase.Fibigr J, et al. Journal of Pharmaceutical and Biomedical Analysis, 134, 203-213 (2017) Effect of the flavanolignans of Silybum marianum L. on lipid peroxidation in rat liver microsomes and freshly isolated hepatocytes.E Bosisio et al.Pharmacological research, 25(2), 147-154 (1992-02-01) Topical delivery of silymarin constituents via the skin route.Chi-feng Hung et al.Acta pharmacologica Sinica, 31(1), 118-126 (2009-12-22) Effect of silybin and its congeners on human liver microsomal cytochrome P450 activities.Roman Zuber et al.Phytotherapy research : PTR, 16(7), 632-638 (2002-11-01)

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