4-Chloropyrrolo[2,3-d]pyrimidine | CAS:3680-69-1
4-Chloropyrrolo[2,3-d]pyrimidine
- Name：4-Chloropyrrolo[2,3-d]pyrimidine
- CAS：3680-69-1
- Synonyms：4-Chloro-1H-pyrrolo[2,3-d]pyrimidine; 6-Chloro-7-deazapurine
- Molecular Formula：C6H4ClN3
- Molecular Weight：153.57
- EINESC：
Synthetic Route
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RelatedAPI's
| Name |
CAS |
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| CP 690550 |
477600-75-2 |
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|
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Peer-Reviewed Papers
Syndiospecific living polymerization of 4-methylstyrene and styrene with (trimethyl) pentamethylcyclopentadienyltitanium/tris (pentafluorophenyl) borane/trioctylaluminum catalytic system. Kawabe M and Murata M. Journal of Polymer Science Part A: Polymer Chemistry, 39(21), 3692-3706 (2001)
An efficient palladium-catalyzed Heck coupling of aryl chlorides with alkenes. Yi C and Hua R. Tetrahedron Letters, 47(15), 2573-2576 (2006)
Synthesis and study of cationic, two-coordinate triphenylphosphine-gold-π complexes.Rachel E M Brooner et al.Chemistry (Weinheim an der Bergstrasse, Germany), 19(25), 8276-8284 (2013-04-18)
Mercapturic acid metabolites from 2-, 3-, and 4-ethenyl-methylbenzenes in the rat.T Kühler Xenobiotica; the fate of foreign compounds in biological systems, 14(5), 417-428 (1984-05-01)
Origin of threefold symmetric torsional potential of methyl group in 4-methylstyrene.Rajeev K Sinha et al.The Journal of chemical physics, 124(14), 144316-144316 (2006-04-22)
Remarks
Description for route of synthesis:
Add 4-hydroxypyrrolo [2,3-d] pyrimidine to excess phosphorus oxychloride, heat to reflux for chlorination reaction, and convert hydroxyl groups into chlorine atoms; After the reaction is complete, excess phosphorus trichloride is removed under reduced pressure. The residue is slowly poured into ice water, neutralized to neutrality with sodium bicarbonate, extracted with ethyl acetate, washed, dried, concentrated, and purified by recrystallization or distillation to obtain the target product 4-chloropyrrolopyrimidine.
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RelatedAPI's
| Name |
CAS |
|
| CP 690550 |
477600-75-2 |
View
|
