Melting point	-21 ºC
Water Solubility	freely soluble
Boiling point	73-74 ºC (1 mmHg)
Flash point	100 ºC
Density	1.062
Refractive index	1.55-1.552

Symbol(GHS)	C
Hazard Codes	R34
SDS/MSDS	S25;S36/37/39;S45

Source	SDS/MSDS Samples
Alfa-Aesar	View & Download
Sigma-Aldrich	View & Download
TCI	View & Download

Synthetic Route

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Name	CAS

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Articles

Peer-Reviewed Papers

Formation of alpha-hydroxyglutaric acid by Aspergillus glaucus.A S Bleiweis et al.Journal of bacteriology, 94(5), 1560-1564 (1967-11-01) Inhibition of mutant IDH1 decreases D-2-HG levels without affecting tumorigenic properties of chondrosarcoma cell lines.Johnny Suijker et al.Oncotarget, 6(14), 12505-12519 (2015-04-22) Robust detection of oncometabolic aberrations by 1H-13C heteronuclear single quantum correlation in intact biological specimens.Yasaman Barekatain et al.Communications biology, 3(1), 328-328 (2020-06-27) Abundance of d-2-hydroxyglutarate in G2/M is determined by FOXM1 in mutant IDH1-expressing cells.Kancharana Bala Bhaskara Rao et al.FEBS letters, 593(16), 2177-2193 (2019-06-19) The oncometabolite D-2-hydroxyglutarate induced by mutant IDH1 or -2 blocks osteoblast differentiation in vitro and in vivo.Johnny Suijker et al.Oncotarget, 6(17), 14832-14842 (2015-06-06) Deficiency in SLC25A1, encoding the mitochondrial citrate carrier, causes combined D-2- and L-2-hydroxyglutaric aciduria.Benjamin Nota et al.American journal of human genetics, 92(4), 627-631 (2013-04-09) Oncometabolite D-2-Hydroxyglurate Directly Induces Epithelial-Mesenchymal Transition and is Associated with Distant Metastasis in Colorectal Cancer.Hugh Colvin et al.Scientific reports, 6, 36289-36289 (2016-11-09) Prognostic significance of 2-hydroxyglutarate levels in acute myeloid leukemia in China.Jiang-Han Wang et al.Proceedings of the National Academy of Sciences of the United States of America, 110(42), 17017-17022 (2013-10-02) Rapid separation of some common intermediates of microbial metabolism by thin-layer chromatography.A S Bleiweis et al.Analytical biochemistry, 20(2), 335-338 (1967-08-01) 2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling.Xudong Fu et al.Cell metabolism, 22(3), 508-515 (2015-07-21) Registered report: Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases.Brad Evans et al.eLife, 4, e07420-e07420 (2015-08-01) Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation.Peppi Koivunen et al.Nature, 483(7390), 484-488 (2012-02-22) Serum 2-hydroxyglutarate production in IDH1- and IDH2-mutated de novo acute myeloid leukemia: a study by the Acute Leukemia French Association group.Maxime Janin et al.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 32(4), 297-305 (2013-12-18) Validation of a hypoxia-inducible factor-1 alpha specimen collection procedure and quantitative enzyme-linked immunosorbent assay in solid tumor tissues.Sook Ryun Park et al.Analytical biochemistry, 459, 1-11 (2014-05-07) The production of alpha-hydroxyglutaric acid from glutamic acid by cell-free preparations of Peptococcus aerogenes.W M Johnson et al.Canadian journal of biochemistry, 47(12), 1103-1107 (1969-12-01)

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