Melting point	95 ºC**
Boiling point	62-63 ºC (5 Torr)***
Flash point	71.0±18.5 ºC, 计算值*
Density	1.089±0.06 g/cm3 (20 º

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Source	SDS/MSDS Samples
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Articles

Peer-Reviewed Papers

Lethal Poisoning of Cancer Cells by Respiratory Chain Inhibition plus Dimethyl α-Ketoglutarate.Valentina Sica et al.Cell reports, 27(3), 820-834 (2019-04-18) RETRACTED: Polysaccharide from Angelica sinensis ameliorates high-fat diet and STZ-induced hepatic oxidative stress and inflammation in diabetic mice by activating the Sirt1-AMPK pathway.Kaiping Wang et al.The Journal of nutritional biochemistry, 43, 88-97 (2017-03-11) The CD38/NAD/SIRTUIN1/EZH2 Axis Mitigates Cytotoxic CD8 T Cell Function and Identifies Patients with SLE Prone to Infections.Eri Katsuyama et al.Cell reports, 30(1), 112-123 (2020-01-09) SIRT1 Protects the Heart from ER Stress-Induced Injury by Promoting eEF2K/eEF2-Dependent Autophagy.Julie Pires Da Silva et al.Cells, 9(2) (2020-02-16) Spinal miR-34a regulates inflammatory pain by targeting SIRT1 in complete Freund's adjuvant mice.Shuangdong Chen et al.Biochemical and biophysical research communications, 516(4), 1196-1203 (2019-07-13) Rhinovirus-Induced SIRT-1 via TLR2 Regulates Subsequent Type I and Type III IFN Responses in Airway Epithelial Cells.Nathaniel Xander et al.Journal of immunology (Baltimore, Md. : 1950), 203(9), 2508-2519 (2019-09-25) Diallyl disulfide induces downregulation and inactivation of cofilin 1 differentiation via the Rac1/ROCK1/LIMK1 pathway in leukemia cells.Hui Ling et al.International journal of oncology, 56(3), 772-782 (2020-03-04) Functional characterization of NAD dependent de-acetylases SIRT1 and SIRT2 in B-Cell Chronic Lymphocytic Leukemia (CLL).Savita Bhalla et al.Cancer biology & therapy, 17(3), 300-309 (2016-01-23) GDF-15 prevents lipopolysaccharide-mediated acute lung injury via upregulating SIRT1.Hengya Song et al.Biochemical and biophysical research communications, 526(2), 439-446 (2020-04-02) Lysine Deacetylation by HDAC6 Regulates the Kinase Activity of AKT in Human Neural Progenitor Cells.Jonathan Iaconelli et al.ACS chemical biology, 12(8), 2139-2148 (2017-06-20) Downregulation of pathways implicated in liver inflammation and tumorigenesis of glycogen storage disease type Ia mice receiving gene therapy.Goo-Young Kim et al.Human molecular genetics, 26(10), 1890-1899 (2017-03-24) Astragalin Exerted Antidepressant-like Action through SIRT1 Signaling Modulated NLRP3 Inflammasome Deactivation.Yue Tong et al.ACS chemical neuroscience, 11(10), 1495-1503 (2020-05-05) Danshensu Ameliorates Cardiac Ischaemia Reperfusion Injury through Activating Sirt1/FoxO1/Rab7 Signal Pathway.Da-Wei Sun et al.Chinese journal of integrative medicine, 26(4), 283-291 (2019-06-30) A Rise in ATP, ROS, and Mitochondrial Content upon Glucose Withdrawal Correlates with a Dysregulated Mitochondria Turnover Mediated by the Activation of the Protein Deacetylase SIRT1Song S and Hwang E Cells, 8(1), 11-11 (2019) The acetylation of cyclin-dependent kinase 5 at lysine 33 regulates kinase activity and neurite length in hippocampal neurons.Juhyung Lee et al.Scientific reports, 8(1), 13676-13676 (2018-09-14) Resveratrol Mitigates High-Fat Diet-Induced Vascular Dysfunction by Activating the Akt/eNOS/NO and Sirt1/ER Pathway.Jiung-Pang Huang et al.Journal of cardiovascular pharmacology, 72(5), 231-241 (2018-11-07) GLP‑1 improves palmitate‑induced insulin resistance in human skeletal muscle via SIRT1 activity.Ja Young Jeon et al.International journal of molecular medicine, 44(3), 1161-1171 (2019-09-17) TGFβ2-induced formation of lipid droplets supports acidosis-driven EMT and the metastatic spreading of cancer cells.Cyril Corbet et al.Nature communications, 11(1), 454-454 (2020-01-25) Adipocyte differentiation is regulated by mitochondrial trifunctional protein α-subunit via sirtuin 1.Hong-Xia Liu et al.Experimental cell research, 357(2), 271-281 (2017-05-30) Ambient particulate matter attenuates Sirtuin1 and augments SREBP1-PIR axis to induce human pulmonary fibroblast inflammation: molecular mechanism of microenvironment associated with COPD.Chia-Ping Tien et al.Aging, 11(13), 4654-4671 (2019-07-13) MicroRNA-22 inhibition prevents doxorubicin-induced cardiotoxicity via upregulating SIRT1.Can Xu et al.Biochemical and biophysical research communications, 521(2), 485-491 (2019-11-05) Metformin Mitigates Cartilage Degradation by Activating AMPK/SIRT1-Mediated Autophagy in a Mouse Osteoarthritis Model.Chenzhong Wang et al.Frontiers in pharmacology, 11, 1114-1114 (2020-08-15) Attenuation of Palmitic Acid-Induced Lipotoxicity by Chlorogenic Acid through Activation of SIRT1 in Hepatocytes.Lele Yang et al.Molecular nutrition & food research, e1801432-e1801432 (2019-06-07) Sirtuin 1 Regulates Dendritic Cell Activation and Autophagy during Respiratory Syncytial Virus-Induced Immune Responses.Anna B Owczarczyk et al.Journal of immunology (Baltimore, Md. : 1950), 195(4), 1637-1646 (2015-07-15) Adversity in childhood and depression: linked through SIRT1.L Lo Iacono et al.Translational psychiatry, 5, e629-e629 (2015-09-04) High Mobility Group Box 1 Mediates Interferon-γ-Induced Phenotypic Modulation of Vascular Smooth Muscle Cells.Kun Wang et al.Journal of cellular biochemistry, 118(3), 518-529 (2016-09-01) SIRT1-Dependent Upregulation of Antiglycative Defense in HUVECs Is Essential for Resveratrol Protection against High Glucose Stress.Silvano Jr Santini et al.Antioxidants (Basel, Switzerland), 8(9) (2019-09-05) The Function of PPARγ/AMPK/SIRT-1 Pathway in Inflammatory Response of Human Articular Chondrocytes Stimulated by Advanced Glycation End Products.Hao Huang et al.Biological & pharmaceutical bulletin, 42(8), 1303-1309 (2019-08-02) Lowering oxidative stress in ghrelin cells stimulates ghrelin secretion.Bharath K Mani et al.American journal of physiology. Endocrinology and metabolism, 319(2), E330-E337 (2020-06-17) SIRT1-Dependent Upregulation of Antiglycative Defense in HUVECs Is Essential for Resveratrol Protection against High Glucose Stress.Silvano Jr Santini et al.Antioxidants (Basel, Switzerland), 8(9) (2019-09-05) The Function of PPARγ/AMPK/SIRT-1 Pathway in Inflammatory Response of Human Articular Chondrocytes Stimulated by Advanced Glycation End Products.Hao Huang et al.Biological & pharmaceutical bulletin, 42(8), 1303-1309 (2019-08-02) Effects of sorbitol and lactate on erythropoietin production in HepG2 cells.Kazuhiko Nishimura et al.Biochemical and biophysical research communications, 523(1), 54-59 (2019-12-14) Cervical cancer is addicted to SIRT1 disarming the AIM2 antiviral defense.Daeho So et al.Oncogene, 37(38), 5191-5204 (2018-05-31) Resveratrol alleviates the cytotoxicity induced by the radiocontrast agent, ioxitalamate, by reducing the production of reactive oxygen species in HK-2 human renal proximal tubule epithelial cells in vitro.Yen Ta Huang et al.International journal of molecular medicine, 37(1), 83-91 (2015-11-18) Inhibition of sirtuins 1 and 2 impairs cell survival and migration and modulates the expression of P-glycoprotein and MRP3 in hepatocellular carcinoma cell lines.María Paula Ceballos et al.Toxicology letters, 289, 63-74 (2018-03-17) Over-expression of heat shock protein 70 protects mice against lung ischemia/reperfusion injury through SIRT1/AMPK/eNOS pathway.Shumei Liu et al.American journal of translational research, 8(10), 4394-4404 (2016-11-11) Liraglutide attenuates NLRP3 inflammasome-dependent pyroptosis via regulating SIRT1/NOX4/ROS pathway in H9c2 cells.Ao Chen et al.Biochemical and biophysical research communications, 499(2), 267-272 (2018-03-25) Hydrogen sulfide attenuates mitochondrial dysfunction-induced cellular senescence and apoptosis in alveolar epithelial cells by upregulating sirtuin 1.Ruijuan Guan et al.Aging, 11(24), 11844-11864 (2019-12-28) Hesperetin is a potent bioactivator that activates SIRT1-AMPK signaling pathway in HepG2 cells.Hajar Shokri Afra et al.Journal of physiology and biochemistry, 75(2), 125-133 (2019-05-17) Modification of mitochondrial function, cytoplasmic lipid content and cryosensitivity of bovine embryos by resveratrol.Takahito Abe et al.The Journal of reproduction and development, 63(5), 455-461 (2017-06-13) Preferential expression of PAPPA in human preadipocytes from omental fat.Caroline Davidge-Pitts et al.The Journal of endocrinology, 222(1), 87-97 (2014-05-02) CTRP3 attenuates high-fat diet-induced male reproductive dysfunction in mice.Yang Mu et al.Clinical science (London, England : 1979), 132(8), 883-899 (2018-03-25) Hydroxyurea induces a hypersensitive apoptotic response in mouse embryonic stem cells through p38-dependent acetylation of p53.Sun-Hee Heo et al.Stem cells and development, 23(20), 2435-2442 (2014-05-20) AMPK-SIRT1-independent inhibition of ANGPTL3 gene expression is a potential lipid-lowering mechanism of metformin.Li Lin et al.The Journal of pharmacy and pharmacology, 71(9), 1421-1428 (2019-07-06) Sirtuin1 Targeting Reverses Innate and Adaptive Immune Tolerance in Septic Mice.Ayana N Martin et al.Journal of immunology research, 2018, 2402593-2402593 (2018-08-03) Pyrroloquinoline Quinone, a Redox-Active o-Quinone, Stimulates Mitochondrial Biogenesis by Activating the SIRT1/PGC-1α Signaling Pathway.Kazuhiro Saihara et al.Biochemistry, 56(50), 6615-6625 (2017-12-01) Ginkgetin aglycone ameliorates LPS-induced acute kidney injury by activating SIRT1 via inhibiting the NF-κB signaling pathway.Junwei Zhang et al.Cell & bioscience, 7, 44-44 (2017-08-31) Atorvastatin promotes bone formation in aged apoE-/- mice through the Sirt1-Runx2 axis.Wei Hong et al.Journal of orthopaedic surgery and research, 15(1), 303-303 (2020-08-09) A novel sirtuin 2 (SIRT2) inhibitor with p53-dependent pro-apoptotic activity in non-small cell lung cancer.Gesine Hoffmann et al.The Journal of biological chemistry, 289(8), 5208-5216 (2014-01-01) Shear stress regulates endothelial cell autophagy via redox regulation and Sirt1 expression.J Liu et al.Cell death & disease, 6, e1827-e1827 (2015-07-17) Resveratrol, an activator of SIRT1, improves ER stress by increasing clusterin expression in HepG2 cells.Jinmi Lee et al.Cell stress & chaperones, 24(4), 825-833 (2019-06-12) The Role of Sirt1 in EpileptogenesisHall Alicia M, et al. eNeuro, 4(1) (2017) N1-Methylnicotinamide Improves Hepatic Insulin Sensitivity via Activation of SIRT1 and Inhibition of FOXO1 Acetylation.Jingfan Zhang et al.Journal of diabetes research, 2020, 1080152-1080152 (2020-04-14) Sirtuin 1 represses PKC-ζ activity through regulating interplay of acetylation and phosphorylation in cardiac hypertrophy.Jingyan Li et al.British journal of pharmacology, 176(3), 416-435 (2018-11-11) Melatonin protects against COPD by attenuating apoptosis and endoplasmic reticulum stress via upregulating SIRT1 expression in rats.Baimei He et al.Canadian journal of physiology and pharmacology, 97(5), 386-391 (2019-01-24) The enriched environment ameliorates chronic unpredictable mild stress-induced depressive-like behaviors and cognitive impairment by activating the SIRT1/miR-134 signaling pathway in hippocampus.Jun Shen et al.Journal of affective disorders, 248, 81-90 (2019-02-05) EX-527 Prevents the Progression of High-Fat Diet-Induced Hepatic Steatosis and Fibrosis by Upregulating SIRT4 in Zucker Rats.Amit Kundu et al.Cells, 9(5) (2020-05-06) SIRT1/2 orchestrate acquisition of DNA methylation and loss of histone H3 activating marks to prevent premature activation of inflammatory genes in macrophages.Tianlu Li et al.Nucleic acids research, 48(2), 665-681 (2019-12-05) The Sirtuin1 activator SRT3025 down-regulates sclerostin and rescues ovariectomy-induced bone loss and biomechanical deterioration in female mice.Hanna Artsi et al.Endocrinology, 155(9), 3508-3515 (2014-06-21) SIRT1-dependent effects of resveratrol and grape juice in an in vitro model of preeclampsia.Sarah Viana-Mattioli et al.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 131, 110659-110659 (2020-09-01) Cannabinoid-1 Receptor Antagonism Improves Glycemic Control and Increases Energy Expenditure Through Sirtuin-1/Mechanistic Target of Rapamycin Complex 2 and 5'Adenosine Monophosphate-Activated Protein Kinase Signaling.Jie Liu et al.Hepatology (Baltimore, Md.), 69(4), 1535-1548 (2018-12-07) Synthetic 4-Hydroxy Auxarconjugatin B, a Novel Autophagy Inducer, Attenuates Gouty Inflammation by Inhibiting the NLRP3 Inflammasome.Chih-Yu Hsieh et al.Cells, 9(2) (2020-01-26) 4-Hydroxybenzaldehyde Restricts the Intracellular Growth of Toxoplasma gondii by Inducing SIRT1-Mediated Autophagy in Macrophages.Jina Lee et al.The Korean journal of parasitology, 58(1), 7-14 (2020-03-09) The protective effects of Resveratrol against radiation-induced intestinal injuryZhang H, et al. BMC Complementary and Alternative Medicine, 17(1), 410-410 (2017)

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