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The role of mitochondria in shaping odor responses in Drosophila melanogaster olfactory sensory neurons.Jan Lucke et al.Cell calcium, 87, 102179-102179 (2020-02-20) The contribution of thioredoxin-2 reductase and glutathione peroxidase to H2O2 detoxification of rat brain mitochondriaKudin, A.P., et al. Biochimica et Biophysica Acta, doi: 10-doi: 10 (2012) Disulfiram causes selective hypoxic cancer cell toxicity and radio-chemo-sensitization via redox cycling of copper.Kelly C Falls-Hubert et al.Free radical biology & medicine, 150, 1-11 (2020-02-08) Mononuclear gold(iii) complexes with l-histidine-containing dipeptides: tuning the structural and biological properties by variation of the N-terminal amino acid and counter anion.Beata Warżajtis et al.Dalton transactions (Cambridge, England : 2003), 46(8), 2594-2608 (2017-02-06) Image-Based Measurement of HMark Jelcic et al.Biophysical journal, 112(9), 2011-2018 (2017-05-13) Redox-Mediated Mechanisms Fuel Monocyte Responses to CXCL12/HMGB1 in Active Rheumatoid Arthritis.Valentina Cecchinato et al.Frontiers in immunology, 9, 2118-2118 (2018-10-05) Sensitization of acute lymphoblastic leukemia cells for LCL161-induced cell death by targeting redox homeostasis.Christina Haß et al.Biochemical pharmacology, 105, 14-22 (2016-01-18) Perturbation of redox balance after thioredoxin reductase deficiency interrupts autophagy-lysosomal degradation pathway and enhances cell death in nutritionally stressed SH-SY5Y cells.Pandian Nagakannan et al.Free radical biology & medicine, 101, 53-70 (2016-11-05) A method for studies on interactions between a gold-based drug and plasma proteins based on capillary electrophoresis with inductively coupled plasma mass spectrometry detection.Tam T T N Nguyen et al.Analytical and bioanalytical chemistry, 407(28), 8497-8503 (2015-09-04) Mitochondrial TXNRD3 confers drug resistance via redox-mediated mechanism and is a potential therapeutic target in vivo.Xiaoxia Liu et al.Redox biology, 36, 101652-101652 (2020-08-05) Development of a health care utilisation data-based index for rheumatoid arthritis severity: a preliminary study.Gladys Ting et al.Arthritis research & therapy, 10(4), R95-R95 (2008-08-23) Pharmacokinetics, Safety, and Tolerability of Selonsertib, an Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitor, Following First-in-Human Single and Multiple Ascending Doses in Healthy Subjects.Cara H Nelson et al.Clinical pharmacokinetics, 59(9), 1109-1117 (2020-04-26) mTOR and HDAC Inhibitors Converge on the TXNIP/Thioredoxin Pathway to Cause Catastrophic Oxidative Stress and Regression of RAS-Driven Tumors.Clare F Malone et al.Cancer discovery, 7(12), 1450-1463 (2017-10-01) NMDA-receptor inhibition and oxidative stress during hippocampal maturation differentially alter parvalbumin expression and gamma-band activity.Luisa A Hasam-Henderson et al.Scientific reports, 8(1), 9545-9545 (2018-06-24) Ultrasensitive Genetically Encoded Indicator for Hydrogen Peroxide Identifies Roles for the Oxidant in Cell Migration and Mitochondrial Function.Valeriy V Pak et al.Cell metabolism, 31(3), 642-653 (2020-03-05) Serum thioredoxin reductase levels increase in response to chemically induced acute liver injury.Kang Sun et al.Biochimica et biophysica acta, 1840(7), 2105-2111 (2014-03-13) A salvage pathway maintains highly functional respiratory complex I.Karolina Szczepanowska et al.Nature communications, 11(1), 1643-1643 (2020-04-04) Targeting the thioredoxin system as a novel strategy against B-cell acute lymphoblastic leukemia.Klaudyna Fidyt et al.Molecular oncology, 13(5), 1180-1195 (2019-03-13) In Vitro Investigation of Auranofin as a Treatment for Clostridium difficile Infection.Christine Roder et al.Drugs in R&D, 20(3), 209-216 (2020-05-08) Annexin A5 suppresses cyclooxygenase-2 expression by downregulating the protein kinase C-ζ-nuclear factor-κB signaling pathway in prostate cancer cells.Hyoung-Seok Baek et al.Oncotarget, 8(43), 74263-74275 (2017-11-02) Xanthine oxidase-mediated oxidative stress promotes cancer cell-specific apoptosis.Haixia Xu et al.Free radical biology & medicine, 139, 70-79 (2019-05-20) The thioredoxin reductase inhibitor auranofin induces heme oxygenase-1 in lung epithelial cells via Nrf2-dependent mechanisms.Katelyn Dunigan et al.American journal of physiology. Lung cellular and molecular physiology, 315(4), L545-L552 (2018-07-20) Nicotinamide nucleotide transhydrogenase regulates mitochondrial metabolism in NSCLC through maintenance of Fe-S protein function.Nathan P Ward et al.The Journal of experimental medicine, 217(6) (2020-03-21) A Heterologous Reporter Defines the Role of the Tetanus Toxin Interchain Disulfide in Light-Chain Translocation.Madison Zuverink et al.Infection and immunity, 83(7), 2714-2724 (2015-04-22) High Expression of c-Met, PKCλ and ALDH1A3 Predicts a Poor Prognosis in Late-stage Breast Cancer.Hitomi Motomura et al.Anticancer research, 40(1), 35-52 (2020-01-02) Comprehensive chemical proteomics for target deconvolution of the redox active drug auranofin.Amir Ata Saei et al.Redox biology, 32, 101491-101491 (2020-03-22) Thioredoxin system-mediated regulation of mutant Kras associated pancreatic neoplasia and cancer.Michelle A Schultz et al.Oncotarget, 8(54), 92667-92681 (2017-12-02) Disruption of thioredoxin metabolism enhances the toxicity of transforming growth factor β-activated kinase 1 (TAK1) inhibition in KRAS-mutated colon cancer cells.Jennifer E Hrabe et al.Redox biology, 5, 319-327 (2015-06-27) Pharmacological levels of hydrogen sulfide inhibit oxidative cell injury through regulating the redox state of thioredoxin.Zhimin Mao et al.Free radical biology & medicine, 134, 190-199 (2019-01-15) N-methyl-D-aspartate receptor-dependent denitrosylation of neuronal nitric oxide synthase increase the enzyme activity.Zhong-Wei Qu et al.PloS one, 7(12), e52788-e52788 (2013-01-04) A salvage pathway maintains highly functional respiratory complex I.Karolina Szczepanowska et al.Nature communications, 11(1), 1643-1643 (2020-04-04) The role of mitochondria in shaping odor responses in Drosophila melanogaster olfactory sensory neurons.Jan Lucke et al.Cell calcium, 87, 102179-102179 (2020-02-20) Image-Based Measurement of HMark Jelcic et al.Biophysical journal, 112(9), 2011-2018 (2017-05-13) Mononuclear gold(iii) complexes with l-histidine-containing dipeptides: tuning the structural and biological properties by variation of the N-terminal amino acid and counter anion.Beata Warżajtis et al.Dalton transactions (Cambridge, England : 2003), 46(8), 2594-2608 (2017-02-06) Sensitization of acute lymphoblastic leukemia cells for LCL161-induced cell death by targeting redox homeostasis.Christina Haß et al.Biochemical pharmacology, 105, 14-22 (2016-01-18) Redox-Mediated Mechanisms Fuel Monocyte Responses to CXCL12/HMGB1 in Active Rheumatoid Arthritis.Valentina Cecchinato et al.Frontiers in immunology, 9, 2118-2118 (2018-10-05) Xanthine oxidase-mediated oxidative stress promotes cancer cell-specific apoptosis.Haixia Xu et al.Free radical biology & medicine, 139, 70-79 (2019-05-20) Nicotinamide nucleotide transhydrogenase regulates mitochondrial metabolism in NSCLC through maintenance of Fe-S protein function.Nathan P Ward et al.The Journal of experimental medicine, 217(6) (2020-03-21) A Heterologous Reporter Defines the Role of the Tetanus Toxin Interchain Disulfide in Light-Chain Translocation.Madison Zuverink et al.Infection and immunity, 83(7), 2714-2724 (2015-04-22) Annexin A5 suppresses cyclooxygenase-2 expression by downregulating the protein kinase C-ζ-nuclear factor-κB signaling pathway in prostate cancer cells.Hyoung-Seok Baek et al.Oncotarget, 8(43), 74263-74275 (2017-11-02) The thioredoxin reductase inhibitor auranofin induces heme oxygenase-1 in lung epithelial cells via Nrf2-dependent mechanisms.Katelyn Dunigan et al.American journal of physiology. Lung cellular and molecular physiology, 315(4), L545-L552 (2018-07-20) The contribution of thioredoxin-2 reductase and glutathione peroxidase to H2O2 detoxification of rat brain mitochondriaKudin, A.P., et al. Biochimica et Biophysica Acta, doi: 10-doi: 10 (2012) Antiproliferative effect of gold(I) compound auranofin through inhibition of STAT3 and telomerase activity in MDA-MB 231 human breast cancer cells.Nam-Hoon Kim et al.BMB reports, 46(1), 59-64 (2013-01-29) Drug susceptibility testing in microaerophilic parasites: Cysteine strongly affects the effectivities of metronidazole and auranofin, a novel and promising antimicrobial.David Leitsch International journal for parasitology. Drugs and drug resistance, 7(3), 321-327 (2017-09-15) Targeting the thioredoxin system as a novel strategy against B-cell acute lymphoblastic leukemia.Klaudyna Fidyt et al.Molecular oncology, 13(5), 1180-1195 (2019-03-13) In Vitro Investigation of Auranofin as a Treatment for Clostridium difficile Infection.Christine Roder et al.Drugs in R&D, 20(3), 209-216 (2020-05-08) A heterometallic ruthenium-gold complex displays antiproliferative, antimigratory, and antiangiogenic properties and inhibits metastasis and angiogenesis-associated proteases in renal cancer.Benelita T Elie et al.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 23(3), 399-411 (2018-03-07) A method for studies on interactions between a gold-based drug and plasma proteins based on capillary electrophoresis with inductively coupled plasma mass spectrometry detection.Tam T T N Nguyen et al.Analytical and bioanalytical chemistry, 407(28), 8497-8503 (2015-09-04) Antibacterial activity and mechanism of action of auranofin against multi-drug resistant bacterial pathogens.Shankar Thangamani et al.Scientific reports, 6, 22571-22571 (2016-03-05) Cytosolic thioredoxin reductase 1 is required for correct disulfide formation in the ER.Greg J Poet et al.The EMBO journal, 36(5), 693-702 (2017-01-18) Organogold drug Auranofin exhibits anti-melanogenic activity in B16F10 and MNT-1 melanoma cells.Shilpi Goenka et al.Archives of dermatological research, 312(3), 213-221 (2019-09-11) Antiprotozoal Activity Profiling of Approved Drugs: A Starting Point toward Drug Repositioning.Marcel Kaiser et al.PloS one, 10(8), e0135556-e0135556 (2015-08-14) Identification and binding mode of a novel Leishmania Trypanothione reductase inhibitor from high throughput screening.Lorenzo Turcano et al.PLoS neglected tropical diseases, 12(11), e0006969-e0006969 (2018-11-27) Development and validation of a Medicines Comorbidity Index for older people.Sujita W Narayan et al.European journal of clinical pharmacology, 73(12), 1665-1672 (2017-09-13) Investigation of auranofin and gold-containing analogues antibacterial activity against multidrug-resistant Neisseria gonorrhoeae.Ahmed Elkashif et al.Scientific reports, 10(1), 5602-5602 (2020-03-30) Time- and cell-resolved dynamics of redox-sensitive Nrf2, HIF and NF-κB activities in 3D spheroids enriched for cancer stem cells.Anna P Kipp et al.Redox biology, 12, 403-409 (2017-03-21) Cross-talk between Bcr-abl and the Thioredoxin System in Chronic Myeloid Leukaemia: Implications for CML Treatment.Erin Clapper et al.Antioxidants (Basel, Switzerland), 9(3) (2020-03-07) Auranofin, an inhibitor of thioredoxin reductase, induces apoptosis in hepatocellular carcinoma Hep3B cells by generation of reactive oxygen species.Hyun Hwang-Bo et al.General physiology and biophysics, 36(2), 117-128 (2017-02-22) The first wide-scale drug repurposing screen using the Prestwick Chemical Library (1200 bioactive molecules) against Neisseria gonorrhoeae identifies high in vitro activity of auranofin and many additional drugs.Sunniva Foerster et al.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 128(3), 242-250 (2019-12-08) SK channel activation potentiates auranofin-induced cell death in glio- and neuroblastoma cells.Inge E Krabbendam et al.Biochemical pharmacology, 171, 113714-113714 (2019-11-19) Auranofin Enhances Ibrutinib's Anticancer Activity in EGFR-Mutant Lung Adenocarcinoma.Jing Hu et al.Molecular cancer therapeutics, 17(10), 2156-2163 (2018-08-02) The first wide-scale drug repurposing screen using the Prestwick Chemical Library (1200 bioactive molecules) against Neisseria gonorrhoeae identifies high in vitro activity of auranofin and many additional drugs.Sunniva Foerster et al.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 128(3), 242-250 (2019-12-08) SK channel activation potentiates auranofin-induced cell death in glio- and neuroblastoma cells.Inge E Krabbendam et al.Biochemical pharmacology, 171, 113714-113714 (2019-11-19) Gold(i)-BODIPY-imidazole bimetallic complexes as new potential anti-inflammatory and anticancer trackable agents.Audrey Trommenschlager et al.Dalton transactions (Cambridge, England : 2003), 46(25), 8051-8056 (2017-06-09) ProTargetMiner as a proteome signature library of anticancer molecules for functional discovery.Amir Ata Saei et al.Nature communications, 10(1), 5715-5715 (2019-12-18) Inhibition of TXNRD or SOD1 overcomes NRF2-mediated resistance to β-lapachone.Laura Torrente et al.Redox biology, 30, 101440-101440 (2020-02-03) Repurposing of auranofin: Thioredoxin reductase remains a primary target of the drug.Xiaonan Zhang et al.Biochimie, 162, 46-54 (2019-04-05) Auranofin-mediated inhibition of PI3K/AKT/mTOR axis and anticancer activity in non-small cell lung cancer cells.Hongyu Li et al.Oncotarget, 7(3), 3548-3558 (2015-12-15) Attenuation of MUC4 potentiates the anticancer activity of auranofin via regulation of the Her2/Akt/FOXO3 pathway in ovarian cancer cells.Jun Sang Bae et al.Oncology reports, 38(4), 2417-2425 (2017-08-03) Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis.Bernadette Carroll et al.Nature communications, 9(1), 256-256 (2018-01-19) Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis.Rodrigo Romero et al.Nature medicine, 23(11), 1362-1368 (2017-10-03) The diterpenoid 7-keto-sempervirol, derived from Lycium chinense, displays anthelmintic activity against both Schistosoma mansoni and Fasciola hepatica.Jennifer Edwards et al.PLoS neglected tropical diseases, 9(3), e0003604-e0003604 (2015-03-15) Repurposing Auranofin, an Anti-Rheumatic Gold Compound, to Treat Acne Vulgaris by Targeting the NLRP3 Inflammasome.Gabsik Yang et al.Biomolecules & therapeutics, 28(5), 437-442 (2020-04-23) Auranofin Inhibits Retinal Pigment Epithelium Cell Survival through Reactive Oxygen Species-Dependent Epidermal Growth Factor Receptor/ Mitogen-Activated Protein Kinase Signaling Pathway.Xiaodong Chen et al.PloS one, 11(11), e0166386-e0166386 (2016-11-16) The L-type Voltage-Gated Calcium Channel co-localizes with Syntaxin 1A in nano-clusters at the plasma membrane.Julia Sajman et al.Scientific reports, 7(1), 11350-11350 (2017-09-14) Auranofin Rapidly Eradicates Methicillin-resistant Staphylococcus aureus (MRSA) in an Infected Pressure Ulcer Mouse Model.Haroon Mohammad et al.Scientific reports, 10(1), 7251-7251 (2020-05-01) A gold-containing drug against parasitic polyamine metabolism: the X-ray structure of trypanothione reductase from Leishmania infantum in complex with auranofin reveals a dual mechanism of enzyme inhibition.Andrea Ilari et al.Amino acids, 42(2-3), 803-811 (2011-08-13) Altered cellular redox homeostasis and redox responses under standard oxygen cell culture conditions versus physioxia.Daniel C J Ferguson et al.Free radical biology & medicine, 126, 322-333 (2018-08-25) HBEGF+ macrophages in rheumatoid arthritis induce fibroblast invasiveness.David Kuo et al.Science translational medicine, 11(491) (2019-05-10) Redox effects and cytotoxic profiles of MJ25 and auranofin towards malignant melanoma cells.Marijke C C Sachweh et al.Oncotarget, 6(18), 16488-16506 (2015-06-02) Jadomycins Inhibit Type II Topoisomerases and Promote DNA Damage and Apoptosis in Multidrug-Resistant Triple-Negative Breast Cancer Cells.Steven R Hall et al.The Journal of pharmacology and experimental therapeutics, 363(2), 196-210 (2017-09-15) Antibiofilm and antibacterial activities of repurposing auranofin against Bacteroides fragilis.Hye-In Jang et al.Archives of microbiology, 202(3), 473-482 (2019-11-11) Bcl-2/Bcl-xL inhibition predominantly synergistically enhances the anti-neoplastic activity of a low-dose CUSP9 repurposed drug regime against glioblastoma.Marc-Eric Halatsch et al.British journal of pharmacology, 176(18), 3681-3694 (2019-06-22) Blocking mitochondrial calcium release in Schwann cells prevents demyelinating neuropathies.Sergio Gonzalez et al.The Journal of clinical investigation, 126(3), 1023-1038 (2016-02-16) Cell-mediated reduction of human β-defensin 1: a major role for mucosal thioredoxin.S U Jaeger et al.Mucosal immunology, 6(6), 1179-1190 (2013-04-11) Synergistic lethality between PARP-trapping and alantolactone-induced oxidative DNA damage in homologous recombination-proficient cancer cells.Hongge Wang et al.Oncogene, 39(14), 2905-2920 (2020-02-08) Auranofin induces mesothelioma cell death through oxidative stress and GSH depletion.Bo Ra You et al.Oncology reports, 35(1), 546-551 (2015-11-05) Melanoma differentiation associated gene-7/interleukin-24 induces caspase-3 denitrosylation to facilitate the activation of cancer cell apoptosis.Hui Tian et al.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 35(3), 157-167 (2014-10-28) Auranofin is highly efficacious against Toxoplasma gondii in vitro and in an in vivo experimental model of acute toxoplasmosis.Rosa M Andrade et al.PLoS neglected tropical diseases, 8(7), e2973-e2973 (2014-08-01) Abrin immunotoxin: targeted cytotoxicity and intracellular trafficking pathway.Sudarshan Gadadhar et al.PloS one, 8(3), e58304-e58304 (2013-03-09) H2O2 metabolism in liver and heart mitochondria: Low emitting-high scavenging and high emitting-low scavenging systems.Collins Kamunde et al.Free radical biology & medicine, 124, 135-148 (2018-05-29) Auranofin promotes mitochondrial apoptosis by inducing annexin A5 expression and translocation in human prostate cancer cells.Nahee Park et al.Journal of toxicology and environmental health. Part A, 77(22-24), 1467-1476 (2014-10-25) A Flow Cytometry Method for Dissecting the Cell Differentiation Process of Entamoeba Encystation.Fumika Mi-Ichi et al.Frontiers in cellular and infection microbiology, 8, 250-250 (2018-08-09) Gold(i) phosphine compounds as parasite attenuating agents for malaria vaccine and drug development.Aloysious Ssemaganda et al.Metallomics : integrated biometal science, 10(3), 444-454 (2018-02-22) Redox Modulation and Induction of Ferroptosis as a New Therapeutic Strategy in Hepatocellular Carcinoma.Jana Lippmann et al.Translational oncology, 13(8), 100785-100785 (2020-05-18) Differential redox sensitivity of cathepsin B and L holds the key to autophagy-apoptosis interplay after Thioredoxin reductase inhibition in nutritionally stressed SH-SY5Y cells.Pandian Nagakannan et al.Free radical biology & medicine, 108, 819-831 (2017-05-10) The efficacy of a coordinated pharmacological blockade in glioblastoma stem cells with nine repurposed drugs using the CUSP9 strategy.Erlend Skaga et al.Journal of cancer research and clinical oncology, 145(6), 1495-1507 (2019-04-28) Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis.Irina Ingold et al.Cell, 172(3), 409-422 (2018-01-02) Antibacterial and antivirulence activities of auranofin against Clostridium difficile.Ahmed AbdelKhalek et al.International journal of antimicrobial agents, 53(1), 54-62 (2018-10-03) Characterization of Entamoeba histolytica adenosine 5'-phosphosulfate (APS) kinase; validation as a target and provision of leads for the development of new drugs against amoebiasis.Fumika Mi-Ichi et al.PLoS neglected tropical diseases, 13(8), e0007633-e0007633 (2019-08-20) Cystatin SN inhibits auranofin-induced cell death by autophagic induction and ROS regulation via glutathione reductase activity in colorectal cancer.Byung Moo Oh et al.Cell death & disease, 8(3), e2682-e2682 (2017-03-17) Quorum sensing N-Acyl homoserine lactones are a new class of anti-schistosomal.Helen Whiteland et al.PLoS neglected tropical diseases, 14(10), e0008630-e0008630 (2020-10-20) Securinine disturbs redox homeostasis and elicits oxidative stress-mediated apoptosis via targeting thioredoxin reductase.Junmin Zhang et al.Biochimica et biophysica acta, 1863(1), 129-138 (2016-10-30) A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target.Anjan Debnath et al.Nature medicine, 18(6), 956-960 (2012-05-23) Nicotinamide Nucleotide Transhydrogenase as a Novel Treatment Target in Adrenocortical Carcinoma.Vasileios Chortis et al.Endocrinology, 159(8), 2836-2849 (2018-06-01) Selenium-independent antioxidant and anti-inflammatory effects of thioredoxin reductase inhibition in alveolar macrophages.Sara Staples et al.Life sciences, 259, 118285-118285 (2020-08-18) Auranofin displays anticancer activity against ovarian cancer cells through FOXO3 activation independent of p53.See-Hyoung Park et al.International journal of oncology, 45(4), 1691-1698 (2014-08-07) Development and validation of a quantitative, high-throughput, fluorescent-based bioassay to detect schistosoma viability.Emily Peak et al.PLoS neglected tropical diseases, 4(7), e759-e759 (2010-07-30) Daucosterol disturbs redox homeostasis and elicits oxidative-stress mediated apoptosis in A549 cells via targeting thioredoxin reductase by a p53 dependent mechanism.Tamilselvam Rajavel et al.European journal of pharmacology, 855, 112-123 (2019-05-07) Disulfiram/copper causes redox-related proteotoxicity and concomitant heat shock response in ovarian cancer cells that is augmented by auranofin-mediated thioredoxin inhibition.Margarita Papaioannou et al.Oncoscience, 1(1), 21-29 (2015-01-17) Optimization of a High-Throughput 384-Well Plate-Based Screening Platform with Staphylococcus aureus ATCC 25923 and Pseudomonas aeruginosa ATCC 15442 Biofilms.Shella Gilbert-Girard et al.International journal of molecular sciences, 21(9) (2020-04-30) Lysine oxidase exposes a dependency on the thioredoxin antioxidant pathway in triple-negative breast cancer cells.Olga E Chepikova et al.Breast cancer research and treatment, 183(3), 549-564 (2020-07-23) Novel action and mechanism of auranofin in inhibition of vascular endothelial growth factor receptor-3-dependent lymphangiogenesis.Xiaodong Chen et al.Anti-cancer agents in medicinal chemistry, 14(7), 946-954 (2014-06-11) Development and validation of a luminescence-based, medium-throughput assay for drug screening in Schistosoma mansoni.Cristiana Lalli et al.PLoS neglected tropical diseases, 9(1), e0003484-e0003484 (2015-01-31) Curcuminoid B63 induces ROS-mediated paraptosis-like cell death by targeting TrxR1 in gastric cells.Xi Chen et al.Redox biology, 21, 101061-101061 (2018-12-28) Induction of Airway Allergic Inflammation by Hypothiocyanite via Epithelial Cells.Shoichi Suzuki et al.The Journal of biological chemistry, 291(53), 27219-27227 (2016-11-20) Evaluation of Giardia lamblia thioredoxin reductase as drug activating enzyme and as drug target.David Leitsch et al.International journal for parasitology. Drugs and drug resistance, 6(3), 148-153 (2016-10-23) Micelles based on gold-glycopolymer complexes as new chemotherapy drug delivery agents.Samuel Pearson et al.Chemical communications (Cambridge, England), 48(39), 4695-4697 (2012-04-05) TLR2 activation induces antioxidant defence in human monocyte-macrophage cell line models.Iwona Karwaciak et al.Oncotarget, 8(33), 54243-54264 (2017-09-15) Red fluorescent redox-sensitive biosensor Grx1-roCherry.Arina G Shokhina et al.Redox biology, 21, 101071-101071 (2018-12-24) Evaluation of Giardia lamblia thioredoxin reductase as drug activating enzyme and as drug target.David Leitsch et al.International journal for parasitology. Drugs and drug resistance, 6(3), 148-153 (2016-10-23) Micelles based on gold-glycopolymer complexes as new chemotherapy drug delivery agents.Samuel Pearson et al.Chemical communications (Cambridge, England), 48(39), 4695-4697 (2012-04-05) Zeta Inhibitory Peptide Disrupts Electrostatic Interactions That Maintain Atypical Protein Kinase C in Its Active Conformation on the Scaffold p62.Li-Chun Lisa Tsai et al.The Journal of biological chemistry, 290(36), 21845-21856 (2015-07-19) Targeting of the Glutathione, Thioredoxin, and Nrf2 Antioxidant Systems in Head and Neck Cancer.Jong-Lyel Roh et al.Antioxidants & redox signaling, 27(2), 106-114 (2016-10-14) Red fluorescent redox-sensitive biosensor Grx1-roCherry.Arina G Shokhina et al.Redox biology, 21, 101071-101071 (2018-12-24) A fast and specific fluorescent probe for thioredoxin reductase that works via disulphide bond cleavage.Xinming Li et al.Nature communications, 10(1), 2745-2745 (2019-06-23) Synergistic Induction of Apoptosis by the Combination of an Axl Inhibitor and Auranofin in Human Breast Cancer Cells.Yeon-Sang Ryu et al.Biomolecules & therapeutics, 28(5), 473-481 (2020-06-17) Repurposing auranofin as an intestinal decolonizing agent for vancomycin-resistant enterococci.Ahmed AbdelKhalek et al.Scientific reports, 8(1), 8353-8353 (2018-05-31) Peroxiredoxin 6 is the primary antioxidant enzyme for the maintenance of viability and DNA integrity in human spermatozoa.Maria C Fernandez et al.Human reproduction (Oxford, England) (2018-06-19) Highly tunable thiosulfonates as a novel class of cysteine protease inhibitors with anti-parasitic activity against Schistosoma mansoni.D J Ward et al.Bioorganic & medicinal chemistry, 27(13), 2857-2870 (2019-05-28) D-penicillamine combined with inhibitors of hydroperoxide metabolism enhances lung and breast cancer cell responses to radiation and carboplatin via HSebastian J Sciegienka et al.Free radical biology & medicine, 108, 354-361 (2017-04-09) Thioredoxin reductase deficiency potentiates oxidative stress, mitochondrial dysfunction and cell death in dopaminergic cells.Pamela Lopert et al.PloS one, 7(11), e50683-e50683 (2012-12-12) Auranofin Protects Intestine against Radiation Injury by Modulating p53/p21 Pathway and Radiosensitizes Human Colon Tumor.Dhrubajyoti Nag et al.Clinical cancer research : an official journal of the American Association for Cancer Research, 25(15), 4791-4807 (2019-04-04) Gold compounds as cysteine protease inhibitors: perspectives for pharmaceutical application as antiparasitic agents.Lara Massai et al.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 30(2), 313-320 (2017-03-12) Intra-membrane signaling between the voltage-gated Ca2+-channel and cysteine residues of syntaxin 1A coordinates synchronous release.Niv Bachnoff et al.Scientific reports, 3, 1620-1620 (2013-04-10) Antioxidative effects of diallyl trisulfide on hydrogen peroxide-induced cytotoxicity through regulation of nuclear factor-E2-related factor-mediated thioredoxin reductase 1 expression in C2C12 skeletal muscle myoblast cells.Ji Sook Kang et al.General physiology and biophysics, 36(2), 129-139 (2017-02-22) Leishmania donovani Encodes a Functional Selenocysteinyl-tRNA Synthase.Reetika Manhas et al.The Journal of biological chemistry, 291(3), 1203-1220 (2015-11-21) Repurposing auranofin to combat uropathogenic Escherichia coli biofilms.H-I Jang et al.Journal of applied microbiology, 127(2), 459-471 (2019-05-16) Prostaglandin D2-ethanolamide induces skin cancer apoptosis by suppressing the activity of cellular antioxidants.Ahmed E M Elhassanny et al.Prostaglandins & other lipid mediators, 142, 9-23 (2019-03-13)

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