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Peer-Reviewed Papers

Human urate transporter 1 (hURAT1) mediates the transport of orotate.Daisaku Miura et al.The journal of physiological sciences : JPS, 61(3), 253-257 (2011-02-26) Gout--is Lee's 2008 risk:benefit conclusion for benzbromarone hepatotoxicity still relevant today?Lance Gravatt The New Zealand medical journal, 126(1382), 118-119 (2013-10-25) Benzbromarone: availability for general prescribing in New Zealand (a response to letters by Dr Lance Gravatt onbenzbromarone).Richard Day et al.The New Zealand medical journal, 126(1382), 124-126 (2013-10-25) Serum CRP in patients with gout and effects of benzbromarone.C Okuda et al.International journal of clinical pharmacology and therapeutics, 49(3), 191-197 (2011-02-19) [Impact of serum uric acid level on the cardiovascular system as a risk factor].Ichiro Hisatome Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 136(6), 325-329 (2010-12-09) Potent human uric acid transporter 1 inhibitors: in vitro and in vivo metabolism and pharmacokinetic studies.Michael F Wempe et al.Drug design, development and therapy, 6, 323-339 (2012-11-16) Benzbromarone stabilizes ΔF508 CFTR at the cell surface.Tip W Loo et al.Biochemistry, 50(21), 4393-4395 (2011-04-28) The EYA tyrosine phosphatase activity is pro-angiogenic and is inhibited by benzbromarone.Emmanuel Tadjuidje et al.PloS one, 7(4), e34806-e34806 (2012-05-01) Anti-inflammatory and immunomodulatory effects of iridoid glycosides from Paederia scandens (LOUR.) MERRILL (Rubiaceae) on uric acid nephropathy rats.Wenjing Zhu et al.Life sciences, 91(11-12), 369-376 (2012-08-23) Relationship between serum allantoin and urate in healthy subjects and effects of benzbromarone in gout patients.Masafumi Kurajoh et al.International journal of clinical pharmacology and therapeutics, 50(4), 265-271 (2012-03-30) Efficacy of benzbromarone in hyperuricemic patients associated with chronic kidney disease.S Fujimori et al.Nucleosides, nucleotides & nucleic acids, 30(12), 1035-1038 (2011-12-03) A high throughput in vitro mrp2 assay to predict in vivo biliary excretion.Federico Colombo et al.Xenobiotica; the fate of foreign compounds in biological systems, 42(2), 157-163 (2011-10-04) CYP2C9-mediated metabolic activation of losartan detected by a highly sensitive cell-based screening assay.Atsushi Iwamura et al.Drug metabolism and disposition: the biological fate of chemicals, 39(5), 838-846 (2011-02-16) [Treatment of hyperuricemia and gout based on the guideline for the management of hyperuricemia and gout].Atsuo Taniguchi Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 136(6), 330-334 (2010-12-09) Giant tophi in the calf.Jsun-Liang Kao et al.Internal medicine (Tokyo, Japan), 51(3), 335-336 (2012-02-02) [Drug-induced hepatic injury, the challenge for cause investigation].Kazuhiko Matsumoto Rinsho byori. The Japanese journal of clinical pathology, 59(12), 1117-1122 (2012-02-22) [A case of fulminant hepatitis, possibly caused by benzbromarone].T Suzuki et al.Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 98(4), 421-425 (2001-06-13) Interactions of urate transporter URAT1 in human kidney with uricosuric drugs.Ho Jung Shin et al.Nephrology (Carlton, Vic.), 16(2), 156-162 (2011-01-29) Use of uric acid-lowering agents limits experimental cyclosporine nephropathy.Fernanda Cristina Mazali et al.Nephron. Experimental nephrology, 120(1), e12-e19 (2011-12-01) Corrector-mediated rescue of misprocessed CFTR mutants can be reduced by the P-glycoprotein drug pump.Tip W Loo et al.Biochemical pharmacology, 83(3), 345-354 (2011-12-06) Hepatocellular toxicity of benzbromarone: effects on mitochondrial function and structure.Andrea Felser et al.Toxicology, 324, 136-146 (2014-08-12) [Clinical strategies for prevention of drug-induced urinary calculi].Yasuo Kohjimoto et al.Clinical calcium, 21(10), 1457-1463 (2011-10-01) Is hyperuricemia a risk factor for arteriosclerosis? Uric acid and arteriosclerosis in apolipoprotein e-deficient mice.Hirokazu Wakuda et al.Biological & pharmaceutical bulletin, 37(12), 1866-1871 (2014-12-03) Intrabony tibial tophi in chronic gout.Cristóbal M Rodríguez Leal et al.Reumatologia clinica, 8(5), 294-297 (2012-01-10) Direct radical scavenging activity of benzbromarone provides beneficial antioxidant properties for hyperuricemia treatment.Daisuke Kadowaki et al.Biological & pharmaceutical bulletin, 38(3), 487-492 (2015-03-12) [Assessment on the clinical efficacy and safety of xiezhuo chubi recipe in treating hyperuricemia].Xian-xian Zhang et al.Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 31(9), 1216-1219 (2011-10-22) [Benzbromarone in the treatment of gout].E Kawenoki-Minc et al.Reumatologia, 18(1), 61-67 (1980-01-01) Metabolism studies of benzbromarone in rats by high performance liquid chromatography-quadrupole time of flight mass spectrometry.Haiqing Wu et al.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 911, 122-132 (2012-12-12) Resolution of massive tophaceous gout with three urate-lowering drugs.Carlos Mejía-Chew et al.The American journal of medicine, 126(11), e9-10 (2013-08-28) The uric acid transporter SLC2A9 is a direct target gene of the tumor suppressor p53 contributing to antioxidant defense.Y Itahana et al.Oncogene, 34(14), 1799-1810 (2014-05-27) Benzbromarone: a double-edged sword that cuts the liver?Bernhard Haring et al.European journal of gastroenterology & hepatology, 25(1), 119-121 (2012-12-01) [Gout - regardless of therapeutic options a "forgotten" disease].U Müller-Ladner et al.Deutsche medizinische Wochenschrift (1946), 136(33), 1660-1664 (2011-08-13) Benzbromarone: a review of its pharmacological properties and therapeutic use in gout and hyperuricaemia.R C Heel et al.Drugs, 14(5), 349-366 (1977-11-01) Functional expression of the TMEM16 family of calcium-activated chloride channels in airway smooth muscle.George Gallos et al.American journal of physiology. Lung cellular and molecular physiology, 305(9), L625-L634 (2013-09-03) The vesicular transport assay: validated in vitro methods to study drug-mediated inhibition of canalicular efflux transporters ABCB11/BSEP and ABCC2/MRP2.Krisztina Herédi-Szabó et al.Current protocols in toxicology, Chapter 23, Unit 23-Unit 23 (2012-11-22) Post-acquisition analysis of untargeted accurate mass quadrupole time-of-flight MS(E) data for multiple collision-induced neutral losses and fragment ions of glutathione conjugates.Andreas Brink et al.Rapid communications in mass spectrometry : RCM, 28(24), 2695-2703 (2014-11-08) A benefit-risk assessment of benzbromarone in the treatment of gout. Was its withdrawal from the market in the best interest of patients?Ming-Han H Lee et al.Drug safety, 31(8), 643-665 (2008-07-19) Identification of CYP isozymes involved in benzbromarone metabolism in human liver microsomes.Kaoru Kobayashi et al.Biopharmaceutics & drug disposition, 33(8), 466-473 (2012-08-31) Effects of chicory inulin on serum metabolites of uric acid, lipids, glucose, and abdominal fat deposition in quails induced by purine-rich diets.Zhijian Lin et al.Journal of medicinal food, 17(11), 1214-1221 (2014-10-15)

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