Melting point	851 ºC
Water Solubility	22 g/100 mL (20 ºC)
Boiling point	1600 ºC
Density	2.53

Symbol(GHS)	Xi
Hazard Codes	R36
SDS/MSDS	S22;S26

Source	SDS/MSDS Samples
Alfa-Aesar	View & Download
Sigma-Aldrich	View & Download
Acros-Organics	View & Download

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Peer-Reviewed Papers

Comparative study of systemic psoralen and ultraviolet A and narrowband ultraviolet B in treatment of chronic urticaria.Naziha Hafez Khafagy et al.Photodermatology, photoimmunology & photomedicine, 29(1), 12-17 (2013-01-04) Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.E Fontana et al.Current drug metabolism, 6(5), 413-454 (2005-10-27) Systematic review of combination therapies for mycosis fungoides.Daniel Humme et al.Cancer treatment reviews, 40(8), 927-933 (2014-07-07) Early viral protein synthesis is necessary for NF-kappaB activation in modified vaccinia Ankara (MVA)-infected 293 T fibroblast cells.Stefani Martin et al.Virology, 390(2), 298-306 (2009-06-23) Sequence of pathogenic events in cynomolgus macaques infected with aerosolized monkeypox virus.J A Tree et al.Journal of virology, 89(8), 4335-4344 (2015-02-06) Virtual screening against nuclear factor κB (NF-κB) of a focus library: Identification of bioactive furocoumarin derivatives inhibiting NF-κB dependent biological functions involved in cystic fibrosis.Laura Piccagli et al.Bioorganic & medicinal chemistry, 18(23), 8341-8349 (2010-10-29) Inhibitors of mitochondrial Kv1.3 channels induce Bax/Bak-independent death of cancer cells.Luigi Leanza et al.EMBO molecular medicine, 4(7), 577-593 (2012-04-13) Fanconi anemia group J helicase and MRE11 nuclease interact to facilitate the DNA damage response.Avvaru N Suhasini et al.Molecular and cellular biology, 33(11), 2212-2227 (2013-03-27) RNA structure analysis of human spliceosomes reveals a compact 3D arrangement of snRNAs at the catalytic core.Maria Anokhina et al.The EMBO journal, 32(21), 2804-2818 (2013-09-05) 7',8'-Dihydroobolactone, a typanocidal alpha-pyrone from the rainforest tree Cryptocarya obovata.Rohan A Davis et al.Bioorganic & medicinal chemistry letters, 20(14), 4057-4059 (2010-06-19) Psoralen induced liver injury by attenuating liver regenerative capabilityZhou W, et al. Frontiers in Pharmacology, 9, 1179-1179 (2018) In vitro responses of fish melanophores to lyophilized extracts of Psoralea corylifolia seeds and pure psoralenAli SA, et al. Pharmaceutical biology, 49(4), 422-427 (2011) Rotavirus increases levels of lipidated LC3 supporting accumulation of infectious progeny virus without inducing autophagosome formation.Francesca Arnoldi et al.PloS one, 9(4), e95197-e95197 (2014-04-17) Effect of polyamines on shoot multiplication and furanocoumarin production in Ruta graveolens cultures.Renuka Diwan et al.Natural product communications, 7(7), 895-898 (2012-08-23) RNF4-mediated polyubiquitination regulates the Fanconi anemia/BRCA pathway.Jenny Xie et al.The Journal of clinical investigation, 125(4), 1523-1532 (2015-03-10) Killed but metabolically active vaccines.Thomas W Dubensky et al.Current opinion in biotechnology, 23(6), 917-923 (2012-05-23) Psoralen and ultraviolet a light therapy for psoriasis.Robert S Stern The New England journal of medicine, 357(7), 682-690 (2007-08-19) Application of the equivalency factor concept to the phototoxicity and -genotoxicity of furocoumarin mixtures.Nicole Raquet et al.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 68, 257-266 (2014-04-01) Fundamentals of the psoralen-based Helinx technology for inactivation of infectious pathogens and leukocytes in platelets and plasma.S Wollowitz Seminars in hematology, 38(4 Suppl 11), 4-11 (2001-12-01) Acquired dermal melanocytosis induced by psoralen plus ultraviolet A therapy.Kotaro Nagase et al.Acta dermato-venereologica, 92(6), 691-692 (2012-02-02) Permanent scalp alopecia related to breast cancer chemotherapy by sequential fluorouracil/epirubicin/cyclophosphamide (FEC) and docetaxel: a prospective study of 20 patients.N Kluger et al.Annals of oncology : official journal of the European Society for Medical Oncology, 23(11), 2879-2884 (2012-05-11) Treatment of pustular psoriasis: from the Medical Board of the National Psoriasis Foundation.Amanda Robinson et al.Journal of the American Academy of Dermatology, 67(2), 279-288 (2012-05-23) [Study on the chemical constituents of Psoralea corylifolia].Rong-Li Qiu et al.Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 34(8), 1211-1213 (2012-01-12) Transcription-dependent dynamic supercoiling is a short-range genomic force.Fedor Kouzine et al.Nature structural & molecular biology, 20(3), 396-403 (2013-02-19) In vivo mapping of nucleosomes using psoralen-DNA crosslinking and primer extension.R E Wellinger et al.Methods in molecular biology (Clifton, N.J.), 119, 161-173 (2000-05-11) Psoralen reverses docetaxel-induced multidrug resistance in A549/D16 human lung cancer cells lines.Ming-Ju Hsieh et al.Phytomedicine : international journal of phytotherapy and phytopharmacology, 21(7), 970-977 (2014-04-08) Furanocoumarins: novel topoisomerase I inhibitors from Ruta graveolens L.Renuka Diwan et al.Bioorganic & medicinal chemistry, 17(19), 7052-7055 (2009-09-09) Assessment of a candidate marker constituent predictive of a dietary substance-drug interaction: case study with grapefruit juice and CYP3A4 drug substrates.Garrett R Ainslie et al.The Journal of pharmacology and experimental therapeutics, 351(3), 576-584 (2014-09-26) Efficacy and safety of non-laser, targeted UVB phototherapy alone and in combination with psoralen gel or calcipotriol ointment in the treatment of localized, chronic, plaque-type psoriasis.Ilker Ozkan et al.International journal of dermatology, 51(5), 609-613 (2012-04-21) Prolonged antigen presentation following an acute virus infection requires direct and then cross-presentation.Erica L Heipertz et al.Journal of immunology (Baltimore, Md. : 1950), 193(8), 4169-4177 (2014-09-17) The mitochondrial effects of novel apoptogenic molecules generated by psoralen photolysis as a crucial mechanism in PUVA therapyCaffieri S, et al. Blood, 109(11), 4988-4994 (2007) Biochemical aspects of psoralen photochemotherapy.A C Moor et al.Clinics in dermatology, 14(4), 353-365 (1996-07-01) Bypass of a psoralen DNA interstrand cross-link by DNA polymerases β, ι, and κ in vitro.Leigh A Smith et al.Biochemistry, 51(44), 8931-8938 (2012-10-31) miR-TRAP: a benchtop chemical biology strategy to identify microRNA targets.Huricha Baigude et al.Angewandte Chemie (International ed. in English), 51(24), 5880-5883 (2012-05-09) Mitochondrial DNA replication proceeds via a 'bootlace' mechanism involving the incorporation of processed transcripts.Aurelio Reyes et al.Nucleic acids research, 41(11), 5837-5850 (2013-04-19) The contribution of medical physics to the development of psoralen photochemotherapy (PUVA) in the UK: a personal reminiscence.Brian Diffey Physics in medicine and biology, 51(13), R229-R244 (2006-06-23) Structural modification of a specific antimicrobial lead against Helicobacter pylori discovered from traditional Chinese medicine and a structure-activity relationship study.Bang-Le Zhang et al.European journal of medicinal chemistry, 45(11), 5258-5264 (2010-09-14) Psoralen plus long-wave UV-A (PUVA) and bexarotene therapy: An effective and synergistic combined adjunct to therapy for patients with advanced cutaneous T-cell lymphoma.Karen S McGinnis et al.Archives of dermatology, 139(6), 771-775 (2003-06-18) Psoralen phototoxicity: correlation with serum and epidermal 8-methoxypsoralen and 5-methoxypsoralen in the guinea pig.A Kornhauser et al.Science (New York, N.Y.), 217(4561), 733-735 (1982-08-20) Development of a novel furocoumarin derivative inhibiting NF-κB dependent biological functions: design, synthesis and biological effects.Monica Borgatti et al.European journal of medicinal chemistry, 46(10), 4870-4877 (2011-08-26) Synthesis and photochemotherapeutic activity of thiopyrano[2,3-e]indol-2-ones.Paola Barraja et al.Bioorganic & medicinal chemistry letters, 15(9), 2291-2294 (2005-04-20) Kv1.3 channels as a potential target for immunomodulation of CD4+ CD28null T cells in patients with acute coronary syndrome.Rende Xu et al.Clinical immunology (Orlando, Fla.), 142(2), 209-217 (2011-12-16) Psoralen and ultraviolet a light treatment directly affects phosphatidylinositol 3-kinase signal transduction by altering plasma membrane packingVan Aelst B, et al. The Journal of Biological Chemistry, 291(47), 24364-24376 (2016) Diffuse cutaneous mastocytosis treated with psoralen photochemotherapy: case report and review of the literature.V A Kinsler et al.The British journal of dermatology, 152(1), 179-180 (2005-01-20) Scoring function for DNA-drug docking of anticancer and antiparasitic compounds based on spectral moments of 2D lattice graphs for molecular dynamics trajectories.Lázaro G Pérez-Montoto et al.European journal of medicinal chemistry, 44(11), 4461-4469 (2009-07-17) Inhibition of human aldehyde oxidase activity by diet-derived constituents: structural influence, enzyme-ligand interactions, and clinical relevance.John T Barr et al.Drug metabolism and disposition: the biological fate of chemicals, 43(1), 34-41 (2014-10-19) The RecQ helicase RECQL5 participates in psoralen-induced interstrand cross-link repair.Mahesh Ramamoorthy et al.Carcinogenesis, 34(10), 2218-2230 (2013-05-30) c-MYC coordinately regulates ribosomal gene chromatin remodeling and Pol I availability during granulocyte differentiation.Gretchen Poortinga et al.Nucleic acids research, 39(8), 3267-3281 (2010-12-24) Psoralen stimulates osteoblast proliferation through the activation of nuclear factor-kappaB-mitogen-activated protein kinase signalingLi F, et al. Experimental and Therapeutic Medicine, 14(3), 2385-2391 (2017) Photo(chemo)therapy reduces circulating Th17 cells and restores circulating regulatory T cells in psoriasis.Takuya Furuhashi et al.PloS one, 8(1), e54895-e54895 (2013-02-01) Phototherapy for pityriasis lichenoides: our experience.Vasco Coelho Macias et al.Cutaneous and ocular toxicology, 32(2), 124-127 (2012-09-15) Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells.Ralph Zellweger et al.The Journal of cell biology, 208(5), 563-579 (2015-03-04) Markedly reduced incidence of melanoma and nonmelanoma skin cancer in a nonconcurrent cohort of 10,040 patients with vitiligo.Andrea Paradisi et al.Journal of the American Academy of Dermatology, 71(6), 1110-1116 (2014-09-23) The osteoprotective effect of psoralen in ovariectomy-induced osteoporotic rats via stimulating the osteoblastic differentiation from bone mesenchymal stem cells.Zhu Yang et al.Menopause (New York, N.Y.), 19(10), 1156-1164 (2012-07-12) Ruta graveolens extracts and metabolites against Spodoptera frugiperdaAyil-Gutierrez B, et al. Natural Product Communications, 10(11), 1934578X1501001137-1934578X1501001137 (2015) The melanocortin 1 receptor (MC1R) inhibits the inflammatory response in Raw 264.7 cells and atopic dermatitis (AD) mouse model.Wei Chen et al.Molecular biology reports, 40(2), 1987-1996 (2012-10-24) Structure-activity relationships for naturally occurring coumarins as β-secretase inhibitor.Shinsuke Marumoto et al.Bioorganic & medicinal chemistry, 20(2), 784-788 (2012-01-10) DNA interstrand crosslinks induce a potent replication block followed by formation and repair of double strand breaks in intact mammalian cells.Daniel Vare et al.DNA repair, 11(12), 976-985 (2012-10-27) Accumulation of furanocoumarins by Bituminaria bituminosa in relation to plant development and environmental stress.David J Walker et al.Plant physiology and biochemistry : PPB, 54, 133-139 (2012-03-31) Psoralen plus UVA (PUVA) induced premature senescence as a model for stress-induced premature senescence.Wenjian Ma et al.Experimental gerontology, 37(10-11), 1197-1201 (2002-12-10) A method for in situ localization of single-strand and double-strand RNA elements contained in the hepatitis C virus genome 3?-untranslated regionRance E, et al. advanced techniques in biology & medicine, 4, 171-183 (2016) Molecular aspects of drug photosensitivity with special emphasis on psoralen photosensitization reaction.M A Pathak Journal of the National Cancer Institute, 69(1), 163-170 (1982-07-01) Fig leaf extract and its bioactive compound psoralen induces skin darkening effect in reptilian melanophores via cholinergic receptor stimulation.Keisham V Meitei et al.In vitro cellular & developmental biology. Animal, 48(6), 335-339 (2012-06-19) Psoralen and isopsoralen ameliorate sex hormone deficiency-induced osteoporosis in female and male miceYuan X, et al. BioMed Research International, 2016 (2016) [Kinetic study on pyrolysis of psoralen].Haiyan Fan et al.Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 37(2), 207-211 (2012-06-29) Ruta graveolens Extracts and Metabolites against Spodoptera frugiperda.Benjamin A Ayil-Gutiérrez et al.Natural product communications, 10(11), 1955-1958 (2016-01-12) Psoralen photochemotherapy, clinical efficacy, and photomutagenicity: the role of molecular epidemiology in minimizing risks.F P Gasparro et al.Environmental and molecular mutagenesis, 31(2), 105-112 (1998-04-17) Inefficient Codon Usage Impairs mRNA Accumulation: the Case of the v-FLIP Gene of Kaposi's Sarcoma-Associated Herpesvirus.Priya Bellare et al.Journal of virology, 89(14), 7097-7107 (2015-05-01) Psoralen ultraviolet A therapy in 2004.Warwick L Morison Photodermatology, photoimmunology & photomedicine, 20(6), 315-320 (2004-11-10) Psoralen photochemotherapy.P B McClelland et al.Dermatology nursing, 9(6), 403-415 (1998-02-14) Iatrogenic skin cancer: induction by psoralen/ultraviolet A and immunosuppression of organ transplant recipients.K E McKenna Photodermatology, photoimmunology & photomedicine, 20(6), 289-296 (2004-11-10) DNA interstrand cross-links induced by psoralen are not repaired in mammalian mitochondria.C Cullinane et al.Cancer research, 58(7), 1400-1404 (1998-04-16) Preparation of DNA-polyintercalator conjugate and its functional property.Masanori Yamada et al.International journal of biological macromolecules, 51(3), 215-220 (2012-05-29) NEIL1 responds and binds to psoralen-induced DNA interstrand crosslinks.Daniel R McNeill et al.The Journal of biological chemistry, 288(18), 12426-12436 (2013-03-20)

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