没有数据	没有数据

Symbol(GHS)	Xn;N
Hazard Codes	R20/21/22;R38;R43;R50/53
SDS/MSDS	S36/37/39;S46;S60;S61

Source	SDS/MSDS Samples
Sigma-Aldrich	View & Download
Accu-Standard	View & Download
Matrix	View & Download

Synthetic Route

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Peer-Reviewed Papers

USP47 is a deubiquitylating enzyme that regulates base excision repair by controlling steady-state levels of DNA polymerase β.Jason L Parsons et al.Molecular cell, 41(5), 609-615 (2011-03-03) Purification, cDNA cloning, and gene mapping of the small subunit of human DNA polymerase epsilon.Y Li et al.The Journal of biological chemistry, 272(51), 32337-32344 (1998-01-24) Early-onset familial parkinsonism due to POLG mutations.Guido Davidzon et al.Annals of neurology, 59(5), 859-862 (2006-04-25) Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen.Li Liu et al.The Journal of biological chemistry, 278(12), 10041-10047 (2003-01-11) HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins.R A Poot et al.The EMBO journal, 19(13), 3377-3387 (2000-07-06) Dendrite complexity of sympathetic neurons is controlled during postnatal development by BMP signaling.Afsaneh Majdazari et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(38), 15132-15144 (2013-09-21) Novel inhibition of archaeal family-D DNA polymerase by uracil.Tomas T Richardson et al.Nucleic acids research, 41(7), 4207-4218 (2013-02-15) Handling the 3-methylcytosine lesion by six human DNA polymerases members of the B-, X- and Y-families.Antonia Furrer et al.Nucleic acids research, 42(1), 553-566 (2013-10-08) POLG mutations in neurodegenerative disorders with ataxia but no muscle involvement.G Van Goethem et al.Neurology, 63(7), 1251-1257 (2004-10-13) Roles of PCNA ubiquitination and TLS polymerases κ and η in the bypass of methyl methanesulfonate-induced DNA damage.Niek Wit et al.Nucleic acids research, 43(1), 282-294 (2014-12-17) Mitochondrial 8-oxoguanine glycosylase decreases mitochondrial fragmentation and improves mitochondrial function in H9C2 cells under oxidative stress conditions.Moises Torres-Gonzalez et al.American journal of physiology. Cell physiology, 306(3), C221-C229 (2013-12-07) Single-molecule DNA repair in live bacteria.Stephan Uphoff et al.Proceedings of the National Academy of Sciences of the United States of America, 110(20), 8063-8068 (2013-05-01) Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans.M Barbulescu et al.Current biology : CB, 9(16), 861-868 (1999-09-02) Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon.Y Li et al.The Journal of biological chemistry, 275(30), 23247-23252 (2000-05-10) Characterization of the metal ion binding helix-hairpin-helix motifs in human DNA polymerase beta by X-ray structural analysis.H Pelletier et al.Biochemistry, 35(39), 12778-12787 (1996-10-01) Sequence of human DNA polymerase beta mRNA obtained through cDNA cloning.D N SenGupta et al.Biochemical and biophysical research communications, 136(1), 341-347 (1986-04-14) POLG mutations and Alpers syndrome.Guido Davidzon et al.Annals of neurology, 57(6), 921-923 (2005-06-02) Autosomal recessive mitochondrial ataxic syndrome due to mitochondrial polymerase gamma mutations.S Winterthun et al.Neurology, 64(7), 1204-1208 (2005-04-13) The DNA sequence and analysis of human chromosome 14.Roland Heilig et al.Nature, 421(6923), 601-607 (2003-01-01) TRIP/NOPO E3 ubiquitin ligase promotes ubiquitylation of DNA polymerase η.Heather A Wallace et al.Development (Cambridge, England), 141(6), 1332-1341 (2014-02-21) High-efficiency cloning of full-length cDNA.H Okayama et al.Molecular and cellular biology, 2(2), 161-170 (1982-02-01) Parkinsonism, premature menopause, and mitochondrial DNA polymerase gamma mutations: clinical and molecular genetic study.Petri Luoma et al.Lancet (London, England), 364(9437), 875-882 (2004-09-08) Alternative splicing, genomic structure, and fine chromosome localization of REV3L.C Morelli et al.Cytogenetics and cell genetics, 83(1-2), 18-20 (1999-02-02) PrimPol, an archaic primase/polymerase operating in human cells.Sara García-Gómez et al.Molecular cell, 52(4), 541-553 (2013-11-12) PrimPol bypasses UV photoproducts during eukaryotic chromosomal DNA replication.Julie Bianchi et al.Molecular cell, 52(4), 566-573 (2013-11-26) Mutations of mitochondrial DNA polymerase gammaA are a frequent cause of autosomal dominant or recessive progressive external ophthalmoplegia.Eleonora Lamantea et al.Annals of neurology, 52(2), 211-219 (2002-09-05) Human DNA polymerase kappa bypasses and extends beyond thymine glycols during translesion synthesis in vitro, preferentially incorporating correct nucleotides.Paula L Fischhaber et al.The Journal of biological chemistry, 277(40), 37604-37611 (2002-07-30) Proofreading exonuclease on a tether: the complex between the E. coli DNA polymerase III subunits α, epsilon, θ and β reveals a highly flexible arrangement of the proofreading domain.Kiyoshi Ozawa et al.Nucleic acids research, 41(10), 5354-5367 (2013-04-13) Involvement of DNA polymerase mu in the repair of a specific subset of DNA double-strand breaks in mammalian cells.Jean-Pascal Capp et al.Nucleic acids research, 35(11), 3551-3560 (2007-05-08) A novel polymerase gamma mutation in a family with ophthalmoplegia, neuropathy, and Parkinsonism.Michelangelo Mancuso et al.Archives of neurology, 61(11), 1777-1779 (2004-11-10) The human specialized DNA polymerases and non-B DNA: vital relationships to preserve genome integrity.Anne-Sophie Boyer et al.Journal of molecular biology, 425(23), 4767-4781 (2013-10-08) Sequence-controlled polymers.Jean-François Lutz et al.Science (New York, N.Y.), 341(6146), 1238149-1238149 (2013-08-10) Genomes and G-quadruplexes: for better or for worse.Madalena Tarsounas et al.Journal of molecular biology, 425(23), 4782-4789 (2013-10-01) The history and advances of reversible terminators used in new generations of sequencing technology.Fei Chen et al.Genomics, proteomics & bioinformatics, 11(1), 34-40 (2013-02-19) Human mitochondrial DNA polymerase holoenzyme: reconstitution and characterization.A A Johnson et al.Biochemistry, 39(7), 1702-1708 (2000-02-26) [Effect of Mn(II) on the error-prone DNA polymerase iota activity in extracts from human normal and tumor cells].A V Lakhin et al.Molekuliarnaia genetika, mikrobiologiia i virusologiia, (1)(1), 14-20 (2013-06-22) Novel POLG mutations in progressive external ophthalmoplegia mimicking mitochondrial neurogastrointestinal encephalomyopathy.Gert Van Goethem et al.European journal of human genetics : EJHG, 11(7), 547-549 (2003-06-26) PPL2 translesion polymerase is essential for the completion of chromosomal DNA replication in the African trypanosome.Sean G Rudd et al.Molecular cell, 52(4), 554-565 (2013-11-26) The active site of TthPolX is adapted to prevent 8-oxo-dGTP misincorporation.Patricia Garrido et al.Nucleic acids research, 42(1), 534-543 (2013-10-03) The human DNA polymerase beta gene structure. Evidence of alternative splicing in gene expression.Y J Chyan et al.Nucleic acids research, 22(14), 2719-2725 (1994-07-25) Archaeal DNA polymerase D but not DNA polymerase B is required for genome replication in Thermococcus kodakarensis.Lubomira Cubonová et al.Journal of bacteriology, 195(10), 2322-2328 (2013-03-19) Extensive intracranial calcifications in a patient with a novel polymerase γ-1 mutation.Christos Sidiropoulos et al.Neurology, 81(2), 197-198 (2013-07-10) Functional association of poly(ADP-ribose) polymerase with DNA polymerase alpha-primase complex: a link between DNA strand break detection and DNA replication.F Dantzer et al.Nucleic acids research, 26(8), 1891-1898 (1998-06-06) Replication by human DNA polymerase-iota occurs by Hoogsteen base-pairing.Deepak T Nair et al.Nature, 430(6997), 377-380 (2004-07-16) BRCT domain-containing protein TopBP1 functions in DNA replication and damage response.M Mäkiniemi et al.The Journal of biological chemistry, 276(32), 30399-30406 (2001-06-08) A direct proofreader-clamp interaction stabilizes the Pol III replicase in the polymerization mode.Slobodan Jergic et al.The EMBO journal, 32(9), 1322-1333 (2013-02-26) Polymerase mu is a DNA-directed DNA/RNA polymerase.Stephanie A Nick McElhinny et al.Molecular and cellular biology, 23(7), 2309-2315 (2003-03-18) The helicase FBH1 is tightly regulated by PCNA via CRL4(Cdt2)-mediated proteolysis in human cells.Agathe Bacquin et al.Nucleic acids research, 41(13), 6501-6513 (2013-05-17) The error-prone DNA polymerase ι provides quantitative resistance to lung tumorigenesis and mutagenesis in mice.M Iguchi et al.Oncogene, 33(27), 3612-3617 (2013-08-21) Association of novel POLG mutations and multiple mitochondrial DNA deletions with variable clinical phenotypes in a Spanish population.Emiliano González-Vioque et al.Archives of neurology, 63(1), 107-111 (2006-01-13) CAPNS1 regulates USP1 stability and maintenance of genome integrity.Francesca Cataldo et al.Molecular and cellular biology, 33(12), 2485-2496 (2013-04-17) Rapid detection of HIV-1 proviral DNA for early infant diagnosis using recombinase polymerase amplification.David S Boyle et al.mBio, 4(2), doi:10-doi:10 (2013-04-04) The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta.C Masutani et al.Nature, 399(6737), 700-704 (1999-06-29) Molecular pathogenesis of polymerase γ-related neurodegeneration.Charalampos Tzoulis et al.Annals of neurology, 76(1), 66-81 (2014-05-21) T-antigen-DNA polymerase alpha complex implicated in simian virus 40 DNA replication.S T Smale et al.Molecular and cellular biology, 6(11), 4077-4087 (1986-11-01) Human DNA polymerase lambda diverged in evolution from DNA polymerase beta toward specific Mn(++) dependence: a kinetic and thermodynamic study.Giuseppina Blanca et al.Biochemistry, 42(24), 7467-7476 (2003-06-18) A quantitative atlas of mitotic phosphorylation.Noah Dephoure et al.Proceedings of the National Academy of Sciences of the United States of America, 105(31), 10762-10767 (2008-08-02) [Mitochondria, oxidative stress and aging].András Szarka et al.Orvosi hetilap, 155(12), 447-452 (2014-03-19) Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.Viveka Mayya et al.Science signaling, 2(84), ra46-ra46 (2009-08-20) A tumor necrosis factor alpha- and interleukin 6-inducible protein that interacts with the small subunit of DNA polymerase delta and proliferating cell nuclear antigen.H He et al.Proceedings of the National Academy of Sciences of the United States of America, 98(21), 11979-11984 (2001-10-11) Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'.Thomas E Mullen et al.Genes & development, 22(1), 50-65 (2008-01-04) Genomic structure, chromosomal localization and identification of mutations in the xeroderma pigmentosum variant (XPV) gene.M Yuasa et al.Oncogene, 19(41), 4721-4728 (2000-10-14) Yeast cells expressing the human mitochondrial DNA polymerase reveal correlations between polymerase fidelity and human disease progression.Yufeng Qian et al.The Journal of biological chemistry, 289(9), 5970-5985 (2014-01-09) Fatal congenital myopathy and gastrointestinal pseudo-obstruction due to POLG1 mutations.C Giordano et al.Neurology, 72(12), 1103-1105 (2009-03-25) 5'-Deoxyribose phosphate lyase activity of human DNA polymerase iota in vitro.K Bebenek et al.Science (New York, N.Y.), 291(5511), 2156-2159 (2001-03-17) Mitochondrial DNA polymerase W748S mutation: a common cause of autosomal recessive ataxia with ancient European origin.Anna H Hakonen et al.American journal of human genetics, 77(3), 430-441 (2005-08-05) Arginine methylation regulates DNA polymerase beta.Nazim El-Andaloussi et al.Molecular cell, 22(1), 51-62 (2006-04-08) Genomic assay reveals tolerance of DNA damage by both translesion DNA synthesis and homology-dependent repair in mammalian cells.Lior Izhar et al.Proceedings of the National Academy of Sciences of the United States of America, 110(16), E1462-E1469 (2013-03-27) The DNA sequence of the human X chromosome.Mark T Ross et al.Nature, 434(7031), 325-337 (2005-03-18) Mutations in human DNA polymerase eta motif II alter bypass of DNA lesions.E Glick et al.The EMBO journal, 20(24), 7303-7312 (2001-12-18) Catalytic center of DNA polymerase beta for excision of deoxyribose phosphate groups.Y Matsumoto et al.Biochemistry, 37(18), 6456-6464 (1998-06-13) Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination.Pedro A Mateos-Gomez et al.Nature, 518(7538), 254-257 (2015-02-03) Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.S Wiemann et al.Genome research, 11(3), 422-435 (2001-03-07) Primary structure of the catalytic subunit of human DNA polymerase delta and chromosomal location of the gene.D W Chung et al.Proceedings of the National Academy of Sciences of the United States of America, 88(24), 11197-11201 (1991-12-15) Comparison of six commercially-available DNA polymerases for direct PCR.Masashi Miura et al.Revista do Instituto de Medicina Tropical de Sao Paulo, 55(6), 401-406 (2013-11-12) [The effect of Luteococcus japonicus subsp. Casei reactivating factor on the expression of SOS response genes].N G Loĭko et al.Mikrobiologiia, 82(2), 139-146 (2013-07-03) Elucidation of kinetic mechanisms of human translesion DNA polymerase κ using tryptophan mutants.Linlin Zhao et al.The FEBS journal, 281(19), 4394-4410 (2014-07-30) Rpd3- and spt16-mediated nucleosome assembly and transcriptional regulation on yeast ribosomal DNA genes.Joseph M Johnson et al.Molecular and cellular biology, 33(14), 2748-2759 (2013-05-22) Structural organization and splice variants of the POLE1 gene encoding the catalytic subunit of human DNA polymerase epsilon.D Huang et al.The Biochemical journal, 339 ( Pt 3), 657-665 (1999-04-24) Two novel human and mouse DNA polymerases of the polX family.S Aoufouchi et al.Nucleic acids research, 28(18), 3684-3693 (2000-09-13) DNA repair: Familiar ends with alternative endings.Nam Woo Cho et al.Nature, 518(7538), 174-176 (2015-02-03) How DNA polymerases catalyze DNA replication, repair, and mutation.Ming-Daw Tsai Biochemistry, 53(17), 2749-2751 (2014-04-11) Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.Sharon Gauci et al.Analytical chemistry, 81(11), 4493-4501 (2009-05-06) Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair.Raphael Ceccaldi et al.Nature, 518(7538), 258-262 (2015-02-03) Nick translation.J Meinkoth et al.Methods in enzymology, 152, 91-94 (1987-01-01) System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.Kristoffer T G Rigbolt et al.Science signaling, 4(164), rs3-rs3 (2011-03-17) Age-dependent changes in DNA repair in radiation-exposed mice.Igor P Kovalchuk et al.Radiation research, 182(6), 683-694 (2014-11-20) The small subunits of human and mouse DNA polymerase epsilon are homologous to the second largest subunit of the yeast Saccharomyces cerevisiae DNA polymerase epsilon.M Jokela et al.Nucleic acids research, 26(3), 730-734 (1998-03-14) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).Daniela S Gerhard et al.Genome research, 14(10B), 2121-2127 (2004-10-19) Human DNA polymerase kappa uses template-primer misalignment as a novel means for extending mispaired termini and for generating single-base deletions.William T Wolfle et al.Genes & development, 17(17), 2191-2199 (2003-09-04) DNA sequence and analysis of human chromosome 18.Chad Nusbaum et al.Nature, 437(7058), 551-555 (2005-09-24) A role for DNA polymerase θ in promoting replication through oxidative DNA lesion, thymine glycol, in human cells.Jung-Hoon Yoon et al.The Journal of biological chemistry, 289(19), 13177-13185 (2014-03-22) A high-throughput and quantitative method to assess the mutagenic potential of translesion DNA synthesis.David J Taggart et al.Nucleic acids research, 41(8), e96-e96 (2013-03-09) The δ subunit of RNA polymerase guides promoter selectivity and virulence in Staphylococcus aureus.Andy Weiss et al.Infection and immunity, 82(4), 1424-1435 (2014-02-05) A structural basis for metal ion mutagenicity and nucleotide selectivity in human DNA polymerase beta.H Pelletier et al.Biochemistry, 35(39), 12762-12777 (1996-10-01) A simple and very efficient method for generating cDNA libraries.U Gubler et al.Gene, 25(2-3), 263-269 (1983-11-01) Characterization of the 5'-flanking region of the gene encoding the 50 kDa subunit of human DNA polymerase delta.A Perez et al.Biochimica et biophysica acta, 1493(1-2), 231-236 (2000-09-09) Crystal structure of human REV7 in complex with a human REV3 fragment and structural implication of the interaction between DNA polymerase zeta and REV1.Kodai Hara et al.The Journal of biological chemistry, 285(16), 12299-12307 (2010-02-19) Mutagenesis of human DNA polymerase lambda: essential roles of Tyr505 and Phe506 for both DNA polymerase and terminal transferase activities.Igor Shevelev et al.Nucleic acids research, 31(23), 6916-6925 (2003-11-25) Molecular analysis of ANT1, TWINKLE and POLG in patients with multiple deletions or depletion of mitochondrial DNA by a dHPLC-based assay.Mourad Naïmi et al.European journal of human genetics : EJHG, 14(8), 917-922 (2006-04-28) The human DNA polymerase lambda interacts with PCNA through a domain important for DNA primer binding and the interaction is inhibited by p21/WAF1/CIP1.Giovanni Maga et al.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 18(14), 1743-1745 (2004-09-11) Enzymatic synthesis of deoxyribonucleic acid. 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