Density	1.657±0.06 g/cm3 (20 º

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Source	SDS/MSDS Samples
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Synthetic Route

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Articles

Peer-Reviewed Papers

Telemetry as a tool to measure sedative effects of a valerian root extract and its single constituents in mice.Nicholas K Chow et al.Planta medica, 77(8), 795-803 (2010-12-15) Positive GABA(A) receptor modulators from Acorus calamus and structural analysis of (+)-dioxosarcoguaiacol by 1D and 2D NMR and molecular modeling.Janine Zaugg et al.Journal of natural products, 74(6), 1437-1443 (2011-05-14) Relaxing effects of Valeriana officinalis extracts on isolated human non-pregnant uterine muscle.Francesco Occhiuto et al.The Journal of pharmacy and pharmacology, 61(2), 251-256 (2009-01-31) The design, synthesis, and anti-inflammatory evaluation of a drug-like library based on the natural product valerenic acidEgbewande.AF Bioorganic & Medicinal Chemistry Letters, 27, 3185-3189 (2017) Modulation of GABAA receptors by valerian extracts is related to the content of valerenic acid.Gabriele Trauner et al.Planta medica, 74(1), 19-24 (2007-12-21) Valerenic acid potentiates and inhibits GABA(A) receptors: molecular mechanism and subunit specificity.S Khom et al.Neuropharmacology, 53(1), 178-187 (2007-06-26) Pharmacokinetics of valerenic acid after single and multiple doses of valerian in older women.Gail D Anderson et al.Phytotherapy research : PTR, 24(10), 1442-1446 (2010-09-30) Valeriana officinalis root extracts have potent anxiolytic effects in laboratory rats.K Murphy et al.Phytomedicine : international journal of phytotherapy and phytopharmacology, 17(8-9), 674-678 (2010-01-01) Three phases hollow fiber LPME combined with HPLC-UV for extraction, preconcentration and determination of valerenic acid in Valeriana officinalis.Mohamad Mirzaei et al.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 879(21), 1870-1874 (2011-06-07) Total synthesis of valerenic acid, a potent GABAA receptor modulatorRamharter J and Mulzer J Organic Letters, 11, 1151-1153 (2009) Esters of valerenic acid as potential prodrugs.Juliane Hintersteiner et al.European journal of pharmacology, 735, 123-131 (2014-04-01) Iridoids of Valeriana fauriei contribute to alleviating hepatic steatosis in obese mice by lipophagy.Da-Hye Lee et al.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 125, 109950-109950 (2020-02-15) Antioxidant effect and study of bioactive components of Valeriana sisymbriifolia and Nardostachys jatamansii in comparison to Valeriana officinalis.Mehdi Ansari Dugaheh et al.Pakistan journal of pharmaceutical sciences, 26(1), 53-58 (2012-12-25) GABA A receptors as in vivo substrate for the anxiolytic action of valerenic acid, a major constituent of valerian root extracts.Dietmar Benke et al.Neuropharmacology, 56(1), 174-181 (2008-07-08) Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro.Birgit M Dietz et al.Brain research. Molecular brain research, 138(2), 191-197 (2005-06-01) Total synthesis of valerenic acid, a potent GABAA receptor modulator.Jürgen Ramharter et al.Organic letters, 11(5), 1151-1153 (2009-01-31) Efficient and scalable one-pot synthesis of 2,4-dienols from cycloalkenones: optimized total synthesis of valerenic acid.Juergen Ramharter et al.Organic letters, 13(19), 5310-5313 (2011-09-08) Hepatic metabolism and biliary excretion of valerenic acid in isolated perfused rat livers: role of Mrp2 (Abcc2).Alexandra Maier-Salamon et al.Journal of pharmaceutical sciences, 98(10), 3839-3849 (2009-01-22) Concise synthesis of Valerena-4,7(11)-diene, a highly active sedative, from valerenic acid.Takashi Kitayama et al.Bioscience, biotechnology, and biochemistry, 74(9), 1963-1964 (2010-09-14) Highly potent modulation of GABA(A) receptors by valerenic acid derivatives.Sascha Kopp et al.ChemMedChem, 5(5), 678-681 (2010-03-18) Root colonization by symbiotic arbuscular mycorrhizal fungi increases sesquiterpenic acid concentrations in Valeriana officinalis L.Monika Nell et al.Planta medica, 76(4), 393-398 (2009-10-08) Pharmacokinetics of valerenic acid after administration of valerian in healthy subjects.Gail D Anderson et al.Phytotherapy research : PTR, 19(9), 801-803 (2005-10-13) Valerian extract characterized by high valerenic acid and low acetoxy valerenic acid contents demonstrates anxiolytic activity.F Felgentreff et al.Phytomedicine : international journal of phytotherapy and phytopharmacology, 19(13), 1216-1222 (2012-09-05) The scientific basis for the reputed activity of Valerian.P J Houghton The Journal of pharmacy and pharmacology, 51(5), 505-512 (1999-07-20) [Studies on chemical constituents of Valeriana officinalis].Xia Jiang et al.Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 30(11), 1391-1393 (2008-03-08) Valerenic acid derivatives as novel subunit-selective GABAA receptor ligands - in vitro and in vivo characterization.S Khom et al.British journal of pharmacology, 161(1), 65-78 (2010-08-20) Anxiolytic properties of Valeriana officinalis in the zebrafish: a possible role for metabotropic glutamate receptors.Lisa M Del Valle-Mojica et al.Planta medica, 78(16), 1719-1724 (2012-08-28) Chemical fingerprinting of valeriana species: simultaneous determination of valerenic acids, flavonoids, and phenylpropanoids using liquid chromatography with ultraviolet detection.Andres Navarrete et al.Journal of AOAC International, 89(1), 8-15 (2006-03-04) Pharmacokinetics of valerenic acid in rats after intravenous and oral administrations.Chethan Sampath et al.Planta medica, 78(6), 575-581 (2012-03-14) Effect of valerian, valerian/hops extracts, and valerenic acid on glucuronidation in vitro.K M Alkharfy et al.Xenobiotica; the fate of foreign compounds in biological systems, 37(2), 113-123 (2007-05-09)

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