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A repurposing approach identifies off-patent drugs with fungicidal cryptococcal activity, a common structural chemotype, and pharmacological properties relevant to the treatment of cryptococcosis.Arielle Butts et al.Eukaryotic cell, 12(2), 278-287 (2012-12-18) cDNA cloning and tissue-specific expression of the gene encoding human adenylate kinase isozyme 2.T Noma et al.Biochimica et biophysica acta, 1395(1), 34-39 (1998-01-20) Investigation of LKB1 Ser431 phosphorylation and Cys433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity.Vanessa P Houde et al.The Biochemical journal, 458(1), 41-56 (2013-12-04) Chronological changes and effects of AMP-activated kinase in the hippocampal CA1 region after transient forebrain ischemia in gerbils.Han Ga Wi Nam et al.Neurological research, 35(4), 395-405 (2013-04-02) Coordinated elevation of mitochondrial oxidative phosphorylation and autophagy help drive hepatocyte polarization.Dong Fu et al.Proceedings of the National Academy of Sciences of the United States of America, 110(18), 7288-7293 (2013-04-17) Autophagic cell death induced by resveratrol depends on the Ca(2+)/AMPK/mTOR pathway in A549 cells.Jun Zhang et al.Biochemical pharmacology, 86(2), 317-328 (2013-05-18) A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity.Miki Okada-Iwabu et al.Nature, 503(7477), 493-499 (2013-11-01) Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism.Filipe Cabreiro et al.Cell, 153(1), 228-239 (2013-04-02) The DNA sequence and analysis of human chromosome 14.Roland Heilig et al.Nature, 421(6923), 601-607 (2003-01-01) The DNA sequence and comparative analysis of human chromosome 5.Jeremy Schmutz et al.Nature, 431(7006), 268-274 (2004-09-17) Living without creatine: unchanged exercise capacity and response to chronic myocardial infarction in creatine-deficient mice.Craig A Lygate et al.Circulation research, 112(6), 945-955 (2013-01-18) Structural and catalytic characteristics of Escherichia coli adenylate kinase.I Saint Girons et al.The Journal of biological chemistry, 262(2), 622-629 (1987-01-15) Induction of AMPK activity corrects early pathophysiological alterations in the subtotal nephrectomy model of chronic kidney disease.Joseph Satriano et al.American journal of physiology. Renal physiology, 305(5), F727-F733 (2013-07-05) Mechanistic studies of substrate-assisted inhibition of ubiquitin-activating enzyme by adenosine sulfamate analogues.Jesse J Chen et al.The Journal of biological chemistry, 286(47), 40867-40877 (2011-10-05) Essential ribosome assembly factor Fap7 regulates a hierarchy of RNA-protein interactions during small ribosomal subunit biogenesis.Ute A Hellmich et al.Proceedings of the National Academy of Sciences of the United States of America, 110(38), 15253-15258 (2013-09-05) Role of the neural pathway from hindbrain to hypothalamus in interaction of GLP1 and leptin in rats.Sayaka Akieda-Asai et al.The Journal of endocrinology, 220(2), 109-116 (2013-11-14) AMPK regulates ER morphology and function in stressed pancreatic β-cells via phosphorylation of DRP1.Jakob D Wikstrom et al.Molecular endocrinology (Baltimore, Md.), 27(10), 1706-1723 (2013-08-28) hCINAP is an atypical mammalian nuclear adenylate kinase with an ATPase motif: structural and functional studies.Christina E Drakou et al.Proteins, 80(1), 206-220 (2011-11-01) Phenformin activates the unfolded protein response in an AMP-activated protein kinase (AMPK)-dependent manner.Liu Yang et al.The Journal of biological chemistry, 288(19), 13631-13638 (2013-04-04) AMPK-dependent degradation of TXNIP upon energy stress leads to enhanced glucose uptake via GLUT1.Ning Wu et al.Molecular cell, 49(6), 1167-1175 (2013-03-05) Ginsenoside Rg3 improves cardiac mitochondrial population quality: mimetic exercise training.Mengwei Sun et al.Biochemical and biophysical research communications, 441(1), 169-174 (2013-10-22) Myokinase, ATP-AMP Transphosphorylase.Noda, L., and Kuby, S.A. Methods in Enzymology, 6, 223-230 (1962) The characterization of human adenylate kinases 7 and 8 demonstrates differences in kinetic parameters and structural organization among the family of adenylate kinase isoenzymes.Christakis Panayiotou et al.The Biochemical journal, 433(3), 527-534 (2010-11-18) Adenosine triphosphate-adenosine monophosphate transphosphorylase. III. Kinetic studies.L NODA The Journal of biological chemistry, 232(1), 237-250 (1958-05-01) Nucleotide transphosphorylases from liver. I. Purification and properties of an adenosine triphosphate-adenosine monophosphate transphosphorylase from swine liver.M CHIGA et al.The Journal of biological chemistry, 235, 3260-3265 (1960-11-01) Metformin induces up-regulation of blood-brain barrier functions by activating AMP-activated protein kinase in rat brain microvascular endothelial cells.Fuyuko Takata et al.Biochemical and biophysical research communications, 433(4), 586-590 (2013-03-26) AMPK: a target for drugs and natural products with effects on both diabetes and cancer.D Grahame Hardie Diabetes, 62(7), 2164-2172 (2013-06-27) Adenosine triphosphate-adenosine monophosphate transphosphorylase (myokinase). II. Homogeneity measurements and physicochemical properties.L NODA et al.The Journal of biological chemistry, 226(1), 551-558 (1957-05-01) The DNA sequence and biological annotation of human chromosome 1.S G Gregory et al.Nature, 441(7091), 315-321 (2006-05-20) Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.Sharon Gauci et al.Analytical chemistry, 81(11), 4493-4501 (2009-05-06) Glucose deprivation converts poly(ADP-ribose) polymerase-1 hyperactivation into a transient energy-producing process.Daniela Buonvicino et al.The Journal of biological chemistry, 288(51), 36530-36537 (2013-11-07) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).Daniela S Gerhard et al.Genome research, 14(10B), 2121-2127 (2004-10-19) MDMA induces cardiac contractile dysfunction through autophagy upregulation and lysosome destabilization in rats.Kaori Shintani-ishida et al.Biochimica et biophysica acta, 1842(5), 691-700 (2014-02-05) Cloning and expression of human adenylate kinase 2 isozymes: differential expression of adenylate kinase 1 and 2 in human muscle tissues.Y Lee et al.Journal of biochemistry, 123(1), 47-54 (1998-03-21) Biosynthetic tailoring of existing ascaroside pheromones alters their biological function in C. elegans.Yue Zhou et al.eLife, 7 (2018-06-05) The Med1 subunit of the mediator complex induces liver cell proliferation and is phosphorylated by AMP kinase.Navin Viswakarma et al.The Journal of biological chemistry, 288(39), 27898-27911 (2013-08-15) Kinetic basis for the conjugation of auxin by a GH3 family indole-acetic acid-amido synthetase.Qingfeng Chen et al.The Journal of biological chemistry, 285(39), 29780-29786 (2010-07-20) Evolution of a plant gene cluster in Solanaceae and emergence of metabolic diversity.Pengxiang Fan et al.eLife, 9 (2020-07-03) S6 kinase inhibits intrinsic axon regeneration capacity via AMP kinase in Caenorhabditis elegans.Thomas Hubert et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(3), 758-763 (2014-01-17) Mitochondrial respiratory chain Complex I defects in Fanconi anemia complementation group A.Silvia Ravera et al.Biochimie, 95(10), 1828-1837 (2013-06-25) A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels.Alessia Peserico et al.Cellular and molecular life sciences : CMLS, 70(11), 2015-2029 (2013-01-04) Isochorismate-derived biosynthesis of the plant stress hormone salicylic acid.Dmitrij Rekhter et al.Science (New York, N.Y.), 365(6452), 498-502 (2019-08-03) Hypothalamic AMPK activation blocks lipopolysaccharide inhibition of glucose production in mice liver.G A Santos et al.Molecular and cellular endocrinology, 381(1-2), 88-96 (2013-08-07) Myostatin knockout drives browning of white adipose tissue through activating the AMPK-PGC1α-Fndc5 pathway in muscle.Tizhong Shan et al.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 27(5), 1981-1989 (2013-01-31) Myokinase activity in microorganisms.I T OLIVER et al.Biochimica et biophysica acta, 20(2), 390-392 (1956-05-01) Roles of histone deacetylation and AMP kinase in regulation of cardiomyocyte PGC-1α gene expression in hypoxia.Angela Ramjiawan et al.American journal of physiology. Cell physiology, 304(11), C1064-C1072 (2013-03-22) pRb is an obesity suppressor in hypothalamus and high-fat diet inhibits pRb in this location.Zhonglei Lu et al.The EMBO journal, 32(6), 844-857 (2013-02-14) Enhancement of TWIK-related acid-sensitive potassium channel 3 (TASK3) two-pore domain potassium channel activity by tumor necrosis factor α.Mickael-F El Hachmane et al.The Journal of biological chemistry, 289(3), 1388-1401 (2013-12-07) The role of myokinase in transphosphorylations I. The enzymatic phosphorylation of hexoses by adenyl pyrophosphateColowick, S. and H. Kalcka The Journal of Biological Chemistry, 148, 117-126 (1943) The sulfhydryl groups of rabbit muscle adenosine triphosphate-adenosine monophosphate phosphotransferase. Activity of enzyme treated with mercurials.L F Kress et al.The Journal of biological chemistry, 241(10), 2293-2300 (1966-05-25) Human adenylate kinase 2 deficiency causes a profound hematopoietic defect associated with sensorineural deafness.Chantal Lagresle-Peyrou et al.Nature genetics, 41(1), 106-111 (2008-12-02) Role of AMPK activation in oxidative cell damage: Implications for alcohol-induced liver disease.Brice Sid et al.Biochemical pharmacology, 86(2), 200-209 (2013-05-22) Identification of a novel human adenylate kinase. cDNA cloning, expression analysis, chromosome localization and characterization of the recombinant protein.A R Van Rompay et al.European journal of biochemistry, 261(2), 509-517 (1999-04-24) Focal energy deprivation underlies arrhythmia susceptibility in mice with calcium-sensitized myofilaments.Sabine Huke et al.Circulation research, 112(10), 1334-1344 (2013-03-28) Reticular dysgenesis (aleukocytosis) is caused by mutations in the gene encoding mitochondrial adenylate kinase 2.Ulrich Pannicke et al.Nature genetics, 41(1), 101-105 (2008-12-02) Global transitions of proteins explored by a multiscale hybrid methodology: application to adenylate kinase.Mert Gur et al.Biophysical journal, 105(7), 1643-1652 (2013-10-08) Energy policy of the kidney: launch of AMPK as a novel therapeutic target.Masaomi Nangaku American journal of physiology. Renal physiology, 305(7), F977-F978 (2013-07-12) Antagonistic Activities of Vegfr3/Flt4 and Notch1b Fine-tune Mechanosensitive Signaling during Zebrafish Cardiac Valvulogenesis.Federica Fontana et al.Cell reports, 32(2), 107883-107883 (2020-07-16) Studies on adenosine triphosphate transphosphorylases. XVIII. Synthesis and preparation of peptides and peptide fragments of rabbit muscle ATP-AMP transphosphorylase (adenylate kinase) and their nucleotide-binding properties.S A Kuby et al.Journal of protein chemistry, 8(4), 549-562 (1989-08-01) Human adenylate kinase deficiency associated with hemolytic anemia. A single base substitution affecting solubility and catalytic activity of the cytosolic adenylate kinase.S Matsuura et al.The Journal of biological chemistry, 264(17), 10148-10155 (1989-06-15) Energy sensing in developing chicken embryos and posthatch chicks from different size eggs.Q Hu et al.Poultry science, 92(6), 1650-1654 (2013-05-21) Adenosine triphosphate-adenosine monophosphate transphosphorylase (myokinase). I. Isolation of the crystalline enzyme from rabbit skeletal muscle.L NODA et al.The Journal of biological chemistry, 226(1), 541-549 (1957-05-01) Human protein factory for converting the transcriptome into an in vitro-expressed proteome,.Naoki Goshima et al.Nature methods, 5(12), 1011-1017 (2008-12-05) Identification of two active functional domains of human adenylate kinase 5.Nicola Solaroli et al.FEBS letters, 583(17), 2872-2876 (2009-08-04) mTOR regulates lysosomal ATP-sensitive two-pore Na(+) channels to adapt to metabolic state.Chunlei Cang et al.Cell, 152(4), 778-790 (2013-02-12) Inactivation of rabbit muscle adenosine triphosphate-adenosine 5'-phosphate phosphotransferase by alkylation of methionine residues.L F Kress et al.The Journal of biological chemistry, 242(4), 558-564 (1967-02-25) Characterization of hCINAP, a novel coilin-interacting protein encoded by a transcript from the transcription factor TAFIID32 locus.Niovi Santama et al.The Journal of biological chemistry, 280(43), 36429-36441 (2005-08-05) Structural topology and activation of an initial adenylate kinase-substrate complex.Jörgen Ådén et al.Biochemistry, 52(6), 1055-1061 (2013-01-24) Initial characterization of the human central proteome.Thomas R Burkard et al.BMC systems biology, 5, 17-17 (2011-01-29) Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.R M Hu et al.Proceedings of the National Academy of Sciences of the United States of America, 97(17), 9543-9548 (2000-08-10) Cloning and characterization of cDNA for human adenylate kinase 2A.Y Lee et al.Biochemistry and molecular biology international, 39(4), 833-842 (1996-07-01) The crystal structure of human adenylate kinase 6: An adenylate kinase localized to the cell nucleus.Hui Ren et al.Proceedings of the National Academy of Sciences of the United States of America, 102(2), 303-308 (2005-01-05) Genistein suppresses LPS-induced inflammatory response through inhibiting NF-κB following AMP kinase activation in RAW 264.7 macrophages.Guiyuan Ji et al.PloS one, 7(12), e53101-e53101 (2013-01-10) Protein preparation, crystallization and preliminary X-ray analysis of human adrenal gland protein AD-004.Hui Ren et al.Acta crystallographica. Section D, Biological crystallography, 60(Pt 7), 1292-1294 (2004-06-24) Severe erythrocyte adenylate kinase deficiency due to homozygous A-->G substitution at codon 164 of human AK1 gene associated with chronic haemolytic anaemia.A Qualtieri et al.British journal of haematology, 99(4), 770-776 (1998-01-31) Resistance exercise induced mTORC1 signaling is not impaired by subsequent endurance exercise in human skeletal muscle.William Apró et al.American journal of physiology. Endocrinology and metabolism, 305(1), E22-E32 (2013-05-02) Calorie restriction in overweight males ameliorates obesity-related metabolic alterations and cellular adaptations through anti-aging effects, possibly including AMPK and SIRT1 activation.Munehiro Kitada et al.Biochimica et biophysica acta, 1830(10), 4820-4827 (2013-06-27) Primary and tertiary structure of the principal human adenylate kinase.I Von Zabern et al.European journal of biochemistry, 68(1), 281-290 (1976-09-01) Anti-diabetic and anti-lipidemic effects of chlorogenic acid are mediated by ampk activation.Khang Wei Ong et al.Biochemical pharmacology, 85(9), 1341-1351 (2013-02-19) [When regulation of cell energy meets regulation of inflammation: AMPK triggers skewing of macrophage phenotype during skeletal muscle regeneration].Marine Théret et al.Medecine sciences : M/S, 30(1), 35-38 (2014-01-30) Lkb1 regulates organogenesis and early oncogenesis along AMPK-dependent and -independent pathways.Bryan Lo et al.The Journal of cell biology, 199(7), 1117-1130 (2012-12-26) Complete sequencing and characterization of 21,243 full-length human cDNAs.Toshio Ota et al.Nature genetics, 36(1), 40-45 (2004-01-01) Differential regulation of glucose transport activity in yeast by specific cAMP signatures.Clara Bermejo et al.The Biochemical journal, 452(3), 489-497 (2013-03-19) Identification and biochemical characterization of adenylate kinase 1 from Clonorchis sinensis.Pei Liang et al.Parasitology research, 112(4), 1719-1727 (2013-03-05) Molecular and functional characterization of a Trypanosoma cruzi nuclear adenylate kinase isoform.María de los Milagros Cámara et al.PLoS neglected tropical diseases, 7(2), e2044-e2044 (2013-02-15) Red cell adenylate kinase deficiency: molecular study of 3 new mutations (118G>A, 190G>A, and GAC deletion) associated with hereditary nonspherocytic hemolytic anemia.Joan-Lluis Vives Corrons et al.Blood, 102(1), 353-356 (2003-03-22) CaMKIα regulates AMP kinase-dependent, TORC-1-independent autophagy during lipopolysaccharide-induced acute lung neutrophilic inflammation.Lanping Guo et al.Journal of immunology (Baltimore, Md. : 1950), 190(7), 3620-3628 (2013-03-01) Riluzole increases the rate of glucose transport in L6 myotubes and NSC-34 motor neuron-like cells via AMPK pathway activation.Bareket Daniel et al.Amyotrophic lateral sclerosis & frontotemporal degeneration, 14(5-6), 434-443 (2013-07-10) Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.C H Lai et al.Genome research, 10(5), 703-713 (2000-05-16) Elimination and utilization of oxidized guanine nucleotides in the synthesis of RNA and its precursors.Takeshi Sekiguchi et al.The Journal of biological chemistry, 288(12), 8128-8135 (2013-02-05) Scopoletin prevents alcohol-induced hepatic lipid accumulation by modulating the AMPK-SREBP pathway in diet-induced obese mice.Hae-In Lee et al.Metabolism: clinical and experimental, 63(4), 593-601 (2014-02-25) A novel mechanism by which SDF-1β protects cardiac cells from palmitate-induced endoplasmic reticulum stress and apoptosis via CXCR7 and AMPK/p38 MAPK-mediated interleukin-6 generation.Yuguang Zhao et al.Diabetes, 62(7), 2545-2558 (2013-02-21) ATP and AMP mutually influence their interaction with the ATP-binding cassette (ABC) adenylate kinase cystic fibrosis transmembrane conductance regulator (CFTR) at separate binding sites.Christoph O Randak et al.The Journal of biological chemistry, 288(38), 27692-27701 (2013-08-08) Angiotensin II reduces cardiac AdipoR1 expression through AT1 receptor/ROS/ERK1/2/c-Myc pathway.Li Li et al.PloS one, 8(1), e49915-e49915 (2013-01-26) Muscle lipogenesis balances insulin sensitivity and strength through calcium signaling.Katsuhiko Funai et al.The Journal of clinical investigation, 123(3), 1229-1240 (2013-02-05) Metformin interferes with bile acid homeostasis through AMPK-FXR crosstalk.Fleur Lien et al.The Journal of clinical investigation, 124(3), 1037-1051 (2014-02-18) Differential expression of adenylate kinase 4 in the context of disparate stress response strategies of HEK293 and HepG2 cells.Fanzhi Kong et al.Archives of biochemistry and biophysics, 533(1-2), 11-17 (2013-03-12) Fast sampling of A-to-B protein global conformational transitions: from Galileo Galilei to Monte Carlo anisotropic network modeling.Riccardo Baron Biophysical journal, 105(7), 1545-1546 (2013-10-08) AMP-activated protein kinase induces p53 by phosphorylating MDMX and inhibiting its activity.Guifen He et al.Molecular and cellular biology, 34(2), 148-157 (2013-11-06) Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK.Y Storozhuk et al.British journal of cancer, 108(10), 2021-2032 (2013-05-02) 1'-acetoxychavicol acetate inhibits adipogenesis in 3T3-L1 adipocytes and in high fat-fed rats.Rie Ohnishi et al.The American journal of Chinese medicine, 40(6), 1189-1204 (2012-12-12) Identifying natural substrates for dipeptidyl peptidases 8 and 9 using terminal amine isotopic labeling of substrates (TAILS) reveals in vivo roles in cellular homeostasis and energy metabolism.Claire H Wilson et al.The Journal of biological chemistry, 288(20), 13936-13949 (2013-03-23) Liver kinase b1 is required for white adipose tissue growth and differentiation.Wencheng Zhang et al.Diabetes, 62(7), 2347-2358 (2013-02-12) DNA sequence and analysis of human chromosome 9.S J Humphray et al.Nature, 429(6990), 369-374 (2004-05-28) Mechanism and regulation of mycobactin fatty acyl-AMP ligase FadD33.Olivia Vergnolle et al.The Journal of biological chemistry, 288(39), 28116-28125 (2013-08-13)

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