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Synthetic Route

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Peer-Reviewed Papers

Identification and molecular characterization of acyl-CoA synthetase in human erythrocytes and erythroid precursors.K T Malhotra et al.The Biochemical journal, 344 Pt 1, 135-143 (1999-11-05) Human long-chain acyl-CoA synthetase: structure and chromosomal location.T Abe et al.Journal of biochemistry, 111(1), 123-128 (1992-01-01) The functional interaction between Acyl-CoA synthetase 4, 5-lipooxygenase and cyclooxygenase-2 controls tumor growth: a novel therapeutic target.Ulises D Orlando et al.PloS one, 7(7), e40794-e40794 (2012-07-19) An in vitro fatty acylation assay reveals a mechanism for Wnt recognition by the acyltransferase PorcupineAsciolla JJ, et al. The Journal of Biological Chemistry, 292(33), 13507-13513 (2017) The Sjögren-Larsson syndrome gene encodes a hexadecenal dehydrogenase of the sphingosine 1-phosphate degradation pathway.Kanae Nakahara et al.Molecular cell, 46(4), 461-471 (2012-05-29) Apicobasal domain identities of expanding tubular membranes depend on glycosphingolipid biosynthesis.Hongjie Zhang et al.Nature cell biology, 13(10), 1189-1201 (2011-09-20) Characterization of two long-chain fatty acid CoA ligases in the Gram-positive bacterium Geobacillus thermodenitrificans NG80-2.Yanpeng Dong et al.Microbiological research, 167(10), 602-607 (2012-06-15) Physiological role of acyl coenzyme A synthetase homologs in lipid metabolism in Neurospora crassaRoche CM, et al. Eukaryotic Cell, 12(9), 1244-1257 (2013) Human intestinal acyl-CoA synthetase 5 is sensitive to the inhibitor triacsin C.Elke Kaemmerer et al.World journal of gastroenterology, 17(44), 4883-4889 (2011-12-16) Participation of two members of the very long-chain acyl-CoA synthetase family in bile acid synthesis and recycling.Stephanie J Mihalik et al.The Journal of biological chemistry, 277(27), 24771-24779 (2002-05-01) Mechanism of a Standalone β-Lactone Synthetase: New Continuous Assay for a Widespread ANL Superfamily Enzyme.Serina L Robinson et al.Chembiochem : a European journal of chemical biology, 20(13), 1701-1711 (2019-03-12) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).Daniela S Gerhard et al.Genome research, 14(10B), 2121-2127 (2004-10-19) Long-chain Acyl-CoA synthetase 4A regulates Smad activity and dorsoventral patterning in the zebrafish embryo.Rosa Linda Miyares et al.Developmental cell, 27(6), 635-647 (2013-12-18) Tyrosine phosphatase SHP2 regulates the expression of acyl-CoA synthetase ACSL4.Mariana Cooke et al.Journal of lipid research, 52(11), 1936-1948 (2011-09-10) The acyl-CoA synthetase "bubblegum" (lipidosin): further characterization and role in neuronal fatty acid beta-oxidation..Zhengtong Pei et al.The Journal of biological chemistry, 278(47), 47070-47078 (2003-09-17) Overexpression of human fatty acid transport protein 2/very long chain acyl-CoA synthetase 1 (FATP2/Acsvl1) reveals distinct patterns of trafficking of exogenous fatty acids.Elaina M Melton et al.Biochemical and biophysical research communications, 440(4), 743-748 (2013-10-12) FACL4, a new gene encoding long-chain acyl-CoA synthetase 4, is deleted in a family with Alport syndrome, elliptocytosis, and mental retardation.M Piccini et al.Genomics, 47(3), 350-358 (1998-04-16) MiR-205 modulates abnormal lipid metabolism of hepatoma cells via targeting acyl-CoA synthetase long-chain family member 1 (ACSL1) mRNA.Ming Cui et al.Biochemical and biophysical research communications, 444(2), 270-275 (2014-01-28) [Peroxisomes--functions and disturbances in human metabolism].Teresa J Stradomska Postepy biochemii, 57(2), 183-190 (2011-09-15) Synthesis of bisphosphonate derivatives of ATP by T4 DNA ligase, ubiquitin activating enzyme (E1) and other ligasesSillero MAG, et al. Biochemical Pharmacology, 75(10), 1959-1965 (2008) Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.Daisuke Nakajima et al.DNA research : an international journal for rapid publication of reports on genes and genomes, 9(3), 99-106 (2002-08-10) Acyl-CoA synthetase 3 promotes lipid droplet biogenesis in ER microdomains.Adam Kassan et al.The Journal of cell biology, 203(6), 985-1001 (2013-12-26) Human fatty acid transport protein 2a/very long chain acyl-CoA synthetase 1 (FATP2a/Acsvl1) has a preference in mediating the channeling of exogenous n-3 fatty acids into phosphatidylinositol.Elaina M Melton et al.The Journal of biological chemistry, 286(35), 30670-30679 (2011-07-20) Intrinsic acyl-CoA thioesterase activity of a peroxisomal ATP binding cassette transporter is required for transport and metabolism of fatty acids.Carine De Marcos Lousa et al.Proceedings of the National Academy of Sciences of the United States of America, 110(4), 1279-1284 (2013-01-05) Long chain acyl-CoA synthetase 3-mediated phosphatidylcholine synthesis is required for assembly of very low density lipoproteins in human hepatoma Huh7 cells.Hongbing Yao et al.The Journal of biological chemistry, 283(2), 849-854 (2007-11-16) Diacylglycerol acyltransferases from Vernonia and Stokesia prefer substrates with vernolic acidYu K, et al. Lipids, 41(6), 557-566 (2006) Blood cells as a source of transcriptional biomarkers of childhood obesity and its related metabolic alterations: results of the IDEFICS study.Juana Sánchez et al.The Journal of clinical endocrinology and metabolism, 97(4), E648-E652 (2012-01-27) Fatty acid transport protein 1 and long-chain acyl coenzyme A synthetase 1 interact in adipocytes.M Rachel Richards et al.Journal of lipid research, 47(3), 665-672 (2005-12-17) The consensus coding sequences of human breast and colorectal cancers.Tobias Sjöblom et al.Science (New York, N.Y.), 314(5797), 268-274 (2006-09-09) Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.S Wiemann et al.Genome research, 11(3), 422-435 (2001-03-07) Protein mediated fatty acid uptake: synergy between CD36/FAT-facilitated transport and acyl-CoA synthetase-driven metabolism.Hannah Schneider et al.Archives of biochemistry and biophysics, 546, 8-18 (2014-02-08) Involvement of cholesterol in hepatitis B virus X protein-induced abnormal lipid metabolism of hepatoma cells via up-regulating miR-205-targeted ACSL4.Ming Cui et al.Biochemical and biophysical research communications, 445(3), 651-655 (2014-03-01) dAcsl, the Drosophila ortholog of acyl-CoA synthetase long-chain family member 3 and 4, inhibits synapse growth by attenuating bone morphogenetic protein signaling via endocytic recycling.Zhihua Liu et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(8), 2785-2796 (2014-02-21) Levels of acyl-coenzyme A synthetase 5 in urothelial cells and corresponding neoplasias reflect cellular differentiation.Nadine T Gaisa et al.Histology and histopathology, 28(3), 353-364 (2013-01-26) An evaluation of fatty acid-CoA ligase 4 in breast cancer.Chin-Hua Tsai et al.Anticancer research, 34(3), 1239-1243 (2014-03-07) Role of long-chain acyl-coenzyme A synthetases in the regulation of arachidonic acid metabolism in interleukin 1β-stimulated rat fibroblasts.Hiroshi Kuwata et al.Biochimica et biophysica acta, 1841(1), 44-53 (2013-10-08) Long-chain acyl-CoA synthetase 4 is regulated by phosphorylation.María Emilia Smith et al.Biochemical and biophysical research communications, 430(1), 272-277 (2012-11-20) Very long-chain acyl-CoA synthetases. Human "bubblegum" represents a new family of proteins capable of activating very long-chain fatty acids.S J Steinberg et al.The Journal of biological chemistry, 275(45), 35162-35169 (2000-08-24) Acyl-coenzyme-A synthetase I from Candida lipolytica. Purification, properties and immunochemical studies.K Hosaka et al.European journal of biochemistry, 93(1), 197-203 (1979-01-02) Probing protein palmitoylation at the yeast vacuole.Christoph T A Meiringer et al.Methods (San Diego, Calif.), 40(2), 171-176 (2006-10-03) The DNA sequence and comparative analysis of human chromosome 5.Jeremy Schmutz et al.Nature, 431(7006), 268-274 (2004-09-17) Multiple erythroid isoforms of human long-chain acyl-CoA synthetases are produced by switch of the fatty acid gate domains.Eric Soupene et al.BMC molecular biology, 7, 21-21 (2006-07-13) Genomic organization and transcription units of the human acyl-CoA synthetase 3 gene.H Minekura et al.Gene, 278(1-2), 185-192 (2001-11-15) Human acyl-coenzyme A synthetase 3 cDNA and localization of its gene (ACS3) to chromosome band 2q34-q35.H Minekura et al.Genomics, 42(1), 180-181 (1997-05-15) Fusion of TEL/ETV6 to a novel ACS2 in myelodysplastic syndrome and acute myelogenous leukemia with t(5;12)(q31;p13).F Yagasaki et al.Genes, chromosomes & cancer, 26(3), 192-202 (1999-09-29) FACL4, encoding fatty acid-CoA ligase 4, is mutated in nonspecific X-linked mental retardation.Ilaria Meloni et al.Nature genetics, 30(4), 436-440 (2002-03-13) Differentially localized acyl-CoA synthetase 4 isoenzymes mediate the metabolic channeling of fatty acids towards phosphatidylinositol.Eva-Maria Küch et al.Biochimica et biophysica acta, 1841(2), 227-239 (2013-11-10) Drosophila long-chain acyl-CoA synthetase acts like a gap gene in embryonic segmentation.Yi Zhang et al.Developmental biology, 353(2), 259-265 (2011-03-10) Complete sequencing and characterization of 21,243 full-length human cDNAs.Toshio Ota et al.Nature genetics, 36(1), 40-45 (2004-01-01) Xq22.3-q23 deletion including ACSL4 in a patient with intellectual disability.Anastasia Gazou et al.American journal of medical genetics. Part A, 161A(4), 860-864 (2013-03-23) Diversity and history of the long-chain acyl-CoA synthetase (Acsl) gene family in vertebrates.Mónica Lopes-Marques et al.BMC evolutionary biology, 13, 271-271 (2013-12-18) Initial characterization of the human central proteome.Thomas R Burkard et al.BMC systems biology, 5, 17-17 (2011-01-29) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.Jesper V Olsen et al.Science signaling, 3(104), ra3-ra3 (2010-01-14) A novel mammalian bubblegum-related acyl-CoA synthetase restricted to testes and possibly involved in spermatogenesis.Peter Fraisl et al.Archives of biochemistry and biophysics, 451(1), 23-33 (2006-06-10) Structural snapshots for the conformation-dependent catalysis by human medium-chain acyl-coenzyme A synthetase ACSM2AKochan G, et al. Journal of Molecular Biology, 388(5), 997-1008 (2009) Identification of acyl-CoA synthetases involved in the mammalian sphingosine 1-phosphate metabolic pathway.Aya Ohkuni et al.Biochemical and biophysical research communications, 442(3-4), 195-201 (2013-11-26) Promotion of glioma cell survival by acyl-CoA synthetase 5 under extracellular acidosis conditions.T Mashima et al.Oncogene, 28(1), 9-19 (2008-09-23) Acyl-CoA synthetase as a cancer survival factor: its inhibition enhances the efficacy of etoposide.Tetsuo Mashima et al.Cancer science, 100(8), 1556-1562 (2009-05-23) Gestational diabetes mellitus decreases placental uptake of long-chain polyunsaturated fatty acids: involvement of long-chain acyl-CoA synthetase.João R Araújo et al.The Journal of nutritional biochemistry, 24(10), 1741-1750 (2013-06-25) The N-terminal region of acyl-CoA synthetase 3 is essential for both the localization on lipid droplets and the function in fatty acid uptake.Margarete Poppelreuther et al.Journal of lipid research, 53(5), 888-900 (2012-02-24) The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.Hilary F Clark et al.Genome research, 13(10), 2265-2270 (2003-09-17) Evaluation of the porcine ACSL4 gene as a candidate gene for meat quality traits in pigs.J Corominas et al.Animal genetics, 43(6), 714-720 (2012-04-14) Lignoceroyl-coenzyme A synthetase from developing rat brain: partial purification, characterization and comparison with palmitoyl-coenzyme A synthetase activity and liver enzyme.K Nagamatsu et al.Biochimica et biophysica acta, 836(1), 80-88 (1985-08-22) High ACSL5 transcript levels associate with systemic lupus erythematosus and apoptosis in Jurkat T lymphocytes and peripheral blood cells.Antonio Catalá-Rabasa et al.PloS one, 6(12), e28591-e28591 (2011-12-14) Identical subcellular distribution of palmitoyl-CoA and arachidonoyl-CoA synthetase activities in human blood platelets.A M Bakken et al.The Biochemical journal, 261(1), 71-76 (1989-07-01) The DNA sequence and comparative analysis of human chromosome 10.P Deloukas et al.Nature, 429(6990), 375-381 (2004-05-28) Cloning, expression, and chromosomal localization of human long-chain fatty acid-CoA ligase 4 (FACL4).Y Cao et al.Genomics, 49(2), 327-330 (1998-05-23) The TIP30 protein complex, arachidonic acid and coenzyme A are required for vesicle membrane fusion.Chengliang Zhang et al.PloS one, 6(6), e21233-e21233 (2011-07-07) Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.K Ishikawa et al.DNA research : an international journal for rapid publication of reports on genes and genomes, 5(3), 169-176 (1998-09-12) A quantitative atlas of mitotic phosphorylation.Noah Dephoure et al.Proceedings of the National Academy of Sciences of the United States of America, 105(31), 10762-10767 (2008-08-02) Identification and characterization of the BGR-like gene with a potential role in human testicular development/spermatogenesis.Ying Zheng et al.Asian journal of andrology, 7(1), 21-32 (2005-02-03) Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.Henrik Daub et al.Molecular cell, 31(3), 438-448 (2008-08-12) Purification and properties of long-chain acyl-coenzyme-A synthetase from rat liver.T Tanaka et al.European journal of biochemistry, 98(1), 165-172 (1979-07-01) Overexpressed FATP1, ACSVL4/FATP4 and ACSL1 increase the cellular fatty acid uptake of 3T3-L1 adipocytes but are localized on intracellular membranes.Tianzuo Zhan et al.PloS one, 7(9), e45087-e45087 (2012-10-02) Adult cerebral adrenoleukodystrophy and Addison's disease in a female carrier.Xiaoyan Chen et al.Gene, 544(2), 248-251 (2014-04-29) The association between acyl-CoA synthetase (ACSL4) polymorphism and intramuscular fat content in (Landrace × Yorkshire) × Duroc pigs.A Ruść et al.Meat science, 89(4), 440-443 (2011-06-10) Molecular cloning and sequencing of human palmitoyl-CoA ligase and its tissue specific expression.B Ghosh et al.Molecular and cellular biochemistry, 151(1), 77-81 (1995-10-04) Peroxisomal fatty acid uptake mechanism in Saccharomyces cerevisiae.Carlo W T van Roermund et al.The Journal of biological chemistry, 287(24), 20144-20153 (2012-04-12) Discovery of novel glucose-regulated proteins in isolated human pancreatic islets using LC-MS/MS-based proteomics.Alexandra C Schrimpe-Rutledge et al.Journal of proteome research, 11(7), 3520-3532 (2012-05-15) Functional roles of TGF-β1 in intestinal epithelial cells through Smad-dependent and non-Smad pathways.Yumi Yamada et al.Digestive diseases and sciences, 58(5), 1207-1217 (2013-01-12) Analysis of the DNA sequence and duplication history of human chromosome 15.Michael C Zody et al.Nature, 440(7084), 671-675 (2006-03-31) Toll-like receptor agonists promote prolonged triglyceride storage in macrophages.Ying-ling Huang et al.The Journal of biological chemistry, 289(5), 3001-3012 (2013-12-18) Effect of acetate formation pathway and long chain fatty acid CoA-ligase on the free fatty acid production in E. coli expressing acy-ACP thioesterase from Ricinus communis.Mai Li et al.Metabolic engineering, 14(4), 380-387 (2012-04-07) Synthesis of ATP derivatives of compounds of the mevalonate pathway (isopentenyl di-and triphosphate; geranyl di-and triphosphate, farnesyl di-and triphosphate, and dimethylallyl diphosphate) catalyzed by T4 RNA ligase, T4 DNA ligase and other ligases: Potential relationship with the effect of bisphosphonates on osteoclastsSillero MAG, et al. Biochemical Pharmacology, 78(4), 335-343 (2009) The second member of the human and murine bubblegum family is a testis- and brainstem-specific acyl-CoA synthetase.Zhengtong Pei et al.The Journal of biological chemistry, 281(10), 6632-6641 (2005-12-24) Identification of novel schizophrenia loci by homozygosity mapping using DNA microarray analysis.Naohiro Kurotaki et al.PloS one, 6(5), e20589-e20589 (2011-06-10) Regulation of enterocyte apoptosis by acyl-CoA synthetase 5 splicing.Nikolaus Gassler et al.Gastroenterology, 133(2), 587-598 (2007-08-08) Human very-long-chain acyl-CoA synthetase: cloning, topography, and relevance to branched-chain fatty acid metabolism.S J Steinberg et al.Biochemical and biophysical research communications, 257(2), 615-621 (1999-04-13) Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.T Nagase et al.DNA research : an international journal for rapid publication of reports on genes and genomes, 5(6), 355-364 (1999-02-27) Intestinal acyl-CoA synthetase 5: activation of long chain fatty acids and behind.Christina Klaus et al.World journal of gastroenterology, 19(42), 7369-7373 (2013-11-22)

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