Melting point	168-170 ºC (water )**
Boiling point	240.5±23.0 ºC (760 Tor
Flash point	108.5±15.0 ºC, 计算值*
Density	1.150±0.06 g/cm3 (20 º

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Source	SDS/MSDS Samples
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Peer-Reviewed Papers

Radial Glial Cell-Neuron Interaction Directs Axon Formation at the Opposite Side of the Neuron from the Contact Site.Chundi Xu et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(43), 14517-14532 (2015-10-30) A volumetric and viscosity study for the mixtures of 1-n-butyl-3-methylimidazolium tetrafluoroborate ionic liquid with acetonitrile, dichloromethane, 2-butanone and N, N-dimethylformamide.Wang J, et al. Green Chemistry, 5(5), 618-622 (2003) Asymmetric synthesis of (R)-1,3-butanediol from 4-hydroxy-2-butanone by a newly isolated strain Candida krusei ZJB-09162.Ren-Chao Zheng et al.Applied microbiology and biotechnology, 94(4), 969-976 (2012-03-01) Activation of spinal chemokine receptor CXCR3 mediates bone cancer pain through an Akt-ERK crosstalk pathway in rats.Xue-Hai Guan et al.Experimental neurology, 263, 39-49 (2014-10-05) The toxicology of methyl ethyl ketone.R S Yang Residue reviews, 97, 121-143 (1986-01-01) Carbonyl compound emissions from passenger cars fueled with methanol/gasoline blends.Hong Zhao et al.The Science of the total environment, 408(17), 3607-3613 (2010-06-01) ERK phosphorylation and miR-181a expression modulate activation of human memory TH17 cells.Federico Mele et al.Nature communications, 6, 6431-6431 (2015-03-17) Interplay of Oxidative Stress and Autophagy in PAMAM Dendrimers-Induced Neuronal Cell Death.Yubin Li et al.Theranostics, 5(12), 1363-1377 (2015-10-31) MiR-199a/b-3p suppresses migration and invasion of breast cancer cells by downregulating PAK4/MEK/ERK signaling pathway.Shou-Qing Li et al.IUBMB life, 67(10), 768-777 (2015-09-25) Interleukin-17A and Toll-Like Receptor 3 Ligand Poly(I:C) Synergistically Induced Neutrophil Chemoattractant Production by Bronchial Epithelial Cells.Hirotaka Matsuzaki et al.PloS one, 10(10), e0141746-e0141746 (2015-10-28) Histone deacetylase inhibitor-mediated cell death is distinct from its global effect on chromatin.Victoria L Luchenko et al.Molecular oncology, 8(8), 1379-1392 (2014-06-24) Application Of Small Molecules Favoring Naïve Pluripotency during Human Embryonic Stem Cell Derivation.Margot Van der Jeught et al.Cellular reprogramming, 17(3), 170-180 (2015-06-09) Prolyl isomerase Pin1 regulates the osteogenic activity of Osterix.Sung Ho Lee et al.Molecular and cellular endocrinology, 400, 32-40 (2014-12-03) Dynamics of elongation factor 2 kinase regulation in cortical neurons in response to synaptic activity.Justin W Kenney et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(7), 3034-3047 (2015-02-24) Lignosus rhinocerotis (Cooke) Ryvarden mimics the neuritogenic activity of nerve growth factor via MEK/ERK1/2 signaling pathway in PC-12 cells.Syntyche Ling-Sing Seow et al.Scientific reports, 5, 16349-16349 (2015-11-07) Diphlorethohydroxycarmalol Suppresses Ultraviolet B-Induced Matrix Metalloproteinases via Inhibition of JNK and ERK Signaling in Human Keratinocytes.Mei Jing Piao et al.Biomolecules & therapeutics, 23(6), 557-563 (2015-11-05) Molecular targets in the treatment of non-small-cell lung cancer: is there hope on the horizon?Corey A Carter et al.Postgraduate medicine, 126(7), 139-148 (2014-11-12) Solid phase microextraction, mass spectrometry and metabolomic approaches for detection of potential urinary cancer biomarkers--a powerful strategy for breast cancer diagnosis.Catarina L Silva et al.Talanta, 89, 360-368 (2012-01-31) High Glucose-induced Retinal Pericyte Apoptosis Depends on Association of GAPDH and Siah1.Sandra Suarez et al.The Journal of biological chemistry, 290(47), 28311-28320 (2015-10-07) Performance of a biotrickling filter in the removal of waste gases containing low concentrations of mixed VOCs from a paint and coating plant.Jianjun Li et al.Biodegradation, 23(1), 177-187 (2011-08-03) Differential effects of MAPK pathway inhibitors on migration and invasiveness of BRAF(V600E) mutant thyroid cancer cells in 2D and 3D culture.Camilla Ingeson-Carlsson et al.Experimental cell research, 338(2), 127-135 (2015-09-20) Hydroxyl radical yields from reactions of terpene mixtures with ozone.C D Forester et al.Indoor air, 21(5), 400-409 (2011-04-08) The novel organic arsenical darinaparsin induces MAPK-mediated and SHP1-dependent cell death in T-cell lymphoma and Hodgkin lymphoma cells and human xenograft models.Dashnamoorthy Ravi et al.Clinical cancer research : an official journal of the American Association for Cancer Research, 20(23), 6023-6033 (2014-10-16) Mga is essential for the survival of pluripotent cells during peri-implantation development.Andrew J Washkowitz et al.Development (Cambridge, England), 142(1), 31-40 (2014-12-18) MUC1-C confers EMT and KRAS independence in mutant KRAS lung cancer cells.Akriti Kharbanda et al.Oncotarget, 5(19), 8893-8905 (2014-09-24) Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanoma.Judith Müller et al.Nature communications, 5, 5712-5712 (2014-12-17) Occupational assessment of exposure to organic solvents in an adhesive producing company in Sfax, Tunisia.Imed Gargouri et al.Journal of occupational and environmental hygiene, 9(4), D71-D76 (2012-04-04) The B-vitamins in malnutrition with alcoholism. A model of intervitamin relationships.D K Dastur et al.The British journal of nutrition, 36(2), 143-159 (1976-09-01) SPECT-imaging of activity-dependent changes in regional cerebral blood flow induced by electrical and optogenetic self-stimulation in mice.Angela Kolodziej et al.NeuroImage, 103, 171-180 (2014-09-23) Hyaluronic acid induces COX-2 expression via CD44 in orbital fibroblasts from patients with thyroid-associated ophthalmopathy.Hun Sub Lim et al.Investigative ophthalmology & visual science, 55(11), 7441-7450 (2014-10-25) OPN induces FoxM1 expression and localization through ERK 1/2, AKT, and p38 signaling pathway in HEC-1A cells.Yunpeng Xie et al.International journal of molecular sciences, 15(12), 23345-23358 (2014-12-19) Analysis of volatile organic compounds released during food decaying processes.Nhu-Thuc Phan et al.Environmental monitoring and assessment, 184(3), 1683-1692 (2011-05-05) Interleukin-17A and Toll-Like Receptor 3 Ligand Poly(I:C) Synergistically Induced Neutrophil Chemoattractant Production by Bronchial Epithelial Cells.Hirotaka Matsuzaki et al.PloS one, 10(10), e0141746-e0141746 (2015-10-28) Radial Glial Cell-Neuron Interaction Directs Axon Formation at the Opposite Side of the Neuron from the Contact Site.Chundi Xu et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(43), 14517-14532 (2015-10-30) ERK phosphorylation and miR-181a expression modulate activation of human memory TH17 cells.Federico Mele et al.Nature communications, 6, 6431-6431 (2015-03-17) Diphlorethohydroxycarmalol Suppresses Ultraviolet B-Induced Matrix Metalloproteinases via Inhibition of JNK and ERK Signaling in Human Keratinocytes.Mei Jing Piao et al.Biomolecules & therapeutics, 23(6), 557-563 (2015-11-05) Anticonvulsant effects of methyl ethyl ketone and diethyl ketone in several types of mouse seizure models.Nobuyoshi Hasebe et al.European journal of pharmacology, 642(1-3), 66-71 (2010-06-18) Drinking drivers in Sweden who consume denatured alcohol preparations: an analytical-toxicological study.A W Jones et al.Journal of analytical toxicology, 13(4), 199-203 (1989-07-01) Development and performance evaluation of a novel dynamic headspace vacuum transfer "In Trap" extraction method for volatile compounds and comparison with headspace solid-phase microextraction and headspace in-tube extraction.Pascal Fuchsmann et al.Journal of chromatography. A, 1601, 60-70 (2019-06-11) Relationship between omega-3 fatty acids and plasma neuroactive steroids in alcoholism, depression and controls.L R G Nieminen et al.Prostaglandins, leukotrienes, and essential fatty acids, 75(4-5), 309-314 (2006-09-09) Lignosus rhinocerotis (Cooke) Ryvarden mimics the neuritogenic activity of nerve growth factor via MEK/ERK1/2 signaling pathway in PC-12 cells.Syntyche Ling-Sing Seow et al.Scientific reports, 5, 16349-16349 (2015-11-07) High Glucose-induced Retinal Pericyte Apoptosis Depends on Association of GAPDH and Siah1.Sandra Suarez et al.The Journal of biological chemistry, 290(47), 28311-28320 (2015-10-07) MiR-199a/b-3p suppresses migration and invasion of breast cancer cells by downregulating PAK4/MEK/ERK signaling pathway.Shou-Qing Li et al.IUBMB life, 67(10), 768-777 (2015-09-25) Performance of a biotrickling filter in the removal of waste gases containing low concentrations of mixed VOCs from a paint and coating plant.Jianjun Li et al.Biodegradation, 23(1), 177-187 (2011-08-03) Interplay of Oxidative Stress and Autophagy in PAMAM Dendrimers-Induced Neuronal Cell Death.Yubin Li et al.Theranostics, 5(12), 1363-1377 (2015-10-31) Histone deacetylase inhibitor-mediated cell death is distinct from its global effect on chromatin.Victoria L Luchenko et al.Molecular oncology, 8(8), 1379-1392 (2014-06-24) Application Of Small Molecules Favoring Naïve Pluripotency during Human Embryonic Stem Cell Derivation.Margot Van der Jeught et al.Cellular reprogramming, 17(3), 170-180 (2015-06-09) Prolyl isomerase Pin1 regulates the osteogenic activity of Osterix.Sung Ho Lee et al.Molecular and cellular endocrinology, 400, 32-40 (2014-12-03) Dynamics of elongation factor 2 kinase regulation in cortical neurons in response to synaptic activity.Justin W Kenney et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(7), 3034-3047 (2015-02-24) Carbonyl compound emissions from passenger cars fueled with methanol/gasoline blends.Hong Zhao et al.The Science of the total environment, 408(17), 3607-3613 (2010-06-01) Molecular targets in the treatment of non-small-cell lung cancer: is there hope on the horizon?Corey A Carter et al.Postgraduate medicine, 126(7), 139-148 (2014-11-12) Fluorofenidone attenuates oxidative stress and renal fibrosis in obstructive nephropathy via blocking NOX2 (gp91phox) expression and inhibiting ERK/MAPK signaling pathway.Jiao Qin et al.Kidney & blood pressure research, 40(1), 89-99 (2015-06-02) Stimulation of EphB2/ephrin-B1 signalling by tumour necrosis factor alpha in human dental pulp stem cells.Lifang Zhu et al.Cell proliferation, 48(2), 231-238 (2015-02-04) Protective Effects of Everolimus against N-Methyl-D-aspartic Acid-Induced Retinal Damage in Rats.Ikumi Hayashi et al.Biological & pharmaceutical bulletin, 38(11), 1765-1771 (2015-11-03) EPHA2 is a mediator of vemurafenib resistance and a novel therapeutic target in melanoma.Benchun Miao et al.Cancer discovery, 5(3), 274-287 (2014-12-30) Combined MEK and PI3K inhibition in a mouse model of pancreatic cancer.Brinda Alagesan et al.Clinical cancer research : an official journal of the American Association for Cancer Research, 21(2), 396-404 (2014-10-29) Methyl ethyl ketone. Reviews of environmental contamination and toxicology, 106, 165-174 (1988-01-01) Coordinate hyperactivation of Notch1 and Ras/MAPK pathways correlates with poor patient survival: novel therapeutic strategy for aggressive breast cancers.Suruchi Mittal et al.Molecular cancer therapeutics, 13(12), 3198-3209 (2014-09-26) The B-vitamins in malnutrition with alcoholism. A model of intervitamin relationships.D K Dastur et al.The British journal of nutrition, 36(2), 143-159 (1976-09-01) Occupational assessment of exposure to organic solvents in an adhesive producing company in Sfax, Tunisia.Imed Gargouri et al.Journal of occupational and environmental hygiene, 9(4), D71-D76 (2012-04-04) Solid phase microextraction, mass spectrometry and metabolomic approaches for detection of potential urinary cancer biomarkers--a powerful strategy for breast cancer diagnosis.Catarina L Silva et al.Talanta, 89, 360-368 (2012-01-31) mir-155 regulates cardiac allograft rejection by targing the expression of suppressor of cytokine signaling-1 (DOCS1) in dendritic cells.Yi Gao et al.International journal of clinical and experimental medicine, 7(11), 4572-4583 (2015-01-01) Tri-iodothyronine preconditioning protects against liver ischemia reperfusion injury through the regulation of autophagy by the MEK/ERK/mTORC1 axis.Jinghui Yang et al.Biochemical and biophysical research communications, 467(4), 704-710 (2015-10-27) IFNλ Stimulates MxA Production in Human Dermal Fibroblasts via a MAPK-Dependent STAT1-Independent Mechanism.Adewonuola A Alase et al.The Journal of investigative dermatology, 135(12), 2935-2943 (2015-08-20) Differential regulation of pericyte function by the CXC receptor 3.Richard J Bodnar et al.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 23(6), 785-796 (2015-07-25) Cancer-associated adipose tissue promotes breast cancer progression by paracrine oncostatin M and Jak/STAT3 signaling.Lore Lapeire et al.Cancer research, 74(23), 6806-6819 (2014-09-26) An in vitro evaluation of the effect of probiotics and prebiotics on the metabolic profile of human microbiota.Beatrice Vitali et al.Anaerobe, 18(4), 386-391 (2012-05-15) Melanoma patient-derived xenografts accurately model the disease and develop fast enough to guide treatment decisions.Berglind O Einarsdottir et al.Oncotarget, 5(20), 9609-9618 (2014-09-18) Slug signaling is up-regulated by CCL21/CCR7 [corrected] to induce EMT in human chondrosarcoma.Guosong Li et al.Medical oncology (Northwood, London, England), 32(2), 478-478 (2015-01-06) Computational identification of multi-omic correlates of anticancer therapeutic response.Lindsay C Stetson et al.BMC genomics, 15 Suppl 7, S2-S2 (2015-01-13) Cytotoxic and apoptotic activities of the plancitoxin I from the venom of crown-of-thorns starfish (Acanthaster planci) on A375.S2 cells.Chi-Chiu Lee et al.Journal of applied toxicology : JAT, 35(4), 407-417 (2014-07-23) ECM1 promotes the Warburg effect through EGF-mediated activation of PKM2.Kyung-Min Lee et al.Cellular signalling, 27(2), 228-235 (2014-12-03) Wogonin induces cell cycle arrest and erythroid differentiation in imatinib-resistant K562 cells and primary CML cells.Hao Yang et al.Oncotarget, 5(18), 8188-8201 (2014-08-26) Serum 7 alpha-hydroxy-4-cholesten-3-one and selenohomocholyltaurine (SeHCAT) whole body retention in the assessment of bile acid induced diarrhoea.W G Brydon et al.European journal of gastroenterology & hepatology, 8(2), 117-123 (1996-02-01) Widdrol-induced lipolysis is mediated by PKC and MEK/ERK in 3T3-L1 adipocytes.Hyun Young Jeong et al.Molecular and cellular biochemistry, 410(1-2), 247-254 (2015-09-12) Fabrication and mechanical properties of Al2O3/SiC/ZrO2 functionally graded material by electrophoretic deposition.E Askari et al.Journal of the mechanical behavior of biomedical materials, 12, 144-150 (2012-06-27) Removal of benzene and methyl ethyl ketone vapor: comparison of hypercrosslinked polymeric adsorbent with activated carbon.Chao Long et al.Journal of hazardous materials, 203-204, 251-256 (2011-12-30) Angiotensin AT2 receptor stimulation is anti-inflammatory in lipopolysaccharide-activated THP-1 macrophages via increased interleukin-10 production.Isha Dhande et al.Hypertension research : official journal of the Japanese Society of Hypertension, 38(1), 21-29 (2014-09-12) The dual RAF/MEK inhibitor CH5126766/RO5126766 may be a potential therapy for RAS-mutated tumor cells.Makoto Wada et al.PloS one, 9(11), e113217-e113217 (2014-11-26) Purification and characterization of the acetone carboxylase of Cupriavidus metallidurans strain CH34.Caroline Rosier et al.Applied and environmental microbiology, 78(12), 4516-4518 (2012-04-12) Inhibition of dual specificity phosphatase-2 by hypoxia promotes interleukin-8-mediated angiogenesis in endometriosis.Kuei-Yang Hsiao et al.Human reproduction (Oxford, England), 29(12), 2747-2755 (2014-10-16) Epigenetic balance of aberrant Rasal1 promoter methylation and hydroxymethylation regulates cardiac fibrosis.Xingbo Xu et al.Cardiovascular research, 105(3), 279-291 (2015-01-27) Inhibition of ABCB1 Overcomes Cancer Stem Cell-like Properties and Acquired Resistance to MET Inhibitors in Non-Small Cell Lung Cancer.Teppei Sugano et al.Molecular cancer therapeutics, 14(11), 2433-2440 (2015-09-10) Separation of the isomers of benzene poly(carboxylic acid)s by quaternary ammonium salt via formation of deep eutectic solvents.Yucui Hou et al.The journal of physical chemistry. B, 118(47), 13646-13650 (2014-10-30) Cross-talk between alpha1D-adrenoceptors and transient receptor potential vanilloid type 1 triggers prostate cancer cell proliferation.Maria Beatrice Morelli et al.BMC cancer, 14, 921-921 (2014-12-08) Promotion of insulin-induced glucose uptake in C2C12 myotubes by osteocalcin.Shintaro Tsuka et al.Biochemical and biophysical research communications, 459(3), 437-442 (2015-03-05) Effect of mycophenolic acid on proliferation of dermal papilla cells and induction of anagen hair follicles.K H Jeong et al.Clinical and experimental dermatology, 40(8), 894-902 (2015-03-27) Spaced training rescues memory and ERK1/2 signaling in fragile X syndrome model mice.Ronald R Seese et al.Proceedings of the National Academy of Sciences of the United States of America, 111(47), 16907-16912 (2014-11-12) Vinculin negatively regulates transcription of MT1-MMP through MEK/ERK pathway.Taisuke Yoshimoto et al.Biochemical and biophysical research communications, 455(3-4), 251-255 (2014-12-03) Optimization of the radiosynthesis of the Alzheimer tracer 2-(4-N-[11C]methylaminophenyl)-6-hydroxybenzothiazole ([11C]PIB).C Philippe et al.Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 69(9), 1212-1217 (2011-05-10) Oncogenic c-Myc and prothymosin-alpha protect hepatocellular carcinoma cells against sorafenib-induced apoptosis.Yi-Te Lin et al.Biochemical pharmacology, 93(1), 110-124 (2014-12-03) Targeting Tuberculosis and HIV Infection-Specific Regulatory T Cells with MEK/ERK Signaling Pathway Inhibitors.Nora V Lieske et al.PloS one, 10(11), e0141903-e0141903 (2015-11-07) Thrombin decreases expression of the glutamate transporter GLAST and inhibits glutamate uptake in primary cortical astrocytes via the Rho kinase pathway.Chunshu Piao et al.Experimental neurology, 273, 288-300 (2015-09-24) Adhesion of maxillofacial silicone elastomer to a fiber-reinforced composite resin framework.Rosita Kantola et al.The International journal of prosthodontics, 24(6), 582-588 (2011-12-08) Protein kinase C-dependent growth-associated protein 43 phosphorylation regulates gephyrin aggregation at developing GABAergic synapses.Chen-Yu Wang et al.Molecular and cellular biology, 35(10), 1712-1726 (2015-03-11) Cross-talk between alpha1D-adrenoceptors and transient receptor potential vanilloid type 1 triggers prostate cancer cell proliferation.Maria Beatrice Morelli et al.BMC cancer, 14, 921-921 (2014-12-08) Effect of mycophenolic acid on proliferation of dermal papilla cells and induction of anagen hair follicles.K H Jeong et al.Clinical and experimental dermatology, 40(8), 894-902 (2015-03-27) Functional characterization and application of a tightly regulated MekR/P mekA expression system in Escherichia coli and Pseudomonas putida.Nadja Graf et al.Applied microbiology and biotechnology, 97(18), 8239-8251 (2013-06-19) Systematic analysis of BRAF(V600E) melanomas reveals a role for JNK/c-Jun pathway in adaptive resistance to drug-induced apoptosis.Mohammad Fallahi-Sichani et al.Molecular systems biology, 11(3), 797-797 (2015-03-31) Dasatinib reverses the multidrug resistance of breast cancer MCF-7 cells to doxorubicin by downregulating P-gp expression via inhibiting the activation of ERK signaling pathway.Ting Chen et al.Cancer biology & therapy, 16(1), 106-114 (2014-12-09) Bio-inspired oligovitronectin-grafted surface for enhanced self-renewal and long-term maintenance of human pluripotent stem cells under feeder-free conditions.Hyun-Ji Park et al.Biomaterials, 50, 127-139 (2015-03-05) Effect of perioperative treatment with a hypoxia-inducible factor-1-alpha inhibitor in an orthotopic surgical mouse model of thyroid cancer.Wonjae Cha et al.Anticancer research, 35(4), 2049-2054 (2015-04-12) Dilong prevents the high-KCl cardioplegic solution administration-induced apoptosis in H9c2 cardiomyoblast cells mediated by MEK.Chien-Kuo Han et al.The American journal of Chinese medicine, 42(6), 1507-1519 (2014-12-09) Dependence of fibroblast infiltration in tumor stroma on type IV collagen-initiated integrin signal through induction of platelet-derived growth factor.Sheng-Yi Chen et al.Biochimica et biophysica acta, 1853(5), 929-939 (2015-02-18) CCR7 pathway induces epithelial-mesenchymal transition through up-regulation of Snail signaling in gastric cancer.Jianping Zhang et al.Medical oncology (Northwood, London, England), 32(2), 467-467 (2015-01-13) Extracellular matrix protein 1 regulates cell proliferation and trastuzumab resistance through activation of epidermal growth factor signaling.Kyung-min Lee et al.Breast cancer research : BCR, 16(6), 479-479 (2014-12-17) Postmitotic diversification of olfactory neuron types is mediated by differential activities of the HMG-box transcription factor SOX-2.Amel Alqadah et al.The EMBO journal, 34(20), 2574-2589 (2015-09-06) Construction of monomer-free, highly crosslinked, water-compatible polymers.E A Dailing et 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