Melting point	-30 ºC
Boiling point	194-196 ºC
Flash point	64 ºC
Density	1.28
Refractive index	1.582-1.586

Symbol(GHS)	Xn
Hazard Codes	R22;R43
SDS/MSDS	S24;S37

Source	SDS/MSDS Samples
Alfa-Aesar	View & Download
Sigma-Aldrich	View & Download
TCI	View & Download

Synthetic Route

More

Name	CAS

More

Articles

Peer-Reviewed Papers

gyrA and parC associated with quinolone resistance in Vibrio anguillarum.C Rodkhum et al.Journal of fish diseases, 31(5), 395-399 (2008-04-11) Chemical genetics reveals a complex functional ground state of neural stem cells.Phedias Diamandis et al.Nature chemical biology, 3(5), 268-273 (2007-04-10) Synthesis of oligodeoxynucleotides with 5'-caps binding RNA targets.Simone Egetenmeyer et al.Current protocols in nucleic acid chemistry, Chapter 4, Unit4-Unit4 (2012-12-21) Are liquid chromatography/electrospray tandem quadrupole fragmentation ratios unequivocal confirmation criteria?Anton Kaufmann et al.Rapid communications in mass spectrometry : RCM, 23(7), 985-998 (2009-02-26) Nickel-quinolones interaction. Part 5-Biological evaluation of nickel(II) complexes with first-, second- and third-generation quinolones.Kalliopi C Skyrianou et al.Journal of inorganic biochemistry, 105(10), 1273-1285 (2011-08-09) Differential gene expression in black tiger shrimp, Penaeus monodon, following administration of oxytetracycline and oxolinic acid.Fernand F Fagutao et al.Developmental and comparative immunology, 33(10), 1088-1092 (2009-06-06) Monitoring Antibiotic Use and Residue in Freshwater Aquaculture for Domestic Use in Vietnam.Dang Kim Pham et al.EcoHealth, 12(3), 480-489 (2015-01-07) Characterization of Salmonella Typhimurium DNA gyrase as a target of quinolones.Siriporn Kongsoi et al.Drug testing and analysis, 7(8), 714-720 (2014-11-11) Degradation of oxolinic acid and flumequine in aquaculture pond waters and sediments.Hong-Thih Lai et al.Chemosphere, 75(4), 462-468 (2009-02-24) Quantitation and identity confirmation of residues of quinolones in tilapia fillets by LC-ESI-MS-MS QToF.Jonas Augusto Rizzato Paschoal et al.Analytical and bioanalytical chemistry, 394(8), 2213-2221 (2009-06-26) Determination of quinolone residues in infant and young children powdered milk combining solid-phase extraction and ultra-performance liquid chromatography-tandem mass spectrometry.Antonio V Herrera-Herrera et al.Journal of chromatography. A, 1218(42), 7608-7614 (2011-06-21) Treatment of vibriosis in European sea bass larvae, Dicentrarchus labrax L., with oxolinic acid administered by bath or through medicated nauplii of Artemia franciscana (Kellogg): efficacy and residual kinetics.M Touraki et al.Journal of fish diseases, 35(7), 513-522 (2012-06-08) Effects of light regime and oxygen profile on transformation of oxolinic acid in pond sediment.Hong-Thih Lai et al.Bioresource technology, 102(9), 5425-5430 (2010-12-07) Salmon aquaculture and antimicrobial resistance in the marine environment.Alejandro H Buschmann et al.PloS one, 7(8), e42724-e42724 (2012-08-21) Improved sample treatment for the determination of 17 strong sorbed quinolone antibiotics from compost by ultra high performance liquid chromatography tandem mass spectrometry.N Dorival-García et al.Talanta, 138, 247-257 (2015-04-13) Oxolinic acid photo-oxidation using immobilized TiO(2).R A Palominos et al.Journal of hazardous materials, 158(2-3), 460-464 (2008-04-11) The PneuCarriage Project: A Multi-Centre Comparative Study to Identify the Best Serotyping Methods for Examining Pneumococcal Carriage in Vaccine Evaluation Studies.Catherine Satzke et al.PLoS medicine, 12(11), e1001903-e1001903 (2015-11-18) Ultra-high performance liquid chromatography-electrospray tandem mass spectrometry for the analysis of antibiotic residues in environmental waters.Qiang Xue et al.Environmental science and pollution research international, 22(21), 16857-16867 (2015-06-25) A simple, fast and cheap non-SPE screening method for antibacterial residue analysis in milk and liver using liquid chromatography-tandem mass spectrometry.Magda Targa Martins et al.Talanta, 129, 374-383 (2014-08-17) Contribution of reactive oxygen species to pathways of quinolone-mediated bacterial cell death.Xiuhong Wang et al.The Journal of antimicrobial chemotherapy, 65(3), 520-524 (2010-01-14) Synthesis of amino acid derivatives of quinolone antibiotics.Alan R Katritzky et al.Organic & biomolecular chemistry, 7(11), 2359-2362 (2009-05-23) Suppression of pine wilt disease by an antibacterial agent, oxolinic acid.Hyeok Ran Kwon et al.Pest management science, 66(6), 634-639 (2010-02-13) Novel copper(II) complex of N-propyl-norfloxacin and 1,10-phenanthroline with enhanced antileukemic and DNA nuclease activities.Maria E Katsarou et al.Journal of medicinal chemistry, 51(3), 470-478 (2008-01-22) Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.Naomi L Kruhlak et al.Toxicology mechanisms and methods, 18(2-3), 217-227 (2008-01-01) Measurement of trace levels of antibiotics in river water using on-line enrichment and triple-quadrupole LC-MS/MS.Quoc Tuc Dinh et al.Talanta, 85(3), 1238-1245 (2011-08-03) Expression and purification of an active form of the Mycobacterium leprae DNA gyrase and its inhibition by quinolones.Stéphanie Matrat et al.Antimicrobial agents and chemotherapy, 51(5), 1643-1648 (2007-02-28) Contribution of oxidative damage to antimicrobial lethality.Xiuhong Wang et al.Antimicrobial agents and chemotherapy, 53(4), 1395-1402 (2009-02-19) Antimicrobial studies with the Pseudomonas aeruginosa two-allele library require caution.Xiangli Wu et al.Antimicrobial agents and chemotherapy, 52(10), 3826-3827 (2008-08-13) Nickel-quinolones interaction. Part 2--interaction of nickel(II) with the antibacterial drug oxolinic acid.Kalliopi C Skyrianou et al.Journal of inorganic biochemistry, 104(2), 161-170 (2009-11-27) Study on the interaction between oxolinic acid aggregates and protein and its analytical application.Xia Wu et al.Analytica chimica acta, 596(1), 16-22 (2007-07-10) Are all the DNA gyrase mutations found in Mycobacterium leprae clinical strains involved in resistance to fluoroquinolones?Stéphanie Matrat et al.Antimicrobial agents and chemotherapy, 52(2), 745-747 (2007-12-12) Supramolecular solvents in solid sample microextractions: application to the determination of residues of oxolinic acid and flumequine in fish and shellfish.Esther María Costi et al.Journal of chromatography. A, 1217(9), 1447-1454 (2010-01-12) Drug therapy reviews: oxolinic acid.R Gleckman et al.American journal of hospital pharmacy, 36(8), 1077-1079 (1979-08-01) Zinc complexes of the antibacterial drug oxolinic acid: structure and DNA-binding properties.Alketa Tarushi et al.Journal of inorganic biochemistry, 103(6), 898-905 (2009-04-28) First- and second-generation quinolone antibacterial drugs interacting with zinc(II): structure and biological perspectives.Alketa Tarushi et al.Journal of inorganic biochemistry, 121, 53-65 (2013-01-29) Microarray analyses of shrimp immune responses.Takashi Aoki et al.Marine biotechnology (New York, N.Y.), 13(4), 629-638 (2010-04-16) Luminescent determination of quinolones in milk samples by liquid chromatography/post-column derivatization with terbium oxide nanoparticles.G S Yánez-Jácome et al.Journal of chromatography. A, 1405, 126-132 (2015-06-17) Multiresidue determination of fluoroquinolones in poultry muscle and kidney according to the regulation 2002/657/EC. A systematic comparison of two different approaches: Liquid chromatography coupled to high-resolution mass spectrometry or tandem mass spectrometry.Diego G Rocha et al.Journal of chromatography. A, 1379, 83-91 (2015-01-13) Colistin-oxolinic acid blood agar: a selective medium for the isolation of Gardnerella vaginalis.J S Thompson Journal of clinical microbiology, 21(5), 843-843 (1985-05-01) In vivo modulation of immune response and antioxidant defense in Atlantic cod, Gadus morhua following oral administration of oxolinic acid and florfenicol.Christopher Marlowe A Caipang et al.Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 150(4), 459-464 (2009-07-15) Development of a novel genetically modified bioluminescent-bacteria-based assay for detection of fluoroquinolones in animal-derived foods.Guyue Cheng et al.Analytical and bioanalytical chemistry, 406(30), 7899-7910 (2014-10-31) Behavioural and neurochemical evidence that the antimicrobial agent oxolinic acid is a dopamine uptake inhibitor.J Garcia de Mateos-Verchere et al.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 8(4), 255-259 (1999-02-03) Targeting the gyrase of Plasmodium falciparum with topoisomerase poisons.Sonya C Tang Girdwood et al.Biochemical pharmacology, 95(4), 227-237 (2015-04-18) Analysis of sulfonamides, trimethoprim, fluoroquinolones, quinolones, triphenylmethane dyes and methyltestosterone in fish and shrimp using liquid chromatography-mass spectrometry.Joseph M Storey et al.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 972, 38-47 (2014-10-14) Multi-residue Determination of Polar Veterinary Drugs in Livestock and Fishery Products by Liquid Chromatography/Tandem Mass Spectrometry.Maki Kanda et al.Journal of AOAC International, 98(1), 230-247 (2015-04-11) gyrA and parC Mutations and associated quinolone resistance in Vibrio anguillarum serotype O2b strains isolated from farmed Atlantic cod (Gadus morhua) in Norway.D J Colquhoun et al.Antimicrobial agents and chemotherapy, 51(7), 2597-2599 (2007-05-16) Structure, antimicrobial activity, DNA- and albumin-binding of manganese(II) complexes with the quinolone antimicrobial agents oxolinic acid and enrofloxacin.Marianthi Zampakou et al.Journal of inorganic biochemistry, 121, 88-99 (2013-01-29) Degradation of the antibiotic oxolinic acid by photocatalysis with TiO2 in suspension.Ana L Giraldo et al.Water research, 44(18), 5158-5167 (2010-07-17)

Remarks