Density	1.19±0.1 g/cm3 (20 ºC

没有数据	没有数据

Source	SDS/MSDS Samples
没有数据	没有数据

Synthetic Route

More

Name	CAS

More

Articles

Peer-Reviewed Papers

Synthesis and structure-activity relationship of (1-halo-2-naphthyl) carbamate-based inhibitors of KIAA1363 (NCEH1/AADACL1).Kevin R Shreder et al.Bioorganic & medicinal chemistry letters, 22(17), 5748-5751 (2012-08-11) Sulforaphane induced adipolysis via hormone sensitive lipase activation, regulated by AMPK signaling pathway.Ju-Hee Lee et al.Biochemical and biophysical research communications, 426(4), 492-497 (2012-09-18) Enzymatic determination of total serum cholesterol.C C Allain et al.Clinical chemistry, 20(4), 470-475 (1974-04-01) Ezetimibe markedly attenuates hepatic cholesterol accumulation and improves liver function in the lysosomal acid lipase-deficient mouse, a model for cholesteryl ester storage disease.Jen-Chieh Chuang et al.Biochemical and biophysical research communications, 443(3), 1073-1077 (2013-12-29) Cloning, phylogenetic analysis and 3D modeling of a putative lysosomal acid lipase from the camel, Camelus dromedarius.Farid Shokry Ataya Molecules (Basel, Switzerland), 17(9), 10399-10413 (2012-09-01) Alternate substrate inhibition of cholesterol esterase by thieno[2,3-d][1,3]oxazin-4-ones.Markus Pietsch et al.The Journal of biological chemistry, 277(27), 24006-24013 (2002-04-18) ω-Phthalimidoalkyl Aryl Ureas as Potent and Selective Inhibitors of Cholesterol Esterase.Florian M Dato et al.ChemMedChem, 13(17), 1833-1847 (2018-07-14) Cooperation between hepatic cholesteryl ester hydrolase and scavenger receptor BI for hydrolysis of HDL-CE.Quan Yuan et al.Journal of lipid research, 54(11), 3078-3084 (2013-08-31) Enzymatic quantification of cholesterol and cholesterol esters from silicone hydrogel contact lenses.Pucker AD, et al. Investigative Ophthalmology & Visual Science, 51(6), 2949-2954 (2010) Esterified and total 7 alpha-hydroxycholesterol in human serum as an indicator for hepatic bile acid synthesis.H Oda et al.Journal of lipid research, 31(12), 2209-2218 (1990-12-01) Studies on sterol-ester hydrolase from Fusarium oxysporum. I. Partial purification and properties.Y Okawa et al.Journal of biochemistry, 81(5), 1209-1215 (1977-05-01) Therapy for lysosomal acid lipase deficiency: replacing a missing link.Gregory Grabowski Hepatology (Baltimore, Md.), 58(3), 850-852 (2013-03-09) Cholesterol transport function of pancreatic cholesterol esterase: directed sterol uptake and esterification in enterocytes.A Lopez-Candales et al.Biochemistry, 32(45), 12085-12089 (1993-11-16) Clinical effect and safety profile of recombinant human lysosomal acid lipase in patients with cholesteryl ester storage disease.Manisha Balwani et al.Hepatology (Baltimore, Md.), 58(3), 950-957 (2013-01-26) Exome sequencing and directed clinical phenotyping diagnose cholesterol ester storage disease presenting as autosomal recessive hypercholesterolemia.Nathan O Stitziel et al.Arteriosclerosis, thrombosis, and vascular biology, 33(12), 2909-2914 (2013-09-28) Absence of cumulus cells during in vitro maturation affects lipid metabolism in bovine oocytes.Sylvain Auclair et al.American journal of physiology. Endocrinology and metabolism, 304(6), E599-E613 (2013-01-17) Effects of lipoic acid on lipolysis in 3T3-L1 adipocytes.Marta Fernández-Galilea et al.Journal of lipid research, 53(11), 2296-2306 (2012-09-04) Weight loss and regain in obese individuals: a link with adipose tissue metabolism indices?P Mauriège et al.Journal of physiology and biochemistry, 69(3), 497-505 (2013-01-29) Cholesteryl ester accumulation and accelerated cholesterol absorption in intestine-specific hormone sensitive lipase-null mice.Sascha Obrowsky et al.Biochimica et biophysica acta, 1821(11), 1406-1414 (2012-07-31) Fas activates lipolysis in a Ca2+-CaMKII-dependent manner in 3T3-L1 adipocytes.Reto A Rapold et al.Journal of lipid research, 54(1), 63-70 (2012-10-24) Adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL) deficiencies affect expression of lipolytic activities in mouse adipose tissues.Maria Morak et al.Molecular & cellular proteomics : MCP, 11(12), 1777-1789 (2012-09-18) Mechanisms of action of hormone-sensitive lipase in mouse Leydig cells: its role in the regulation of the steroidogenic acute regulatory protein.Pulak R Manna et al.The Journal of biological chemistry, 288(12), 8505-8518 (2013-01-31) Frequency of the cholesteryl ester storage disease common LIPA E8SJM mutation (c.894G>A) in various racial and ethnic groups.Stuart A Scott et al.Hepatology (Baltimore, Md.), 58(3), 958-965 (2013-02-21) Inhibition of stearoyl-CoA desaturase 1 reduces lipogenesis in primary bovine adipocytes.A K G Kadegowda et al.Lipids, 48(10), 967-976 (2013-08-10) MmPPOX inhibits Mycobacterium tuberculosis lipolytic enzymes belonging to the hormone-sensitive lipase family and alters mycobacterial growth.Vincent Delorme et al.PloS one, 7(9), e46493-e46493 (2012-10-03) Palmitoleic acid (n-7) increases white adipocyte lipolysis and lipase content in a PPARα-dependent manner.Andressa Bolsoni-Lopes et al.American journal of physiology. Endocrinology and metabolism, 305(9), E1093-E1102 (2013-09-12) Identification of triacylglycerol and steryl ester synthases of the methylotrophic yeast Pichia pastoris.Vasyl A Ivashov et al.Biochimica et biophysica acta, 1831(6), 1158-1166 (2013-03-26) Studies on the substrate and stereo/regioselectivity of adipose triglyceride lipase, hormone-sensitive lipase, and diacylglycerol-O-acyltransferases.Thomas O Eichmann et al.The Journal of biological chemistry, 287(49), 41446-41457 (2012-10-16) Cholesterol and phospholipids in frontal cortex and synaptosomes of suicide completers: relationship with endosomal lipid trafficking genes.Erika Freemantle et al.Journal of psychiatric research, 47(2), 272-279 (2012-11-21) Hepatic cholesteryl ester accumulation in lysosomal acid lipase deficiency: non-invasive identification and treatment monitoring by magnetic resonance.Peter E Thelwall et al.Journal of hepatology, 59(3), 543-549 (2013-04-30) Porcine pancreas: a superior source of cholesterol esterase for total serum cholesterol assay by the enzymatic kinetic method.Pornpen Srisawasdi et al.Journal of clinical laboratory analysis, 26(6), 420-430 (2012-11-13) Changes in glucose and carnitine levels and their transporters in utero-tubal junction in relation to sperm storage in the vespertilionid bat, Scotophilus heathi.Vikas Kumar Roy et al.Journal of experimental zoology. Part A, Ecological genetics and physiology, 319(9), 517-526 (2013-09-17) Carboxyl ester lipase: structure-function relationship and physiological role in lipoprotein metabolism and atherosclerosis.David Y Hui et al.Journal of lipid research, 43(12), 2017-2030 (2002-11-28) Enzyme-catalyzed hydrolysis of gamma-oryzanol.Miller A, et al. European Food Research and Technology, 218(4), 349-354 (2004) Cholesterol esterase enzyme inhibitory and antioxidant activities of leaves of Camellia sinensis (l) kuntze. using in vitro modelsKumar International Journal of Pharmaceutical Sciences and Research, 2(11), 2923-2928 (2011) Fat-reducing effects of dehydroepiandrosterone involve upregulation of ATGL and HSL expression, and stimulation of lipolysis in adipose tissue.Joanna Karbowska et al.Steroids, 77(13), 1359-1365 (2012-09-07) Artificial sweeteners stimulate adipogenesis and suppress lipolysis independently of sweet taste receptors.Becky R Simon et al.The Journal of biological chemistry, 288(45), 32475-32489 (2013-09-27) Active form Notch4 promotes the proliferation and differentiation of 3T3-L1 preadipocytes.Peng-Yeh Lai et al.Biochemical and biophysical research communications, 430(3), 1132-1139 (2012-12-15) Extramitochondrial OPA1 and adrenocortical function.László Fülöp et al.Molecular and cellular endocrinology, 381(1-2), 70-79 (2013-08-03) A functional polymer designed for bone tissue engineering.You Z, et al. Acta Biomaterialia, 8(2), 502-510 (2012) Hydrolytic and oxidative degradation of electrospun supramolecular biomaterials: In vitro degradation pathways.M C P Brugmans et al.Acta biomaterialia, 27, 21-31 (2015-09-01) The immunosuppressive agents rapamycin, cyclosporin A and tacrolimus increase lipolysis, inhibit lipid storage and alter expression of genes involved in lipid metabolism in human adipose tissue.Maria J Pereira et al.Molecular and cellular endocrinology, 365(2), 260-269 (2012-11-20) A simple method for the determination of the cholesterol esterase activity.Agnieszka Ewa Stępień et al.Acta biochimica Polonica, 60(3), 401-403 (2013-09-21) Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance.Chong Wee Liew et al.Nature medicine, 19(2), 217-226 (2013-01-08) The glucagon-like peptide-1 receptor agonist Exendin 4 has a protective role in ischemic injury of lean and steatotic liver by inhibiting cell death and stimulating lipolysis.Nitika A Gupta et al.The American journal of pathology, 181(5), 1693-1701 (2012-09-11) Modest hypoxia significantly reduces triglyceride content and lipid droplet size in 3T3-L1 adipocytes.Takeshi Hashimoto et al.Biochemical and biophysical research communications, 440(1), 43-49 (2013-09-18) Dietary capsaicin prevents nonalcoholic fatty liver disease through transient receptor potential vanilloid 1-mediated peroxisome proliferator-activated receptor δ activation.Qiang Li et al.Pflugers Archiv : European journal of physiology, 465(9), 1303-1316 (2013-04-23) Structural and functional analyses of a bacterial homologue of hormone-sensitive lipase from a metagenomic library.Tri Duc Ngo et al.Acta crystallographica. Section D, Biological crystallography, 69(Pt 9), 1726-1737 (2013-09-04) Cholesterol esterification as a mediator of proliferation of vascular smooth muscle cells and peripheral blood mononuclear cells during atherogenesis.Maria Franca Mulas et al.Journal of vascular research, 51(1), 14-26 (2013-11-28) Enzymatic quantification of cholesterol and cholesterol esters from silicone hydrogel contact lenses.Andrew D Pucker et al.Investigative ophthalmology & visual science, 51(6), 2949-2954 (2010-01-22) [Wolman disease with novel mutation of LIPA gene in a Chinese infant].Yong-lan Huang et al.Zhonghua er ke za zhi = Chinese journal of pediatrics, 50(8), 601-605 (2012-11-20) Endurance exercise training up-regulates lipolytic proteins and reduces triglyceride content in skeletal muscle of obese subjects.Katie Louche et al.The Journal of clinical endocrinology and metabolism, 98(12), 4863-4871 (2013-11-02) FoxO1 controls lysosomal acid lipase in adipocytes: implication of lipophagy during nutrient restriction and metformin treatment.D Lettieri Barbato et al.Cell death & disease, 4, e861-e861 (2013-10-19) Cholesterol esterase bound to intestinal brush border membranes does not accelerate incorporation of micellar cholesterol into absorptive cells.Ikuo Ikeda et al.Bioscience, biotechnology, and biochemistry, 67(11), 2381-2387 (2003-12-04) Enzymatic synthesis and hydrolysis of cholesterol esters.G V Vahouny et al.Methods of biochemical analysis, 16, 219-272 (1968-01-01) Glucocorticoids antagonize tumor necrosis factor-α-stimulated lipolysis and resistance to the antilipolytic effect of insulin in human adipocytes.Mi-Jeong Lee et al.American journal of physiology. Endocrinology and metabolism, 303(9), E1126-E1133 (2012-09-06) An amperometric bienzymatic cholesterol biosensor based on functionalized graphene modified electrode and its electrocatalytic activity towards total cholesterol determination.Revanasiddappa Manjunatha et al.Talanta, 99, 302-309 (2012-09-13) Cholesteryl ester storage disease: a rare and possibly treatable cause of premature vascular disease and cirrhosis.Tim Reynolds Journal of clinical pathology, 66(11), 918-923 (2013-09-04) Structure of bovine pancreatic cholesterol esterase at 1.6 ?: novel structural features involved in lipase activation.Chen JCH, et al. Biochemistry, 37(15), 5107-5117 (1998) Macrophage-Driven Biomaterial Degradation Depends on Scaffold Microarchitecture.Tamar B Wissing et al.Frontiers in bioengineering and biotechnology, 7, 87-87 (2019-05-14) Bile salt-stimulated lipase plays an unexpected role in arthritis development in rodents.Susanne Lindquist et al.PloS one, 7(10), e47006-e47006 (2012-10-17) Single nucleotide polymorphisms within LIPA (Lysosomal Acid Lipase A) gene are associated with susceptibility to premature coronary artery disease. a replication in the genetic of atherosclerotic disease (GEA) Mexican study.Gilberto Vargas-Alarcón et al.PloS one, 8(9), e74703-e74703 (2013-09-27) Extended use of a selective inhibitor of acid lipase for the diagnosis of Wolman disease and cholesteryl ester storage disease.G Civallero et al.Gene, 539(1), 154-156 (2014-02-11) HSL-knockout mouse testis exhibits class B scavenger receptor upregulation and disrupted lipid raft microdomains.María Emilia Casado et al.Journal of lipid research, 53(12), 2586-2597 (2012-09-19) Injection of phosphatidylcholine and deoxycholic acid regulates gene expression of lipolysis-related factors, pro-inflammatory cytokines, and hormones on mouse fat tissue.Tae Joon Won et al.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 60, 263-268 (2013-08-06) Phloretin and phlorizin promote lipolysis and inhibit inflammation in mouse 3T3-L1 cells and in macrophage-adipocyte co-cultures.Wen-Chung Huang et al.Molecular nutrition & food research, 57(10), 1803-1813 (2013-06-19) Antiobesity activity of a sphingosine 1-phosphate analogue FTY720 observed in adipocytes and obese mouse model.Myung Hee Moon et al.Experimental & molecular medicine, 44(10), 603-614 (2012-08-04) Purification and properties of pancreatic juice cholesterol esterase.J Hyun et al.The Journal of biological chemistry, 244(7), 1937-1945 (1969-04-10)

Remarks