
4-[[[4-[(4-Bromo-2-fluorophenyl)amino]-6-methoxy-7-quinazolinyl]oxy]methyl]-1-piperidinecarboxylic acid tert-butyl ester | CAS:338992-20-4
4-[[[4-[(4-Bromo-2-fluorophenyl)amino]-6-methoxy-7-quinazolinyl]oxy]methyl]-1-piperidinecarboxylic acid tert-butyl ester
- Name:4-[[[4-[(4-Bromo-2-fluorophenyl)amino]-6-methoxy-7-quinazolinyl]oxy]methyl]-1-piperidinecarboxylic acid tert-butyl ester
- CAS:338992-20-4
- Synonyms:
- Molecular Formula:C26H30BrFN4O4
- Molecular Weight:561.44
- EINESC:
Description
Properties
Density | 1.385 |
---|
Safety
没有数据 | 没有数据 |
---|
SDS
Source | SDS/MSDS Samples |
---|---|
Matrix | View & Download |
Synthetic Route
Name | CAS |
---|
More
Articles
Peer-Reviewed Papers
Mixed gastric carcinomas show similar chromosomal aberrations in both their diffuse and glandular components.Carvalho B, et al. Analytical Cellular Pathology, 28(5-6), 283-294 (2006)
Fluorescence tomography of rapamycin-induced autophagy and cardioprotection in vivo.Howard H Chen et al.Circulation. Cardiovascular imaging, 6(3), 441-447 (2013-03-30)
Over-expression of an inactive mutant cathepsin D increases endogenous alpha-synuclein and cathepsin B activity in SH-SY5Y cells.Donna Crabtree et al.Journal of neurochemistry, 128(6), 950-961 (2013-10-22)
Scavenger Receptor A Mediates the Clearance and Immunological Screening of MDA-Modified Antigen by M2-Type MacrophagesWarnecke A, et al. Neuromolecular Medicine, 19(4), 463-479 (2017)
[Mitochondrial and lysosomal pathways of death of hepatocytes of lamprey Lampetra fluviatilis L].S A Konovalova et al.Zhurnal evoliutsionnoi biokhimii i fiziologii, 48(6), 557-561 (2013-02-14)
Molecular cloning and characterization of a cathepsin B gene from the Chinese shrimp Fenneropenaeus chinensis.Xupeng Li et al.Fish & shellfish immunology, 35(5), 1604-1612 (2013-09-18)
Quantitative proteomic study identified cathepsin B associated with doxorubicin-induced damage in H9c2 cardiomyocytes.G Y Bao et al.Bioscience trends, 6(6), 283-287 (2013-01-23)
Cathepsin B & L are not required for ebola virus replication.Andrea Marzi et al.PLoS neglected tropical diseases, 6(12), e1923-e1923 (2012-12-14)
SORLA-dependent and -independent functions for PACS1 in control of amyloidogenic processes.Tilman Burgert et al.Molecular and cellular biology, 33(21), 4308-4320 (2013-09-05)
Mitochondrial reactive oxygen species induces NLRP3-dependent lysosomal damage and inflammasome activation.Michelle E Heid et al.Journal of immunology (Baltimore, Md. : 1950), 191(10), 5230-5238 (2013-10-04)
Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease.Sarah Mueller-Steiner et al.Neuron, 51(6), 703-714 (2006-09-20)
Prognostic value of erythrocyte sedimentation rate and C-reactive protein in the blood of patients with glioma.Tadej Strojnik et al.Anticancer research, 34(1), 339-347 (2014-01-10)
Cathepsin B inhibition limits bone metastasis in breast cancer.Nimali P Withana et al.Cancer research, 72(5), 1199-1209 (2012-01-24)
Identification of pathogenic T cell epitopes near cathepsin cleavage sites in thyroglobulin.Panayota Kolypetri et al.Journal of immunology (Baltimore, Md. : 1950), 190(4), 1466-1471 (2013-01-15)
Proteolysis and cathepsin activities in the processing of dry-cured duck.D Y Wang et al.Poultry science, 93(3), 687-694 (2014-03-08)
Wild type and mutant amyloid precursor proteins influence downstream effects of proteasome and autophagy inhibition.Valentina Cecarini et al.Biochimica et biophysica acta, 1842(2), 127-134 (2013-11-13)
Cysteine cathepsins are not critical for TRAIL- and CD95-induced apoptosis in several human cancer cell lines.Aleš Špes et al.Biological chemistry, 393(12), 1417-1431 (2013-05-15)
Autophagic-lysosomal pathway is the main proteolytic system modified in the skeletal muscle of esophageal cancer patients.Nicolas Tardif et al.The American journal of clinical nutrition, 98(6), 1485-1492 (2013-10-11)
Abundance of MMPs and cysteine cathepsins in caries-affected dentin.C M P Vidal et al.Journal of dental research, 93(3), 269-274 (2013-12-21)
Cathepsin B and cystatin B in HIV-seropositive women are associated with infection and HIV-1-associated neurocognitive disorders.Yisel Cantres-Rosario et al.AIDS (London, England), 27(3), 347-356 (2013-01-08)
Multiple cell death pathways are independently activated by lethal hypertonicity in renal epithelial cells.Soo Youn Choi et al.American journal of physiology. Cell physiology, 305(10), C1011-C1020 (2013-08-30)
Patulin induces pro-survival functions via autophagy inhibition and p62 accumulation.X Guo et al.Cell death & disease, 4, e822-e822 (2013-10-05)
Active center differences between cathepsins L and B: the S1 binding region.H Kirschke et al.FEBS letters, 228(1), 128-130 (1988-02-08)
Residue-specific annotation of disorder-to-order transition and cathepsin inhibition of a propeptide-like crammer from D. melanogaster.Tien-Sheng Tseng et al.PloS one, 8(1), e54187-e54187 (2013-01-26)
The cathepsin B inhibitor, z-FA-CMK is toxic and readily induced cell death in human T lymphocytes.K Y Liow et al.Toxicology and applied pharmacology, 272(3), 559-567 (2013-08-13)
Cathepsin B activity has a crucial role in the developmental competence of bovine cumulus-oocyte complexes exposed to heat shock during in vitro maturation.A Z Balboula et al.Reproduction (Cambridge, England), 146(4), 407-417 (2013-07-31)
uPAR and cathepsin B shRNA impedes TGF-β1-driven proliferation and invasion of meningioma cells in a XIAP-dependent pathway.V R Gogineni et al.Cell death & disease, 3, e439-e439 (2012-12-12)
Peroxisome proliferator-activated receptor-γ agonist 15d-prostaglandin J2 mediates neuronal autophagy after cerebral ischemia-reperfusion injury.Feng Xu et al.PloS one, 8(1), e55080-e55080 (2013-02-02)
Differential transcytosis and toxicity of the hNGAL receptor ligands cadmium-metallothionein and cadmium-phytochelatin in colon-like Caco-2 cells: implications for in vivo cadmium toxicity.Christian Langelueddecke et al.Toxicology letters, 226(2), 228-235 (2014-02-13)
Cathepsins B, H, L and cysteine protease inhibitors in malignant prostate cell lines, primary cultured prostatic cells and prostatic tissueFriedrich B, et al. European Journal of Cancer, 35(1), 138-144 (1999)
NLRP3 inflammasome activation in murine alveolar macrophages and related lung pathology is associated with MWCNT nickel contamination.Raymond F Hamilton et al.Inhalation toxicology, 24(14), 995-1008 (2012-12-12)
Non-canonical maturation of two papain-family proteases in Toxoplasma gondii.Zhicheng Dou et al.The Journal of biological chemistry, 288(5), 3523-3534 (2012-12-20)
Biochemistry. How to solve protein structures with an X-ray laser.John R Helliwell Science (New York, N.Y.), 339(6116), 146-147 (2013-01-12)
Cathepsin B-Cleavable Cyclopeptidic Chemotherapeutic Prodrugs.Viktorija Herceg et al.Molecules (Basel, Switzerland), 25(18) (2020-09-24)
Nicotinamide inhibits the lysosomal cathepsin b-like protease and kills African trypanosomes.Juan D Unciti-Broceta et al.The Journal of biological chemistry, 288(15), 10548-10557 (2013-02-28)
Anticancer effects of Ac‑Phe‑Lys‑PABC‑doxorubicin via mitochondria‑centered apoptosis involving reactive oxidative stress and the ERK1/2 signaling pathway in MGC‑803 cells.Yan-Jun Zhong et al.Oncology reports, 30(4), 1681-1686 (2013-07-24)
Ebola virus exploits a monocyte differentiation program to promote its entry.Osvaldo Martinez et al.Journal of virology, 87(7), 3801-3814 (2013-01-25)
Differential pathways for interleukin-1β production activated by chromogranin A and amyloid β in microglia.Zhou Wu et al.Neurobiology of aging, 34(12), 2715-2725 (2013-07-09)
4-tert-Octylphenol stimulates the expression of cathepsins in human breast cancer cells and xenografted breast tumors of a mouse model via an estrogen receptor-mediated signaling pathway.Hye-Rim Lee et al.Toxicology, 304, 13-20 (2012-12-12)
Cathepsin C is a tissue-specific regulator of squamous carcinogenesis.Brian Ruffell et al.Genes & development, 27(19), 2086-2098 (2013-09-26)
Tooth bleaching increases dentinal protease activity.C Sato et al.Journal of dental research, 92(2), 187-192 (2012-12-18)
Potent inhibition of feline coronaviruses with peptidyl compounds targeting coronavirus 3C-like protease.Yunjeong Kim et al.Antiviral research, 97(2), 161-168 (2012-12-12)
Acetate-induced apoptosis in colorectal carcinoma cells involves lysosomal membrane permeabilization and cathepsin D release.C Marques et al.Cell death & disease, 4, e507-e507 (2013-02-23)
Dissociation of ionizing groups in the binding cleft inversely controls the endo- and exopeptidase activities of cathepsin B.L Polgár et al.The Journal of biological chemistry, 262(30), 14448-14453 (1987-10-25)
MicroRNA 218 acts as a tumor suppressor by targeting multiple cancer phenotype-associated genes in medulloblastoma.Sujatha Venkataraman et al.The Journal of biological chemistry, 288(3), 1918-1928 (2012-12-06)
Cathepsin B and uPAR regulate self-renewal of glioma-initiating cells through GLI-regulated Sox2 and Bmi1 expression.Sreelatha Gopinath et al.Carcinogenesis, 34(3), 550-559 (2012-12-12)
Expression and characterization of cathepsin B from tsetse (Glossina morsitans morsitans).Ngasaman Ruttayaporn et al.The Japanese journal of veterinary research, 61(4), 137-147 (2014-01-11)
Degradation of fructose-1,6-bisphosphate aldolase by cathepsin B.J S Bond et al.The Biochemical journal, 189(1), 17-25 (1980-07-01)
Inflammasome activation by altered proteostasis.Jin Na Shin et al.The Journal of biological chemistry, 288(50), 35886-35895 (2013-11-02)
V-ATPase inhibition by archazolid leads to lysosomal dysfunction resulting in impaired cathepsin B activation in vivo.Rebekka Kubisch et al.International journal of cancer, 134(10), 2478-2488 (2013-10-30)
Development of new cathepsin B inhibitors: combining bioisosteric replacements and structure-based design to explore the structure-activity relationships of nitroxoline derivatives.Izidor Sosič et al.Journal of medicinal chemistry, 56(2), 521-533 (2012-12-21)
Impairment of autophagic flux promotes glucose reperfusion-induced neuro2A cell death after glucose deprivation.Bong Geom Jang et al.PloS one, 8(10), e76466-e76466 (2013-10-15)
C1q-tumour necrosis factor-related protein 8 (CTRP8) is a novel interaction partner of relaxin receptor RXFP1 in human brain cancer cells.Aleksandra Glogowska et al.The Journal of pathology, 231(4), 466-479 (2013-09-10)
Preparation and evaluation of a new releasable PEGylated tumor necrosis factor-α (TNF-α) conjugate for therapeutic application.ChuanYun Dai et al.Science China. Life sciences, 56(1), 51-58 (2013-01-15)
Erythropoietin-directed erythropoiesis depends on serpin inhibition of erythroblast lysosomal cathepsins.Arvind Dev et al.The Journal of experimental medicine, 210(2), 225-232 (2013-01-16)
Cathepsin B contributes to autophagy-related 7 (Atg7)-induced nod-like receptor 3 (NLRP3)-dependent proinflammatory response and aggravates lipotoxicity in rat insulinoma cell line.Shali Li et al.The Journal of biological chemistry, 288(42), 30094-30104 (2013-08-30)
Novel off-target effect of tamoxifen--inhibition of acid ceramidase activity in cancer cells.Samy A F Morad et al.Biochimica et biophysica acta, 1831(12), 1657-1664 (2013-08-14)
Three-dimensional cultures modeling premalignant progression of human breast epithelial cells: role of cysteine cathepsins.Stefanie R Mullins et al.Biological chemistry, 393(12), 1405-1416 (2013-05-15)
Cathepsin B degradable star-shaped peptidic macromolecules for delivery of 2-methoxyestradiol.Ravi Shankar et al.Molecular pharmaceutics, 10(10), 3776-3788 (2013-08-27)
Remarks
Products protected by valid patents are not offered for sale in countries where the sale of such products constitutes a patent infringement and its liability is at buyer's risk.
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271 +A13(1).
Name | CAS |
---|

Related Products
Related News
Question
Hot Tags
Inquiry
Fill in related informations ;please!
- Please fill in product name !
- CAS
- Please fill in your company information correctly!
- Please fill in liaison information correctly!
- Please fill in your telephone number correctly!
- Please fill in your email correctly!
- Please describe the problem of products!