Melting point	58-61 ºC

Symbol(GHS)	Xi
Hazard Codes	R36/37/38
SDS/MSDS	S26;S36

Source	SDS/MSDS Samples
Alfa-Aesar	View & Download
Sigma-Aldrich	View & Download
TCI	View & Download

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Articles

Peer-Reviewed Papers

Alpha-phenyl-N-tert-butylnitrone prevents oxidative stress in a haloperidol-induced animal model of tardive dyskinesia: investigating the behavioural and biochemical changes.Ritesh P Daya et al.Brain research, 1412, 28-36 (2011-08-06) Proteome expression and carbonylation changes during Trypanosoma cruzi infection and Chagas disease in rats.Jian-Jun Wen et al.Molecular & cellular proteomics : MCP, 11(4), M111-M111 (2011-12-27) Modulation of ethoxyquin genotoxicity by free radical scavengers and DNA damage repair in human lymphocytes.Janusz J Skolimowski et al.Toxicology letters, 193(2), 194-199 (2010-01-23) Decreased brainstem function following cardiac arrest and resuscitation in aged rat.Kui Xu et al.Brain research, 1328, 181-189 (2010-03-10) Systematic and Molecular Basis of the Antibacterial Action of Quinoxaline 1,4-Di-N-Oxides against Escherichia coli.Guyue Cheng et al.PloS one, 10(8), e0136450-e0136450 (2015-08-22) Reactive oxygen species-mediated cellular genotoxic stress is involved in 1-nitropyrene-induced trophoblast cycle arrest and fetal growth restriction.Bo Wang et al.Environmental pollution (Barking, Essex : 1987), 260, 113984-113984 (2020-02-12) Induction of neurite outgrowth by alpha-phenyl-N-tert-butylnitrone through nitric oxide release and Ras-ERK pathway in PC12 cells.Hironobu Yasui et al.Free radical research, 44(6), 645-654 (2010-04-08) Alpha-phenyl-N-tert-butylnitrone (PBN) prevents light-induced degeneration of the retina by inhibiting RPE65 protein isomerohydrolase activity.Md Nawajes A Mandal et al.The Journal of biological chemistry, 286(37), 32491-32501 (2011-07-26) microRNA-34a-mediated down-regulation of the microglial-enriched triggering receptor and phagocytosis-sensor TREM2 in age-related macular degenerationBhattacharjee S, et al. Testing, 11(3), e0150211-e0150211 (2016) A mouse model of peripheral postischemic dysesthesia: involvement of reperfusion-induced oxidative stress and TRPA1 channel.Atsushi Sasaki et al.The Journal of pharmacology and experimental therapeutics, 351(3), 568-575 (2014-09-18) Na-K-Cl cotransporter-1 in the mechanism of cell swelling in cultured astrocytes after fluid percussion injury.Arumugam R Jayakumar et al.Journal of neurochemistry, 117(3), 437-448 (2011-02-11) Cadmium-induced teratogenicity: association with ROS-mediated endoplasmic reticulum stress in placenta.Zhen Wang et al.Toxicology and applied pharmacology, 259(2), 236-247 (2012-01-19) Inhibition of ROS-induced apoptosis in endothelial cells by nitrone spin traps via induction of phase II enzymes and suppression of mitochondria-dependent pro-apoptotic signaling.Amlan Das et al.Biochemical pharmacology, 84(4), 486-497 (2012-05-15) Exercise-induced lipid peroxidation: Implications for deoxyribonucleic acid damage and systemic free radical generation.Mark C Fogarty et al.Environmental and molecular mutagenesis, 52(1), 35-42 (2010-09-15) PBN fails to suppress in delayed neuronal death of hippocampal CA1 injury following transient forebrain ischemia in gerbils.Wael Goda et al.Neuroscience letters, 517(1), 47-51 (2012-04-24) The role of Nav1.7 and methylglyoxal-mediated activation of TRPA1 in itch and hypoalgesia in a murine model of type 1 diabetes.Ruo-Xiao Cheng et al.Theranostics, 9(15), 4287-4307 (2019-07-10) A Free Radical Scavenger Ameliorates Teratogenic Activity of a DNA Hypomethylating Hematological Therapeutic.Nikola Sobočan et al.Stem cells and development, 28(11), 717-733 (2019-01-24) A role for glutathione, independent of oxidative stress, in the developmental toxicity of methanol.Michelle T Siu et al.Toxicology and applied pharmacology, 273(3), 508-515 (2013-10-08) Hydroxychloroquine-inhibited dengue virus is associated with host defense machinery.Li-Fong Wang et al.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 35(3), 143-156 (2014-10-17) Up-regulation of NF-kB-sensitive miRNA-125b and miRNA-146a in metal sulfate-stressed human astroglial (HAG) primary cell cultures.Aileen I Pogue et al.Journal of inorganic biochemistry, 105(11), 1434-1437 (2011-11-22) The effect of normoxia and hypoxia on a prostate (PC-3) CD44/CD41 cell side fraction.K M Anderson et al.Anticancer research, 31(2), 487-494 (2011-03-08) Structural and functional changes in proteins induced by free radical-mediated oxidative stress and protective action of the antioxidants N-tert-butyl-alpha-phenylnitrone and vitamin E.D A Butterfield et al.Annals of the New York Academy of Sciences, 854, 448-462 (1999-02-03) Nitrone-based therapeutics for neurodegenerative diseases: their use alone or in combination with lanthionines.Robert A Floyd et al.Free radical biology & medicine, 62, 145-156 (2013-02-20) Genome-wide mapping of 8-oxo-7, 8-dihydro-2?-deoxyguanosine reveals accumulation of oxidatively-generated damage at DNA replication origins within transcribed long genes of mammalian cellsAmente S, et al. Nucleic Acids Research, 47(1), 221-236 (2018) Progression of genotype-specific oral cancer leads to senescence of cancer-associated fibroblasts and is mediated by oxidative stress and TGF-betaHassona Y, et al. Carcinogenesis, 34(6), 1286-1295 (2013) Reactive oxygen species contribute to neuropathic pain by reducing spinal GABA release.June Yowtak et al.Pain, 152(4), 844-852 (2011-02-08) Anti-cancer activity of nitrones and observations on mechanism of action.Robert A Floyd et al.Anti-cancer agents in medicinal chemistry, 11(4), 373-379 (2011-06-10) Global inhibition of reactive oxygen species (ROS) inhibits paclitaxel-induced painful peripheral neuropathy.Mehmet Fidanboylu et al.PloS one, 6(9), e25212-e25212 (2011-10-04) Complement component 3 inhibition by an antioxidant is neuroprotective after cerebral ischemia and reperfusion in mice.Jiwon Yang et al.Journal of neurochemistry, 124(4), 523-535 (2012-12-04) Using cyclodextrins to encapsulate oxygen-centered and carbon-centered radical adducts: the case of DMPO, PBN, and MNP spin traps.Mariana Spulber et al.The journal of physical chemistry. A, 114(21), 6217-6225 (2010-05-14) Interleukin-1beta-induced brain injury and neurobehavioral dysfunctions in juvenile rats can be attenuated by alpha-phenyl-n-tert-butyl-nitrone.L W Fan et al.Neuroscience, 168(1), 240-252 (2010-03-30) Genome-wide mapping of 8-oxo-7,8-dihydro-2'-deoxyguanosine reveals accumulation of oxidatively-generated damage at DNA replication origins within transcribed long genes of mammalian cells.Stefano Amente et al.Nucleic acids research, 47(1), 221-236 (2018-11-22) Synthesis of tris-hydroxymethyl-based nitrone derivatives with highly reactive nitronyl carbon.Fanny Choteau et al.The Journal of organic chemistry, 77(2), 938-948 (2011-12-23) Phenyl-alpha-tert-butyl-nitrone and benzonidazole treatment controlled the mitochondrial oxidative stress and evolution of cardiomyopathy in chronic chagasic Rats.Jian-Jun Wen et al.Journal of the American College of Cardiology, 55(22), 2499-2508 (2010-06-01) Determining radical penetration into membranes using ESR splitting constants.Efrat Bodner et al.Free radical biology & medicine, 49(3), 427-436 (2010-05-07) 2-Benzazepine nitrones protect dopaminergic neurons against 6-hydroxydopamine-induced oxidative toxicity.Ramón Soto-Otero et al.Archiv der Pharmazie, 345(8), 598-609 (2012-04-26) Cytotoxicity of dihydroartemisinin toward Molt-4 cells attenuated by N-tert-butyl-alpha-phenylnitrone and deferoxamine.Ho Wing Chan et al.Anticancer research, 33(10), 4389-4393 (2013-10-15) Reactive oxygen species (ROS) modulate AMPA receptor phosphorylation and cell-surface localization in concert with pain-related behavior.Daniel Z Lee et al.Pain, 153(9), 1905-1915 (2012-07-10) Cholesterol-based α-phenyl-N-tert-butyl nitrone derivatives as antioxidants against light-induced retinal degeneration.Fanny Choteau et al.Bioorganic & medicinal chemistry letters, 20(24), 7405-7409 (2010-11-13)

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