Melting point	34-35 ºC
Water Solubility	sparingly soluble
Flash point	33 ºC
Density	1.349
Refractive index	1.5905

Symbol(GHS)	F;Xn
Hazard Codes	R11;R68
SDS/MSDS	S16;S36/37

Source	SDS/MSDS Samples
Alfa-Aesar	View & Download
Sigma-Aldrich	View & Download
TCI	View & Download

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Articles

Peer-Reviewed Papers

Specificity of intersubunit general anesthetic-binding sites in the transmembrane domain of the human α1β3γ2 γ-aminobutyric acid type A (GABAA) receptor.David C Chiara et al.The Journal of biological chemistry, 288(27), 19343-19357 (2013-05-17) In situ IRRAS studies of molecular recognition of barbituric acid lipids to melamine at the air-water interface.Xianming Kong et al.The journal of physical chemistry. B, 115(45), 13191-13198 (2011-10-14) State-dependent plasticity of the corticostriatal pathway.C R Stoetzner et al.Neuroscience, 165(4), 1013-1018 (2009-11-26) Acute encephalitis with refractory, repetitive partial seizures (AERRPS): a peculiar form of childhood encephalitis.H Sakuma et al.Acta neurologica Scandinavica, 121(4), 251-256 (2009-12-24) (13)C hyperpolarization of a barbituric acid derivative via parahydrogen induced polarization.Meike Roth et al.Journal of magnetic resonance (San Diego, Calif. : 1997), 204(1), 50-55 (2010-03-09) Specificity of intersubunit general anesthetic-binding sites in the transmembrane domain of the human α1β3γ2 γ-aminobutyric acid type A (GABAA) receptor.David C Chiara et al.The Journal of biological chemistry, 288(27), 19343-19357 (2013-05-17) Synthesis of 5-alkylated barbituric acids and 3-alkylated indoles via microwave-assisted three-component reactions in solvent-free conditions using Hantzsch 1,4-dihydropyridines as reducing agents.Biswajita Baruah et al.Molecular diversity, 16(2), 291-298 (2012-02-03) Inhibitory effects of 5-benzylidene barbiturate derivatives on mushroom tyrosinase and their antibacterial activities.Qin Yan et al.European journal of medicinal chemistry, 44(10), 4235-4243 (2009-06-26) Lewis acid-catalyzed intramolecular [3+2] cycloaddition of cyclopropane 1,1-diesters with alkynes for the synthesis of cyclopenta[c]chromene skeletons.Xiao-Feng Xia et al.Chemistry, an Asian journal, 7(7), 1538-1541 (2012-04-11) Self-assembly of supramolecular fullerene ribbons via hydrogen-bonding interactions and their impact on fullerene electronic interactions and charge carrier mobility.Cheng-Che Chu et al.Journal of the American Chemical Society, 132(36), 12717-12723 (2010-08-25) Initial observations of combination barbiturate coma and decompressive craniectomy for the management of severe pediatric traumatic brain injury.Roberta P Glick et al.Pediatric neurosurgery, 47(2), 152-157 (2011-09-22) Barbiturate ingestion in three adult captive tigers (Panthera tigris) and concomitant fatal botulism of one.J H Williams et al.Journal of the South African Veterinary Association, 82(4), 244-249 (2012-05-24) The laccase-catalyzed domino reaction between catechols and heterocyclic 1,3-dicarbonyls and the unambiguous structure elucidation of the products by NMR spectroscopy and X-ray crystal structure analysis.Szilvia Hajdok et al.The Journal of organic chemistry, 74(19), 7230-7237 (2009-09-11) Endoplasmic Reticulum Is Involved in Myocardial Injury in a Miniature Swine Model of Coronary Artery Stenosis Exposed to Acceleration-Associated Stress.Haitao Zhang et al.PloS one, 10(7), e0132654-e0132654 (2015-07-15) Inhibitory effects of 5-benzylidene barbiturate derivatives on mushroom tyrosinase and their antibacterial activities.Qin Yan et al.European journal of medicinal chemistry, 44(10), 4235-4243 (2009-06-26) Lewis acid-catalyzed intramolecular [3+2] cycloaddition of cyclopropane 1,1-diesters with alkynes for the synthesis of cyclopenta[c]chromene skeletons.Xiao-Feng Xia et al.Chemistry, an Asian journal, 7(7), 1538-1541 (2012-04-11) Preparation of 5-diaminomethylenebarbiturates by barbituric acid addition to carbodiimides.Jursic BS et al. Tetrahedron, 59(19), 3427-3432 (2003) (13)C hyperpolarization of a barbituric acid derivative via parahydrogen induced polarization.Meike Roth et al.Journal of magnetic resonance (San Diego, Calif. : 1997), 204(1), 50-55 (2010-03-09) A novel agonist of PPAR-γ based on barbituric acid alleviates the development of non-alcoholic fatty liver disease by regulating adipocytokine expression and preventing insulin resistance.Hao Zheng et al.European journal of pharmacology, 659(2-3), 244-251 (2011-04-06) Is there new hope for therapeutic matrix metalloproteinase inhibition?Roosmarijn E Vandenbroucke et al.Nature reviews. Drug discovery, 13(12), 904-927 (2014-11-08) Synthesis of highly functionalized barbituric acids and study of their interactions with p-glycoprotein and Mg2+--potential candidates for multi drug resistance modulation.Palwinder Singh et al.European journal of medicinal chemistry, 45(3), 1256-1262 (2010-01-08) Selective reduction of barbituric acids using SmI2/H2O: synthesis, reactivity, and structural analysis of tetrahedral adducts.Michal Szostak et al.Angewandte Chemie (International ed. in English), 52(48), 12559-12563 (2013-10-15) Discovery of thiazolidine-2,4-dione/biphenylcarbonitrile hybrid as dual PPAR α/γ modulator with antidiabetic effect: in vitro, in silico and in vivo approaches.Sergio Hidalgo-Figueroa et al.Chemical biology & drug design, 81(4), 474-483 (2013-01-08) Identifying barbiturate binding sites in a nicotinic acetylcholine receptor with [3H]allyl m-trifluoromethyldiazirine mephobarbital, a photoreactive barbiturate.Ayman K Hamouda et al.Molecular pharmacology, 85(5), 735-746 (2014-02-25) A simple method for knoevenagel condensation of a, ?-conjugated and aromatic aldehydes with barbituric acid.Jursic BS. Journal of Heterocyclic Chemistry, 38(3), 655-657 (2001) Hydrogen-bond motifs in N-monosubstituted derivatives of barbituric acid: 5-allyl-5-isopropyl-1-methylbarbituric acid (enallylpropymal) and 1,5-di(but-2-enyl)-5-ethylbarbituric acid.Thomas Gelbrich et al.Acta crystallographica. Section C, Crystal structure communications, 66(Pt 1), o55-o58 (2010-01-06) Chromeno[2,3-d]pyrimidine-triones synthesis by a three-component coupling reaction.Ramin Ghahremanzadeh et al.Chemical & pharmaceutical bulletin, 58(4), 516-520 (2010-04-23) A novel fluorescence microscopy approach to estimate quality loss of stored fruit fillings as a result of browning.Janna Cropotova et al.Food chemistry, 194, 175-183 (2015-10-17) New one-pot synthesis of spiro[furo[2,3-d]pyrimidine-6,5'-pyrimidine]pentaones and their sulfur analogues.Mohammad Jalilzadeh et al.Molecular diversity, 15(3), 721-731 (2011-02-01) Hydrolytic pathway of 5-fluorouracil in aqueous solutions for clinical use.Rémi Legay et al.Journal of pharmaceutical and biomedical analysis, 98, 446-462 (2014-07-20) Single-Crystal X-ray Diffraction Structure of the Stable Enol Tautomer Polymorph of Barbituric Acid at 224 and 95 K.Madalynn G Marshall et al.Angewandte Chemie (International ed. in English), 55(4), 1309-1312 (2015-12-15) Photocatalytic reduction of CO2 by graphitic carbon nitride polymers derived from urea and barbituric acid. Qin J, et al. Applied Catalysis. B, Environmental, 179, 1-8 (2015) Correction for nonspecific binding to various components of ultrafiltration apparatus and impact on estimating in vivo rat clearance for a congeneric series of 5-ethyl, 5-n-alkyl barbituric acids.Peter Ballard et al.Drug metabolism and disposition: the biological fate of chemicals, 39(12), 2165-2168 (2011-09-02) Complementary hydrogen bonding of a carboxylato-barbiturate with urea and acetamide: experimental and theoretical approach.Md Amin Hasan et al.Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 83(1), 532-539 (2011-09-29) Epigenetic changes of the Klotho gene in age-related cataracts.S-L Jin et al.European review for medical and pharmacological sciences, 19(14), 2544-2553 (2015-07-30) The crystal structure of anhydrous barbituric acid. Bolton W. Acta Crystallographica, 16(3), 166-173 (1963) [The extended amygdala system and self-stimulation of the lateral hypothalamus in rats: modulation with opiates and opioids].P D Shabanov et al.Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 97(2), 180-188 (2011-05-24) Synthesis and biological activity of novel barbituric and thiobarbituric acid derivatives against non-alcoholic fatty liver disease.Liang Ma et al.European journal of medicinal chemistry, 46(6), 2003-2010 (2011-03-25) New insights into pharmacological profile of LASSBio-579, a multi-target N-phenylpiperazine derivative active on animal models of schizophrenia.Gilda Neves et al.Behavioural brain research, 237, 86-95 (2012-09-25) A review of our development of dental adhesives--effects of radical polymerization initiators and adhesive monomers on adhesion.Kunio Ikemura et al.Dental materials journal, 29(2), 109-121 (2010-04-10) Electrokinetic supercharging in CE for the separation and preconcentration of barbiturate drugs in urine samples.Igor Botello et al.Journal of separation science, 36(3), 524-531 (2013-01-11)

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