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5-Chloro-2-cyclopropyl-1,6-dihydro-6-oxo-4-pyrimidinecarboxylic acid | CAS:858956-26-0
5-Chloro-2-cyclopropyl-1,6-dihydro-6-oxo-4-pyrimidinecarboxylic acid
  • Name:5-Chloro-2-cyclopropyl-1,6-dihydro-6-oxo-4-pyrimidinecarboxylic acid
  • CAS:858956-26-0
  • Synonyms:
  • Molecular Formula:C8H7ClN2O3
  • Molecular Weight:214.61
  • EINESC:

Description

Properties

Density 1.86±0.1 g/cm3 (20 ºC

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SDS

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Peer-Reviewed Papers
Homocysteine and its thiolactone impair plasmin activity induced by urokinase or streptokinase in vitro.Joanna Kolodziejczyk-Czepas et al.International journal of biological macromolecules, 50(3), 754-758 (2011-12-27) Inhibition of the neuronal nitric oxide synthase potentiates homocysteine thiolactone-induced seizures in adult rats.Dragan Hrncić et al.Medicinal chemistry (Shariqah (United Arab Emirates)), 8(1), 59-64 (2012-03-17) Root-growth inhibition by DL-homocysteine thiolactone and its related compounds.Inamori Y, et al. Bioscience, Biotechnology, and Biochemistry, 59(3), 523-525 (1995) Aronia melanocarpa extract suppresses the biotoxicity of homocysteine and its metabolite on the hemostatic activity of fibrinogen and plasma.Joanna Malinowska et al.Nutrition (Burbank, Los Angeles County, Calif.), 28(7-8), 793-798 (2012-01-21) Chemical biology of homocysteine thiolactone and related metabolites.Hieronim Jakubowski et al.Advances in clinical chemistry, 55, 81-103 (2011-12-01) Changes of blood platelet adhesion to collagen and fibrinogen induced by homocysteine and its thiolactone.Joanna Malinowska et al.Clinical biochemistry, 45(15), 1225-1228 (2012-05-29) Effect of homocysteine thiolactone on structure and aggregation propensity of bovine pancreatic insulin.Shima Jalili et al.The protein journal, 30(5), 299-307 (2011-05-17) Homocysteine and its thiolactone-mediated modification of fibrinogen affect blood platelet adhesion.Joanna Malinowska et al.Platelets, 23(5), 409-412 (2011-10-21) Electrosprayed polyelectrolyte complexes between mucoadhesive N,N,N,-trimethylchitosan-homocysteine thiolactone and alginate/carrageenan for camptothecin delivery.Kotchakorn Juntapram et al.Carbohydrate polymers, 90(4), 1469-1479 (2012-09-05) Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine).O W Griffith et al.The Journal of biological chemistry, 254(16), 7558-7560 (1979-08-25) Biomolecules bearing the S- or SeAsMe2 function: amino acid and steroid derivatives.C H Banks et al.Journal of medicinal chemistry, 22(5), 572-575 (1979-05-01) The disturbance of hemostasis induced by hyperhomocysteinemia; the role of antioxidants.Joanna Malinowska et al.Acta biochimica Polonica, 59(2), 185-194 (2012-05-12) Comparison of the effect of homocysteine in the reduced form, its thiolactone and protein homocysteinylation on hemostatic properties of plasma.Joanna Malinowska et al.Thrombosis research, 127(3), 214-219 (2010-12-28) The polyphenol-rich extract from grape seeds suppresses toxicity of homocysteine and its thiolactone on the fibrinolytic system.Joanna Kołodziejczyk et al.Thrombosis research, 127(5), 489-491 (2011-01-22) Quality control in tRNA charging -- editing of homocysteine.Hieronim Jakubowski Acta biochimica Polonica, 58(2), 149-163 (2011-06-07) Anticonvulsive effect of folic acid in homocysteine thiolactone-induced seizures.Aleksandra Rašić Marković et al.Cellular and molecular neurobiology, 31(8), 1221-1228 (2011-06-23) An enzyme that synthesizes cystathionine and deaminates L-serine.A S SELIM et al.The Journal of biological chemistry, 234(6), 1474-1480 (1959-06-01) The enhancing effect of homocysteine thiolactone on insulin fibrillation and cytotoxicity of insulin fibril.Reza Yousefi et al.International journal of biological macromolecules, 51(3), 291-298 (2012-05-29) Metabolism and neurotoxicity of homocysteine thiolactone in mice: evidence for a protective role of paraoxonase 1.Kamila Borowczyk et al.Journal of Alzheimer's disease : JAD, 30(2), 225-231 (2012-03-13) Synthesis and in vitro antitumor effect of diclofenac and fenoprofen thiolated and nonthiolated polyaspartamide-drug conjugates.M Barbarić et al.European journal of medicinal chemistry, 42(1), 20-29 (2006-10-03) Effect of the combined use of γ-cyclodextrin and a chiral ionic liquid on the enantiomeric separation of homocysteine by capillary electrophoresis.Maider Greño et al.Journal of chromatography. A, 1568, 222-228 (2018-07-22) Paradoxical sleep deprivation potentiates epilepsy induced by homocysteine thiolactone in adult rats.Dragan Hrncić et al.Experimental biology and medicine (Maywood, N.J.), 238(1), 77-83 (2013-03-13) [L-[methyl-(11C)]-methionine of high enantiomeric purity production via on-line 11C-methylation of L-homocysteine thiolactone hydrochloride].N A Gomzina et al.Bioorganicheskaia khimiia, 37(2), 216-222 (2011-07-05) Analysis of site-specific N-homocysteinylation of human serum albumin in vitro and in vivo using MALDI-ToF and LC-MS/MS mass spectrometry.Lukasz Marczak et al.Journal of proteomics, 74(7), 967-974 (2011-02-19) Phenolic fractions from Trifolium pallidum and Trifolium scabrum aerial parts in human plasma protect against changes induced by hyperhomocysteinemia in vitro.Joanna Malinowska et al.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 50(11), 4023-4027 (2012-08-18) Water determination in active pharmaceutical ingredients using ionic liquid headspace gas chromatography and two different detection protocols.Lillian A Frink et al.Journal of pharmaceutical and biomedical analysis, 94, 111-117 (2014-02-25) The effect of N-methyl-D-aspartate receptor antagonists on D,L-homocysteine thiolactone induced seizures in adult rats.A Rašić-Marković et al.Acta physiologica Hungarica, 98(1), 17-26 (2011-03-11) 1,25-Dihydroxyvitamin D3 increases the methionine cycle, CD4+ T cell DNA methylation and Helios+Foxp3+ T regulatory cells to reverse autoimmune neurodegenerative disease.Jerott R Moore et al.Journal of neuroimmunology, 324, 100-114 (2018-09-30) Response of blood platelets to resveratrol during a model of hyperhomocysteinemia.Joanna Malinowska et al.Platelets, 22(4), 277-283 (2011-05-12) Paraoxonase 1 and homocysteine metabolism.Joanna Perła-Kaján et al.Amino acids, 43(4), 1405-1417 (2012-05-31) Metabolism and neurotoxicity of homocysteine thiolactone in mice: protective role of bleomycin hydrolase.Kamila Borowczyk et al.Amino acids, 43(3), 1339-1348 (2012-01-10) The effects of homocysteine-related compounds on cardiac contractility, coronary flow, and oxidative stress markers in isolated rat heart.Vladimir Zivkovic et al.Molecular and cellular biochemistry, 370(1-2), 59-67 (2012-07-24) Intravitreal homocysteine-thiolactone injection leads to the degeneration of multiple retinal cells, including photoreceptors.Han-Hsin Chang et al.Molecular vision, 17, 1946-1956 (2011-08-19)
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